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7608437 |
Method of constructing amino acid producing bacterial strains, and method of preparing amino acids by fermentation with the constructed amino acid producing bacterial strains
A method of producing coryneform bacteria having an improved amino acid or nucleic acid-productivity comprises the steps of introducing a mutation in a promoter sequence of amino acid- or nucleic...
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7604969 |
Mutant glucose dehydrogenase
A mutant glucose dehydrogenase having an improved substrate specificity to glucose, which is a protein comprising the amino acid sequence depicted in SEQ ID NO:3 or an amino acid sequence having...
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7598063 |
Process for producing ethanol by using recombinant coryneform bacterium
The present invention provides a process for highly efficiently producing ethanol at a high productivity consisting of using a coryneform bacterium which has been transformed by a DNA containing a...
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7585400 |
Chip for electrochemical immunoassay
The present invention provides a chip 100 that enables an immunoassay with high accuracy and without requiring a high volatile reagent. The chip 100 includes a chip substrate 20 , a reagent...
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7582460 |
3-phosphoglycerate dehydrogenase variants whose inhibition by L-serine is reduced, and genes encoding them
A 3-phosphoglycerate dehydrogenase (PGD) which exhibits a susceptibility to inhibition by serine which is reduced a as compared with that of an Escherichia coli wild-type PGD and which possesses...
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7575884 |
Test piece for measuring high-density lipoprotein (HDL) cholesterol
The present invention relates to a test piece having a simple structure, by which HDL cholesterol can be measured easily using a small amount of specimen. A reagent layer ( 2 ) is formed on a...
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7560239 |
Homogeneous enzyme immunoassay for simultaneous detection of multiple analytes
Methods and kits are provided for the simultaneous detection of multiple analytes, i.e. to the determination of whether one or more of a plurality of analytes is present in a sample, particularly...
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7553615 |
Compounds, methods, complexes, apparatuses and uses relating to stabile forms of NAD/NADH
The invention concerns stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives, enzyme complexes of these derivatives and their...
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7547524 |
Genetically engineered pyrroloquinoline quinone dependent glucose dehydrogenase comprising an amino acid insertion
The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH) comprising an amino acid insertion between positions 428 and...
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7547441 |
PAI-2 conjugates for the treatment and imaging of cancer
A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises...
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7524872 |
Method and composition for treating cancer using cellular organelle crystallizing agents
This invention provides a method for treating cancer in mammals through cellular-organelle-crystallization-induced-death (herein defined as “Cocid”), a method for treating cancer using cellular...
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7517664 |
Inactivated enzyme variants and associated process and reagent system
The present invention relates to oxidoreductase apoenzyme variants which are enzymatically inactive but have coenzyme-binding properties. Further, the present invention relates to DNA sequences...
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7514247 |
Systems and processes for cellulosic ethanol production
A cellulosic ethanol production process. An implementation of a process for producing fuel ethanol and biodiesel from cellulose may include: providing a raw cellulose stream by mixing a waste...
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7507551 |
Multiple quantification method for cholesterol in low-density lipoproteins
The present invention is intended to provide a method for simultaneously measuring cholesterol in low density lipoprotein and total cholesterol as test components in blood. Specifically, a method...
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7491542 |
Test device for determining the concentration of LDL-cholesterol in a sample
The present invention provides a test device for determining the concentration of LDL-cholesterol in a sample. The test device has a continuous solid surface with at least one reaction area on the...
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7488602 |
Method for detecting and compensating an underdosage of test strips
The invention concerns a method for detecting an underdosage of an analytical test element and optionally for compensating the underdosage. The invention also concerns an analytical system and a...
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7485705 |
Water-soluble tetrazolium compounds
The purpose of the present invention is to provide a water-soluble tetrazolium compound that will form a water-soluble formazan exhibiting long-wavelength absorption and is stable in aqueous...
