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7135330 |
Nucleic acid detecting cassette, nucleic and detecting apparatus utilizing nucleic acid detecting cassette, and nucleic acid detecting system utilizing nucleic acid detecting cassette
A nucleic acid detecting cassette comprises a fluid holding channel capable of varying the inner volume and holding a reagent, an inlet-outlet port connected to the fluid holding channel and...
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7135329 |
Immunoassay device for diagnosing congestive heart failure and predicting mortality in congestive heart failure patients
An immunochemical assay device for determining the presence of NT-proBNP alone or conjunctively with Cardiac Troponin I comprising a base member, an array disposed on the base member, and at least...
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7135295 |
Detection of small molecules by use of a piezoelectric sensor
A protein comprising an antigen-binding portion formed by two cooperating peptide sequences of FIGS. 3 A and 3 B of the application. The protein may alternatively comprise an altered...
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7135284 |
Primer extension methods for production of high specific activity nucleic acid probes
The present invention provides novel nucleic acid labeling techniques that generate nucleic acid probes with specific activities at least ten fold higher than the levels obtained using standard...
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7132078 |
Assay apparatus
Assay apparatus comprising: a moulded cartridge containing a lateral flow test strip which has a label pad containing an enzyme antibody or antigen conjugate having affinity for an analyte; a...
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7129047 |
Method for manufacturing a nucleotide detector
A nucleotide detector 10 includes: metal particles 12 having a size of the order of nanometers (diameter: about 6 nm) placed on a surface of a substrate 11 at high density with high precision...
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7129046 |
Linking to chemical array assemblies with metal layers
A method of producing a front surface modified substrate, which substrate includes a metal layer, and which is useful in the fabrication of an array of multiple probes bonded to a front surface of...
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7129041 |
Polymerase chain reaction assays for monitoring antiviral therapy and making therapeutic decisions in the treatment of acquired immunodeficiency syndrome
The present invention relates to methods of monitoring, via polymerase chain reaction, the clinical progression of human immunodeficiency virus infection and its response to antiretroviral therapy....
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7125710 |
Apparatus for measuring the genetic sequence of biopolymers
The present invention relates to apparatus for measuring the genetic sequence of electrically charged biopolymers by means of hybridization. The measuring apparatus comprises a container that...
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7122303 |
Arrays comprising background features that provide for a measure of a non-specific binding and methods for using the same
Methods for substantially improved detection and analysis in nucleic acid hybridization assays are described. The methods provide the reliable estimation of background signal which derives...
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7122378 |
Carriers having biological substance
By the present invention, there is provided a fiber having nucleic acid immobilized thereon, an alignment of fibers having nucleic acid immobilized thereon, and a slice thereof.
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7122304 |
Methods for the storage and synthesis of nucleic acids using a solid support
The invention relates to storage of nucleic acid (particularly mRNA) on a solid support and to using such nucleic acid in nucleic acid synthesis or amplification reactions. In a preferred aspect,...
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7118907 |
Single molecule detection systems and methods
A microfluidic system is provided that includes a substrate, a first microchannel disposed in the substrate for providing a reactant to a reaction zone, a second microchannel disposed in the...
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7118892 |
Automated process for preparing and amplifying a target nucleic acid sequence
An automated process for preparing and amplifying a target nucleic acid sequence within a stand-alone unit.
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7118922 |
System and method for immunosensor regeneration
The present invention allows for regeneration of any chemical and biological sensor systems without totally destroying the primary antibodies in the system. The present invention provides...
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7118863 |
Methods for detecting NTR3 nucleic acids by hybridization
The present invention provides a purified polynucleotide encoding a novel receptor, designated NTR3, which belongs to the TNF receptor gene superfamily; to purified NTR3 polypeptide molecules; to...
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7118855 |
Diffraction-based diagnostic devices
A biosensor includes a substrate with a layer of receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of active and inactive areas of the...
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7115400 |
Methods of nucleic acid amplification and sequencing
Methods for amplification and sequencing of at least one nucleic acid comprising the following steps: (1) forming at least one nucleic acid template comprising the nucleic acid(s) to be amplified...
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7115362 |
Electrochemical test device and related methods
An electrochemical test device is provided for determining the presence or concentration of an analyte in an aqueous fluid sample. The electrochemical test device includes a working electrode and a...
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7112451 |
Biosensor
A biosensor is provided with an area in which a reagent having bleaching action is carried in a state where it can be dissolved, at least in a part of a sample application area to which an...
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7112453 |
Retentate chromatography and protein chip arrays with applications in biology and medicine
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity...
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7112452 |
Method and sensor for detecting the binding of biomolecules by shear stress measurement
A method and sensor are provided for detecting the binding of a probe and a target biomolecule by measuring a difference in the shear stress on the surface of the sensor before and after...
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7109042 |
Assays
An analytical test device useful for example in pregnancy testing, comprises a hollow casing ( 500 ) constructed of moisture-impervious solid material, such as plastics materials, containing a dry...
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7109024 |
Biomolecule-bound substrates
This invention features a biomolecule-bound substrate that includes a support made of an organic polymer and having an unmodified surface; and a plurality of unmodified biomolecules immobilized on...
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7109023 |
Immunossay device for diagnosing congestive heart failure and predicting mortality in congestive heart failure patients
An immunochemical assay device for determining the presence of NT-proBNP alone or conjunctively with Cardiac Troponin I comprising a base member, an array disposed on the base member, and at least...
