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6140134 |
Analyte detection with a gradient lateral flow device
A method of determining the concentration of an analyte in a sample, said method comprising bringing said analyte in contact with an indicator zone comprising a concentration gradient of a mobile...
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6136274 |
Matrices with memories in automated drug discovery and units therefor
Automated drug discovery protocols, or partially automated protocols, in which matrices-with-memories serve as the platform on which all manipulations are performed or serve as the repository of...
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6120666 |
Microfabricated device and method for multiplexed electrokinetic focusing of fluid streams and a transport cytometry method using same
A microfabricated device and method for electrokinetic transport of a liquid phase biological or chemical material is described. In accordance with one aspect of the present invention there is...
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6117397 |
System and methods for parallel synthesis of organic compounds
The invention provides systems, devices and methods for synthesizing various chemicals onto solid supports, cleaving the synthesized compounds and preparing samples for analysis. In one exemplary...
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6103199 |
Capillary electroflow apparatus and method
The present invention concerns an apparatus for conducting a microfluidic process. The apparatus comprises integral first and second plates. The first plate comprises an array of sample receiving...
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6090541 |
Method and device for detecting bacteriophage using contrast-coloring and precipitable dyes
The use of a precipitable dye and a contrast-coloring dye together enhance visualization of plaques in confluent lawns of bacteria in bacteriophage and bacteria assays. A test sample suspected of...
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6087157 |
Device and method for analyzing tumor cell invasion of an extracellular matrix
A device for analyzing the in-vitro growth properties of cells is disclosed. The device comprises an upper and lower chamber separated by a growth substrate interface comprising submucosa,...
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6057150 |
Biaxial strain system for cultured cells
Biological cells plated on an elastic membrane are placed under biaxial strain for purposes of observation by a device that includes a support with an opening over which the membrane is secured, a...
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6048723 |
Flexible bottom culture plate for applying mechanical load to cell cultures
A cell culture plate having a flexible membrane sandwiched between a base and a body. Each of the base and body have a plurality of mutually aligned openings. A wall surrounds each opening in the...
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6045758 |
Test sample card with cored features
A test sample card has a fluid passage network provided on both sides of the card to provide for maximum separation distance between adjacent growth wells. The card also has cored sections along...
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6043027 |
Multi-well single-membrane permeation device and methods
The invention provides exemplary testing devices, systems, and methods for evaluating the permeation of various chemicals through different types of cells. In one exemplary embodiment, a testing...
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6042789 |
System for parallel synthesis of organic compounds
The invention provides systems, devices and methods for synthesizing various chemicals onto solid supports, cleaving the synthesized compounds and preparing samples for analysis. In one exemplary...
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6037141 |
Culture compression device
A culture compression device including an enclosure having a wall and a base made from a flexible membrane. A sample support member is positioned on the membrane and retains a cell culture thereon....
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6037168 |
Microbiological assembly comprising resealable closure means
A microbiological assembly is provided having a resealable seal between a support and a cover. The support has a surface which includes a patterned layer and defines at least one sample retention...
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6027695 |
Apparatus for holding small volumes of liquids
An apparatus for holding liquid, such as a microtiter plate, in which a plurality of wells are formed. Each of the wells have side walls that intersect in an edge that defines the boundary between...
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6027694 |
Spillproof microplate assembly
A microplate assembly comprising a multi-well microplate, a plurality of vent caps and a porous vent film. The microplate includes a frame that houses a plurality of open wells in a rectangular...
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6022734 |
Disposable apparatus for determining antibiotic sensitivity of bacteria
A disposable cassette for testing the minimum inhibitory concentration of antibiotic for a target microorganism is provided. The cassette includes a body, a sheet of microorganism growth medium,...
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6022700 |
High throughput biological sample preparation device and methods for use thereof
Disclosed is a novel biological sample preparation (BSP) device and a method of using such a device that enables inexpensive and flexible high throughput sample preparation and visualization for...
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6018388 |
Microtiter plate
A microtiter plate is formed of a bottom plate which is transparent for light and a cavity plate which is open at two surfaces facing one another and which has a matrix-shaped arrangement of...
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6017767 |
Assay device
A chromatographic assay device for use with immunoassays allows rapid and convenient assays of analytes of biological interest, and permits extractions to be carried out in situ, avoiding the use...
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5980839 |
Apparatus and process for conducting combinational chemical syntheses
The objective of combinatorial chemical synthesis is the preparation of a very large number of different molecular entities by a randomized process of sequential chemical syntheses. The present...
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5976797 |
Method for quantifying total mRNA with poly(A)-complementary oligonucleotide-immobilized microtiter plate
A method for quantifying total mRNA in a biological sample containing RNA such as crude cell lysates containing cytosolic mRNA, which method comprises the steps of: (a) incubating the sample with...
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5972694 |
Multi-well plate
The invention relates to an improved multiwell cluster plate. The wells of the plate each have an upper chamber and a lower chamber separated by a microporous membrane. Adjacent to each well is a...
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5962250 |
Split multi-well plate and methods
The invention provides exemplary testing devices, systems, and methods for evaluating the permeation of various chemicals through different types of cells. In one exemplary embodiment, a testing...
