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6867035 |
Cell libraries indexed to nucleic acid microarrays
This invention provides a method for selecting a clone of an ES cell containing a mutation in a gene that is expressed in a test cell comprising: (a) providing cDNA obtained by reverse...
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6864102 |
Device for performing an assay, a method for manufacturing said device, and use of a membrane in the manufacture of said device
The present invention relates to a device for performing an assay, which device comprises a substrate having oriented through-going channels, said channels opening out on a surface for sample...
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6861260 |
Lipid membrane, method for measuring membrane permeability, and method for screening
The object of the present invention is to provide a lipid membrane whose permeability to substances is high and strongly correlated with the permeability of biomembranes to drugs and which...
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6858440 |
Tapered tubular optical waveguide probe for magnetic focusing immunosensors
A waveguide probe for the detection of pathogens in a sample which comprises a laser, a first and a second tubes that converge at a point to form a proximal end. A magnet is positioned in the end...
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6858403 |
Polymer matrix containing catalase co-immobilized with analytic enzyme that generates hydrogen peroxide
Hydrogels containing catalase co-immobilized with an analyte-sensitive enzyme such as glucose oxidase are disclosed. The hydrogels may be pH-sensitive, and preferably are thin and lightly...
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6855556 |
Binding protein as biosensors
The invention is directed to compositions of mutated binding proteins containing reporter groups, analyte biosensor devices derived there from, and their use as analyte biosensor both in vitro and...
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6852289 |
Methods and apparatus for determining analytes in various matrices
Methods and apparatus for qualitatively or quantitatively determining one or more analytes in matrices such as foods, biological fluids, etc. An embodiment for determination of a single analyte...
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6852524 |
Probe carrier, probe fixing carrier and method of manufacturing the same
A carrier having indexes in a probe non-fixing region is used and solutions containing probes are applied to respective specific positions on the carrier by referring to said indexes and fixed. The...
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6848299 |
Quartz crystal microbalance with feedback loop for automatic gain control
An analytical apparatus, such as a quartz crystal microbalance, comprises a piezoelectric sensor and an oscillator circuit, coupled to the sensor, to oscillate at a frequency substantially...
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6849414 |
Assay devices and methods of analyte detection
Assay devices, kits, and methods for detection of one or more analytes in a sample are provided. The assay device features the controlled release of reagents and hence is particularly suitable for...
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6846639 |
Method for detecting pathogens attached to specific antibodies
The use of impedance measurements to detect the presence of pathogens attached to antibody-coated beads. In a fluidic device antibodies are immobilized on a surface of a patterned interdigitated...
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6846638 |
Method and system for rapid biomolecular recognition of amino acids and protein sequencing
Methods, compositions, kits, and apparatus are provided wherein the aminoacyl-tRNA synthetase system is used to analyze amino acids. The method allows very small devices for quantitative or...
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RE38688 |
Sheet-like diagnostic device
A solid diagnostic device for the quantitative determination of substances of biological affinity in biological fluids is described. A process is also described in which the biological fluid is...
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6844200 |
Device for carrying out lateral-flow assays involving more than one analyte
Disclosed is an improvement to a dry assay device for determining the concentration of a first analyte in a sample of body fluid and a second analyte in the same sample of body fluid. The device...
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6838292 |
Detection of biological warfare agents
Methods and devices are provided for the detection of bacterial agents such agents as Bacillus anthracis and Clostridium botulinum with high sensitivity and selectivity. More specifically,...
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6835552 |
Impedance measurements for detecting pathogens attached to antibodies
The use of impedance measurements to detect the presence of pathogens attached to antibody-coated beads. In a fluidic device antibodies are immobilized on a surface of a patterned interdigitated...
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6833267 |
Tissue collection devices containing biosensors
The present disclosure provides tissue collection devices comprising biosensors that can be used for the detection of target analytes, such as nucleic acids and proteins, including antibodies and...
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6824987 |
Small molecule printing
The present invention provides compositions and methods to facilitate the identification of compounds that are capable of interacting with a biological macromolecule of interest. In one aspect, a...
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6825032 |
High capacity assay platforms
A high capacity assay platform capable of binding target molecules includes a substrate and a polymer matrix attached to the substrate. The polymer matrix comprises a plurality of polymer molecules...
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6821730 |
Carbon nanotube molecular labels
The methods and compositions disclosed herein concern highly diverse, novel labels comprising carbon nanotubes of discrete lengths and/or diameters. In certain embodiments, the nanotube labels may...
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6818455 |
Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
An analytical test device useful for example in pregnancy testing, comprises a hollow casing ( 500 ) constructed of moisture-impervious solid material, such as; plastics materials, containing a dry...
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6815197 |
Apparatus for conducting electrophysiological measurements on cells
Apparatus for conducting electrophysiological measurements on cells wherein a measuring head is provided with at least one electrode in a common support for impaling the cells.
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6815209 |
Laser-induced cell lysis system
A method of determining laser parameters for lysing cells involves exposing cells from a sub-sample of a sample to laser light. At least one parameter of the laser is varied, and damage to...
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6811969 |
Retentate chromatography—profiling with biospecific interaction adsorbents
This invention provides methods of retentate chromatography for resolving analytes in a sample. The methods involve adsorbing the analytes to a substrate under a plurality of different selectivity...
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6811973 |
Methods of using labeled probe molecules to quantify target molecules
An assay system using labeled probe molecules to identify and quantify target molecules in a sample is disclosed. Where labeled probe molecules are present on a substrate such as a microarray, the...
