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6632655 |
Manipulation of microparticles in microfluidic systems
Arrays of flowable or fixed particle sets are used in microfluidic systems for performing assays and modifying hydrodynamic flow. Also provided are assays utilizing flowable or fixed particle sets...
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6627410 |
Processing proteins from gels for analysis using mass spectrometry
The invention relates to methods and devices used for digesting small amounts of protein in tiny cut gel pieces and for extracting the peptides resulting from the digestion in preparation for...
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6627447 |
Methods and apparatus for high throughput plate to plate or plate to membrane transfer
Techniques for high throughput parallel separation, filtration and plate-to-plate transfer are described. Cells, proteins, chemical compounds and the like are being developed in multi-well, small...
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6627433 |
Multi-channel analyte-separation device employing side-entry excitation
A side-entry excitation arrangement is provided with a multi-channel analyte-separation device. In various embodiments, a plurality of channels are disposed in an array, with a laser disposed to...
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6620612 |
Device for conducting biochemical and microbiological reactions
The invention relates to a device for conducting biochemical and microbiological reactions, comprising a support ( 2 ) for receiving at least one reaction vessel ( 3 ) and a device ( 5 ) for...
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6613512 |
Apparatus and method for correcting for variable velocity in microfluidic systems
Electrokinetic devices having a computer for correcting for electrokinetic effects are provided. Methods of correcting for electrokinetic effects by establishing the velocity of reactants and...
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6605473 |
Method for characterizing libraries of different materials using x-ray scattering
A method for preparing a library is provided in which the library contains an array of elements and each element contains a different combination of materials. A related apparatus includes an x-ray...
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6602474 |
Multi-vessel container for testing fluids
In comparison with the treatment using only a single vessel, this invention can more efficiently and more completely facilitate the temperature of liquid to be kept at a predetermined temperature...
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6602702 |
Detection system based on an analyte reactive particle
A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into...
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6589790 |
Method and device for filling an analysis card with a liquid medium
Device for filling, with a liquid medium ( 1 ), an analysis card ( 2 ) comprising a body ( 3 ) in which at least one reading cavity ( 3 a ) is formed, and an orifice ( 4 ) communicating with the...
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6585939 |
Microstructures for use in biological assays and reactions
The present invention relates to microstructures which a fabricated from a cast or molded polymer material, such as polydimethylsiloxane (PDMS). The invention describes and claims methods and...
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6582929 |
Method for minimizing optical interference during antibiotic susceptibility readings in a microbiological analyzer
Performing antibiotic testing on samples contained in test arrays by orienting the arrays relative to the direction of gravity so that test solution within the microwells is drawn downwards and air...
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6582912 |
Device, method and apparatus for implementing the method, for dosing at least a particular constituent in a product sample
A device for dosing at least a particular constituent in a product sample has a receptacle and a cover assembled to form a closed container having a vertical axis. The receptacle and cover bear...
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6562213 |
Electrophoresis apparatus for simultaneous loading of multiple samples
Apparatus for simultaneous loading of multiple samples for molecular separation, including a separation area with walls, at least one of the walls has apertures having loading sites, a gel located...
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6558631 |
Multi-well plates
A multi-well plate comprising a plurality of discrete tubes held together in an array by a plate portion, characterised in that one or more section lines are provided in the plate portion in...
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6558947 |
Thermal cycler
A thermal cycling device for a titration plate enables selected sample wells to be individually subjected to heating and cooling cycles independent of the temperature of adjacent sample wells. Each...
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6558633 |
Chemical reaction apparatus and methods
Chemical reaction apparatus, materials and methods are provided for the automatable, efficient synthesis of chemical species and libraries. In accordance with preferred embodiments, chemical...
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6558627 |
Temperature control apparatus and method for pipetting robot
A temperature control apparatus in the form of a plate is provided for pipetting robots, the plate having a spiral tube for a temperature control medium and which apparatus is divided into at least...
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6555389 |
Sample evaporative control
Devices and methods are provided using microfluidic devices for manipulating small volumes and determining a variety of chemical and physical events. The devices rely upon an opening to the...
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6555361 |
Hybridization chamber for high density nucleic acid arrays
The present invention provides a hybridization chamber that contains a built-in mechanism for saturating the air within the chamber when sealed thereby preventing drying of the liquid sample. The...
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6555387 |
Method for producing thin liquid samples for microscopic analysis
The present invention relates to the field of diagnostics by means of microscopic sample analysis, and specifically relates to a method and apparatus for preparing thin microscopic samples of...
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6555792 |
Thermocycler and lifting element
Some of the blind holes ( 6 ) between indentations ( 4 ) of a heating surface ( 3 ) contain lifting elements ( 7 ) which, after opening of a cover, release a microtitre plate ( 13 ) from the...
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6551841 |
Device and method for the detection of an analyte utilizing mesoscale flow systems
Disclosed are devices for detecting the presence of a preselected analyte in a fluid sample. The devices comprise a substrate microfabricated to define a sample inlet port, and a mesoscale flow...
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6551838 |
Microfabricated devices for the storage and selective exposure of chemicals and devices
Microchip devices are provided which include a substrate having a plurality of reservoirs containing a secondary device, a reacting component, or a combination thereof. At least one barrier layer...
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6541233 |
β-glucanase from a bacillus
A β-Glucanase enzyme capable of hydrolytically cleaving mixed glucans is presented. The β-Glucanase is sufficiently stable under alkaline conditions for use in industrial cleaning processes,...