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5958675 |
Method for detecting bacteria using bacteriophage, contrast-coloring dye and precipitable dye
Bacteria are detected in a test sample by contacting the test sample with a bacteriophage that is capable of replicating in the bacteria, adding the resultant sample to a water-proof surface of a...
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5955352 |
Instruments for chemical and microbiological tests
An instrument for chemical and microbiological tests comprises a sample container for temporarily storing a liquid sample; a plurality of sample-holding portions formed on the bottom face of the...
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5952240 |
Discrete matrix plate positioner
A positive displacement positioner employs rigid stops and actuators to position a work piece, such as a microtiter plate, in any one of at least three positions. Positioner platforms, each of...
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5952191 |
Method of growing several samples of microorganisms on a single flat surface of solid growth medium
A method and apparatus for growth and analysis of microbiological clones. A divider (6) is introduced into a layer of solid growth medium, separating the open surface of the medium into...
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5948363 |
Micro-well strip with print tabs
A micro-well test unit and a micro-well strip which comprises a plurality of wells arranged along an axis and print tabs provided for use in marking individual wells with desired indicia. One...
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5948685 |
Analytic plate with containment border and method of use
An analytic plate such as a microscope slide or a diagnostic plate and kit having the slide or plate, the slide or plate having a containment border for containing a liquid or liquid sample. The...
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5942432 |
Apparatus for a fluid impingement thermal cycler
Apparatus are disclosed that thermally cycles samples between at least two temperatures. These apparatus operate by impinging fluid jets onto the outer walls of a sample containing region. Because...
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5912134 |
Disposable cartridge and method for an assay of a biological sample
A cartridge is provided to present a biological sample for analysis by an imaging instrument. The cartridge of the invention utilizes a series of channels, capillaries, reservoirs and stop...
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5908776 |
Cell culture chamber for multiple well plates
Cell culture chambers and incubators are operated to grow cells under a wide variety of conditions. Where those conditions result in too rapid evaporation of the well media for low volume wells...
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5891712 |
Gamete/embryo micro drop culture dish
The present invention relates to an improved micro drop culture dish which is comprised of a substantially flat bottom surface portion and a wall portion integrally secured thereto. The bottom...
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5891739 |
Multiple sample container
The present invention describes a multiple sample container for use in a method and apparatus for detecting microorganisms in a culture container. The container includes a block having a plurality...
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5869345 |
Opposable-element assay device employing conductive barrier
A chromatographic assay device for use with immunoassays allows rapid and convenient assays of analytes of biological interest, and permits extractions to be carried out in situ, avoiding the use...
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5866345 |
Apparatus for the detection of an analyte utilizing mesoscale flow systems
Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow...
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5861306 |
Multi-well bone culture device for use in assessment of bone cell activity
The present invention describes a multi-well bone cell culture device for use in the quantitative and/or qualitative assessment of bone cell activity, the device comprising a flat base having a...
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5858804 |
Immunological assay conducted in a microlaboratory array
The present invention provides a method of performing an immunological assay separately and in parallel for each of at least a first sample containing or prospectively containing a first binding...
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5851492 |
Microtiter plate sealing system
An apparatus for sealing and maintaining a desired temperature of a sample holder includes a non-deformable support, a deformable diaphragm secured to the lower surface of the support and a thermal...
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5849569 |
Assessment of bone cell activity
A calcium phosphate based thin film on which bone cells may be cultured to permit evaluation of bone cell functional properties comprises calcium phosphate entities which provide for varying...
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5846493 |
System for analyzing a substance from a solution following filtering of the substance from the solution
A system is provided for filtering a substance from a solution for subsequent analysis of the substance. The system has a manifold and a removable cover capable of latching onto a base defining an...
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5843380 |
Test sample card with raised rails
A test sample card has a fluid passage network provided on both sides of the card to provide for maximum separation distance between adjacent growth wells. The card also has cored sections along...
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5843295 |
Gel electrophoresis well-forming and loading-guide comb
A well-forming and loading-guide comb for electrophoresis gels. The comb includes a comb body, to which well-forming teeth and a loading guide are attached in an opposing fashion. The comb can be...
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5830411 |
Device for carrying out erythrocytic reactions
The present invention provides a device for carrying out erythrocytic reactions, wherein the device includes a molded plate having multiple individual reaction compartments, each formed by an upper...
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5830659 |
Active microtubule-based separations by kinesins
A method and system for separating a selected molecule from a heterogeneous mixture of molecules in aqueous solution are described. The method comprises (a) providing a separation device comprising...
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5824494 |
Method for enumerating bacterial populations
A method for determining the number of microorganisms in a liquid sample, including the steps of dividing the liquid sample into a plurality of separate sub-samples, measuring the magnitude of at...
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5811256 |
Method for measuring sensory irritation in vitro
Methods for ascertaining the sensory irritation of chemicals in vitro are described. The methods include the cultivation of neuronal cells alone, with target tissue cells, and with target tissue...
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5807751 |
Apparatus and method for detection of analytes in a sample
Apparatus for detection one or more analyte in a fluid sample. The apparatus includes one or more fluid including the fluid sample to be tested for the analyte(s) and one or more vessels for...
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5798215 |
Device for use in analyte detection assays
A device and method for its use in diagnostic assays are provided. The device comprises at least one assay path, where an assay path includes a main flow path and at least one side reagent channel....
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