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7390676 System and method for programmable illumination pattern generation  
A method and apparatus for the manipulation of colloidal particulates and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution....
7390648 Microelectromechanical devices useful for manipulating cells or embryos, kits thereof, method of making same, and methods of use thereof  
The present invention relates generally to microelectromechanical systems (MEMS) devices for the manipulation of cells or groups of cells, such as oocytes, embryos, and sperm. In particular, the...
7390463 Microcolumn-based, high-throughput microfluidic device  
A biological assay device for use in molecular biology, pharmaceutical research, genomic analysis, combinatorial chemistry, and in the general field of the analysis of molecules that may be...
7384779 Porous substrate plates and the use thereof  
A substrate plate or device adapted for use with biological or chemical assays is disclosed. The device may take the form of a multi-well plate having a three-dimensional, porous layer as part of a...
7381571 Device and method for analyte detection  
The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention...
7381570 Device and method for multiple analyte detection  
The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention...
7381375 Assay systems with adjustable fluid communication  
Systems, including apparatus and methods, for performing assays with adjustable fluid communication between samples.
7381374 Immunoassay devices and methods of using same  
An immunoassay cartridge for sensing at least one analyte in a biological sample is disclosed. The immunoassay cartridge comprises a supporting plate, a reaction cavity made within the supporting...
7381315 Multi-channel analyte-separation device employing side-entry excitation  
A side-entry excitation arrangement is provided with a multi-channel analyte-separation device. In various embodiments, a plurality of channels are disposed in an array, with a laser disposed to...
7374906 Biological assays using gradients formed in microfluidic systems  
The present invention discloses a device for monitoring chemotaxis or chemoinvasion. The present invention further provides a flexible assay system and numerous assays that can be used to test...
7373968 Method and apparatus for manipulating an organic liquid sample  
A lid for a well plate, which has pins that penetrate the lid and project downwardly into the wells of the well plate. Thermal energy is applied to the upper end of the pin to regulate the...
7371581 Process for the monitoring of contaminant removal during the purification process of a pharmaceutical product produced by a host cell  
We describe a process for the monitoring of contaminant removal during the purification process of a pharmaceutical product produced by a host cell, wherein at least two different samples taken...
7371563 Peelable and resealable devices for biochemical assays  
Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat...
7371561 In vitro, multiple electrode pair array and multiple treatment cell apparatus for use in electroporation  
A multiple electrode pair array apparatus is provided for use with a multiple well plate which has multiple wells distributed in a two-dimensional matrix array which has R rows and C columns. The...
7371348 Multiple array format  
A multiple array substrate having multiple assay chambers, each assay chamber containing one or more arrays. The assay chambers include a form-in-place gasket between a substrate and a cover....
7364899 Device for monitoring haptotaxis  
The present invention discloses a device for monitoring haptotaxis including a housing defining a chamber. The chamber comprises: a first well region including at least one first well, the first...
7364897 Methods and devices for performing chemical reactions on a solid support  
Apparatus and methods for carrying out biochemical processes directly on a substrate are provided. A substrate assembly includes a cartridge that removably supports a substrate in a fixed position,...
7361472 Methods for providing extended dynamic range in analyte assays  
Methods for enhancing the dynamic range for specific detection of one or more analytes in assays using scattered-light detectable particle labels. The methods involve utilizing variations in...
7358079 Flow cell array and the utilization thereof for multianalyte determination  
A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate...
7351575 Methods for processing biological materials using peelable and resealable devices  
Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat...
7351379 Fluid containment structure  
A fluid containment structure that includes a substrate with a gasket surface and a form-in-place gasket disposed on the gasket surface and a method for forming the fluid containment structure are...
7348181 Self-encoding sensor with microspheres  
A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed...
7347977 Microtitration plate  
A microtitration plate has a frame ( 2 ) made of a first stiff plastic and having a plate ( 4 ) with multiplicity of holes ( 2′ ), and a multiplicity of vessels ( 3 ) made of a second plastic...
7341865 Liquid delivery devices and methods  
Methods and devices are provided for using high-density arrays of diverse chemical entities. In preferred embodiments, small volumes of multiple liquids are delivered to multiple reaction sites on...
7341834 Multiplexed electrochemical detection system and method  
Multiplexed analysis of molecular structures of samples. A plurality of sample wells is arranged on a substrate. A plurality of electrodes is fabricated on a first side of the substrate. The...
7332271 Apparatus and methods for parallel processing of micro-volume liquid reactions  
Disclosed herein are apparatuses and methods for conducting multiple simultaneous micro-volume chemical and biochemical reactions in an array format. In one embodiment, the format comprises an...
