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7611886 |
Enzymatic transformation of a prostaglandin (bimatoprost) intermediate
A method for the selective enzymatic acetylation of a bimatoprost intermediate is provided.
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7582469 |
Method for enantioselectively opening oxetan-2-ones
A method for preparing substantially enantiopure 3-hydroxy carboxylic acids or esters of the general formula (III) by reacting racemic oxetan-2-ones of the general formula (I) with compounds R3-OH...
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7582468 |
Process for preparing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof
The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC...
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7572606 |
Biosyntheses of salinosporamide A and its analogs and related methods of making salinosporamide A and its analogs
Disclosed are methods of modulating biosynthesis of Salinosporamide A and its analogs, which are useful in treating cancer, inflammatory conditions, and/or infectious disease. The methods involve,...
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7514245 |
Method for producing chiral α-hydroxycarboxylic acids by enzymatic hydrolysis of chiral cyanohydrins
The invention relates to a method for producing chiral α-hydroxycarboxylic crystalline acids consisting in transforming cyanhydrins (R) or (S) into α-hydroxycarboxylic acids (R) or (S),...
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7485452 |
Method of making optically active ester derivatives and their acids from racemic esters
The present invention relates to process for the preparing of optically active ester derivatives and their acid derivatives which are used intensively as important chiral intermediates from racemic...
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7465842 |
Enantioselective biotransformation for preparation of protein tyrosine kinase inhibitor intermediates
The invention relates to biocatalytic methods for preparing enantiomerically pure stereoisomers of 1-(2,6-dichloro-3-fluorophenyl)ethanol. Disclosed are methods of preparation of the desired...
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7459301 |
Stereoisomerically enriched N-protected β-lactams using candida antarctica
The present disclosure provides enzymatic methods for generating stereoisomerically pure products by resolving a racemic mixture of N-protected β-lactams with a lipase from Candida antarctica ...
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7452703 |
Uranium enrichment using microorganisms
The present invention provides methods for separating isotopes of actinide elements such as uranium using microorganisms, e.g., metal or sulfate reducing bacteria. The microorganisms reduce the...
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7449325 |
Process for enzymatically producing either optically active N-substituted β-amino acids or esters thereof or optically active N-substituted 2-homopipecolic acids or esters thereof
The present invention discloses a process which comprises selectively hydrolyzing one enantiomer of racemic mixtures of an N-substituted β-amino acid alkyl ester or N-substituted 2-homopipecolic...
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7413883 |
Enantioselective immobilized lipase
Immobilization of Candida rugosa lipase on a carrier selected from the group consisting of macroporous adsorbent resin of the acrylic type, synthetic epoxy activated resin and...
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7405070 |
Method for preparing (s)-indoline-2-carboxylic acid and (s)-indoline-2-carboxylic acid methyl ester using hydrolytic enzyme
Disclosed is a method for preparing (S)-indoline-2-carboxylic acid and (S)-indoline-2-carboxylic acid methyl ester using an inexpensive industrially available enzyme capable of assuring superior...
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7378269 |
Process for the production of amino acids
The present invention relates to the processes of racemization and deprotection of special N-protected amino acids in the acylase/racemase system for the total conversion of special N-protected...
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7374926 |
Enantioconvergent chemoenzymatic synthesis of (R)-γ-amino-β-hydroxybutyric acid ((R)-GABOB)
The present invention particularly relates to a chemoenzymatic process for the stereoselective preparation of both enantiomers of 3-hydroxy-4-trityloxy butanenitrile key intermediates for the...
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7358396 |
Preparation of optically active amines
A process for preparing optically active amines, a process for preparing racemic amines which can be resolved using optically active carboxylic acids or enzymes, and racemic and optically active...
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7354771 |
Method of determining absolute configuration of chiral compound
The absolute configuration of a chiral compound is determined by (i) coordinating the chiral compound to a metalloporphyrin having a carbon chain-crosslinked porphyrin dimer structure in which one...
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7326559 |
Process for preparation of optically active allenes
The present invention provides a process for producing an optically active allene represented by formula (1):
wherein R 2 and R 3 are different and each represents a hydrogen atom, an...
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7267969 |
Thermostable omega-transaminases
Thermostable omega-transaminases, particularly thermostable omega-transaminases which have a high reaction rate and which are tolerant to high concentrations of donor amine, can be used to enrich...
