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RE43389 Vessel for blood sampling  
The present invention relates to a vessel for withdrawing blood, the vessel containing a solution which comprises a guanidinium salt, a buffer substance, a reducing agent, and/or a detergent as...
8178344 System and method for antigen structure-independent detection of antigens captured on antibody arrays  
The present invention provides a system and method for detecting antigens captured on an antibody array. The method comprises the following steps of providing the antibody array having at least...
8178316 Evaluating proteins  
The disclosure features methods that include: providing a substrate that includes (i) a nucleic acid (e.g., DNA or RNA) encoding a hybrid amino acid sequence including a test amino acid sequence...
8173415 Single cell microinjection using flexible and compliant fluidic channels and electroosmotic dosage control  
A microinjection device for injecting a target cell with a reagent. The microinjection device includes a flexible substrate; a target supply channel formed in the flexible substrate for receiving...
8173417 Ruggedized apparatus for analysis of nucleic acid and proteins  
The invention provides methods and systems for ruggedizing a nucleic acid analyzing apparatus. The ruggedized apparatus can be used reliably and effectively in uncontrolled environments, such as,...
8173413 Separation and concentration of biological cells and biological particles using a one-dimensional channel  
This document discloses, among other things, a method and system for a substrate having a bypass region for fluid flow. The substrate includes a plurality of fluid flow channels with each channel...
8168439 Method for measuring an analyte in blood  
An electrochemical immunosensor system with reduced interference, comprising: a first immunosensor that generates an electrochemical signal based on the formation of a sandwich between an...
8168443 Instrument for cassette for sample preparation  
A parallel processing system for processing samples is described. In one embodiment, the parallel processing system includes an instrument interface parallel controller to control a tray motor...
8163538 Device and method for multiple analyte detection  
The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention...
8163535 Devices and processes for nucleic acid extraction  
Devices, processes, and kits for the extraction of nucleic acids from biological samples are disclosed. The devices comprise a first port, a second port, and a binding chamber intermediate and in...
8163534 Estrogenic substance degradable microorganism and use thereof  
A microorganism capable of degrading an estrogenic substance contained in wastewater and the like; a method for the simple and effective degradation of an estrogenic substance contained in...
8158363 Microfluidic immunoassay device  
An optical fiber for use in an immunoassay device having at least one microfluidic channel, the optical fiber being for transmitting excitation light to the microfluidic channel and for...
8158377 Biosensor method and system based on feature vector extraction  
A method of biosensor-based detection of toxins comprises the steps of providing at least one time-dependent control signal generated by a biosensor in a gas or liquid medium, and obtaining a...
8158410 Recovery of rare cells using a microchannel apparatus with patterned posts  
A microflow apparatus for separating or isolating cells from a bodily fluid or other liquid sample uses a flow path where straight-line flow is interrupted by a pattern of transverse posts. The...
8158141 Cell transplant device for treatment of corneal wound  
A device for transplanting a graft such as a layer or layers of cultivated, autologous, allogenic or xenogenic cells to cover an accidental or surgical wound. The graft is cultivated and carried...
8158408 Diffraction-based diagnostic devices  
A biosensor includes a substrate with areas of active receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of the active areas is defined...
8158348 Apparatus and method for preparative scale purification of nucleic acids  
Apparatus and methods are described for pharmaceutical grade manufacture extrachromosomal nucleic acids from cell lysates using flotation to separate and eliminate undesired insoluble cellular...
8153417 Ionic liquid apparatus and method for biological samples  
Apparatus and method for handling biological samples. Segments of ionic liquid can provide voltage across segments of immiscible liquid to concentrate or separate charged species in the biological...
8153367 Amplified array analysis system  
The present invention concerns an array-based analytical system and method having an enhanced sensitivity which allows for simple and rapid analysis of relative unmodified samples which comprises...
8152738 Cytoblock preparation system and methods of use  
An apparatus and method that may be used for collecting target cells or tissue and preparing a cell block are disclosed.
8148141 Peptide-immobilized substrate and method for measuring target protein  
Disclosed is a peptide-immobilized substrate for measuring a target protein, with which the peptide can have a structure required for being recognized by the target protein, with which the...
8148057 Methods, immunoassays and devices for detection of anti-lipoidal antibodies  
Compositions, methods and devices for the detection of anti-lipoidal antibodies and the diagnosis of disease, for example, syphilis, are described. In particular, a method for immobilizing a...
8147757 Filter with memory, communication and concentration sensor  
The present invention describes a system and method for accurately measuring the concentration of a substance within a filter housing. A concentration sensor and a communications device are...
8148139 Light transmitted assay beads  
A micro bead having a digitally coded structure that is partially transmissive and opaque to light. The pattern of transmitted light is determined by to decode the bead. The coded bead may be...
