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6391624 |
Highly sensitive biological agent probe
An improved biological probe is disclosed that employs a plurality of groups of modified single-stranded DNA attached to a single electrode. Using a plurality of such groups increases the inherent...
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6391559 |
Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
Methods of detecting and quantifying genomic nucliec acid molecule sequences are provided using the simultaneous amplification of a plurality of discrete nanoliter-sized samples. A miniaturized...
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6391541 |
Apparatus for analyzing a fluid sample
A cartridge for separating a desired analyte from a fluid sample has a sample flow path and a lysing chamber in the sample flow path. The lysing chamber contains at least one filter for capturing...
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6387671 |
Electrical impedance tomography to control electroporation
Images created by electrical impedance tomography (EIT) are used to adjust one or more electrical parameters and obtain a desired degree of electroporation of cells in tissue. The parameters...
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6379883 |
Microfabricated aperture-based sensor
A chemical sensor includes an enzyme layer, a diffusion layer and an analyte barrier layer positioned over the diffusion layer. Apertures are formed by microfabrication in the analyte barrier layer...
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6379916 |
Device and process for the examination of cells using the patch-clamp method
Disclosed is a device and a process for examining cells using the patch-clamp method. A plane arrangement is used of a first number of micro-cuvettes for receiving cells and a plane arrangement of...
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6379884 |
Methods and systems for monitoring intracellular binding reactions
Intracellular binding reactions, and particularly DNA/DNA binding protein reactions are detected in situ, using intracellular fluorescence polarization detection. The methods comprise providing a...
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6377057 |
Classification of biological agents according to the spectral density signature of evoked changes in cellular electric potential
Biologically active compounds are classified according to their effect on ion channels, changes in membrane potential and ionic currents, and the frequency content of action potentials that the...
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6376256 |
Rapid process for arraying and synthesizing bead-based combinatorial libraries
A mixture of beads of uniform size from is deposited in an array by establishing discrete attachment areas each consisting either of a droplet of adhesive or a small area of a continuous adhesive...
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6376258 |
Resonant bio-assay device and test system for detecting molecular binding events
Systems and methods are presented for detecting molecular binding events and other environmental effects using the unique dielectric properties of the bound molecular structure or structures. A...
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6372483 |
Preparation of biopolymer arrays
A method and apparatus for fabricating an array of biopolymers on a substrate using a biopolymer or biomonomer fluid, and using a fluid dispensing head. The head has at least one jet which can...
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6372447 |
Method of distributing cells as single layer on a substrate from a suspension
An apparatus and method are provided for preparing specimens of biological cells uniformly distributed over a substrate surface. The method comprises providing a suspension of biological cells in...
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6368838 |
Adhering cells to cytophilic islands separated by cytophobic regions to form patterns and manipulate cells
Methods and a device are provided for adhering cells in a specific and predetermined position. The device comprises a plate defining a surface and a plurality of cytophilic islands that adhere...
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6368876 |
One step immunochromatographic device and method of use
This invention relates to a lateral flow immunochromatographic assay device without a plastic housing. The assay includes a sample receiving region, analyte detection region and end region all made...
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6368795 |
Bio-assay device and test system for detecting molecular binding events
Systems and methods for detecting molecular binding events and other environmental effects using the unique dielectric properties of the bound molecular structure or structures are presented. A...
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6365367 |
Environmental chamber for the analysis of live cells
This invention provides environmental control devices and methods for live cell analysis. The devices of the invention combine a plate space that can hold specimen plates of a variety of sizes, gas...
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6365368 |
Rapid method for the detection and quantification of microbes in water
The present invention concerns methods of testing water for microbe contamination. The methods of the invention comprise supplementing existing methods with assays using specific reagents such as...
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6361963 |
Biofilm growth device
A method and apparatus for determining the effect of various agents on the growth of biological material (biofilm), microbially-influenced corrosion and the deposition of organic and inorganic...
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6362004 |
Apparatus and method for using fiducial marks on a microarray substrate
A microarray scanning system for conducting experiments on a planar substrate includes an apparatus for translating the secured substrate in two axes, the substrate having at least one fiducial...
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6358730 |
Filtration assembly and culture device
A filtration assembly can comprise a chamber for holding a fluid sample to be filtered and a cover assembly defining a petri dish into which a filter element can be placed for cultivating...
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6355420 |
Methods and products for analyzing polymers
Methods and products for analyzing polymers are provided. The methods include methods for determining various other structural properties of the polymers.
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6350610 |
Apparatus for measuring a migration ability of ameboidally mobile cells
An apparatus for measuring the ability of ameboidally mobile cells to migrate has a deposit of active substance in the form of a plate, a membrane filter disposed on the deposit and one or more...
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6348319 |
Enzyme detection biosensors
The present invention provides a biosensor for use in detecting the presence of an enzyme or enzymes in a sample. The biosensor comprises a membrane and means for determining the impedance of the...
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6346376 |
Optical sensor unit and procedure for the ultrasensitive detection of chemical or biochemical analytes
This document describes an optical sensor unit and a procedure for the specific detection and identification of biomolecules at high sensitivity in real fluids and tissue homogenates. High...
