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7011948 |
Detection of ligand-antiligand complex formation by electromagnetically detectable bulk property measurement
Disclosed are methods for analyzing molecular binding events in which the formation of ligand/antiligand complexes can be directly detected in a mixture without requiring separation of the...
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7011943 |
Method for detecting a designated genetic sequence in murine genomic DNA
The present invention provides a method and apparatus for to conduct transgenic and targeted mutagenesis screening of genomic DNA. This invention also provides a system for screening DNA for a...
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7011971 |
Method of making random array of microspheres using enzyme digestion
A method of making a microarray comprising the steps of:—providing a support;—coating on the support a fluid composition containing microspheres and gelatin;—immobilizing the microspheres in...
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7011940 |
Quality control for cytochemical assays
The invention describes quality control devices for assays that measure analytes in cells and tissue samples, and methods of use thereof. In particular, the quality control device comprises a...
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7011955 |
Quantitative determination of analytes in a heterogeneous system
The invention concerns a method for quantitative or qualitative determination of an analyte or its interaction or reaction kinetics in a system with at least two different phases, comprising the...
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7011945 |
Random array of micro-spheres for the analysis of nucleic acids
A method of identifying nucleic acid samples comprising: providing a mircoarray including a substrate coated with a composition including a population of micro-spheres dispersed in a fluid...
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7008788 |
Containers for supports comprising biopolymers
Devices and methods are disclosed for containing and processing samples on the surface of supports. Biopolymer features are attached to the surfaces of the supports. A device in accordance with the...
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7008799 |
Analytical test element with a capillary channel
The invention concerns an analytical test element for the determination of an analyte in a liquid containing an inert carrier, a detection element and a channel capable of capillary liquid...
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7008769 |
Nanoscale molecular arrayer
The present invention is a dedicated apparatus for the formation of array that includes one or more deposition domains comprised of one or more deposition materials. The present invention may...
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7008796 |
Assay sonication apparatus and methodology
An assay apparatus includes a cell with a working electrode and a sonicating device structurally coupled to the cell for sonication the contents of the cell.
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7009154 |
Process for manufacturing integrated chemical microreactors of semiconductor material
The microreactor is completely integrated and is formed by a semiconductor body having a surface and housing at least one buried channel accessible from the surface of the semiconductor body...
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7005259 |
Methods for array preparation using substrate rotation
Methods are provided for the preparation of polymer arrays on wafers wherein the wafers are rotated between synthesis steps to provide more uniform results across the entire wafer.
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7005293 |
Multiple axis printhead adjuster for non-contact fluid deposition devices
Non-contact fluid deposition devices having multiple axis printhead adjusters are provided. The subject printhead adjusters are made up of a single rigid frame that holds at least one printhead...
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7005265 |
Nonenzymatic catalytic signal amplification for nucleic acid hybridization assays
Devices, methods, and kits for amplifying the signal from hybridization reactions between nucleic acid probes and their cognate targets are presented. The devices provide partially-duplexed,...
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7001572 |
Analyzing device with biochip
The invention concerns a device for analyzing at least an analyte, comprising a container and a biochip defining together at least a section, attached to the container by a suitable adhesive. The...
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7001792 |
Ultra-fast nucleic acid sequencing device and a method for making and using the same
A system and method employing at least one semiconductor device, or an arrangement of insulating and metal layers, having at least one detecting region which can include, for example, a recess or...
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6998230 |
Array fabrication with drop detection
A drop deposition apparatus, and a method and computer program products using the drop deposition apparatus, for fabricating at least one addressable array of biopolymers on a substrate. The drop...
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6998236 |
Methods for detecting interaction between a test moiety and a plurality of target moieties
This invention relates generally to the field of microarray technology. In particular, the invention provides an integrated microarray device, which device comprises a substrate comprising a...
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6994972 |
Porous substrates for DNA arrays
A planar, rigid substrate made from a porous, inorganic material coated with cationic polymer molecules for attachment of an array of biomolecules, such as DNA, RNA, oligonucleotides, peptides, and...
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6991912 |
Systems and methods for performing magnetic chromatography assays
Novel magnetic assay methods and systems. According to a preferred embodiment, a chromatographic medium, which preferably comprises a test strip, is provided that is designed to be contacted with a...
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6991932 |
Carbon nanotube connected instrument
A gene sequence-reading instrument comprising attractive force-generating probes (terminals) each retaining DNA-constituting bases to carbon nanotubes, a detecting part for detecting the attractive...
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RE38960 |
Isothermal strand displacement nucleic acid amplification
Methods for amplifying target nucleic acid sequences using a nucleic acid polymerase lacking 5′ exonuclease activity and a set of oligonucleotide primers. Preferably, a primer array is used. The...
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6989130 |
Method and automated fluidic system for detecting protein in biological sample
An automated microfluidic system that includes a cartridge reservoir part, a cartridge, a compressed-air storage tank, a buffer storage tank, and a reader is provided. The automated microfluidic...
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6989234 |
Method and apparatus for non-contact electrostatic actuation of droplets
An apparatus for actuating a droplet comprises a first conductive layer, a second conductive layer, a conductive elongate element, and a voltage source. The first conductive layer comprises a first...
