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6573064 |
Method of screening anti-mycobacterial molecules
This invention relates to a novel mycobacterial protein named DES, which appears to share significant amino acid sequence homology with soluble stearoyl-ACP desaturases. The results of allelic...
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6573063 |
Methods and systems for assessing biological materials using optical and spectroscopic detection techniques
Optical detection techniques for the assessment of the physiological state, health and/or viability of biological materials are provided. Biological materials which may be examined using such...
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6573102 |
Lytic reagent composition for determination of nucleated blood cells
A lytic reagent composition for measuring nucleated blood cells in a blood sample is described. The lytic reagent composition contains a quaternary ammonium surfactant, an ethoxylated phenol, and...
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6569640 |
Method of fractionation of biologically-derived materials using critical fluids
Supercritical and near critical fluids are used to fractionate biomass materials such as microbial cells in two steps. In the first step, the biomass is exposed to elevated pressure supercritical...
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6566508 |
Fluorogenic compounds and uses therefor
Disclosed are novel coumarin based fluorogenic compounds useful in assaying for biological activity. Specifically, these fluorogenic compounds exhibit fluorescence at particular wavelengths when...
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6566089 |
Cell-based drug screens for regulators of gene expression
The invention provides methods and compositions for screening for pharmacological agents which regulate gene expression in mammals. An exemplary assay involves (a) contacting a mammalian cell...
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6566497 |
Nucleic acid encoding a family of acetyl-coenzyme-a transporter proteins, and products related thereto
In accordance with the present invention, there are provided isolated mammalian Acetyl-Coenzyme A Transporter (AT) proteins, anti-AT antibodies, therapeutic compositions, and nucleic acids encoding...
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6566062 |
Method for identifying a nucleic acid
A method for identifying a nucleic acid which codes for a polypeptide factor affecting the covalent bonding of polypeptides to the surface of Gram-positive bacteria, comprising the following steps:...
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6562595 |
Dominant selectable marker for gene transformation and disruption in yeasts
The present invention provides a novel dominant selectable marker system in yeast that is based on an aminoglycoside, nourseothricin (NST). This compound possesses a powerful antifungal activity...
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6562563 |
Compositions and mehtods for determining interactions of mitochondrial components, and for identifying agents that alter such interactions
Compositions and methods are provided for identifying agents that alter mitochondrial membrane permeability transition. The screening methods generally detect agents that alter the interaction...
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6558941 |
Delivering lipophilic substances into cells using nanoemulsions
Nanoemulsions are prepared containing oily droplets of a diameter of less than 100 nm in an aqueous phase. The oily droplets contain a lipophilic substance, and have on their surface an amphoteric...
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6555379 |
Device for monitoring a processing liquid
A device for monitoring a processing liquid comprising at least one sensor for generating at least one monitoring signal, and a device for processing the monitoring signal and for generating a...
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6555330 |
Oncogene-induced apoptosis in drug-resistant cells
The present invention relates to a method of identifying a compound (agent) which modulates apoptosis in transformed cells. In one embodiment, the invention is a method of identifying a compound...
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6551831 |
Dyes and methods of detection of nucleic acid in immature red blood cells
The dyes of the present invention are useful for many purposes that include markers or tags for detecting the presence of a molecule or compound to which they are bound. The dyes may be either...
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6540977 |
Cyanidin compositions and therapeutic and diagnostic uses therefor
Compositions comprising cyaniding reagents for binding to FcγRI receptors, and methods and kits for use therefor are provided.
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6541196 |
Method for cAMP production
The present invention provides for novel methods for measuring the levels of cyclic adenosine monophosphate (cAMP) produced by cells. Notably, the methods provided do not require that the cell...
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6541243 |
Perfusion chamber for electrophysiological testing of oocytes
A perfusion chamber includes a porous oocyte support structure. A continuously sloped top surface and a receiving well in the support structure entrap the underside of the oocyte, thereby...
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6537784 |
Self-regulated apoptosis of inflammatory cells by gene therapy
This invention relates to chimeric nucleic acids and to the therapeutic induction of apoptosis in activated inflammatory cells, or cells at a site of inflammation, by introducing into those cells...
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6537765 |
GPR10 as a target for identifying weight modulating compounds
Assays for the identification of compounds useful for the modulation of body weight, metabolic rate, or feeding behavior are disclosed. Such compounds are useful for the treatment body weight...
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6531318 |
Methods and apparatus for cell analysis
A highly specific and sensitive technique for exploring cell physiology is disclosed. The method includes laser capture microdissection (LCM) for selecting small clusters of cells of interest from...
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6528277 |
Indicator systems for determination of sterilization
This invention relates to a container and method for detecting a specific environmental parameter or combination of parameters, or for determining the effectiveness of a sterilization procedure....
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6524806 |
Methods of screening for ligands of human hemetopoietin receptor HU-B1.219
The present invention relates to a novel member of the hematopoietin receptor family, herein referred to as Hu-B1.219. In particular, the invention relates to nucleotide sequences and expression...
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6521412 |
HsReq*1 and hsReq*2proteins and use thereof to detect CDK2
The present invention relates to complexes of the CDK2 protein with proteins identified as interacting with CDK2 by a modified yeast two hybrid assay system. The proteins identified to interact...
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6521408 |
Method for assessing a function of a gene
The invention provides a high capacity binary shuttle vector having T-DNA region and Ri ori and capable to integrate a large genome fragment in it; a genomic library having the ability to transform...
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6518032 |
Rapid methods for identifying modifiers of cellular apoptosis activity
The invention provides a single-well, microscale method of determining the specific apoptotic activity of a cell. The method consists of contacting a cell population of about 1×10 5 cells for a...