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6342143 |
Cutting tool for multiple sample retrieval from gelatinous material
The invention relates to a sample retrieval apparatus of particular benefit in the field of molecular biology. The apparatus permits the rapid collection of numerous specified fractions of samples:...
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6342347 |
Electromagnetic sensor
The present invention relates to a sensor for analyte detection. The sensor makes use of changes in electrostatic fields associated with macromolecular binding agents during their interaction with...
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6342388 |
Culture medium container, with integrated geometry for air suction and air conduction, for the purpose of air bacteria analysis
A container for a culture medium having a dish and a lid, and having an integrated geometry for air suction and air conduction. The container being adapted for analysis of air bacteria according to...
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6342364 |
Cholesterol sensor and method of determining cholesterol
The present invention provides a sensor that electrochemically determines cholesterol in low density lipoprotein by only one feed of a sample. The sensor has: an electrode system that is mounted on...
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6342346 |
Method of producing an electrode membrane combination
Electrode membrane combinations for use in biosensors to detect analytes in a sample and methods for making and storing same are disclosed. In one aspect, a method is provided for producing a first...
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6342355 |
Probe-based analysis of heterozygous mutations using two-color labelling
The invention provides methods of analyzing a nucleic acid in a target sample for variant alleles. In such methods, a first-labelled control sample and a second-labelled target sample are...
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6340588 |
Matrices with memories
Combinations, called matrices with memories, of matrix materials that are encoded with an optically readable code are provided. The matrix materials are those that are used in as supports in solid...
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6340598 |
Apparatus for multichannel fluorescent immunoassays
Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide and optionally has multi-well features and improved evanescent field intensity....
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6335205 |
Method and test strip for determining an analyte
The invention concerns a method for the immunological determination of an analyte on a chromatographic test strip containing one or several absorbent matrices on a carrier material which are in...
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6334980 |
Flexible apparatus with ablation formed chamber(s) for conducting bio-chemical analyses
Miniaturized, self-contained apparatus for conducting bio-chemical reactions and analyses is formed in a compact structure comprising a substrate which includes a plurality of reaction chambers and...
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6331274 |
Advanced active circuits and devices for molecular biological analysis and diagnostics
Devices for performing active biological operations utilize various structures to advantageously collect and provide charged biological materials to an array of microlocations. An active biological...
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6331441 |
Multiplexed molecular analysis apparatus and method
A method and apparatus for analyzing molecular structures within a sample substance using an array having a plurality of test sites upon which the sample substance is applied. The invention is also...
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6329195 |
Cell culture apparatus
A cell culture apparatus includes at least one growth support for cells which borders on at least one side to a culture medium compartment which is suppliable, preferably continuously, with liquid...
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6329160 |
Biosensors
A genetic construct for use in a biosensor comprising: (a) a first nucleic acid molecule including a sequence encoding a reporter molecule having a detectable activity; and (b) a second nucleic...
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6326160 |
Microprocessors for use in a device for predicting physiological values
The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a...
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6322963 |
Sensor for analyte detection
A sensor for detecting analytes is described. Analyte presence or concentration is determined through measurement of changes in induced electromotive force, current or other electrical property in...
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6319705 |
Microchip device for electrophoresis
A microchip device for electrophoresis includes not only a microchip having a separation flow route for separating a sample electrophoretically and an electrical power source for applying a...
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6319472 |
System including functionally separated regions in electrophoretic system
Methods, apparatus, and applications for use of a stacked, reconfigurable system for electrophoretic transport are provided. In one embodiment, a system having a first chamber including at least a...
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6315940 |
Microelement device
A microelement device has a plurality of microelements, which may be configured as microelectrodes, arranged on a substrate and adapted for making contact to cells present in a liquid environment....
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6312943 |
Sample preparation apparatus and spray apparatus for sample preparation
A sample preparation apparatus for preparing a sample to be used for detecting specimens such as microorganisms isolated on a filter so as to enumerate microorganisms in the sample has a turntable...
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6312961 |
Optical sensor using an immunological reaction and a fluorescent marker
A biosensor comprises a waveguide into which light is coupled by a diffraction grating. The sample to be analyzed is placed on a reaction region in which a component of the immunological reaction...
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6309890 |
Locking structure for securing a fluid transfer tube
A test sample card is provided with a locking feature for achieving a positive, locking engagement with a transfer tube that conducts fluid into the interior of the test sample card. The locking...
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6306609 |
Methods for the detection of nitric oxide in fluid media
In accordance with the present invention, there are provided articles for use in non-invasive measurements of nitric oxide levels in a variety of fluid media, e.g., in mammalian body fluids....
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6300141 |
Card-based biosensor device
A diagnostic card device for use in detecting or quantitating an analyte present in a liquid sample, comprising a card substrate having a sample introduction region, a biosensor, and a sample-flow...
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6300124 |
Device and method to directly control the temperature of microscope slides
A thermal cycling device for use with self-heating microscope slides is provided.
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6300123 |
Sensor employing impedance measurements
A sensor uses an immobilized affinity component capable of interacting with analyte species and being associated with a conducting polymer such that the interaction of the affinity component and...
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