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7479383 |
Modified pyrroloquinoline quinone (PQQ) dependent glucose dehydrogenase excellent in substrate specificity
PQQGDH having an improved substrate specificity or having an improved specific activity in an assay system using ferricyanide ion as a mediator is provided. Modified PQQGDH having the enhanced...
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7452505 |
Method for analyzing blood test sample and dry analytical element and analytical kit utilizing the method
Objects of the present invention are to provide a method for analyzing a blood test sample containing blood platelet collected from a human body to detect presence of an analyte in the test sample,...
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7442496 |
Methods and kits for diagnosis of schizophrenia
The present invention provides methods and kits for the diagnosis of schizophrenia, which employ mitochondrial complex I as a peripheral biological marker for schizophrenia. In one embodiment, the...
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7425302 |
Dry chemistry, lateral flow-reconstituted chromatographic enzyme-driven assays
A lateral flow chromatographic assay format for the performance of rapid enzyme-driven assays is described. A combination of components necessary to elicit a specific enzyme reaction, which are...
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7416866 |
Process for the overexpression of dehydrogenases
A process for the overexpression of dehydrogenases, especially for the overexpression of Δ 1 -dehydrogenases, in particular for the overexpression of 3-keto steroid-Δ 1 -dehydrogenases, as well...
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7402387 |
Methods and compositions for detecting dihydropyrimidine dehydrogenase splicing mutations
The present invention provides compositions, methods, and kits for the detection of genetic polymorphisms or mutations of the dihydropyrimidine dehydrogenase deficiency (DPDD). The polymorphisms or...
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7384751 |
Methods of diagnosing muscle damage
A method for assessing muscle damage in a biological sample obtained from a subject is disclosed. The method involves obtaining a biological sample from a subject being assessed for muscle damage,...
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7381540 |
Composition for measuring glucose having improved substrate specificity
The present invention relates to a method for lowering activity with respect to maltose in glucose measurement comprising a step of reacting modified pyrroloquinoline quinone dependent glucose...
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7348135 |
Assay for detecting changes in mitochondrial membrane permeability and method of using same
An assay for assessing the permeability of mitochondrial membranes is provided. The assay is based on enzymatic reactions that produce a detectable signal in the presence of intra-mitochondrial...
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7341846 |
Method of measuring glucose concentration and glucose sensor with the use of glucose dehydrogenase
The present invention relates to a technique for measuring a glucose level by utilizing a reaction system containing an enzyme and an electron carrier. In accordance with the glucose level...
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7341830 |
Method and reagent system having a non-regenerative enzyme-coenzyme complex
The invention relates to a method and reagent system for detecting an analyte in a sample by means of an enzymatic reaction, involving the use of an enzyme-coenzyme complex as a stoichiometric...
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7335483 |
Method of pretreatment of sample for quantitating cholesterol and method for quantitating cholesterol in specific lipoproteins by using the same
A method of a pretreatment of a sample for quantitating cholesterol characterized by, before measuring cholesterol contained in specific lipoproteins, treating the sample containing lipoproteins...
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7329518 |
Enzyme for producing optically active pyridineethanol derivatives
The present invention relates to a method of producing an optically active pyridineethanol derivative. More particularly, it relates to a method of producing an optically active polycyclic...
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7300769 |
Stabilized coenzyme solutions for determining dehydrogenase activity
Stabilized aqueous solution of a coenzyme for hydrogen-transferring enzymes characterized in that the solution contains NAD, NADP or a derivative thereof in an oxidized or reduced form and one or...
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7291256 |
Mediator stabilized reagent compositions and methods for their use in electrochemical analyte detection assays
Mediator stabilized reagent compositions and methods for their use in electrochemical analyte determination assays are provided. The subject reagent compositions include an enzyme, a redox mediator...
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7282348 |
Kit for measuring cytotoxicity of a test agent
Disclosed are a method and a corresponding kit for determining the cytotoxicity of a test agent. The method includes the steps of adding a pre-determined amount of the test agent to a vessel...
