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6665430 |
Fluorescence digital imaging microscopy system
A method of preparing cell samples for viable cell number quantification with a fluorescence digital imaging microscopy system employing digital thresholding technique. The cell sample is stained...
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6660494 |
Detection of microbial metabolites
Chromogenic 3-Indoxyl choline phosphate compounds of formula (I): wherein R is selected from the group consisting of hydrogen and C 1-4 alkyl, such as methyl, ethyl, propyl and butyl while R 1...
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6653135 |
Dynamic protein signature assay
An assay to determine the specific expression and suppression of proteins in response to a stressor is disclosed. An organism exposed to a stressor, including disease caused by exposure to, e.g., a...
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6653089 |
Differential treatment of selected parts of a single cell with different fluid components
The present invention is directed, in certain embodiments, to improved, small scale systems and methods able to selectively treat parts of a single cell, including, in certain embodiments, portions...
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6649366 |
Methods and compositions related to modulators of annexin and cartilage homeostasis
The present invention provides a method of treating a subject with arthritis or an arthritic disease or preventing arthritis or arthritic disease in a subject, comprising administering to the...
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6649365 |
Indolamine derivatives for detecting peptidase activity in culture media
Compounds of formula X—NH—R, in which X represents an optionally substituted indol-3-yl group and R represents the acyl residue of an amino acid or of a peptide, enabling the detection of...
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6649367 |
Human cancer cell line malignantly altered by expression of angiogenic factor
A method for producing a cell to which angiogenesis-inducing ability has been imparted, comprising the steps of introducing a gene of an angiogenic factor into a human or animal cell having low...
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6645944 |
Inhibition of cellular proliferation by oligonucleotide binding to a chromosomal binding site for p53 protein
The present invention provides methods for inhibiting cell growth by providing a growing cell with an oligonucleotide capable of binding to a chromosomal binding site for p53 protein. Moreover, in...
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6645769 |
Reservoir monitoring
A method for monitoring hydrocarbon and water production from different production zones/sections in a hydrocarbon reservoir and/or injection wells and detection of different phenomena such as e.g....
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6645730 |
Noninvasive detection of colorectal cancer and other gastrointestinal pathology
A method for isolating viable, biologically substantially pure exfoliated fecal colonocytes at normal ambient temperature is described. Immunocoprocytes and inflammatory cells indicative of certain...
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6642017 |
Modulating production of pneumococcal capsular polysaccharide
The invention relates to methods of modulating capsular polysaccharide production in pneumococci such as Streptococcus pneumoniae . The invention further relates to methods of alleviating...
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6642012 |
Spectroscopic determination of characteristic of biological material
Method for determining a cellular function or change in cellular function by contacting a sample of cells or a component of cells with an activating agent, directing a beam of infrared light at the...
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6638716 |
Rapid amperometric verification of PCR amplification of DNA
Rapid electrochemical verification of the amplification of DNA by a polymerase chain reaction in a small sample of the PCR product.
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6635440 |
Method of isolation of RNA-binding compounds
The present invention provides a method of isolation of compounds that bind specifically to RNA or that alter the affinity of known compounds for RNA. The method utilizes changes in the levels of a...
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6632622 |
Assay for evaluation of cellular response to allergens
An assay method for detecting the response or activation of cells, including lymphocytes, and a method for detecting immunological sensitization in a subject, which involves the introduction of...
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6630302 |
Methods and compositions for determining species of bacteria and fungi
Methods and compositions are described for methods and compositions for determining the species for an unknown bacterium (or fungus) in a sample. The approach, which utilizes Ribosomal operon...
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6630321 |
Method for identifying a compound that modulates the function of the gene product of an essential gene
A method for identifying a compound which modulates the function of the gene product of an essential gene, which method comprises providing viable cells wherein the gene is expressed under the...
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6627413 |
Method for determining microbial contamination
The present invention discloses a process for quantitative and/or qualitative determination of the microbial contamination of suspensions, emulsions or dispersions containing minerals and/or...
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6627411 |
Method for evaluating matrix metalloprotease inhibitory activity
A method for checking a matrix metalloproteinase-inhibitory activity present in a mammal that has received a compound exhibiting matrix metalloproteinase-inhibitory activity, which comprises...
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6627412 |
Method for detecting microorganisms
There is disclosed a method for detecting microorganisms comprising the steps of: providing a plurality of cultures by culturing said microorganisms on a plurality of different media; making...
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6627759 |
Method of isolating stem cells
The present invention relates, in general, to stem cells, and in particular, to a method of isolating stem cells and to reagents suitable for use in such a method. The invention further relates to...
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6623775 |
Treating or preventing illness growth of Clostridium difficile
The present invention relates to the discovery that hop extract is useful as an antibacterial agent against the dangerous pathogens Clostridium botulinum, Clostridium difficile , and Helicobacter...
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6620583 |
Diagnostic screens for type 1 diabetes (IDDM)
The present invention features a method for identifying genes or proteins important in insulin-dependent diabetes mellitus (IDDM). The genes or proteins are useful in identifying IDDM-susceptible...
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6620593 |
Method for safety evaluation of chemical compound using recombinant yeast expressing human cytochrome P450
There is disclosed a method for evaluation of the safety of a chemical compound, which includes the steps of: (a) reacting a chemical compound with recombinant yeast cells expressing, or in other...
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6617110 |
Cells immortalized with telomerase reverse transcriptase for use in drug screening
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of...