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7264960 |
Enzymatic resolution of propylene glycol alkyl (or aryl) ethers and ether acetates
Glycol ether acetates, and in particular propylene glycol alkyl (or aryl) ether acetates, can be resolved enzymatically by enantioselective hydrolysis with a hydrolase at high concentrations of...
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7247468 |
Method for producing optically active 1,2-diols by microorganism culturing
A method for producing an optically active compound comprising: a first step of culturing a microorganism capable of assimilating either the R-isomer or the S-isomer of a compound represented by...
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7235399 |
Method for producing optically active 3-chloro-2-methyl-1, 2-propanediol taking advantage of microorganism
The present invention provides a method for obtaining optically active 3-chloro-2-methyl-1,2-propanediol, the method comprising: a first step of letting at least one kind of microorganism or...
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7217560 |
Process for preparation of optically active propoxyaniline derivatives
Treatment of a lactic acid ester derivative with an enzyme or the like, which has asymmetric ester-hydrolyzing ability, can specifically hydrolyze the ester moiety of an isomer existing as the pair...
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7208631 |
2-alkylcysteinamide or salt thereof, process for producing these, and use of these
A process for producing a 2-alkylcysteinamide, which comprises hydrolysis of a 4-alkylthiazolidine-4-carboxamide represented by the general formula (2) or a salt thereof:
wherein R represents a...
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7198926 |
Preparation of (E)- and (Z)-2-methyl-2-butenoic acids
A method has been developed to prepare (E)- and (Z)-2-methyl-2-butenoic acids (2M2BA) from a mixture of (E,Z)-2-methyl-2-butenenitriles (2M2BN) by the regioselective hydrolysis of (E)-2M2BN to...
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7169591 |
Preparation of enantio-specific epoxides
A method for converting alkenes into epoxides and, particularly, to convert alkenes into enantio-specific epoxides by the use of enzymes which may be in their naturally-occuring (native) form or in...
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7148055 |
Process for production of optically active 3-hydroxypentanenitrile
The present invention provides a method for preparing optically active 3-hydroxypentanenitrile with high yield. Optically active 3-hydroxypentanenitrile is prepared by stereoselectively reducing...
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7141412 |
Process for preparing optically active 3-hydroxypyrrolidine derivatives by enzymatic hydroxylation
A process for the preparation of optically active 3-hydroxypyrrolidine or N-substituted 3-hydroxypyrrolidines, wherein an oxygen atom is inserted stereoselectively into the corresponding...
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7135328 |
Process for the enantioselective reduction of 8-chloro-6-oxo-octanoic acid alkyl esters
The invention relates to a process for the production of (R)- or (S)-8-chloro-6-hydroxyoctanoic acid alkyl esters of the general formula (R)-II or (S)-II,
in which R means C 1-4 alkyl, from...
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7115412 |
Process for the preparation of optically active 7-substituted-3-(2-aminopropyl)indole derivatives and intermediates therefor
Disclosed are a process for preparation of an optically active 7-substituted 3-(2-aminopropyl)indole compound and an intermediate therefor. In the above preparation process, 7-substituted indole is...
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7112431 |
5-substituted hydantoin racemase, DNA coding for the racemase, and processes for producing optically active amino acids
The present invention relates to a 5-substituted hydantoin racemase, which efficiently catalyzes racemization reactions at a high optimum temperature for racemization reactions, DNA coding for the...
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7102018 |
Intermediates and improved processes for the preparation of neplanocin A
Intermediate compounds, including 2-(t-butyldimethylsilyloxymethyl)-3,4-[(dimethylmethylene)di
oxy]-5-hydroxy-tricyclo[5.2.1.0 2,6 ]dec-8-ene, which are useful for the synthesis of neplanocin A...
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7094594 |
Process for preparing optically active 2-[6-(hydroxy-methyl)-1,3-dioxan-4-yl] acetic acid derivatives
The present invention is to provide a production technology by which an optically active 2-[6-(hydroxymethyl)-1, 3-dioxan-4-yl]acetic acid derivative, which are of value as pharmaceutical...
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7091023 |
Stereoselective esterase from Aspergillus oryzae
An esterase isolated from Aspergillus oryzae is capable of stereoselective hydrolysis of chiral esters and also has arylesterase activity (EC 3.1.1.2) and feruloyl esterase activity (EC...
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7083973 |
Stereoselective reduction of substituted oxo-butanes
The present invention relates to a process for the stereoselective enzymatic reduction of 1-halo-2-oxo-3-(protected)amino-4-substituted-butanes utilizing certain species of Rhodococcus and ...