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7279302 |
Methods for identifying herbicidal compounds
The invention concerns novel enzymes having an arogenate dehydrogenase activity, in particular arogenate dehydrogenase enzymes of plants, and the genes encoding said enzymes. The inventive...
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7270977 |
Polypeptides for identifying fungicidally active compounds
The invention relates to polypeptides from phytopathogenic fungi with the biological activity of an inosine monophosphate dehydrogenase, to nucleic acids encoding them, to the use of the...
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7252931 |
NMR-solve method for rapid identification of bi-ligand drug candidates
Methods for rapidly identifying drug candidates that can bind to an enzyme at both a common ligand site and a specificity ligand site, resulting in high affinity binding. The bi-ligand drug...
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7244581 |
Glucose dehydrogenase
Disclosed is a modified glucose dehydrogenase having pyrroloquinoline quinone as a coenzyme, wherein one or more amino acid residues in a region of amino acid 349-377 of water-soluble PQQGDH...
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7238483 |
Method for detecting catalytic activity
This invention has as its object a method for detecting catalytic activity of a sample, characterized in that it comprises: the incubation of a substrate (S) with the sample that may have the...
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7236236 |
Methods for detecting malaria parasites and reagent kits therefor
Methods for detecting a malaria parasite are described that include: releasing the malaria parasite by allowing an erythrocyte in a specimen to undergo hemolysis; staining the released malaria...
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7235672 |
Probe, assay and kits for detecting 11β-hydroxysteroid dehydrogenase and modulators thereof
A probe, kit comprising the probe, and methods for using the probe are provided where the probe comprises:
wherein DM is a detectable marker; and L is a straight or branched chain moiety...
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7208301 |
Method for producing 6-0-α-D-glucopyranosyl-D-sorbitol
This invention concerns a method for enzymatic preparation of 6-O-α-D-glucopyranosyl-D-sorbitol (1,6-GPS) from isomaltulose. It is specified that the isomaltulose is put into an aqueous reaction...
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7202069 |
(R)-2-octanol dehydrogenases, methods for producing the enzymes, DNA encoding the enzymes, and methods for producing alcohols using the enzymes
This invention provides (R)-2-octanol dehydrogenase that catalyzes oxidation-reduction reaction using NAD + (NADH) as a coenzyme and the genes that encodes them. The enzymes of this invention can...
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7198955 |
Method and apparatus for measurement of blood substitutes
A method is disclosed whereby the concentration of a blood substitute, such as cross-linked hemoglobin, in a serum or plasma specimen is rapidly and accurately identified and quantified. The method...
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7198905 |
Method of screening methods prediabetic state and screening reagent
The present invention provides a screening method by which a prediabetic state can be more accurately determined and many test samples can be treated without physical burden on patients, and a...
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7192727 |
Reagent for measuring alanine aminotransferase activity
A reagent for measuring an alanine aminotransferase activity comprising L-alanine, 2-oxoglutaric acid, lactate dehydrogenase, and reduced nicotinamide adenine dinucleotide, characterized by further...
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7186534 |
Potent inhibitors of human 9-cis retinol dehydrogenase
The cDNA sequence of the human 9-cis-retinol dehydrogenase enzyme is disclosed.
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7148007 |
Method for evaluating immunotoxicity of test substance
The present invention discloses a method of evaluating the immunotoxicity of a hydrophobic test substance, comprising (1) culturing immunocompetent cells in a culture system containing a...
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7122333 |
Method and reagent for visually measuring ATP
The object of the invention is to provide a handy type visually determinable ATP measuring reagent which can be easily handled and has good measuring sensitivity. The invention is an ATP measuring...
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7105128 |
Dry analytical element using water-soluble indicator for colorimetry
This invention relates to a dry analytical element using a water-soluble indicator which improves measuring accuracy, which comprises a water-impermeable support, a water-permeable layer and a...
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7052861 |
Graphitic nanotubes in luminescence assays
Graphitic nanotubes, which include tubular fullerenes (commonly called “buckytubes”) and fibrils, which are functionalized by chemical substitution, are used as solid supports in...
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