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7108969 |
Methods for detecting and diagnosing oral cancer
Methods of monitoring the expression of genes in malignant oral cells is disclosed. Gene expression profiles are used to identify markers associated with malignant oral cells and to diagnose oral...
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7105340 |
On-spot selectively activated hydrophobic slide and preparation thereof
An on-spot selectively activated hydrophobic slide/microarray. The preparation method relates to a hydrophobic copolymer prepared by blending, grafting or co-polymerization of a hydrophobic...
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7105359 |
Specific coupling reaction measuring method and reagent kit and specific coupling reaction measuring apparatus for use in the same
A specific coupling reaction measuring method of this invention for measuring a content of a subject substance in a sample includes the steps of (a) constructing a reaction system including the...
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7105292 |
Screening methods used to identify compounds that modulate a response of a cell to ultraviolet radiation exposure
The cellular response to ultraviolet radiation exposure has been characterized on the molecular level through the use of high density gene array technology. Nucleic acid molecules and protein...
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7105339 |
Retentate chromatography and protein chip arrays with applications in biology and medicine
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity...
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7106889 |
Image analysis systems and devices for use therewith
An image analysis system for automated reading of printed multi-character codes, for example on antibiotic susceptibility testing disks, makes use of an orientation means, for example an underline...
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7101660 |
Method for producing a colorimetric resonant reflection biosensor on rigid surfaces
The invention provides a methods for fabricating colorimetric resonant reflection biosensors.
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7101661 |
Apparatus for active programmable matrix devices
A system for performing molecular biological diagnosis, analysis and multistep and multiplex reactions utilizes a selfaddressable, selfassembling microelectronic system for actively carrying out...
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7098040 |
Self-contained swab-based diagnostic systems
A diagnostic test unit is provided. The test unit comprises a stem having a first end and a second end, the stem defining at least one flow channel extending between the first end and the second...
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7097976 |
Methods of analysis of allelic imbalance
Methods are provided for identification of genes that are imprinted. In another embodiment methods are provided for identification and analysis of genes whose expression shows allelic imbalance....
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7098041 |
Methods to view and analyze the results from diffraction-based diagnostics
An analyzer useful in determining the presence of an analyte using a diffraction based sensing device and methods and systems using this device. The present invention may be used with a variety of...
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7094595 |
Label-free high-throughput optical technique for detecting biomolecular interactions
Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also...
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7094537 |
Micro arrays with structured and unstructured probes
The invention provides an apparatus and method for determining a signal produced by a micro array device. The apparatus provides an unstructured probe and structured probe. The unstructured probe...
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7091034 |
Detection system for disk-based laboratory and improved optical bio-disc including same
A detection system for use in optical disk-based devices for measuring the presence of an analyte in a sample. The detection system includes an analyte detector unit containing a primary detector...
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7090803 |
Lateral flow immunoassay device
A lateral flow immunoassay test device that includes a housing with an elongated slot for holding a test sample collector; an elongated holder member for securing at least one immunoassay test...
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7090003 |
Method and apparatus for temperature control of a microfluidic device
A microfluidic device is provided for regulating the temperature of a sample fluid flowing therethrough, as well as, a method of regulating the temperature of the sample fluid flowing through the...
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7091049 |
Enhanced diffraction-based biosensor devices
An enhanced diffraction based biosensor system and method are provided for detecting an analyte of interest in a test medium. The system incorporates at least one additional detection tag substance...
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7090988 |
Optoelectronic sensor
A device for detecting the presence of an antigen including (1) a cell having antibodies which are expressed on the surface of the cell and are specific for the antigen to be detected, where...
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7090992 |
Bioluminescent bioreporter integrated circuit devices and methods for detecting estrogen
Bioelectronic devices for the detection of estrogen include a collection of eukaryotic cells which harbor a recombinant lux gene from a high temperature microorganism wherein the gene is operably...
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7090984 |
Device and method for detecting substance
A method for detecting a substance, comprising developing a developing liquid through a test region up to a reference region, and a detection device for use therein, wherein the reference region...
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7091033 |
Array of toxicologically relevant canine genes and uses thereof
The invention provides for canine genes indicative of toxicological responses to agents such as drugs, pharmaceutical compounds, or chemicals. Methods of identifying and isolating toxicologically...
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7087379 |
Method of detecting single gene copies in-situ
A method for detecting single copies of a gene in-situ using brightfield microscopy is used in detection of nucleic acid sequences. Probes are directly or indirectly labeled with alkaline...
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7083975 |
Microarray synthesis instrument and method
During the light illumination period of a monomer addition cycle in synthesizing an DNA microarray, undesirable reflections of illumination light from various interfaces that the illumination light...
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7083951 |
Flow cytometric detection method for DNA samples
Disclosed herein are two methods for rapid multiplex analysis to determine the presence and identity of target DNA sequences within a DNA sample. Both methods use reporting DNA sequences, e.g.,...
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7083920 |
Surface assembly for immobilizing DNA capture probes in genetic assays using enzymatic reactions to generate signal in optical bio-discs and methods relating thereto
The present invention relates to methods and systems for the detection of specific sequences of nucleic acids or oligonucleotides. It relates more particularly to a conjugated enzyme based assay...
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