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6989267 |
Methods of making microarrays with substrate surfaces having covalently bound polyelectrolyte films
Methods for stably associating a polyelectrolyte coating or film to a substrate surface, as well as the coated substrates produced thereby, are disclosed herein. In the subject methods, substrate...
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6987018 |
Container for holding cells or viruses for disruption
A container for holding cells or viruses for disruption comprises a chamber defined by two spaced apart, opposing major walls and side walls connecting the major walls to each other. At least one...
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6984516 |
Multilayered microfluidic DNA analysis system and method
A multilayered microfluidic DNA analysis system includes a cell lysis chamber, a DNA separation chamber, a DNA amplification chamber, and a DNA detection system. The multilayered microfluidic DNA...
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6982166 |
Lens assembly for biological testing
The invention relates to an optical detection system for a thermal cycling device including at least one light source, a light detection device for detecting light received from a plurality of...
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6982165 |
Nucleic acid sequencing by raman monitoring of molecular deconstruction
The disclosed methods, apparatus and compositions are of use for nucleic acid sequencing. More particularly, the methods and apparatus concern sequencing single molecules of single stranded DNA or...
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6982149 |
Fiber array and methods for using and making same
An apparatus and method are provided for contacting at least two chemical species, comprising a support plate having a channel for receiving a mobile chemical species and a fiber, having a second...
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6979543 |
Method for detecting biological agents
A sensor is provided including a polymer capable of having an alterable measurable property from the group of luminescence and electrical conductivity, the polymer having an intermediate...
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6979567 |
Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide with an integral semicylindrical lens, and has multi-analyte features and...
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6979576 |
Methods of use of one step immunochromatographic device for Streptococcus A antigen
A method to determine the presence or absence of Streptococcus Group A antigen in a sample, comprising the following steps: extracting the antigen from the sample in an assay chamber with two or...
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6979450 |
Method and compositions for detection and diagnosis of infectious diseases
Methods and compositions for the detection and diagnosis of infectious diseases are provided. In particular, efficient and sensitive methods and compositions for the detection of active...
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6977178 |
System and method for transgenic and targeted mutagenesis screening
The present invention provides a method and apparatus for to conduct transgenic and targeted mutagenesis screening of genomic DNA. This invention also provides a system for screening DNA for a...
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6977180 |
Biosensor
The present invention relates, in general, to biosensors and, in particular, to bioelectronic sensors comprising a macromolecule immobilized on an electrode surface so that a redox cofactor that is...
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6977149 |
Biochemical reaction detection apparatus
A biochemical reaction detection chip capable of controlling the temperature for biochemical reactions including hybridizations and its substrate. The function of the chip is performed by...
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6974693 |
Integrated chemical microreactor, thermally insulated from detection electrodes, and manufacturing and operating methods therefor
Integrated microreactor, formed in a monolithic body and including a semiconductor material region and an insulating layer; a buried channel extending in the semiconductor material region; a first...
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6974673 |
Coupled capillary fiber based waveguide biosensor
An evanescent-wave optical biosensor includes a hollow optical waveguide, preferably in the form of a light-conductive capillary, surrounding a central waveguide preferably in the form of an...
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6974672 |
Gene amplification in cancer
There are disclosed methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers in mammals, for example, humans, utilizing the CTSZ and CD24 genes, which are...
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6969605 |
Miniature immuno-optical rapid analyte sensor platform
A hand held, self-contained, automatic, low power and rapid sensor platform for detecting and quantifying a plurality of analytes. A sample solution potentially containing an unknown amount of an...
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6964862 |
Sample processing device and method
A device for processing a biological sample includes a processing unit having at least one opening to receive a sample vessel and a plurality of processing stations positioned along the opening....
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6962782 |
Method for producing addressed ligands matrixes on a support
A method for fabricating matrices of addressed ligands on a carrier. In the method, an element is used such as a reservoir filled with ligand and containing an electrode to deposit and...
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6962808 |
Method and apparatus for measurement of the effect of test compounds on signal transduction at the level of biological receptors
There is provided an apparatus for screening pharmacological agents for agents which induce regression of cancer. The apparatus includes an evanescent sensing device, at least one sensor having...
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6960467 |
Biochannel assay for hybridization with biomaterial
The invention relates to a microfluidic device with microchannels that have separated regions which have a member of a specific binding pair member such as DNA or RNA bound to porous polymer, beads...
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6960437 |
Nucleic acid amplification utilizing microfluidic devices
The present invention provides microfluidic devices and methods using the same in various types of thermal cycling reactions. Certaom devices include a rotary microfluidic channel and a plurality...
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6958216 |
DNA-bridged carbon nanotube arrays
A class of biological sensing devices that include a substrate comprising an array of carbon nanotubes (CNTs) to which are chemically attached biological molecules is disclosed. The attached...
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6958225 |
Complexity management of genomic DNA
The presently claimed invention provides for novel methods and kits for reducing the complexity of a nucleic acid sample by providing non-gel based methods for amplification of a subset of the...
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6955889 |
Simultaneous determination of forward and reverse ABO blood group
Simultaneous forward and reverse blood group testing is described using both a visual detection system and a fluorescent based labeling and detection system. Forward and reverse tests could be...
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6955881 |
Method and apparatus for producing biochips
A method and apparatus for mass producing biochips quickly and easily, wherein a plurality of DNA molecules are amplified using a PCR (polymerase chain reaction) method and transcribing the...
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