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9040287 Molecular biosensors capable of signal amplification  
The present invention provides molecular biosensors capable of signal amplification, and methods of using the molecular biosensors to detect the presence of a target molecule.
9040285 Sensing device for sensing a fluid  
A sensing device including an inlet port for receiving a fluid, a measurement chamber for sensing the fluid, a fluid channel coupling the inlet port and the measurement chamber for transporting...
9040286 Diagnosis and treatment of cancer  
Provided herein are methods for diagnosing cancer by determining the level of expression of SETDB1 in a biological sample. Also provided herein are methods for treating cancer by administering an...
9040288 Integrated system for processing microfluidic samples, and method of using the same  
This patent application describes an integrated apparatus for processing polynucleotide-containing samples, and for providing a diagnostic result thereon. The apparatus is configured to receive a...
9040237 Sensor arrays and nucleic acid sequencing applications  
Embodiments of the present invention provide devices methods for sequencing DNA using arrays of reaction cavities containing sensors to monitor changes in solutions contained in the reaction...
9040284 Systems and methods of sample processing and temperature control  
Systems and methods of sample processing and temperature control are disclosed. The invention may especially relate to temperature control, and may in some embodiments be methods of temperature...
9034657 Two step lateral flow assay methods and devices  
A two step lateral flow assay method for identifying IgE antibodies in a sample comprises applying a sample to a sample port of a device, wherein the device is adapted to deliver the sample to a...
9034572 Calibratable sensor unit for reaction vessels  
The present invention relates to a calibration method of a sensor unit connected to a reaction vessel, wherein the sensor unit comprises at least one sensor device configured to be calibrated, at...
9034638 Arrayed detector system for measurement of anti-viral immune response  
A sensor chip for detecting an immune response against a virus, the sensor chip including a substrate having a surface and a plurality of virus-like particles or capsid fragments bound to discrete...
9034637 Apparatus and method for molecule detection using nanopores  
A detector device comprises a substrate (50), a source region (S) and a drain region (D), and a channel region (65) between the source and drain regions. A nanopore (54) passes through the channel...
9029132 Sensor for biomolecules  
A sensor for biomolecules includes a silicon fin comprising undoped silicon; a source region adjacent to the silicon fin, the source region comprising heavily doped silicon; a drain region...
9029131 Automatic microfluidic processor  
In a microfluidic processor with integrated active elements for handling process media, the active elements act by changes in their volume, swelling degree, material composition, their strength...
9028772 Methods for forming a channel through a polymer layer using one or more photoresist layers  
A method may involve forming one or more photoresist layers over a sensor located on a structure, such that the sensor is covered by the one or more photoresist layers. The sensor is configured to...
9029128 DNA intercalator detection  
A DNA intercalator detection system can include a filtration unit and control sample conditioner operably coupled with the filtration unit and an analytic unit operably coupled with the filtration...
9028771 Saturation assay  
The invention provides a modified form of saturation assay, which is based on the measurement of a free or unbound labelled reagent fraction (such that there is an increase in signal in the...
9023640 Device for rapid detection of infectious agents  
A portable system for real time detection of the presence of an infectious agent in a biological sample employs a reagent which detects the presence of a specific infectious agent in the sample,...
9023660 Bioweapon-detecting fibrous-network products and methods for making same  
Methods are disclosed for producing a bioweapon-sensitive fibrous-network product, wherein the subject products exhibit a color change in response to exposure to a biological agent (or portion...
9023639 Apparatus for amplifying nucleic acids  
Provided is a nucleic acid amplifying apparatus having a uniform distribution of reaction temperature in a reaction space. The nucleic acid amplifying apparatus includes a substrate providing a...
9017992 In situ hybridization detection method  
The invention provides compositions and methods for the detection of targets in a sample; in particular, an in situ hybridization (ISH) sample. Probes and detectable labels may be provided in...
9017993 System and methods for making and processing emulsions  
An automated on-touch template bead preparation system is provided and includes a membrane-based emulsion generation subsystems, an emulsion PCR (ePCR) thermocycling plate and subsystem, and a...
9019576 Scanning apparatus with patterned probe light  
A 3D scanner for recording the 3D topography of an object, the 3D scanner includes an illumination unit configured for providing probe light for illuminating the object, where the probe light...
9017941 Microchip for analyzing nucleic acid and method of nucleic acid analysis using the same  
A method for nucleic acid analysis including injecting a slight amount of nucleic acid sample for analysis, characterized in that most of a nucleic acid sample which is not used, excluding the...
9011774 Digital barcode nano-wire and system for bio-sensing using the same  
Provided are a barcode nano-wire for decoding a hard magnetic segment by using highly sensitive magnetic sensors and a bio-sensing system using the barcode nano-wire. Integration of hard magnetic...
9012204 Activation and monitoring of cellular transmembrane potentials  
The use of nanostructures to monitor or modulate changes in cellular membrane potentials is disclosed.
9012207 Biosensors including metallic nanocavities  
A biomolecular assay includes a substrate with a metallic layer on at least one surface thereof. The metallic film includes nanocavities. The nanocavities are configured to enhance signals that...
