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7384794 |
Micro-devices and analytical procedures for investigation of biological systems
Fibres with an extraction phase coated thereon in combination with a positioning device are described to perform adsorption of components of interest from an animal or animal tissue for the...
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7368279 |
Three dimensional bioengineered smooth muscle tissue and sphincters and methods therefor
This invention relates to a three dimensional bioengineered sphincter such as a bioengineered internal anal sphincter (IAS) and three-dimensional physiological models of smooth muscle cells. The...
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7348175 |
Bioreactor with plurality of chambers for conditioning intravascular tissue engineered medical products
A microprocessor controlled and instrumented bioreactor for conditioning intravascular tissue engineered medical products. One bioreactor design including an integrated pump to provide a relatively...
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7338461 |
Modified organ support devices
Methods and devices are provided that improve the function of organ support devices, and also provided are improved methods of treating conditions associated with hemodynamic instability.
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7326564 |
Flow system for medical device evaluation and production
In some embodiments, a flow system includes a medical device mount, fluid and a conduit containing the fluid and medical device mount. The conduit is mounted on an assembly that moves the conduit...
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7316922 |
Method for preserving organs for transplant
Methods and apparatus for preserving tissue such as harvested organs for transplant are described. A preferred method includes delivering to a harvested organ an effective amount of electromagnetic...
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7303729 |
Apparatus and method for immunological labeling for thin tissue sections
An apparatus and a method for immunological labeling of thin tissue sections are disclosed. The treatment fluid is applied in the form of liquid droplets onto at least one slide, the arrangement of...
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7297500 |
Use of Troponin I as a species marker protein for meat speciation in both raw and heat-processed products
Monoclonal antibodies are provided which bind to heat-treated proteins of meats. The antibodies are useful in detecting the presence of an exogenous meat in a cooked or raw meat sample....
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7276367 |
Method of etching islands of cells in a grid pattern
An apparatus and process for monitoring migratory cell proliferation with restricted migration on a substrate includes providing a substrate, coating the substrate with extracellular matrix,...
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7232689 |
Calibration procedure for investigating biological systems
Use of calibrant in extraction phase is described for quantification of components of interest in samples in laboratory application as well as in on-site monitoring. This approach is particularly...
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7229820 |
Apparatus and method for culturing and preserving tissue constructs
A disclosure is made of various apparatus and methods for culturing and preserving cells and tissue in ways that minimize contamination potential, direct cells to reside in desired areas, allow...
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7179637 |
Apparatus and method for using intestinal segments or their substitutes in high-throughput analysis of compound absorption
An apparatus for high-throughput analysis of compound absorption in a controlled environment that closely resembles in-vivo conditions. The apparatus includes at least one tissue-receiving...
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7176015 |
Organ preservation apparatus and methods
This invention is a transportable organ preservation system that substantially increases the time during which the organ can be maintained viable for successful implantation into a human recipient....
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7160716 |
Device for inducing an immune response in cancer therapy
A device for inducing an immune response in cancer therapy in which isolated living malignant tissue is enclosed in a space formed by a microporous membrane and a holder which is introduced into a...
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7141386 |
Cell culture device
A culture device for cellular media including a biomedia growth chamber defining a closed environment and an electronically controllable jetting device in communication with a source of material...
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7122151 |
Membrane apparatus with enhanced mass transfer, heat transfer and pumping capabilities via active mixing
A combination mass transfer and pump apparatus, which in a single step actively mixes a first mass and a second mass and simultaneously pumps one of the first mass and the second mass through the...
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7063942 |
System and method to simulate hemodynamics
A system for hemodynamic simulation comprises a vessel having properties of a blood vessel, a reservoir containing a quantity of fluid, tubing connecting the vessel and reservoir, and at least one...
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7011970 |
Automatic bio-manipulation factory system for manipulating a single cell
This new automatic bio-manipulation factory system for manipulating a single cell comprises: a bio-MEMS that transports, separates, and extracts a single cell for manipulation from a plurality of...
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6962789 |
Method for quantitating a protein by image analysis
The present invention provides a method for determining expression levels of one or a multiplicity of target proteins in a tissue or cell sample.
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6946099 |
Methods of using condensed perfusion circuit for cardiopulmonary bypass and cardioplegia
A total condensed circuit for cardiopulmonary bypass and cardioplegia are provided, as well as methods of using the same. The total circuit includes a cardiopulmonary bypass portion including...
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6908766 |
Device and method for capturing biological tissues
A device and method for capturing a biological tissue, comprises cutting a minute biological cellular tissue using a contactless cutting apparatus, wherein, by inverting a biological tissue slide...
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6905871 |
Apparatus for mechanical perfusion of donor's organ during its transport
The invention relates to an apparatus for mechanical organ perfusion during the transport phase of a donor organ, which apparatus comprises an organ receptacle for acommodating the organ,...
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6902928 |
Treatment compartment for treating histological samples
The invention relates to a treatment compartment ( 1 ) for treating histological samples with treating agents ( 2, 2′, 2 ″). The treatment compartment ( 1 ) comprises a housing ( 3 ) with an...
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6881569 |
Apparatus and method for evaluating tissue engineered biological material
An apparatus and method that allows the visualization of leakage of cell culture media through a conduit wall of a tissue-engineered biological construct such as a semilunar heart valve or valve...
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6830763 |
Continuous acidification demineralization process for producing osteoinductive bone; and osteoinductive bone produced thereby
The invention is directed to a process for producing demineralized osteoinductive bone, and demineralized osteoinductive bone produced thereby. The process achieves demineralization of bone by...