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6515197 |
Transgenic mouse expressing a polynucleotide encoding a human ataxin-2 polypeptide
The invention provides a transgenic non-human mammal comprising nucleated cells containing a transgene encoding an ataxin-2 polypeptide comprising a polyglutamine tract. In particular, the...
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6511819 |
Rapid coliform detection system
A rapid method for detecting the presence or absence of coliform bacteria in a liquid or liquified dairy sample, for example, skimmed milk, lowfat milk, or whole milk. A growth medium containing a...
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6511817 |
Methods and device for in vitro detection and characterization of psychoactives using analysis of repetitive electrical activity in a neuronal sample
This relates to methods for the detection of psychoactive compounds in an in vitro neuronal tissue sample by detecting oscillations of extracellular voltage desirably before and after the...
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6511804 |
Selective assay for determining the identity of live microorganisms in a mixed culture
The invention provides a method for determining the identity of an unknown live microorganism in a mixed culture. The microorganism can be a bacterium, fungus, virus, or protozoan. The invention...
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6511818 |
Cancer drug screen based on cell cycle uncoupling
Checkpoint gene-defective human cells are useful for screening potential anti-tumor agents. Potential therapeutic agents are screened for the ability to cause DNA accumulation or cell death in a...
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6509167 |
High throughput sarcomeric assay
The present invention provides high throughput screening systems for identifying compounds that modulate the biological activity of a biochemically functional sarcomere. The method can be performed...
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6509165 |
Detection methods for type I diabetes
Proinsulin peptide compounds that modulate an immunological response by T cells of Type I diabetic subjects are disclosed. The proinsulin peptide compounds of the invention are preferably derived...
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6509168 |
Method for quantification of biological material in a sample
Method for detection of a biological material in a sample. The method includes the steps of liquifying the sample (if necessary) and pouring the liquified sample into the incubation plate. The...
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6506387 |
Method for preparing aloin by extraction
The invention concerns a method for preparing aloin which consists in extracting from a substance containing aloe, in particular the yellow sap of aloe or a derived product, in the presence of an...
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6506574 |
Hepatocyte lineage cells derived from pluripotent stem cells
It has been discovered that when pluripotent stem cells are cultured in the presence of a hepatocyte differentiation agent, a population of cells is derived that has a remarkably high proportion of...
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6506572 |
Inhibitors of cellular niacinamide mononucleotide formation and their use in cancer therapy
New biologically active compounds are described which inhibit the cellular formation of niacinamide mononucleotide, and essential intermediate of the NAD(P) biosynthesis in the cell. These...
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6506576 |
Serum-and steroid-free culture media for cerebellar granule neurons
The invention is a system for maintenance and high-throughput analysis of cerebellar granule neurons in tissue culture plates under chemically defined conditions. The invention includes serum-free...
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6500624 |
Kainate-binding, human CNS receptors of the EAA3 family
Neurotransmission by excitatory amino acids (EAAs) such as glutamate is mediated via membrane-bound surface receptors. DNA coding for one family of the kainate-binding type of EAA receptor, has now...
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6495339 |
Method of identifying a compound that modulates XAF-mediated apoptosis
The invention provides novel XAF nucleic acid sequences. Also provided are XAF polypeptides, anti-XAF antibodies, and methods for modulating apoptosis and detecting compounds which modulate apoptosis.
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6495340 |
Cell carrier grids
An improved cell carrier grid. The grid is capable of containing and retaining individual living cells in an array discrete locations and includes a body that defines having an ordered array of...
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6495341 |
Method and apparatus for monitoring a physical or chemical conversion of a grain material
The present invention is a method and apparatus for monitoring, preferably in real time, the physical or chemical conversion of a grain material. The method employs multivariate analysis of a...
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6492500 |
Modified bioluminescent proteins and their use
A modified bioluminescent protein responds to different physical, chemical, biochemical or biological conditions to product light or radiation of altered characteristics when the bioluminescent...
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6489115 |
Genetic assays for trinucleotide repeat mutations in eukaryotic cells
A method for assaying trinucleotide repeat mutations in eukaryotic cells is provided.
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6479251 |
Colorimetric test for agents that induce mitochondrial dysfunction
Test agents are screened for their effects on mitochondria using a bioassay. Mutant cells with mutations in their mitochondria are readily detectable. Agents which induce such mutations are thereby...
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6479237 |
Methods for detecting interaction among several proteins
The aim of the invention is to use at least one conditional promoter to implement a method for detecting one or more proteins interacting directly or indirectly with at least two other proteins...
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6475719 |
Determination of factors affecting gene regulation and/or gene replication
The invention relates to a method for determining a factor affecting a cell, which affects directly or indirectly the DNA, RNA and/or proteins of the cell or their synthesis machinery, in which...
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6472215 |
Method of analyzing nucleated red blood cells in a blood sample
A method of analyzing nucleated red blood cells (NRBCs) in a blood sample and further enumerating NRBCs is disclosed. The method includes lysing a first aliquot and a second aliquot of a blood...
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6472151 |
Method of screening for compounds that modulate the activity of a molecular target
The present invention provides a method for generating and isolating cell lines that functionally express molecular targets for drug discovery without utilizing information from the nucleic acid or...
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6472165 |
Modulatory binding site in potassium channels for screening and finding new active ingredients
A selective modulatory retigabine binding potassium channel receptor site containing subunits KCNQ2 and KCNQ3, and a method for directly selectively modulating that receptor site by administering...
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RE37892 |
Hypothermic storage technology for biological material
The present invention relates to the optimum bio-storage temperature of biological materials. The temperature is between the melting point depression of the biological material and zero degrees C....
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