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7390652 |
Device for cultivating cells and propagating viruses
This invention relates to methods for the cultivating cells, and in particular to methods for propagating viruses.
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7390651 |
C3A serum-free clonal cell line and methods of use
A serum-free C3A clonal cell line and methods for generating the same are provided. The C3A cell line has a reduced doubling time in serum-free medium compared to a corresponding C3A cell line from...
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7387892 |
Biosensor using microdisk laser
A compact sensor for detecting the presence of biological or chemical species includes a microdisk laser and a wavelength shift detector. The microdisk laser is coated with a biological or chemical...
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7387889 |
Measurement of concentrations and binding energetics
Free-standing microfluidic channels are used to both transport and analyze molecules of interest. In a biochemical context, such molecules may be polypeptides, nucleic acids, or other biomolecules....
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7384737 |
Synthesis of spatially addressed molecular arrays
Methods are disclosed for forming spatially addressable arrays of polynucleotides of known squence, by using blocking groups that prevent the incorporation of multiple nucleotides during each...
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7381533 |
Electrodes linked via oligomers to nucleic acids
The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids...
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7381525 |
AC/DC voltage apparatus for detection of nucleic acids
The invention relates to nucleic acids covalently coupled to electrodes via conductive oligomers. More particularly, the invention is directed to the site-selective modification of nucleic acids...
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7381375 |
Assay systems with adjustable fluid communication
Systems, including apparatus and methods, for performing assays with adjustable fluid communication between samples.
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7381374 |
Immunoassay devices and methods of using same
An immunoassay cartridge for sensing at least one analyte in a biological sample is disclosed. The immunoassay cartridge comprises a supporting plate, a reaction cavity made within the supporting...
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7368280 |
Detection of biospecific interactions using amplified differential time domain spectroscopy signal
A method for detecting specific associations between a tethered molecule and an untethered target molecule. The method comprises (1) selecting a tethered molecule; (2) alternately impinging THz...
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7368238 |
Method for manufacturing a DNA probe array
There is used at least one probe array obtained by arraying particles having various probes, respectively, fixed thereon (probe particles) in a definite order in a holder. A plurality of...
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7364898 |
Customized micro-array construction and its use for target molecule detection
The present invention relates to a detection and quantification method of different sets of target molecules ( 1, 3 ), being possibly present simultaneously in a biological sample by the use of a...
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7364850 |
DNA probe array
There is used at least one probe array obtained by arraying particles having various probes, respectively, fixed thereon (probe particles) in a definite order in a holder. A plurality of...
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7361472 |
Methods for providing extended dynamic range in analyte assays
Methods for enhancing the dynamic range for specific detection of one or more analytes in assays using scattered-light detectable particle labels. The methods involve utilizing variations in...
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7358097 |
Making a matrix of random encoded arrays
Disclosed is an apparatus and method of maintaining chips or arrays of particles, or arrays of particles deposited on chip surfaces, in a designated area on a substrate surface. This is...
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7358081 |
Devices for the electrochemical detection of a nucleotide sequence, analysis cassettes, systems of analysis cassettes, supplemental modules, and methods for producing analysis cassettes
Devices for the electrochemical detection of a nucleotide sequence in a fluid are described that include (a) a working electrode and a counter-electrode wherein the working electrode is attached to...
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7358079 |
Flow cell array and the utilization thereof for multianalyte determination
A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate...
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7351591 |
Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS)
The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and...
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7351575 |
Methods for processing biological materials using peelable and resealable devices
Devices and methods for performing assays on materials, particularly biological materials, are provided. The devices and methods make use of self-sealing members, which can be applied to a flat...
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7349834 |
Molecular motor
A molecular motor in which multiple concentric cylinders (or nested cones) rotate around a common longitudinal axis. Opposing complementary surfaces of the cylinders or cones are coated with...
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7341834 |
Multiplexed electrochemical detection system and method
Multiplexed analysis of molecular structures of samples. A plurality of sample wells is arranged on a substrate. A plurality of electrodes is fabricated on a first side of the substrate. The...
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7338764 |
Polynucleotide microarray including two or more groups of probe polynucleotides immobilized on substrate according to melting temperature and method for detecting target polynucleotides using the same
Provided is a polynucleotide microarray including two or more groups of spots on which probe polynucleotides are immobilized, wherein the probe polynucleotides of each group have melting...
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7337072 |
Fluid sample testing system
A sample testing system may include a housing, a cavity in the housing to receive a chamber, two contact members, and a sensor. The contact members may be positioned to be engageable with...
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7335514 |
Optical biosensor
The present invention relates to an optical biosensor comprising a porous matrix. In the specific case, reference is made to anodized porous alumina, on the surface of which the biological...
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7332330 |
Device for maintaining vascularization near an implant
A device and a method of maintaining vascularization near an implant, especially a bioartificial hemofilter. By associating cells that excrete angiogenic factors with such an implant,...