9012142 Sequence-specific detection of nucleotide sequences  
A method for detecting the presence of a target nucleotide sequence in a sample of DNA is described herein in which a test sample comprising single stranded DNA is exposed to a DNA probe and a...
9012202 Cell-based arrays, methods of making, and methods of using  
Embodiments of the present disclosure provide for arrays, systems, and methods for the analyzing cells, methods of making arrays, and the like.
9012208 Nucleic acid purification  
A self-contained apparatus for isolating nucleic acid, cell lysates and cell suspensions from unprocessed samples apparatus, to be used with an instrument, includes at least one input, and: (i) a...
9007593 Temperature response sensing and classification of analytes with porous optical films  
Methods and systems of the invention can determine the identity and quantity of analytes in a vapor. In preferred methods, a porous optical film is exposed to vapor which contains analyte. The...
9005909 Whole blood assay for measuring AMPK activation  
A method of sample analysis is provided. In certain embodiments, the method comprises: a) labeling cells of a blood sample using an antibody that specifically binds to phospho-AMPK or a...
9005622 Cell wall components of enterococci and uses thereof  
The present invention relates to enterococcal cell wall components and their uses in the prevention and therapy of bacterial infection.
8999729 Device and analyzing system for conducting agglutination assays  
A device for conducting an agglutination assay comprising several reaction vessels, each reaction vessel comprising an upper chamber having an opening for accepting reactants and/or a sample; and...
8999640 Detection of nucleic acids using a cantilever sensor  
Detection of miniscule amounts of nucleic acid is accomplished via binding of target nucleic acid to probe material, composed of nucleic acid, which is bound to a sensor configured to sense mass....
8999652 Biological encoding of large numbers of cells  
Mixtures of cell types can be analyzed by having at least two signal markers, with at least one at three different levels to provide a barcode for each cell type. The mixture of cells may be...
8993348 Exchangeable carriers pre-loaded with reagent depots for digital microfluidics  
The present invention provides exchangeable, reagent pre-loaded carriers (10), preferably in the form of plastic sheets, which can be temporarily applied to an electrode array (16) on a digital...
8992860 Systems and methods for minimization or elimination of diffusion effects in a microfluidic system  
The present invention relates to systems and methods for minimizing or eliminating diffusion effects. Diffused regions of a segmented flow of multiple, miscible fluid species may be vented off to...
8993245 Biosensor for detecting multiple epitopes on a target  
The present invention encompasses a method for detecting a target comprising a repeating epitope.
8993309 Predictive marker for topoisomerase I inhibitors  
The present invention generally relates to the fields of cancer therapy and cancer prevention. More particularly, the present invention generally relates to a diagnostic marker for predicting the...
8993271 Method of nucleic acid amplification  
A nucleic acid molecule can be annealed to an appropriate immobilized primer. The primer can then be extended and the molecule and the primer can be separated from one another. The extended primer...
8993237 Device and method for thermal cycling  
A thermal cycling device for performing nucleic acid amplification on a plurality of biological samples positioned in a sample well tray. The thermal cycling device includes a sample block...
8993241 Reaction device, reaction method and method of synthesizing cDNA  
Provided is a device and a method whereby plural kinds of reaction operations and washing operations can be conducted in parallel without washing or replacing an instrument used in transferring a...
8986926 Compositions comprising oriented, immobilized macromolecules and methods for their preparation  
The present invention provides methods and compositions that facilitate the identification of structures of a variety of macromolecules. For instance, the present invention provides methods for...
8986986 Cell lysis device and methods of lysing cells or viruses  
A method of lysing at least one of a cell and a virus, the method including: contacting a sample, which includes at least one of a cell and a virus, with a plurality of beads which are disposed in...
8986981 Detection of methylated DNA  
The use of ion sensitive field effect transistor (ISFET) to detect methylated nucleotides in a DNA sample is described. A method of detecting methylated nucleotides in a DNA sample may include the...
8986931 Multiplex branched-chain DNA assays  
Methods of detecting two or more nucleic acids in a multiplex branched-chain DNA assay are provided. Different nucleic acids are captured through cooperative hybridization events on different,...
8980621 High-density multiwell-plate  
A high-density multiwell-plate for performing thermocycled amplification reactions of polynucleotides in liquid samples comprising a plurality of reaction wells is disclosed. In order to provide a...
8980177 Fluidic indicator device  
Disclosed is a fluidic assay device for assaying at least one property of a liquid sample, the device comprising: (i) a liquid sample application region;(ii) at least one test flow path in liquid...
8980572 Methods of signal generation and signal localization for improvement of signal readability in solid phase based bioassays  
A method for generating and localizing a signal in a solid phase substrate detection system comprises applying a solution of target material to a substrate; binding the target with a specific...
8975066 DNA analysis apparatus  
Accurate and sensitive sequencing in pyrosequencing is achieved by allowing complementary strand synthesis reaction to proceed homogeneously and completely in a short time while performing...
8969070 Thin-film layered centrifuge device and analysis method using the same  
Disclosed herein is a thin-film layered centrifuge device and an analysis method using the same. One example of an embodiment of the present invention is a thin film layered centrifuge device...