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7381570 |
Device and method for multiple analyte detection
The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention...
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7381525 |
AC/DC voltage apparatus for detection of nucleic acids
The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids...
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7381535 |
Methods and compositions for detecting receptor-ligand interactions in single cells
The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides...
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7378279 |
Examination device and method for examination of chemical and/or biological samples
An analyzing device for analyzing chemical and/or biological samples comprises a plurality of base parts, e. g. object holders, in a receiving device. The base parts are closed by a lid which is...
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7378270 |
Device for analyte measurement
A biochemical analysis instrument for multiple fluid analyses includes a housing. A sensor for sensing a reaction is disposed in the housing. An aperture is formed in the housing. A test tape...
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7378236 |
Method for analyzing gene expression patterns
A method and device for detecting or monitoring the treatment status of a selected physiological state or disease condition. The device has a subarray of genes which show a statistically...
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7374945 |
Method for enhancing the association rates of polynucleotides
The present invention features a method and associated kit for increasing the association rate between polynucleotides having complementary, single-stranded regions, where the method includes...
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7374950 |
Immunoassay device for diagnosing congestive heart failure and predicting mortality in congestive heart failure patients
An immunochemical assay device for determining the presence of NT-proBNP alone or conjunctively with Cardiac Troponin I comprising a base member, an array disposed on the base member, and at least...
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7374927 |
Methods of analysis of degraded nucleic acid samples
The invention provides arrays for analysis of compromised nucleic acid samples, for example, nucleic acids obtained from formalin fixed paraffin embedded samples and methods to analyzed these...
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7371585 |
Membranes incorporating recognition moieties
The present invention provides a thiosulfonate-activated ionophore comprising an ionophore, a spacer group, and an alkylthiosulfonate moiety. A preferred ionophore is gramicidin A. A preferred...
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7371516 |
Methods for determining the specificity and sensitivity of oligonucleo tides for hybridization
The present invention provides materials and methods which may be used to evaluate one or more different probes and select probes that are optimized for sensitivity and specificity for a particular...
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7371564 |
Apparatus for automatically analyzing genetic and protein materials using photodiodes
An apparatus for automatically analyzing genetic and protein materials using photodiodes. The apparatus comprises a computer for controlling the entire operation of the apparatus and analyzing a...
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7371580 |
Use of unstructured nucleic acids in assaying nucleic acid molecules
The present invention provides a system and methods for assaying nucleic acid molecules with reduced levels of background signal and enhanced specificity and sensitivity. In particular, the present...
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7371562 |
Guided mode resonant filter biosensor using a linear grating surface structure
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also...
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7373253 |
Multi-test analysis of real-time nucleic acid amplification
A method and device are described for analyzing a sample for the presence of a nucleic acid wherein the sample is amplified, illustratively using PCR, in the presence of a fluorescent probe capable...
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7371583 |
Apparatus and method for analyte detection
Disclosed is a testing device and methods for the identification of an analyte of interest in a sample. In a preferred embodiment, the testing device includes a front panel having at least one...
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7368238 |
Method for manufacturing a DNA probe array
There is used at least one probe array obtained by arraying particles having various probes, respectively, fixed thereon (probe particles) in a definite order in a holder. A plurality of...
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7368280 |
Detection of biospecific interactions using amplified differential time domain spectroscopy signal
A method for detecting specific associations between a tethered molecule and an untethered target molecule. The method comprises (1) selecting a tethered molecule; (2) alternately impinging THz...
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7368281 |
Label-free evanescent-field detection of biological and chemical agents
An evanescent-field sensor system and method of using the system to detect either liquid- or airborne biological pathogens, chemical agents, and other harmful or toxic species is provided. The...
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7364850 |
DNA probe array
There is used at least one probe array obtained by arraying particles having various probes, respectively, fixed thereon (probe particles) in a definite order in a holder. A plurality of...
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7364896 |
Test strips including flexible array substrates and method of hybridization
Individual and aggregate test strip arrays having a backing strip supporting a flexible array substrate which supports an addressable collection of probes are taught. Hybridization cells for use...
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7364918 |
Colorimetric sensors constructed of diacetylene materials
Colorimetric sensors comprising a receptor incorporated within polydiacetylene assemblies to form a transducer capable of indicating a color change when contacted with an analyte are disclosed....
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7364696 |
Methods and devices for droplet microchromatography
Disclosed devices and methods for droplet microchromatograhy are aimed at optical monitoring and rapid analysis of a drying droplet. The device includes droplet deposition component preferably made...
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7364897 |
Methods and devices for performing chemical reactions on a solid support
Apparatus and methods for carrying out biochemical processes directly on a substrate are provided. A substrate assembly includes a cartridge that removably supports a substrate in a fixed position,...
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7364898 |
Customized micro-array construction and its use for target molecule detection
The present invention relates to a detection and quantification method of different sets of target molecules ( 1, 3 ), being possibly present simultaneously in a biological sample by the use of a...
