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6753159 |
Uric acid assay device with stabilized uricase reagent composition
The invention provides an enzyme-based device and process for manufacture of the device in a shelf-stable form. The device consists of a dry phase test strip useful in detecting the presence and...
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6750036 |
System and method for monitoring cellular activity
A system and method for monitoring cellular activity in a cellular specimen. According to one embodiment, a plurality of excitable markers are applied to the specimen. A multi-photon laser...
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6750033 |
Positive response biosensors and other sensors
A sensor for detecting an analyte in an environment includes a first reaction system including a first enzyme and a substrate for the first enzyme. The analyte inhibits the reaction of the...
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6746863 |
Sterilizable probe for extraction of volatile compounds in liquids and their quantitative determination
An improved tube probe for measuring volatile compounds in a liquid or gas contained in a reactor or in any other environment is disclosed. The probe is made of a single piece of metal, to one end...
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6743638 |
Detection system using liposomes and signal modification
A process for detecting an analyte which process comprises (a) contacting a sample suspected of containing said analyte with a containment means comprising a barrier which separates signal...
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6740518 |
Signal detection techniques for the detection of analytes
The invention relates to the use of signal processing methods in order to acheive higher signal to noise ratios, to increase the detection limits of target analytes. These techniques include the...
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6737277 |
Immunoassay devices and materials
An immunochemical assay device comprising a base member, an array disposed on the base member, and at least one assay indicia zone. The array comprises (i) a reservoir pad to receive sample liquid,...
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6733729 |
Apparatus for generating a temperature gradient and methods for using the gradient to characterize molecular interactions
A novel apparatus for generating temperature gradients is described. The apparatus includes a semiconductive wafer and electrical connectors attached to, preferably, one of the edges of the wafer....
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6734012 |
Low fluorescence nylon/glass composites for micro-analytical diagnostic applications
An improved combination non-luminescent microporous membrane and solid support for use in micro-analytical diagnostic applications is disclosed. Specifically, composite microarray non-luminescent...
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6730199 |
Apparatus for measuring the electrophysiological activity of a group of cells
The invention concerns an apparatus ( 10 ) comprising essentially a support ( 11 ) wherein is placed a measuring card ( 12 ), a perfusion device ( 13 ), a thermostat ( 14 ), a measuring box ( 15 )...
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6730471 |
Method, vessel and device for monitoring metabolic activity of cell cultures in liquid media
The invention relates to a method for monitoring metabolic activity of cells in liquid media, to an appropriate vessel and to a device for implementing said method. The invention aimes at enhancing...
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6723302 |
Model for cell migration and use thereof
The invention provides the development of models for cell migration, including an in vitro model and an in vivo model. The in vitro model for cell migration comprises a first extracellular matrix...
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6723523 |
System and method for investigating the effect of chemical and other factors on cell movement
As disclosed herein, the present invention is directed to a novel system for monitoring cell movement in response to chemotactic and chemokinetic factors. In this system, cells migrate in an...
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6720160 |
Method for simultaneous detection of multiple microbial antigens in biological specimens from mastitic animals
The present invention involves a method and an immuno-analytical device for the rapid and simultaneous detection of multiple micro-organisms in the biological fluids from milk-producing animals...
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6716395 |
Integrated protein affinity capture centrifugation device
A method and apparatus are described for screening a proteome. The method and apparatus include an array of affinity elements, such that a proteome is directed through the array and those...
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6716639 |
Immunoassay apparatus for detecting nicotine or continine
The invention relates to an immunoassay apparatus, comprising a dry, porous substrate having at least two sections ( 1, 2 ), communicating with one another in the moist state by capillary action,...
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6716641 |
Dipstick for carbohydrate-free transferrin assay
The invention relates to a new dipstick assay for detecting and quantifying the content of an target analyte in a sample. The assay is particularly useful for example in the diagnosis and...
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6713260 |
Methods of identifying compounds that bind to target species under isothermal denaturing conditions
The present invention provides a method for identifying a test compound that binds to a target species. The method includes: incubating at least one test mixture under isothermal denaturing...
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6713255 |
DNA chip, PNA chip, and their preparation methods
A DNA chip (or PNA chip) composed of a solid carrier and plural DNA fragments (or PNA fragments) fixed onto is the solid carrier at each one end, wherein a plurality of short chain spacer molecules...
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6713264 |
Process and device for the screening of molecules with regard to their individual binding behaviour towards at least one given ligand
The process is used for the screening of molecules from molecule libraries with regard to their individual binding behavior towards at least one given ligand. For this purpose the ligands labelled...
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6709856 |
Liquid sample measuring device containing electrode sensor with enzyme layer
A device and method are provided using a sensor containing an electrode with an enzyme layer to determine a component in a liquid sample. Inlet and outlet channels feed liquid sample to and from...
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6706481 |
In vitro selection of signaling aptamers
The present invention provides a method for the in vitro selection of signaling aptamers comprising the steps of synthesizing a DNA pool, the DNA having a random insert of nucleotides of a specific...
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6706539 |
Enzyme substrate delivery and product registration in one step enzyme immunoassays
One-step enzyme immunoassays in which enzyme-antibody conjugate or label and enzyme substrate are separated until separation of bound and free enzyme conjugate or label is complete. This separation...
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6703216 |
Methods, compositions and apparatuses for detection of gamma-hydroxybutyric acid (GHB)
Methods, compositions and articles of manufacture for assaying a sample for a GHB source are provided. A sample suspected of containing a GHB source is contacted with a first oxidoreductase...