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6812038 |
Assay device and use thereof
A test device and a kit for conducting an assay for the determination of an analyte in a sample comprises (i) a housing ( 1,2 ), and within said housing, (ii) a flow matrix ( 6 ) allowing liquid to...
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6806050 |
Individually addressable micro-electromagnetic unit array chips
This invention provides electromagnetic chips and electromagnetic biochips having arrays of individually addressable micro-electromagnetic units, as well as methods of utilizing these chips for...
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6803238 |
Methods for multiplexed biochemical analysis
The invention provides methods for detecting a labeled sample molecule bound to an immobilized probe by electrochemiluminescence. The method comprises providing a multiplexed molecular analysis...
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6803239 |
Multi-slide assembly including slide, frame and strip cap, and methods thereof
A multi-slide assembly includes various components that alone or in combination facilitate testing of test samples with minimal manipulation of assay components. Moreover, the various device...
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6800453 |
Nucleic-acid programmable protein arrays
Arrays of polypeptides are generated by translation of nucleic acid sequences encoding the polypeptides at a plurality of addresses on the array.
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6800478 |
Apparatus and method for detecting biofilm in the water conduits of dental units
An apparatus for detecting biofilm in the water conduits of dental units, especially biofilm adhering to the inside surfaces of the conduits, can be used on a water line equipped with a plurality...
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6797463 |
Method and apparatus for detection of microscopic pathogens
Detection apparatus for use in the detection of the presence of a selected pathogen in a sample are disclosed. Such apparatus include: a substrate with a detection region on a surface thereof, the...
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6794196 |
Deposited thin films and their use in detection, attachment and bio-medical applications
The present invention is directed to the use of deposited thin films for chemical or biological analysis. The invention further relates to the use of these thin films in separation adherence and...
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6790652 |
Method and apparatus for high density format screening for bioactive molecules
A method and apparatus for screening an array of test compounds for bioactivity by contacting an array of test compounds with a detector layer capable of detecting bioactivity, and detecting a...
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6787349 |
Biochip reader and labeling reagent
The present invention provides a high-sensitive, inexpensive biochip reader for reading a biochip as compared to a fluorescence method. The biochip reader is provided with an X-Y stage ( 3 ) for...
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6789020 |
Expert system for analysis of DNA sequencing electropherograms
A method of analyzing DNA fragments separated electrophoretically is presented. The method includes the use of an expert system that interprets raw or preprocessed signal from the separation. The...
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6787368 |
Biosensor method for detecting analytes in a liquid
A diagnostic method and device for use in detecting or quantitating an analyte present in a liquid sample. The method includes reacting an analyte-containing sample with reagents capable of...
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6780582 |
Arrays of protein-capture agents and methods of use thereof
Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an...
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6780651 |
Device for determination of an analyte in a body fluid
A method of making strip for testing for the presence of an analyte generally comprises providing a support member which includes a spreading layer and a reagent layer, and a capillary in...
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6780605 |
Method of diagnosing cardiovascular disease and early atherosclerosis
The present invention provides a method of diagnosing cardiovascular disease and increased risk of early atherosclerosis in a human wherein the presence and/or concentration of antibodies to...
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6777193 |
Methods for diagnostic and/or treatment of antiphospholipids antibodies-related diseases, and devices
Methods for detecting anti-lipidic particles antibodies and lipidic particles in cellular membranes for the diagnosis of diseases associated to the antiphospholipid syndrome are disclosed. Kits or...
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6770447 |
Optical assay device and method
The present invention involves an optical assay device and method of use for the detection of an analyte of interest in a sample that conveniently allows control of the flow characteristics of the...
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6764859 |
Device and method for mixing magnetic particles with a fluid
This invention relates to the use of magnetic or magnetizable particles, and, in particular, to methods of mixing magnetic or (super)paramagnetic particles efficiently with a fluid and the...
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6764583 |
Using impedance measurements for detecting pathogens trapped in an electric field
Impedance measurements between the electrodes in an electric field is utilized to detect the presence of pathogens trapped in the electric field. Since particles trapped in a field using the...
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6762048 |
System and apparatus for nucleic acid sequencing of single molecules by polymerase synthesis
This invention relates to improved methods for sequencing and genotyping nucleic acid in a single molecule configuration. The method involves single molecule detection of fluorescent labeled PPi...
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6762036 |
Cellular physiology workstations for automated data acquisition and perfusion control
Cellular physiology workstations for automated data acquisition and perfusion control are described. The cellular physiology workstation may be used for physiological and electrophysiological...
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6759235 |
Two-dimensional spectral imaging system
Improved devices, systems, and methods for sensing and/or identifying signals from within a signal detection region are well-suited for identification of spectral codes. Large numbers of...
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6756217 |
Glass composite materials containing alkoxosilane derivative having alterable charge, hydrophobic and hydrophilic groups
A porous glass composite material is prepared comprising a gel containing water and a polymeric network containing at least one alkoxosilane derivative having a group of alterable charge, a...
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6757618 |
Chemical structure identification
A method for generating a numeric or alpha-numeric identifier representative of a chemical structure having at least two atoms connected by a bond includes the step of assigning a numerical value...
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6752966 |
Microfabrication methods and devices
Microfabrication methods and devices in which microscale structural elements are provided in an intermediate polymer layer between two planar substrates. Preferred aspects utilize photoimagable or...
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