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6410281 |
Reducing corrosion in a fermentor by providing sodium with a non-chloride sodium salt
A process is provided for growing the microflora Thraustochytrium, Schizochytrium, and mixtures thereof, which includes the growing of the microflora in fermentation medium containing non-chloride...
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6406876 |
Immobilized enzymes biosensors for chemical toxins
Methods, compositions and materials useful in the detection of organophosphorous and organosulfur compounds are disclosed. In particular, biosensors wherein a porous or a non-porous support having...
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6406903 |
Dynamically controlled crystal growth system
Crystal growth can be initiated and controlled by dynamically controlled vapor diffusion or temperature change. In one aspect, the present invention uses a precisely controlled vapor diffusion...
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6407310 |
Method for preparing entomopathogenic nematodes for storage by mixing with non-fibrous cellulose particles of less than 300 &mgr M
Third stage juvenile (J3) entomopathogenic nematodes are prepared for storage by being induced into a state of cryptobiosis. The induction of cryptobiosis is effected by mixing an aqueous cream of...
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6403338 |
Microfluidic systems and methods of genotyping
Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components...
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6403321 |
Nano-devices using block-copolymers
A structure including a substrate. A first electrode and a second electrode are arranged spaced apart from each other on the substrate. A polymer string is positioned on the substrate between the...
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6399360 |
Apparatus and method for manufacturing electrophysiology harps
The present invention comprises a jig for the manufacture of electrophysiology harps containing a top surface upon which may be placed one or more “U”s and two arrays of strand-securing...
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6399361 |
Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
This invention provides methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. Specifically, the invention provides a microsystem platform for use with a...
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6395493 |
Methods and apparatus for determination of length polymorphisms in DNA
Methods and apparatus are provided for the analysis and determination of the nature of repeat units in a genetic target. In one method of this invention, the nature of the repeat units in the...
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6391623 |
Fluidics station injection needles with distal end and side ports and method of using
The present invention generally provides novel apparatuses for rapidly and efficiently carrying out repeated hybridizations of a target nucleic acid to an array of nucleic acid probes. The...
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6391622 |
Closed-loop biochemical analyzers
Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components...
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6383736 |
Personal drug use indicator
A personal drug testing kit utilizing drug-sensitive pads which are stored in a package that permits the storage of the drug-sensitive pads within its interior without exposing the drug-sensitive...
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6379916 |
Device and process for the examination of cells using the patch-clamp method
Disclosed is a device and a process for examining cells using the patch-clamp method. A plane arrangement is used of a first number of micro-cuvettes for receiving cells and a plane arrangement of...
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6379915 |
Diagnostic compositions and devices utilizing same
A dry chemistry dye indicator composition provides improved shelf life, stable color indication end point and capability for a system at near normal pH. The novel dry chemistry dye indication...
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6379917 |
Apparatus and method for real-time measurement of cellular response
An apparatus and method for real-time measurement of a cellular response of a test compound or series of test compounds ( 303 ) on a flowing suspension of cells ( 349 ), in which a homogenous...
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6375903 |
Method and apparatus for synthesis of arrays of DNA probes
The synthesis of arrays of DNA probes sequences, polypeptides, and the like is carried out using a patterning process on an active surface of a substrate. An image is projected onto the active...
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6375899 |
Electrophoretic buss for transport of charged materials in a multi-chamber system
Methods, apparatus, and applications for use of a stacked, reconfigurable system for electrophoretic transport are provided. In one embodiment, a system having a first chamber including at least a...
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6372483 |
Preparation of biopolymer arrays
A method and apparatus for fabricating an array of biopolymers on a substrate using a biopolymer or biomonomer fluid, and using a fluid dispensing head. The head has at least one jet which can...
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6368838 |
Adhering cells to cytophilic islands separated by cytophobic regions to form patterns and manipulate cells
Methods and a device are provided for adhering cells in a specific and predetermined position. The device comprises a plate defining a surface and a plurality of cytophilic islands that adhere...
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6368799 |
Method to detect gene polymorphisms and monitor allelic expression employing a probe array
The invention provides methods of monitoring expression levels of different polymorphic forms of a gene. Such methods entail analyzing genomic DNA from an individual to determine the presence of...
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6365367 |
Environmental chamber for the analysis of live cells
This invention provides environmental control devices and methods for live cell analysis. The devices of the invention combine a plate space that can hold specimen plates of a variety of sizes, gas...
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6361962 |
Toxin detector
Methods, materials, and systems for detecting toxins are provided. In one aspect, a toxin contamination detector includes a substrate on which a bar code is printed. The bar code has a first color...
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6358474 |
Device and method for isolating cell material out of a tissue medium and/or a liquid
An apparatus for isolating cell material from a tissue system and/or a liquid includes (1) a vessel open at the top, into which the cell material to be isolated can be introduced in the tissue...
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6350609 |
Electrospraying for mass fabrication of chips and libraries
A method of fabricating deposits of non-volatile substances, including biomacromolecules, in the form of spots and filing on a substrate surface by electrospray, where the deposits are used to...
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6342347 |
Electromagnetic sensor
The present invention relates to a sensor for analyte detection. The sensor makes use of changes in electrostatic fields associated with macromolecular binding agents during their interaction with...
