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6432694 |
Cartridge and system for storing and dispensing of reagents
By arranging reagents needed for a specific reaction in separate distinct chambers in a reagent cartridge and combining several such reagent cartridges in a cassette in a format that matches that...
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6428974 |
Microplate for drug susceptibility testing containing a drug, a color reagent, and color suppressant
A reagent for a drug susceptibility testing which is simple and highly reproducible is provided. A microplate for a drug susceptibility testing wherein a drug and a color reagent containing a...
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6423536 |
Low volume chemical and biochemical reaction system
A method and device for preparing nanoscale reactions. An automated system utilizes an array of reaction chambers. The ends of the chambers are temporarily sealed with deformable membranes and...
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6416969 |
Susceptibility plates for microbial antibiotic susceptibility testing
Disposable plates for performing microbial antibiotic susceptibility testing with multiple channels can be inoculated with a microorganism and antimicrobial agent. The antimicrobial agent may be...
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6413784 |
Multi-sectioned fluid delivery devices for detecting target molecules by immunoassay
Multi-sectioned fluid delivery devices with sensor membranes for use in detection of target molecules in gas or liquid samples are provided.
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6410252 |
Methods for measuring T cell cytokines
The present invention relates to devices and methods for detecting cellular products, and in particular for measuring secreted cellular products, including cytokines. Microwells comprising...
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6410310 |
Cell culture expansion plate
An improved cell culture plate for in vitro cultivation of cells and/or tissue cultures, the cell culture plate comprising a base member and a flat removable lid, the base having the external...
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6402369 |
Arrayable thermal assays
Provided are, among other things, devices for and methods for performing thermal signature assays on a two or more samples in an array, using active/control base thermopiles, the method comprising:...
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6399302 |
Signal generating oligonucleotide-based biosensor
The present invention relates to oligonucleotide-based biosensors and a general method for their production and use. Specifically, the invention describes a novel signal-generating ligand complex...
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6395491 |
Method of information storage and recovery
The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of...
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6395559 |
Multiple fluid sample processor with single well addressability
A method for single well addressability in a sample processor with row and column feeds. A sample processor or chip has a matrix of reservoirs or wells arranged in columns and rows. Pressure or...
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6391578 |
Method and devices for partitioning biological sample liquids into microvolumes
A method for partitioning an aqueous biological liquid sample into discrete microvolumes for detection and enumeration of microorganisms is described. The method involves distributing microvolumes...
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6391568 |
Method for determining platelet reactivity in a whole blood sample
The present invention provides a method for the quantification and assessment of platelet activation in whole blood samples and monitoring of antiplatelet pharmacologic agents. The method for...
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6379626 |
Reactor plate clamping system
A clamping system including a cover plate with an underside having at least one step, and a bottom plate having a base connected to a first side, a second side, a third side, and a fourth side. The...
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6379916 |
Device and process for the examination of cells using the patch-clamp method
Disclosed is a device and a process for examining cells using the patch-clamp method. A plane arrangement is used of a first number of micro-cuvettes for receiving cells and a plane arrangement of...
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6376233 |
Device for conducting research on cell specimens and similar materials
A device ( 1 ) serves for conducting investigations on cell specimens, wherein the device has a microtiter plate or similar receiving device with a plurality of individual containers for the cell...
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6361953 |
Cell component recovery method
Different probes each having a specific base sequence are immobilized to each of independent areas formed on the surface of a substrate, complementary polynucleotides in a sample solution are...
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6352853 |
Multi-channel electrode arrays
This invention features high-density electrode arrays for use in electroporation. These arrays contain a plurality of electrode pairs where the electrodes in each electrode pair are flat and...
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6340588 |
Matrices with memories
Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid...
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6331441 |
Multiplexed molecular analysis apparatus and method
A method and apparatus for analyzing molecular structures within a sample substance using an array having a plurality of test sites upon which the sample substance is applied. The invention is also...
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6329210 |
Method and apparatus for high volume polymer synthesis
A scalable synthesis apparatus capable of rapid and efficient oligo synthesis. The apparatus includes a combination of dispensing elements, synthesis elements, and waste removal elements. More...
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6322994 |
Method of freeze-drying organisms
A method is provided for freeze-drying multiple samples of viable microorganisms which method comprises: (i) providing a container comprising multiple wells; (ii) dispensing multiple liquid...
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6315940 |
Microelement device
A microelement device has a plurality of microelements, which may be configured as microelectrodes, arranged on a substrate and adapted for making contact to cells present in a liquid environment....
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6309889 |
Nano-grid micro reactor and methods
The invention provides exemplary devices and methods to facilitate the performance of assays. In one embodiment, one such device comprises a holding member having a top surface, a bottom surface,...
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6309828 |
Method and apparatus for fabricating replicate arrays of nucleic acid molecules
A method and apparatus for fabricating replicate arrays of nucleic acid molecules include the preparation of the molecules and the application the molecules onto a substrate in an ordered array....
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6303389 |
Rapid flow-through binding assay apparatus and method therefor
The invention includes assay cassettes that can be employed during rapid flow-through binding assays. The assay cassettes can be disposable units suitable for one-time use and readily assembled to...