7329538 Methods and compositions for the detection of microbial contaminants  
The invention provides methods and compositions for the detection and/or quantification of a microbial contaminant, for example, a bacterial endotoxin or a glucan, in a sample. In particular, the...
7329537 Micro-pattern embedded plastic optical film device for cell-based assays  
In the present invention, a micro-pattern embedded optical film for cell-based assays is described. The optical film contains micro-patterns in the form of geometric shapes, such as lines and...
7326563 Device and method for monitoring leukocyte migration  
A device for monitoring leukocyte migration is provided. The device generally includes a plurality of chambers, each chamber including a channel in which leukocyte migration mediators or...
7323660 Modular sample processing apparatus kits and modules  
Modular sample processing apparatus kits that can provide a user with the flexibility to customize a disk-based assay in view of a variety of factors are disclosed. The sample processing apparatus...
7323140 Moving microdroplets in a microfluidic device  
The present invention relates to a system and method for moving samples, such as fluid, within a microfluidic system using a plurality of gas actuators for applying pressure at different locations...
7320777 PCR sample handling device  
A device for handling PCR microcards, each having an array of sample chambers closed by a transparent material on one side thereof, in relation to a PCR instrument, the device including a carrier...
7316930 Use of vertically stacked photodiodes in a gene chip system  
An improved gene chip system is arranged with vertically stacked photodiodes for sensing luminescence of genetic material. When genetic samples are combined with a reagent in an array of wells on a...
7311794 Methods of sealing micro wells  
The present invention provides miniaturized instruments for conducting chemical reactions where control of the reaction temperature is desired or required. Specifically, this invention provides...
7297531 Apparatus and method for testing liquid samples  
An article for holding a liquefied sample for the quantification of biological material in the sample includes a device having a reaction chamber enclosing a volume therein, the reaction chamber...
7294812 Non-contact radiant heating and temperature sensing device for a chemical reaction chamber  
An apparatus and methods are provided for heating and sensing the temperature of a chemical reaction chamber without direct physical contact between a heating device and the reaction chamber, or...
7285411 High throughput screening assay systems in microscale fluidic devices  
The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are...
7282362 Tray with protrusions  
A feeding tray for retaining a liquid nutrient liquid is provided for use with a multiwell filter plate. The feeding tray includes a flat support surface surrounded by walls which retain liquid on...
7280727 Micro-well and methods of fabricating and selectively blackening the same  
Well plates adaptable for specimen sampling in the biological, chemical and pharmaceutical sciences are fabricated by dissolving fusedly-retained cores from the cladding material of a fused fiber...
7276369 Method for detecting a substance and microtiter plate  
The invention relates to a method for detecting an analyte A in a liquid, comprising the following steps: (a) a solution containing an analytical reagent N is provided in a container B; (b) the...
7273750 Biological culture growth and observation device  
The present invention provides a biological culture growth and observation device ( 1 ) comprising a cup-shaped tray ( 2 ) for containing or receiving a growth medium for said biological culture...
7264972 Method and apparatus for sorting biological cells with a MEMS device  
A micromechanical actuator for sorting hematopoietic stem cells for use in cancer therapies. The actuator operates by diverting cells into one of a number of possible pathways fabricated in the...
7262048 Biochemical analysis unit  
A biochemical analysis unit comprises a base plate, which has holes, and a porous adsorptive material, which is filled in each of the holes and forms each of adsorptive regions. Each of the...
7258990 Alleviation of non-specific binding in microarray assays  
A post-incubation treatment is employed to effectively remove targets, such as proteins/protein complexes, or other label-bearing moieties that may non-specifically bind to a microarray substrate...
7258799 Method and apparatus for magnetic separation of particles  
A magnetic circuit is shaped to generate an essentially uniform magnetic field parallel across the length of a container, and an essentially uniform magnetic field gradient along the length of the...
7250308 Capture assay utilising a particulate analyte  
Device ( 1 ) for assaying a particulate analyte, comprising (a) a receptacle ( 2 ) for receiving a suspension ( 5 ) of particulate analyte, and containing label ( 3 ) for the particulate analyte,...
7250288 Electrode compositions and configurations for electrochemical bioreactor systems  
Electrodes and configurations for electrochemical bioreactor systems that can use electrical energy as a source of reducing power in fermentation or enzymatic reactions and that can use electron...
7244913 Temperature regulator for microchemical chip  
A temperature regulator regulates a temperature of a microchemical chip that has chemical reaction sections. The temperature regulator includes a temperature measuring unit and a thermoelectric...
7235406 Nucleic acid analysis device  
The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention...
7235400 Laminated microarray interface device  
A device for forming a low volume reaction chamber on a substrate such as a microarray slide and its method of use is disclosed. The reaction chamber forming device has an adhesive laminate design...