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6342364 |
Cholesterol sensor and method of determining cholesterol
The present invention provides a sensor that electrochemically determines cholesterol in low density lipoprotein by only one feed of a sample. The sensor has: an electrode system that is mounted on...
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6342355 |
Probe-based analysis of heterozygous mutations using two-color labelling
The invention provides methods of analyzing a nucleic acid in a target sample for variant alleles. In such methods, a first-labelled control sample and a second-labelled target sample are...
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6340573 |
Chromogenic substrates for detecting bacterial hydrolases
The invention concerns a chromogenous substrate for detecting the presence of at least one enzyme enzymatic activity. The invention also concerns a method for using such a substrate. The invention...
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6337214 |
Detection of DNA, RNA and proteins using a test column with two snares
Methods and apparatuses are disclosed for detecting the presence of a test material in a test sample. The test sample is introduced into a test column which has at least two snares. One of the...
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6334980 |
Flexible apparatus with ablation formed chamber(s) for conducting bio-chemical analyses
Miniaturized, self-contained apparatus for conducting bio-chemical reactions and analyses is formed in a compact structure comprising a substrate which includes a plurality of reaction chambers and...
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6335191 |
Automated system and method for growing bacteria
An automated system and method is provided for cultivating bacteria in a fluid medium and thereafter selectively discharging the fluid medium, wherein an initial supply of the selected strain or...
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6333189 |
Method of making an electrotransport device
Method of making an electrotransport device containing an analog of a parent polypeptide having one or more amino acid residues substituted relative to the parent polypeptide with an amino acid...
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6331274 |
Advanced active circuits and devices for molecular biological analysis and diagnostics
Devices for performing active biological operations utilize various structures to advantageously collect and provide charged biological materials to an array of microlocations. An active biological...
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6331387 |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological...
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6331431 |
Vacuum device and method for isolating periplasmic fraction from cells
A high throughput device is provided for simultaneously isolating periplasmic fractions from multiple samples of host cells. The device can be formatted to operate in a series. A method for...
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6329210 |
Method and apparatus for high volume polymer synthesis
A scalable synthesis apparatus capable of rapid and efficient oligo synthesis. The apparatus includes a combination of dispensing elements, synthesis elements, and waste removal elements. More...
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6322963 |
Sensor for analyte detection
A sensor for detecting analytes is described. Analyte presence or concentration is determined through measurement of changes in induced electromotive force, current or other electrical property in...
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6319664 |
Low protein-binding polymer product produced using low HLB number non-ionic surfactant
Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm 2 are achieved by: (1) applying to a hydrophobic polymer surface a coating solution composed of a solvent...
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6319472 |
System including functionally separated regions in electrophoretic system
Methods, apparatus, and applications for use of a stacked, reconfigurable system for electrophoretic transport are provided. In one embodiment, a system having a first chamber including at least a...
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6312888 |
Diagnostic assay for a sample of biological fluid
An article and a method for monitoring the concentration of an analyte, e. g., glucose, in blood. In one aspect, the invention involves an article comprising a multiple-layer element. In one...
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6312942 |
Apparatus for encapsulating substances in small spherical particles formed from an encapsulating fluid
Substances such as chemical substances and biological substances including animal, vegetable and microbial cells are encapsulated using a process and an apparatus wherein a coil through which...
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6312950 |
Apparatus and method for isolating and recovering cells
There is proposed an apparatus for isolating and recovering an objective cell, which comprises, a filtering device having a filtering member which is capable of setting a porosity thereof to two or...
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6312886 |
Reaction vessels
Apparatus for effecting reactions comprising a plurality of reaction vessels for holding reagents, an electrically conducting polymer which emits heat when an electric current is passed through it,...
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6309831 |
Method of manufacturing biological chips
A method of manufacturing items in parallel. Selected samples of items to be manufactured are subjected to additional steps in a manufacturing process. If such sample items meet the requisite...
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6309602 |
Stacked, reconfigurable system for electrophoretic transport of charged materials
Methods, apparatus, and applications for use of a stacked, reconfigurable system for electrophoretic transport are provided. In one embodiment, a system having a first chamber including at least a...
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6309875 |
Apparatus for biomolecular array hybridization facilitated by agitation during centrifuging
Array hybridization can be facilitated by agitating a reaction cell subject to centrifugal force greater than 1G. A two-dimensional hybridization array is preferably oriented generally orthogonal...
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6306587 |
Template-directed photoligation
Methods, apparatus and compositions are presented for ligating ligands together which bind to a common receptor. One embodiment includes polynucleotide probes having photoreactive functional...
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6306609 |
Methods for the detection of nitric oxide in fluid media
In accordance with the present invention, there are provided articles for use in non-invasive measurements of nitric oxide levels in a variety of fluid media, e.g., in mammalian body fluids....
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6303285 |
Apparatus and method for freezing live cells
An apparatus for freezing live cells, in particular sperm, which cells are included in at least one sample in at least one container, wherein means are provided for cooling the or each container,...
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6300124 |
Device and method to directly control the temperature of microscope slides
A thermal cycling device for use with self-heating microscope slides is provided.
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