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6300142 |
Device and apparatus for conducting an assay
A apparatus for assaying glycated proteins and other analytes in biological samples such as blood, in which a sample is presented to the apparatus, includes an inlet port between moveable between...
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6291249 |
Method using an apparatus for separation of biological fluids
A cell containing sample is separated into a cell containing portion and a substantially cell depleted portion, by mixing the sample with particles to produce a cell containing network, and...
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6284526 |
Method and apparatus for determining the sensitivity of a microorganism to a growth altering agent
A method and an apparatus for determining the concentration at which a growth-altering agent has an appreciable effect on the growth of a target microorganism are provided. The method comprises the...
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6284459 |
Solid support matrices with memories and combinatorial libraries therefrom
Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid...
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6277630 |
Expandable sequencing tray
A DNA sequencing tray (92) holds an array of sample wells (82) in a rank and file pattern by means of rigid file members (85) connected by flexible mechanisms (87) permitting the pattern to be...
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6268210 |
Sandwich arrays of biological compounds
The present invention relates to spatially-addressable sandwich arrays of compounds, particularly biological compounds such as peptides and polynucleotide probes, and methods of making and using...
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6268128 |
Immobilized oligonucleotide probes and uses thereof
The invention is a method of detecting nucleic acids in a sample using oligonucleotide probes which are noncovalently bound to solid supports for rapid, sensitive, hybridization assays. The method...
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6268209 |
Device and method for determination of analyte in a solution
Method and assay devices for the detection of the presence or amount of biological material, analyte(s), or microorganism(s) in a sample. The method includes the steps of liquefying the sample (if...
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6258327 |
Biopsy specimen collection device
The present invention is a biopsy specimen collection device having chambers, for receiving tissue samples of differing sizes from various locations within a particular anatomical organ or system,...
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6238913 |
Apparatus for heating and cooling deep well pharmaceutical microplates
An apparatus for uniformly heating and cooling deep well pharmaceutical microplates when used in fluid connection with a heater/cooler water pump. The apparatus comprises a housing having a divider...
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6238911 |
Culture vessel and microscope for observing sample in culture vessel
The present invention provides a culture vessel and microscope that allows a wide area of favorable observation of the sample in the plural wells even when a negative refractive power is generated...
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6232114 |
Low background multi-well plates for fluorescence measurements of biological and biochemical samples
The invention provides for multi-well plates and platforms that comprise a layer of cycloolefin having low fluorescence and high transmittance. These multi-well plates and platforms are...
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6225079 |
Microtitration unit
A microtitration unit being at least one container of transparent material for accommodating biological test reaction mixtures. The container is subdivided into at least two chambers suitable for...
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6197575 |
Vascularized perfused microtissue/micro-organ arrays
Systems including (1) a micromatrix and perfusion assembly suitable for seeding and attachment of cells within the matrix and for morphogenesis of seeded cells into complex, hierarchical tissue or...
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6197572 |
Thermal cycler having an automatically positionable lid
This invention involves a thermal cycler capable of performing amplification of nucleic acids. This thermal cycler provides for the fully automatic positioning of its movable lid, which can be...
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6193892 |
Magnetic separation assembly and method
Provided are a magnetic particle separation assembly and method for separating a magnetically responsive complex from a non-magnetic test media in which the magnetically responsive complex is...
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6180065 |
Multichannel dilution reservoir
A dilution reservoir (10) with one or more channels (30) is provided in which the channels (30) are easily accessible and which allow improved material manipulation. The dilution reservoir (10)...
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6180417 |
Immunochromatographic assay
Disclosed is a device and method for carrying out an assay for an analyte in a fluid test sample by immunochromatography. The device involves a strip having a non-porous receiving member of a...
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6176609 |
Magnetic tumble stirring method, devices and machines for mixing in vessels
The invention provides a simple method, device and several machines for simultaneously stirring thousands of vessels or wells of microplates in a robust manner and with economy. This method uses...
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6171850 |
Integrated devices and systems for performing temperature controlled reactions and analyses
Reactor systems that include a reaction receptacle that includes a plurality of reservoirs disposed in the surface of a substrate. The reactor system also typically includes a temperature control...
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6157456 |
Cuvette for spectrophotometrical analysis
The present invention relates to a cuvette (4) used for spectrophotometrical analyses, in which electromagnetic energy is passed through a liquid sample (8) contained therein. The object of the...
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6153400 |
Device and method for microbial antibiotic susceptibility testing
A method and apparatus for performing microbial antibiotic susceptibility testing include disposable, multi-chambered susceptibility plates and an automated plate handler and image acquisition and...
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6150158 |
Agricultural product microscreen method and apparatus
Methods and apparati for screening compounds for agricultural activity has now been developed which employ e.g., intact plants grown in microtiter plates on very small amounts of plant growth media...
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6146883 |
Packing device for transporting confluent cell monolayers
A disposable or recyclable device is provided for packaging and transporting ready-to-use viable cell monolayers, particularly confluent cell monolayers. The device includes a liquid impervious...
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