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7250258 |
CDK5 genetic markers associated with galantamine response
Haplotypes in the CDK5 gene associated with cognitive response to galantamine treatment are disclosed. Compositions and methods for detecting and using these CDK5 haplotypes in a variety of...
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7250308 |
Capture assay utilising a particulate analyte
Device ( 1 ) for assaying a particulate analyte, comprising (a) a receptacle ( 2 ) for receiving a suspension ( 5 ) of particulate analyte, and containing label ( 3 ) for the particulate analyte,...
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7247469 |
Non-specific binding resistant protein arrays and methods for making the same
Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an...
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7244611 |
Methods and devices for hybridization and binding assays using thermophoresis
An apparatus and method for performing hybridization or binding assays under thermophoretic conditions is provided.
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7241417 |
Assay device
A device for carrying out a lateral flow assay on a sample comprising: (a) a sample containing unit comprising a sample container, said sample container being closed off at one end by a bottom...
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7241421 |
Miniaturized fluid delivery and analysis system
The present invention provides a method for combining a fluid delivery system with an analysis system for performing immunological, chemical, or biological assays. The method provides a miniature...
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7241624 |
Dendrimer-based DNA extraction methods and biochips
The present invention provides a dendrimer-based biochip, wherein a flow channel through which a solution containing biopolymer molecules is flowed is formed in the substrate of the biochip, a...
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7238519 |
Automated immunoassay cassette, apparatus and method
An immunoassay cassette, apparatus, and method for detecting an analyte in a liquid body-fluid sample are disclosed. The cassette has a body and a support mounted on the body, for movement relative...
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7238520 |
PCR sample preparation holder and method
A simplified Polymerase Chain Reaction (PCR) sample preparation apparatus and method of using a PCR sample preparation for both liquid and dry samples. A portable apparatus comprising a handle...
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7238521 |
Microarray hybridization device having bubble-fracturing elements
A novel hybridization device that improves the efficiency and consistency of microarray hybridization reactions by achieving a greater degree of internal mixing of target solution. The device...
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7238937 |
Substrate adapter for use in mass spectroscopy analysis
Disclosed herein is a device for holding a substrate having one or more samples in a position for ionizing the samples with a light energy source. The device has a receiving plate with a receiving...
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7238538 |
Chromatographic assay device and methods
A chromatographic assay device for the analysis of an analyte in a liquid sample has a proximal sample application zone and a distal test zone. The test zone contains a first ligand capable of...
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7238518 |
Oligonucleotide-immobilized substrate for detecting methylation
The presence or absence of methylation of C's in CpG dinucleotide in a sample DNA that contains a target sequence including the CpG dinucleotide is detected as follows. Multiple kinds of capture...
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7238322 |
Delayed and diffused flow rapid confirmatory immunological testing apparatus and method
A self-contained apparatus using a gravitationally encouraged, interrupted, downward, diffusive and programmed flow of fluid to provide for rapid confirmatory immunological testing (“RCIT”) in,...
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7235400 |
Laminated microarray interface device
A device for forming a low volume reaction chamber on a substrate such as a microarray slide and its method of use is disclosed. The reaction chamber forming device has an adhesive laminate design...
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7235406 |
Nucleic acid analysis device
The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention...
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7235389 |
Molecular detection device and chip including MOSFET
A molecular detection chip including a metal oxide silicon-field effect transistor (MOSFET) on sidewalls of a micro-fluid channel and a molecular detection device including the molecular detection...
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7232691 |
Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres
The present invention is directed to processes of separating, analyzing and/or collecting selected species within a target sample by use of magnetic microspheres including magnetic particles, the...
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7232689 |
Calibration procedure for investigating biological systems
Use of calibrant in extraction phase is described for quantification of components of interest in samples in laboratory application as well as in on-site monitoring. This approach is particularly...
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7232661 |
Diagnostic agents for the prenatal diagnosis of preterm delivery, fetal infection, and fetal damage, and diagnostic kit containing the same
This invention is about a method for the prenatal diagnosis of preterm delivery, fetal infection, and fetal damage, and diagnostic reagent system and diagnostic kit for the diagnosis. The method,...
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7232547 |
Apparatus and method for testing and continuously reading low-volume samples
The present invention is directed to a well sampling tape (otherwise known as “microwell tape” or simply “tape”), a dispenser for dispensing small volumes of liquid into the wells formed in...
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7229799 |
System and method for nucleic acid sequencing by polymerase synthesis
This invention relates to improved methods for sequencing and genotyping nucleic acid in a single molecule configuration. The method involves single molecule detection of fluorescent labeled PPi...
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7229840 |
Surfaces comprising a hydrophilic spacer, covalently bonded to hydrogels
The object with the funtionalized hydrogel surface for detection of analyte molecules is obtainable by a process including (1) providing a hydrogel layer on a base surface; (2) bonding organic...
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7229821 |
Acoustic wave RFID/biosensor assemblies
A deployable acoustic wave RFID/biosensor assembly has at least one protective layer, and an acoustic wave RFID/biosensor within the protective layer or layers. The acoustic wave RFID/biosensor...
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7226777 |
Turbidimetric immunoassay and an apparatus therefor
According to the present invention, the expansion of measurable concentration range for an antigen in a sample solution can be achieved, without a step of dilution or the like. The concentration of...