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6613542 |
Testing system for chemical substances or substance mixtures
In a testing system for chemical substances or substance mixtures, especially for potential plant protection compositions, the chemical substance to be tested or the substance mixture to be tested...
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6608190 |
Nucleic acid fragments for the identification of bacteria in industrial wastewater bioreactors
Unique bacterial strains and identifying 16S rDNA sequences have been isolated from activated wastewater sludge. The 16S rDNA sequences are diagnostic for organisms which are key to the health of...
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6605429 |
Gene functional analysis and discovery using randomized or target-specific ribozyme gene vector libraries
The present invention provides a hairpin ribozyme library having a randomized recognition sequence, packaged in a vector and operably linked to a promoter suitable for high level expression in a...
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6602660 |
Methods of detecting T-cell activation
Methods of detecting activated T-cells involve monitoring levels of MUC-1 mucin expression at the protein and/or mRNA level. Compositions for modulating immune function contain compounds that...
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6602680 |
Production of gabaergic cells
The invention features methods and compositions for the production of GABAergic cells, particularly GABAergic neurons. Production of GABAergic cells is accomplished by increasing activity of a Dlx...
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6602710 |
Screening method for SREBP pathway-specific inhibitors
This invention provides a screening method for sterol regulatory element binding protein (SREBP) pathway-specific inhibitors using a mutant cultured cell, as well as therapeutic agents for...
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6602506 |
Delivery of proteins into eukaryotic cells with recombinant Yersinia
The present invention relates to recombinant Yersinia and the use thereof for delivery of proteins into eukaryotic cells, including related compositions and methods of treatment and related assays.
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6599696 |
Effects of materials and surface coatings on encrustation and biofilm formation
A method for testing the performance of surface coatings on the formation of biofilm and encrustation on materials. The method includes, providing a plurality of material retaining sites, providing...
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6599695 |
Method for assaying for early gene expression in neuroblasts
A method for producing a neuroblast and a cellular composition comprising an enriched population of neuroblast cells is provided. Also disclosed are methods for identifying compositions which...
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6596507 |
Device and method for determining characteristic of a biomass
A device for determining the characteristics of a biomass, includes: a probe (S,S′) including electrodes, two or four in number, for injecting a current into a medium containing biological cells...
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6596506 |
Double and triple readout assay systems
The present invention provides assays for identifying compounds that affect the transcriptional activity of a protein of interest or affect the stability of the protein of interest. The triple...
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6596532 |
Device for isolation and surface culture of microorganisms from bulk fluids
A device and method are provided for isolating and culturing microorganisms from a bulk fluid sample. The device comprises a container having therein a polymeric immobilization layer having...
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6596471 |
Method of cross-linking tissue with a bis-maleimide compound
Herein is disclosed a method of cross-linking a tissue, comprising treating the tissue under effective cross-linking conditions with a diunsaturated organic compound comprising structure I: ...
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6596505 |
Apparatus and methods for testing effects of materials and surface coatings on the formation of biofilms
The present invention relates to an apparatus and methods for testing the formation of biofilms on various materials. The apparatus includes a lid and a vessel, wherein the lid may be configured to...
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6593136 |
Culturing cells in a chamber in a stack of chambers
A chamber has a lid that permits opening and closing of the chamber for inserting or removing a cell culture from the chamber while the chamber is in a stack of chambers without removing any of the...
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6593101 |
Enhancing contrast in biological imaging
Methods for enhancing contrast during imaging to assess cell and nuclear morphology of a sample. A contrast agent such as acetic acid, toluidine blue, hypertonic saline, hypotonic saline, Lugol's...
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6589761 |
Method and apparatus for detecting bacteria
A device and method for detecting bacteria in food substances and the like utilizing a three layer composite consisting of a transparent base, an indicator exhibiting color change when exposed to...
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6589733 |
Methods of preparing compositions comprising chemicals capable of transcriptional modulators
The present invention provides a method of transcriptionally modulating the expression of a gene of interest, the expression of which is associated with a defined physiological or pathological...
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6589745 |
CIF130 inhibits cell cycle progression
A human gene termed CIF130 and its expression products can alter the spatial or temporal patterns of mitosis or cell cycle progression of a human cell. Methods of treating disorders involving...
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6586241 |
Methods to identify compounds affecting mitochondria
The present invention relates to methods for identifying a compound capable of modulating mitochondrial function, comprising contacting a eukaryotic cell with one or more candidate compounds, and...
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6585954 |
Method for searching steroid sulfatase inhibitors
The present invention provides a method of efficiently screening for steroid sulfatase activity-inhibiting compounds which are useful for the treatment of hormone-dependent diseases such as breast...
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6579692 |
Method of screening apoptosis inducing substances
The present invention provides a method of screening substances having property of causing apoptosis, and relates to a method of screening substances having property of causing apoptosis...
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6579693 |
Genetically engineered yeast strains
Yeast strains expressing human genes coding regulating cytochrome P450 expression, a method for making same and applications thereof are described.
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6576422 |
Method for identifying products employing gene expression
A method for identifying a product involves the steps of: (1) associating with the product a marker ligand; and (2) detecting the marker ligand in the product at a later point in time as a means of...
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6572896 |
Methods for inhibiting cell motility
A method is provided for inhibiting and substantially decreasing the motility of cells, and especially melanoma cells. In the invention, a cell is contacted with a motility-inhibiting amount of a...
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