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6803227 |
Organ preservation system including articles comprising a super-coolable composition having long-duration phase change capability
An organ preservation system according to one embodiment of the disclosures herein includes a perfusion liquid delivery apparatus, a perfusion liquid pumping apparatus and a thermal mass. The...
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6794182 |
Hyperbaric oxygen organ preservation system (HOOPS)
A method of delivering oxygen to a biological entity comprising of dissolving oxygen into a perfusate and forcing the perfusate through the biological entity whereby substantially high levels of...
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6783734 |
Convex geometry adhesive film system for laser capture microdissection
A tissue sample is conventionally visualized in a microscope. A selectively activated convex surface is provided, preferably at the distal end of a rod. This selectively activated convex surface...
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6780636 |
Cryoarray system and uses thereof
The present invention provides a method for creating a cryoarray of frozen tissue cores using a cryoarray system. Such system comprises a tissue mold, an embedding medium and a cryoarray device....
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6773903 |
Laser cell purification system
A process and apparatus for cell purification and ablation is disclosed. The present invention comprises a laser system which directs radiant energy at computer or manually selected individual...
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6759245 |
Cell culture systems and methods for organ assist devices
The invention features modular cell culturing devices including one or more flat-plate modules, and is based on the discovery that if the flows of liquid medium and oxygenated fluid are separated...
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6723302 |
Model for cell migration and use thereof
The invention provides the development of models for cell migration, including an in vitro model and an in vivo model. The in vitro model for cell migration comprises a first extracellular matrix...
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6673594 |
Apparatus and method for maintaining and/or restoring viability of organs
An organ perfusion apparatus and method monitor, sustain and/or restore viability of the organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an...
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6667049 |
Relic process for producing bioresorbable ceramic tissue scaffolds
A relic process is used to produce bioresorbable ceramic scaffolds that can be used for in vitro or in vivo growth of human or animal tissue such as bone or cartilage. The process involves...
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6646238 |
Method and device for a accomodating samples on cryosubstrates
For sample picking on a cryosubstrate, on which multiple cryopreserved samples are each positioned at preselected sample positions, individual samples are selectively separated mechanically or...
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6642045 |
System for exsanguinous metabolic support of an organ or tissue
An exsanguinous metabolic support system for maintaining an organ or tissue at a near normal metabolic rate is disclosed. The system employs a warm perfusion solution capable of supporting the...
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6632651 |
Tissue maintenance system that applies rhythmic pulses of pressure
A growth support scaffold for cells and tissue is formed of naturally derived connective or skeletal tissue which has been treated for elimination of cellular and cytosolic elements, and modified...
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6582953 |
Organ chamber for exsanguinous metabolic support system
An exsanguinous metabolic support system for maintaining an organ or tissue at a near normal metabolic rate is disclosed. The system employs an organ chamber comprising a container and a support...
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6582375 |
System for study of global uni-or bi-ventricular function of an explanted, reperfused heart
A system for studying a beating explanted heart comprises a fluid inflow circuit configured for coupling to an explanted heart to direct fluid for flowing into a ventricle of the heart, and a fluid...
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6555057 |
Intravascular methods and apparatus for isolation and selective cooling of the cerebral vasculature during surgical procedures
Patients having diminished circulation in the cerebral vasculature as a result of stroke or from other causes such as cardiac arrest, shock or head trauma, or aneurysm surgery or aortic surgery,...
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6534095 |
Pulsatile acidification wave demineralization process for producing osteoinductive bone; and osteoinductive bone produced thereby
The invention is directed to a process for producing demineralized osteoinductive bone, and demineralized osteoinductive bone produced thereby. The process achieves demineralization of bone by...
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6479072 |
Microfabricated membranes and matrices
The invention relates to microfabricated membranes and matrices that have a highly controlled and complex three-dimensional topography. The new micro fabricated membranes and matrices can be...
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6472200 |
Device and method for performing a biological modification of a fluid
A device for performing a biological modification of a fluid, the device includes (a) a chamber having an inlet for intake of the fluid and an outlet for outflow of the fluid; and (b) a collection...
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6468783 |
Punch-changing tissue array instrument
Arrays of biological tissue can be created by removing cores from regions of interest in a series of donor blocks of embedded tissues. The cores removed are placed in a regular array in a recipient...
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6455303 |
Detection of biologically active molecules by use of pre-activated cell-based biosensors in liquid-based separation systems
The invention provides a method for detection of receptor- or ion channel-modulators (e.g., antagonists, blockers, etc.). The method comprises fractionating a sample by using a liquid-based...
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6448063 |
Experimental apparatus for sliced specimen of biological tissue and specimen holder
An experimental apparatus for performing observations of and experimental operations on a sliced specimen of a biological tissue is disclosed. The apparatus provides a high freedom for experimental...
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6416995 |
Bioreactor mediated recellularization of natural and tissue engineered vascular grafts
The invention provides a device and process for recellularizing essentially acellular or devitalized tissue grafts, including for example essentially acellular or devitalized vascular tissue...
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6383801 |
Double z-drive tissue array instrument
Arrays of biological tissue can be created by removing cores from regions of interest in a series of donor blocks of embedded tissues. The cores removed are placed in a regular array in a recipient...
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6326188 |
Continuous-multi-step dilution process and apparatus, for the removal of cryoprotectants from cryopreserved tissues
The present invention is directed to a continuous, multi-step dilution process for producing tissue suitable for transplantation into a human from cryopreserved tissue. Cryopreserved tissue is...
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6322994 |
Method of freeze-drying organisms
A method is provided for freeze-drying multiple samples of viable microorganisms which method comprises: (i) providing a container comprising multiple wells; (ii) dispensing multiple liquid...
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