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7361468 |
Methods for genotyping polymorphisms in humans
Methods, kits and arrays of nucleic acid probes for genotyping large numbers of human SNPs in parallel are provided. A set of more than 100,000 human SNPs, known to be biallelic in at least two...
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7361466 |
Nucleic acid analysis using terminal-phosphate-labeled nucleotides
The present invention is directed to a method of sequencing a target nucleic acid molecule having a plurality of bases. In its principle, the temporal order of base additions during the...
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7361501 |
Miniaturized spectrometer using optical waveguide and integrated Raman system on-chip
One embodiment relates to an analyzer having an interferometer, a detector and a microprocessor, wherein the analyzer does not contain a spectrometer having a dispersive grating, the interferometer...
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7358078 |
Auto microfluidic hybridization chip platform
An auto microfluidic hybridization chip platform is disclosed to provide a hybrid reaction test system with the features of fast reactions, automatic operations, and a convenient platform. The...
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7358079 |
Flow cell array and the utilization thereof for multianalyte determination
A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate...
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7358049 |
Gene chip technology for determining memory genes
The present invention relates to methods of identifying genes involved in memory formation. This is accomplished by performing a gene chip identification of those genes expressed during...
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7358097 |
Making a matrix of random encoded arrays
Disclosed is an apparatus and method of maintaining chips or arrays of particles, or arrays of particles deposited on chip surfaces, in a designated area on a substrate surface. This is...
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7358081 |
Devices for the electrochemical detection of a nucleotide sequence, analysis cassettes, systems of analysis cassettes, supplemental modules, and methods for producing analysis cassettes
Devices for the electrochemical detection of a nucleotide sequence in a fluid are described that include (a) a working electrode and a counter-electrode wherein the working electrode is attached to...
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7358099 |
Process for (A) separating biological/ligands from dilute solutions and (B) conducting an immunochromatographic assay thereof employing superparamagnetic particles throughout
Superparamagnetic (“SPM”) subunits of 1–30 nm average mean diameter (e.g. ferro fluid) subparticles are treated with a magnetically noninterfering substance capable of coating and covering...
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7354773 |
Method and apparatus for preparing cell samples for intracellular antigen detection using flow cytometry
A method and apparatus for preparing biological cell samples for intracellular analysis. The invention is based upon the recognition that many of the steps of the conventional methods for such...
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7351575 |
Methods for processing biological materials using peelable and resealable devices
Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat...
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7351590 |
Methods and compositions for directed microwave chemistry
The present invention concerns a novel means by which specific chosen reactions can be accelerated through the use of a new type of artificial enzyme. The invention allows specific reactions to...
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7351528 |
Probing of specific nucleic acids
The present invention relates to improved methods for probing of specific nucleic acids using circularizable probes designed such that they report the presence of a target sequence by allowing a...
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7351378 |
Nucleic acid extraction device
The present invention provides an apparatus for extracting nucleic acid from a specimen, including traditionally difficult specimens, in preparation for polymerase chain reaction (PCR) analysis....
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7351591 |
Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS)
The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and...
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7348182 |
Directed microwave chemistry
The present invention concerns a novel means by which chemical preparations can be made. Reactions can be accelerated on special chips using microwave energy. The chips contain materials that...
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7348181 |
Self-encoding sensor with microspheres
A microsphere-based analytic chemistry system is disclosed in which self-encoding microspheres having distinct characteristic optical response signatures to specific target analytes may be mixed...
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7344893 |
Immuno-gold lateral flow assay
A chromatographic lateral-flow assay system for rapid, high sensitivity method of detecting low levels of ligands in body fluids, with few false positives and few false negatives. The lateral-flow...
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7344877 |
Biomolecule microarray support
A biomolecule microarray support is comprised of a frame with upward projecting side walls. A transparent substrate is detachably positioned on the frame within the walls. A printed hydrophobic...
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7341835 |
Methods of analysis of alternative splicing in mouse
The invention provides nucleic acid sequences which are complementary, in one embodiment, to a wide variety of mouse genes. The invention provides the sequences in such a way as to make them...
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7341696 |
Nanoporous membrane immunosensor
A sensor for a selected analyte in a test sample has (a) a semipermeable membrane with pores for retaining the analyte, where the membrane has been chemically modified by attachment of membrane...
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7341865 |
Liquid delivery devices and methods
Methods and devices are provided for using high-density arrays of diverse chemical entities. In preferred embodiments, small volumes of multiple liquids are delivered to multiple reaction sites on...
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7338811 |
Integrated circuit chip for bioassays
The invention is directed to novel IC chips containing substances used particularly in bioassays. Furthermore, the invention is directed to assay methods and kits using these chips.
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7338760 |
Sample preparation integrated chip
The present invention relates to an apparatus comprising a substrate having at least one assay station. The at least one assay station has at least a first assay station channel and at least a...
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7335514 |
Optical biosensor
The present invention relates to an optical biosensor comprising a porous matrix. In the specific case, reference is made to anodized porous alumina, on the surface of which the biological...
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