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7329742 |
Aptamers and methods for their in vitro selection and uses thereof
The present method is an improved in vitro selection protocol that relies on magnetic separations for DNA aptamer production that is relatively easy and scalable without the need for expensive...
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7326560 |
Tissue micro-array builder manual test
The tissue micro-array (TMA) building manual set, which includes a well-known SZK tissue core punch extractor and a TMA block mould ( 1 ) characterized as follows: the TMA block mould ( 1 )...
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7323298 |
Microarray for determining the relative abundances of polynuceotide sequences
A method of determining the relative amounts of individual polynucleotides in a complex mixture of different-sequence polynucleotides is disclosed. The polynucleotides, after fluorescent labeling,...
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7323140 |
Moving microdroplets in a microfluidic device
The present invention relates to a system and method for moving samples, such as fluid, within a microfluidic system using a plurality of gas actuators for applying pressure at different locations...
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7319003 |
Arrays of probes for positional sequencing by hybridization
This invention is directed to methods and reagents useful for sequencing nucleic acid targets utilizing sequencing by hybridization technology comprising probes, arrays of probes and methods...
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7316921 |
Organic waste material treatment system
A multi-stage process and system for treating organic waste materials includes steps of hydrolyzing the materials in an anaerobic vessel, transferring the liquid product of hydrolysis to an...
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7316899 |
Portable sensor array system
A system for the rapid characterization of multi-analyte fluids, in one embodiment, includes a light source, a sensor array, and a detector. The sensor array is formed from a supporting member into...
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7312057 |
Method for reducing binding of organic material to hydrophobic surfaces
Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm 2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant...
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7309568 |
Method in inspecting DNA and apparatus therefor
A method and apparatus of stably obtaining fluorescent images of two or more fluorescent samples includes disposing the samples onto compartments defined on a substrate. The compartments are...
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7306941 |
Biochemical measuring chip and measuring apparatus
A simple and convenient sensor and measuring apparatus utilizing the optical interference effect of an optical thin film capable of measuring the binding between biochemical substances at a high...
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7297529 |
Method and apparatus for performing a lateral flow assay
An embodiment of the present invention provides a method for performing a lateral flow assay. The method includes depositing a sample on a test strip at an application region, detecting a first...
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7294460 |
Supported double layer structure for displaying a nucleic acid associated with a protein
The invention concerns novel biosensors, in particular a support for displaying nucleic acids and for detecting both the presence of nucleic acids in a sample and the linkage between proteins and...
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7291504 |
Assay involving detection and identification with encoded particles
A method and apparatus for the manipulation of colloidal particles and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution....
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RE39915 |
Method for the determination of HDL cholesterol by means of a rapid diagnostic agent with an integrated fractionating step
An apparatus comprising a first porous carrier and a second porous carrier for evaluating biological fluid samples is disclosed. The apparatus is used for separating non high density lipoprotein...
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7285411 |
High throughput screening assay systems in microscale fluidic devices
The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are...
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7282329 |
Suspended microchannel detectors
An apparatus for detecting an analyte in solution that has a suspended beam containing at least one microfluidic channel containing a capture ligand that bonds to or reacts with an analyte. The...
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7279323 |
Method for conducting receptor-ligand association reaction and reactor used therefor
A method for conducting a receptor-ligand association reaction includes the steps of dipping a biochemical analysis unit including a substrate formed with a plurality of absorptive regions which...
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7276369 |
Method for detecting a substance and microtiter plate
The invention relates to a method for detecting an analyte A in a liquid, comprising the following steps: (a) a solution containing an analytical reagent N is provided in a container B; (b) the...
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7276336 |
Methods of fabricating an addressable array of biopolymer probes
A method of fabricating an addressable array of biopolymer probes on a substrate according to a target array pattern using a deposition apparatus, and a deposition apparatus which can execute the...
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7273702 |
Apparatus for purifying nucleic acid and method of purifying nucleic acid
A nucleic acid refining apparatus, being ease in automation thereof, keeping high in contacting frequency between nucleic acid within a sample and a solid phase during nucleic acid capture...
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7271008 |
Quality control of assays
The invention relates to a device and methods for determining the quality of reagents used in an assay process, particularly a multistep immunohistochemical assay. In particular, the device...
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7270786 |
Methods and systems for processing microfluidic samples of particle containing fluids
The present invention relates to a microfluidic system for processing a cell-containing liquid. The system includes a microfabricated substrate having an enrichment channel to prepare an enriched...
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7267938 |
Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks
The present invention describes improved microfluidic systems and procedures for fabricating improved microfluidic systems, which contain one or more levels of microfluidic channels. The methods...
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7258990 |
Alleviation of non-specific binding in microarray assays
A post-incubation treatment is employed to effectively remove targets, such as proteins/protein complexes, or other label-bearing moieties that may non-specifically bind to a microarray substrate...
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7256040 |
Method and apparatus for preparing monolayers of cells
The invention concerns an apparatus for preparing monolayers of cells. The apparatus comprises a container ( 6 ) for a cryosubstitution system and an insert ( 1 ) for the container, the insert ( 1...
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