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6703205 |
Apparatus and methods for correcting for variable velocity in microfluidic systems
Electrokinetic devices having a computer for correcting for electrokinetic effects are provided. Methods of correcting for electrokinetic effects by establishing the velocity of reactants and...
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6699697 |
Planar patch clamp electrodes
The present invention relates to ionic electrodes, particularly microelectrodes and electrode arrays, and also relates to fabrication methods for such electrodes. In particular, the present...
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6696264 |
Method and apparatus for detection of multiple biological materials with a heterogeneous antibody mixture
The present invention relates to bioassay materials useful for the detection of toxic substances and, more particularly, to packaging materials for food and other products, along with methods for...
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6696287 |
System for co-culturing bacteria and eukaryotic cells
The present invention is directed to an apparatus that can be used for co-culturing bacteria and eukaryotic cells. The apparatus allows the bacteria to be grown under steady state conditions and...
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6692974 |
Analytical apparatus
A surface plasmon resonance apparatus for detecting a soluble analyte (e.g. a protein) or a particulate analyte (e.g. a cell), the apparatus comprising: (a) a sensor block adapted to receive a...
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6692973 |
Surface binding of an immunoglobulin to a flexible polymer using a water soluble varnish matrix
The present invention relates to bioassay materials useful for the detection of toxic substances and, more particularly, to packaging materials for food and other products, along with methods for...
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RE38430 |
Solid phase chromatographic immunoassay
A chromatographic test strip comprising a solid support having at least a first portion and a second portion with said portions being in the same plane so as to permit capillary flow communication...
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6689602 |
Bio-sensor
A compact bio-sensor is provided, particularly suitable for measuring biological oxygen demand, which includes micro-organisms for altering a biological parameter and sensors upstream and...
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6689594 |
Device for organic cell culture and for studying their electrophysiological activity and membrane used in said device
The invention concerns a device comprising a support ( 11 ) in the thickness of which is produced a supply chamber ( 12 ) with an inlet duct ( 13 ) for nutrient liquid and a discharge duct ( 14 )...
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6686208 |
Device and method for carrying out fluoresence immunotests
The invention relates to devices and methods for carrying out quantitative fluorescence immunoassays using evanescent field excitation. Light from at least one light source is directed onto the...
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6682927 |
Methods and apparatus for the high through-put detection of binding interactions in vivo
An apparatus for screening for translocation of a first protein of interest in vivo in a plurality of cells comprises (a) a thin unitary total internal reflection member having a surface portion,...
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6677132 |
Device and method for monitoring and controlling biologically active fluids
The present invention relates to a device and a method for determining the concentration of organisms in a fluid, where metabolite parameters are recorded by means of a data acquisition unit and...
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6673630 |
Method and apparatus for producing visual results using colorimetric strips
One embodiment of the present invention improves the visual use of urine test strips and reagent pads by providing a single color from a reference color spectrum directly on the colorimetric strip...
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6673315 |
Method and apparatus for accessing a site on a biological substrate
The present invention provides a method and an apparatus for facilitating the creation and study of biological substrates. In particular, the present invention allows the location of materials...
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6670198 |
Test piece and system for reading out image information from the test piece
A test piece for use in biological analyses includes a plurality of different known specific binding substances disposed in predetermined positions on a substrate. The specific binding substances...
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6670115 |
Devices and methods for detecting analytes using electrosensor having capture reagent
The present invention relates to devices comprising electrosensors containing capture reagents, their preparation thereof, and their use for detecting, preferably, quantitative measurement, of...
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6667159 |
Optical fiber biosensor array comprising cell populations confined to microcavities
A biosensor, sensor array, sensing method and sensing apparatus are provided in which individual cells or randomly mixed populations of cells, having unique response characteristics to chemical and...
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6663833 |
Integrated assay device and methods of production and use
An assay device for the detection of analyte in a sample, methods and immunoassay formats for performing an assay with or without the device, and methods for manufacturing the device are provided....
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6663837 |
Housing box for electronic chip with biological probes
The invention concerns a housing box for an electronic chip with biological probes, comprising a flat support device formed by assembling a first lower support and a second upper support, whereof...
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6660532 |
Modular assembly for reagentless affinity separation and detection of analyte
The invention provides a reagentless assay kit for analyte in a sample comprising a modular affinity assembly including at least one sensor unit comprising a ligand having binding affinity for the...
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6653152 |
Sensor disk having radial grooves and optical assaying method using same
An optical assaying method and system having a movable sensor is described. In one aspect, the present invention is a sensing system having a rotating sensor disk coated with indicator dyes...
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6653089 |
Differential treatment of selected parts of a single cell with different fluid components
The present invention is directed, in certain embodiments, to improved, small scale systems and methods able to selectively treat parts of a single cell, including, in certain embodiments, portions...
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6653095 |
Hydrogen peroxide monitoring
A method and apparatus for determining the hydrogen peroxide content of a fluid. The method includes: (a) contacting the fluid with a catalyst so as to permit decomposition of the hydrogen peroxide...
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6649404 |
Method for using and making a fiber array
The invention provides a method for contacting at least two chemical species by immobilizing an immobilized chemical species on a fiber, placing the fiber on a support having a channel, and...
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6649361 |
Surface plasmon resonance enzyme sensor
A surface plasmon resonance enzyme sensor including a sensing part 6 having an optically transparent base 1 , a thin metal film 2 made of gold or silver, and a film 4 provided on the metal...
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6649418 |
Internally referenced competitive assays
The present invention provides internally calibrated competitive assays for use on a solid support. Additionally, the invention provides a method of using such assays.
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