8143070 Optical cell  
A use composition monitor determines the concentration of peracid and/or peroxide in a use composition using a kinetic assay procedure. A sample mixture containing a sample of the use composition,...
8137983 Method of maintaining a protein concentration at a tangential flow filter  
The present invention describes a system and method for accurately measuring the concentration of a substance within a filter housing. A concentration sensor and a communications device are...
8137988 Fluidic force discrimination  
This invention describes a method of using controlled fluidic forces to improve the performance of a biochemical binding assay where a target molecule is captured by specific molecular recognition...
8133497 Systems and methods for delivery of a therapeutic agent  
Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G...
8129174 Separating method and an apparatus performing such a method  
A method for separating carriers from a solution, the carriers being adapted to have biomolecules, such as DNA, RNA, proteins, polypeptides or carbohydrates attached thereto. The method includes...
8129188 Cell culture apparatus and method of fabricating the apparatus  
A cell culture apparatus and a method for fabricating the cell culture apparatus are disclosed, the method comprises forming at least one fillister on a biomaterial composite layer by...
8129195 Method for the production of an analytical element  
A method is provided for producing an analytical element comprising at least one test field for analyzing a liquid sample, wherein provision is made for a carrier on which a polymer fabric is...
8129113 Analysis chip with reference range, kits and methods of analysis  
Analysis chip of at least one analyte, said chip comprising at least one analysis spot for recognition and immobilization specific to the analyte; and a reference range (G) comprising several...
8124025 Membrane system for blood coagulation testing  
Articles for testing a coagulation process in whole blood.
8124402 Encoded beads having oligonucleotides attached in arrays on a patterned surface  
A method and apparatus for the manipulation of colloidal particles and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution....
8119391 Biochip analysis system  
The present invention relates to a biochip readout device for analyzing and reading out biochips in a rotation manner such that a biochip having been adopted in a non-rotation manner is mounted on...
8119423 Device and method for multiple analyte detection  
The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention...
8119392 Biocompatible resists  
This invention relates to biomaterials, biocompatible photoresists, and electroactive photoresists, and methods to engineer the interactions between biomaterials and cells. In one aspect, this...
8114027 Swab for collecting biological specimens  
The present invention relates to a swab for collecting biological specimens of the type consisting of a rod terminating in a tip covered with fiber with hydrophilic properties to allow absorption...
8110349 Method for producing biomolecule diagnostic devices  
A biosensor includes a substrate member with a pattern of active areas of receptive material and a pattern of blocking material layers. The receptive material and blocking material are attached to...
8105633 Method and apparatus for extraction of arthropod gland  
Apparatus and method for the extraction of material from glands of arthropods. The apparatus includes a container in which at least part of the glands are placed and a buffer solution at least...
8105817 Methods and systems for toxin delivery to the nasal cavity  
Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to...
8106428 Nano-scale bridge biosensors  
Devices, systems, and methods for detecting nucleic acid hybridization, including single nucleic base mutations at low concentrations, are disclosed, using capture units having nanoparticles with...
8101405 Nanoparticulate affinity capture for label independent detection system  
A biosensor article including a substrate having nanoparticles on the substrate surface, the nanoparticle including: a polymer of formula (I) where (x), (y), (z), R, R′, R″, S, W, and X, are as...
8101388 Method and structure for extracting molecular species  
The present invention in one embodiment provides a method for extracting molecular material including providing a probe comprising a penetration portion having a nanoscale surface for penetrating...
8093039 Surfaces differentially adhesive to eukaryotic cells and non-eukaryotic cells  
A surface coating comprises a primer coat that permits adhesion of eukaryotic cells thereto, and a plurality of macromolecular structures attached to the primer coat. At least some of the...
8093038 Apparatus and method for encapsulating pancreatic cells  
An apparatus and method for coating micron-sized or sub-micron-sized particles such as living cells. The coating apparatus includes an encapsulation chamber enclosing a two-layer water-oil system...
8093053 Methods and compositions for culturing of neural precursor cells  
The present invention provides methods and compositions for the propagation and expansion of neural precursor cells (NPCs). NPCs may be used in the clinical implementation of stem cell therapy to...
8088578 Method of detecting an analyte  
The invention relates to certain novel approaches to reducing or eliminating the movement of contaminants from one droplet to another on a droplet actuator via liquid filler fluid. In one...
8084259 Method of insuring the integrity of a filtering element  
The present invention describes a system for accurately measuring the concentration of a substance within a filter housing. A concentration sensor and a communications device are coupled so as to...
8084245 Apparatus and method for polymer synthesis using arrays  
A polymer synthesis apparatus (20) for building a polymer chain including a head assembly (21) having an array of nozzles (22) with each nozzle coupled to a reservoir (23) of liquid reagent (24),...