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7226794 |
Surface-enhanced Raman spectroscopy for biosensor systems and methods for determining the presence of biomolecules
Biosensors, methods, and systems for determining the presence of biomolecules using surface-enhanced Raman spectroscopy (SERS) are provided.
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7224474 |
Positioning method for biochip
Disclosed is a positioning method for biochip spotting, which can spot the bio-probe precisely on the specific position of a biochip substrate, and the steps thereof comprising: (a) providing...
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7223609 |
Arrays for multiplexed surface plasmon resonance detection of biological molecules
Arrays are provided for multiplexed evanescent scanning by allowing for high-contrast Surface Plasmon Resonance images thereof. The arrays target features are typically biopolymeric in nature,...
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7223534 |
Diffraction-based diagnostic devices
A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and deactivated areas of the...
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7223592 |
Devices and methods for performing array based assays
Devices and methods for assaying a sample for the presence of at least one analyte are provided. The subject compression devices include a base and a cover configured to apply a compression force...
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7223368 |
Diffraction-based diagnostic devices
A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and inactive areas of the...
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7220573 |
Array assay devices and methods of using the same
Array assay devices and methods for using the same in array based assays are provided. The subject devices are characterized by having a base dimensioned to hold a substrate having at least one...
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7220389 |
Biochemical analysis unit and method of producing thereof
The biochemical analysis unit has a base plate and absorptive regions. The absorptive regions are surrounded by the base plate formed of materials which shield a radioactive ray and a light. In the...
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7220550 |
Molecular wire injection sensors
Disclosed is a sensor for sensing the presence of an analyte component without relying on redox mediators. This sensor includes (a) a plurality of conductive polymer strands each having at least a...
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7220595 |
Automated immunoassay cassette, apparatus and method
An immunoassay cassette, apparatus, and method for detecting an analyte in a liquid body-fluid sample are disclosed. The cassette has a body and a support mounted on the body, for movement toward...
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7220574 |
Hyphen-specific factors from Candida albicans
The present invention relates to biochips, in particular nucleotide chips, which contain hyphen-specific proteins coding nucleotides, protein chips which contain hyphen-specific proteins, and...
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7217562 |
Gradient structures interfacing microfluidics and nanofluidics, methods for fabrication and uses thereof
The present invention relates to a device for interfacing nanofluidic and microfluidic components suitable for use in performing high throughput macromolecular analysis. Diffraction gradient...
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7217573 |
Method of inspecting a DNA chip
A method of inspecting a DNA chip and an apparatus therefor that allow a picture to be reconstructed in the following steps: A plurality of irradiation spots are formed on a DNA probe array mounted...
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7217520 |
Microwell biochip
Microwell biochips ( 11 ) are formed from a thin flat plate ( 13 ) of polymeric material having a plurality of regularly spaced holes ( 15 ) that extend completely therethrough and create...
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7214529 |
Nucleic acid amplification reaction station for disposable test devices
An instrument for conducting nucleic acid amplification reactions in a disposable test device. The test device includes a first reaction chamber containing a first nucleic acid amplification...
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7214528 |
Device for direct electrical detection of molecules and molecule-molecule interactions
An analysis device includes an electrode arrangement, a current/voltage provider, and a circuit analyzer. The electrode arrangement has an interdigitated electrode pair including a first electrode...
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7214492 |
Nucleic acid arrays to monitor water and other ecosystems
Disclosed are arrays for monitoring ecosystems, such as bodies of water, and methods and systems for making such arrays. In one embodiment, the array may include a plurality of oligonucleotides...
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7214531 |
Pressure transduced chemical assay and method
An assay system has a chamber that receives a test strip onto which a sample comprising an analyte has been placed. The chamber is in gaseous communication with a piezoelectric material that...
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7214346 |
Optoelectronic detection system
The invention relates to optoelectronic systems for detecting one or more target particles. The system includes a reaction chamber, a specimen collector, an optical detector, and a reservoir...
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7214530 |
Biomolecule diagnostic devices and method for producing biomolecule diagnostic devices
A biosensor includes a substrate with a layer of receptive material disposed thereon overlying a layer containing a photo-reactive agent. The receptive material is specific for an analyte of...
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7214500 |
Brush-like structured surface of poly(ethylene oxide) having elevated density
A surface on which adsorption of protein (e.g., BSA) is markedly suppressed is provided, by contacting solutions of polymers whose chief component is poly(ethylene oxide) having binding sites to...
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7211444 |
Waveguide and assay
A fluidic waveguide comprising a container and a fluid that fills said container, wherein said fluid has a refractive index greater than the refractive index of the wall of said container and...
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7208276 |
Probe carrier and method for analyzing the probe carrier
Nucleic acid probes arranged on a nucleic acid chip substrate in a matrix form can be analyzed quantitatively by TOF-SIMS with accuracy by forming a phosphorus-containing area which can be used as...
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7208277 |
Method for correcting inter-pin spotting amount error for a microarray
The present invention has an objective of obtaining more accurate data of microarray experiments by correcting an inter-pin spotting amount error caused upon microarray production using a plurality...
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7205159 |
Diagnostic testing process and apparatus
A method and apparatus for use in a flow through assay process is disclosed. The method is characterised by a “pre-incubation step” in which the sample which is to be analysed, (typically for...
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