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7078226 |
Method for producing optically active amines
A process for preparing optically active amines, a process for preparing racemic amines which can be resolved using optically active carboxylic acids or enzymes, and racemic and optically active...
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7078225 |
Method for enzymatically producing an optically active cyanohydrin
The present invention relates to an enzyme reaction method which comprises performing an enzyme reaction, using an immobilized enzyme having a water content of 10% by weight or more as an enzyme...
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7067305 |
Enzymatic process for the resolution for enantiomeric mixtures of β-lactams
A process for the resolution of an enantiomeric mixture of β-lactams containing an ester, the process comprising selectively hydrolyzing the ester of one of the enantiomers by combining the...
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7067291 |
Biocatalytic preparation of enantiomerically enriched aminopentanenitrile
Methods for preparing enantiomerically enriched aminopentanenitriles are provided. The methods involve selective acylation of an enantiomeric mixture of 3-aminopentanenitrile or selective...
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7063977 |
Enzymatic resolution of t-butyl taxane derivatives
A method for the resolution of a mixture of the cis or trans enantiomers of a compound of the formula
wherein R 1 is —O—C(O)alkyl, —O—C(O)aryl or —O—C(O)cycloalkyl by contacting...
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7053225 |
Intermediates and improved processes for the preparation of neplanocin A
Intermediate compounds, including 2-(t-butyldimethylsilyloxymethyl)-3,4-[(dimethylmethylene)di
oxy]-5-hydroxy-tricyclo[5.2.1.0 2,6 ]dec-8-ene, which are useful for the synthesis of neplanocin A...
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7045341 |
Chemoenzymatic process for stereoselective preparation of R and S enatiomers of 2-hydroxy-3-(2-thienyl) propanenitrile
A chemoenzymatic process for the stereoselective preparation of both the (R) and (S) enantiomers of 3-hydroxy-3-(2-thienyl) propanenitrile has been developed. These optically pure key intermediates...
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7026144 |
Process for preparing (-) menthol and similar compounds
A process of separating a single desired stereoisomer from a racemic mixture of eight stereoisomers of a compound of formula (III), wherein R 1 represents an isopropanol group, an isopropyl group...
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7015029 |
Process for producing optically active (4R)-1,3-tiazolidine-4-carboxylic acid
There is provided a novel method for producing an optically active (4R)-1,3-thiazolidine-4-carboxylic acid by allowing cells of a microorganism or a preparation obtained from cells of a...
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7011963 |
Process for synthesis of bead-shaped cross-linked hydrophilic support polymer
The invention relates to a process for synthesis, by inverse bead polymerization of a monomer phase, of a bead-like, cross-linked, hydrophilic copolymer which has binding activity toward ligands...
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7005282 |
Enzymes coated with ionic liquid
Disclosed is an ionic liquid-coated enzyme, wherein the ionic liquid is an organic salt which presents as a liquid phase at a temperature of about 150° C. or below. The ionic liquid-coated enzyme...
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6987010 |
Process for the enzymatic preparation of enantiomer-enriched β-amino acids
The present invention relates to processes for the preparation of enantiomerically enriched β-amino acids. The invention also relates to advantageous esters of β-amino acids of the general...
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6979561 |
Non-homogeneous systems for the resolution of enantiomeric mixtures
The present invention relates to a process for the biocatalyst-mediated enantioselective conversion of enantiomeric mixtures of hydrophobic esters uing a biphasic solvent system. More particularly,...
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6958233 |
Process for the preparation of pharmaceutically acceptable salts of (R,S)-S-adenosyl-L-methionine
The present invention relates to a process for the preparation of pharmaceutically acceptable salts of (R,S)-S-adenosyl-L-methionine and allows to obtain the salified...
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6953678 |
Use of orthoesters for the synthesis of chiral acids in biocatalyzed irreversible esterification processes
A process for the resolution of enantiomeric mixtures of a chiral carboxylic acid, including an esterification reaction of the carboxylic acid in an organic solvent, in the presence of a...
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6939693 |
Enantioselective oligomerization of α-hydroxy carboxylic acids and α-amino acids
An enzymatic synthesis and composition of oligomers and co-oligomers comprised of α-hydroxy carboxylic acids and α-amino acids or peptides is disclosed. In a preferred embodiment, a α-hydroxy...
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