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6541623 |
Interleukin—1 receptor antagonist and uses thereof
The present invention provides novel nucleic acids, the novel polypeptide sequences encoded by these nucleic acids and uses thereof. These novel polynucleotide and polypeptide sequences were...
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6541243 |
Perfusion chamber for electrophysiological testing of oocytes
A perfusion chamber includes a porous oocyte support structure. A continuously sloped top surface and a receiving well in the support structure entrap the underside of the oocyte, thereby...
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6537752 |
Temperature control system for polymerase chain reaction
In a preferred embodiment, a polymerase chain reaction temperature control system, including: a first tank into which a multiwell sample carrier may be placed; apparatus to introduce first...
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6534281 |
Immunoassay for measuring human C-peptide and kit therefor
An immunoassay for selectively measuring human C-peptide as well as a kit therefor is disclosed. In the method, human C-peptide contained in a sample, a first anti-human C-peptide antibody, and a...
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6534014 |
Specimen plate lid and method of using
The specimen plate lid is generally a block, with a cover portion and a side portion. An alignment protrusion extends from the side portion and cooperates with an alignment member of the specimen...
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6528302 |
Thin-well microplate and methods of making same
A thin-well microplate and methods of manufacturing same are provided, wherein the thin-well microplate is conducive for use with automated equipment, such as robotic handling equipment, and in...
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6521447 |
Miniaturized thermal cycler
The invention describes a thermal cycler which permits simultaneous treatment of multiple individual samples in independent thermal protocols, so as to implement large numbers of DNA experiments...
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6514415 |
Method and apparatus for magnetic separation of particles
A method and apparatus for magnetic separation of particles within a container. In one embodiment, a container contains a number of particles and a number of magnetically susceptible particles. A...
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6498032 |
Use of ceramic labels for identifying biomolecule immobilizing subtrates
This invention provides a labeling format for use in assays that require the immobilization of biomolecules on a flat substrate surface. The ceramic labeling indicia of the present invention...
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6492119 |
Hard macro array
A macro array comprises a film-shaped hard porous body and a plurality of spots, which contain test substances and are arrayed on the film-shaped hard porous body. The film-shaped hard porous body...
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6489111 |
Apparatus and methods for immobilized DNA library preparation and gene amplification
A purpose of the present invention is to provide a gene amplification apparatus with simple operation, wherein the apparatus can heat and cool gene rapidly and a thermal cycle can be operated in a...
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6489094 |
Method and device for drug-drug interaction testing sample preparation
A method and device for the automated large scale preparation for testing of drug-drug interactions, particularly with determination of IC 50 and Ki, as a screening tool enhancement for...
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6472144 |
High throughput screening method and apparatus
High-throughput screening method and apparatus are described. The method includes placing cells on a substrate defining a plurality of discrete microwells, at a well density of greater than about...
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6468810 |
Magnetic particle transfer device and method
A device for transfer suitable for capturing and releasing microparticles binding an immobilized substance, which includes a magnet as well as either an extendable membrane, shapable membrane or...
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6468736 |
High efficiency cell analysis system and high throughput drug screening system
A system which can analyze compounds with high efficiency, such as in a high throughput drug screening system. The high throughput drug screening system which can test the action of a drug...
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6458526 |
Method and apparatus to inhibit bubble formation in a fluid
The invention relates to an apparatus for inhibiting bubble formation during a chemical reaction. The apparatus comprises a base having a substantially planar surface with at least a portion of the...
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6458275 |
Multi-well equilibrium dialysis system
This invention relates to an equilibrium dialysis system in a multi-well format for the simultaneous preparation of multiple samples. Such an equilibrium dialysis system can be used for protein...
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6455007 |
Apparatus and method for testing compositions in contact with a porous medium
An apparatus for use in testing a plurality of compositions in parallel. The apparatus includes an upper plate having a plurality of openings extending therethrough to form upper fluid chambers and...
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6455310 |
Cell culture apparatus and method for culturing cells
Provided is a cell culture apparatus for culturing cells, and optionally, for performing magnetic separation of cells desired to be cultured. The cell culture apparatus preferably comprises a...
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6451591 |
Device and method for the determination of protein domain boundaries
A method and device to assist in the determination of protein domain boundaries is described. In particular the device is designed to provide a high throughput of proteolytic digestion of proteins...
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6448002 |
Method to detect clinically relevant mutations of the DNA sequence of ki-ras oncogene, its use and a testkit for early diagnosis of tumors
Disclosed is a method to detect clinically relevant mutations of the DNA sequence of the KI-ras oncogene in stool DNA, its use and a testkit based thereon for early diagnosis of tumors, especially...
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6440645 |
Production of microstructures for use in assays
A process for the production of a device having a surface microstructure of wells or channels. In the process one or more steps of screen-printing the microstructure as a curable material onto a...
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6436698 |
Apparatus for automatic measuring of water toxicity
The present invention relates to an apparatus for automatic measuring of water toxicity. More specifically, the present invention provides an apparatus for automatic and continuous measuring of...
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6436351 |
Microtitre chemical reaction system
A microtiter reaction system ( 15 ), comprising, a support rack ( 16 ) having an array of reaction wells ( 18 ) disposed therein, each reaction well ( 18 ) having an open top end ( 30 ) and a...
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6432366 |
Apparatus for synthesis of multiple organic compounds with pinch valve block
The simultaneous synthesis of diverse organic compounds is performed in stackable modules which are moveable among nesting sites located on work station platforms. The reactor module includes a...
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