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8183004 |
Determination of short-chain SRL alcohol dehydrogenase (DHRS4) as a biomarker for inflammations and infections
The present invention relates to the use of short-chain SRL alcohol dehydrogenase (DHRS4, SEQ ID NO: 1) and peptides thereof as humoral biomarkers for the diagnostic detection and prognosis of the...
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8178311 |
Multiple quantification of cholesterol in low density lipoprotein
The present invention is intended to provide a method for simultaneously measuring cholesterol in low density lipoprotein and total cholesterol as test components in blood. Specifically, a method...
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8080385 |
Crosslinked adduct of polyaniline and polymer acid containing redox enzyme for electrochemical sensor
A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble...
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8012725 |
Method for the production of optically-active alcohols
The present invention relates to enzymic processes for preparing S-butan-2-ol; and to enzymes for carrying out said processes; to nucleic acid sequences coding for said enzymes, to expression...
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8008037 |
Matrix composition with alkylphenazine quaternary salt and a nitrosoaniline
A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary...
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7964372 |
Size self-limiting compositions and test devices for measuring analytes in biological fluids
A test strip or electrochemical sensor for measuring the amount of an analyte in a biological fluid, e.g. the glucose content of whole blood, includes a size self-limiting reagent formulation...
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7964382 |
DNA encoding a protein having D-lactate dehydrogenase activity and uses thereof
This invention provides a polynucleotide that encodes a protein having lactate dehydrogenase activity and such protein that can be used for producing D-lactic acid. This polynucleotide has the...
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7943356 |
Alcohol dehydrogenase for the stereoselective production of hydroxy compounds
The invention relates to a DNA sequence encoding an NADP-dependent alcohol dehydrogenase, to a vector containing at least one copy of the DNA sequence and to prokaryotic or eukaryotic host cells...
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7939309 |
Glucose dehydrogenase polypeptides and related polynucleotides
The present invention is directed to glucose dehydrogenase (GDH) polypeptides that have enhanced GDH activity and/or thermostability relative to the backbone wild-type glucose dehydrogenase...
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7919268 |
Reducing sample turbidity in measurement of enzymatic activity in cell lysates
Disclosed are methods and kits for measuring enzyme activity in which the turbidity of a sample caused by cell components is minimized by particular additives. The methods include the steps of...
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7914663 |
Structure, porous body, sensor, process of structure and detecting method for specimen
A mesoporous silica structure having a plurality of mesopores includes a dendritic framework having mesopores. 90% or more of the mesopores observable in a 500 nm×500 nm area pass through the ...
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7867728 |
Determining the concentration of analytes in sample by direct mediation of enzymes
The glucose content of blood can be determined by contacting a blood sample with a test strip containing a glucose dehydrogenase dependent on PQQ (or derivatives or isomers) thereof as a co-factor,...
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7867729 |
27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 molecules and uses therefor
The invention provides isolated nucleic acids molecules, designated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules. The invention also...
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7833397 |
Amino-acid biosensor, Fischer-ratio biosensor and health information management system
Disclosed is a biosensor capable of measuring a total concentration of plural types of amino acids. An amino-acid biosensor (200) for measuring a total concentration of a plurality of specific...
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7829316 |
Process for production of succinic acid
Disclosed is a process for production of succinic acid, which comprises the step of reacting a bacterium which has been modified so as to increase the expression of a sucE1 gene or a product...
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7824881 |
Glucose level measuring method and glucose sensor utilizing glucose dehydrogenase
The present invention relates to a technique for measuring a glucose level by utilizing a reaction system containing an enzyme and an electron carrier. In accordance with the glucose level...
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7816075 |
Methods and compositions using stearoyl-CoA desaturase to identify triglyceride reducing therapeutic agents
The use of screening assays based on the role of human stearoyl-CoA desaturase-1 (“hSCD1”) in human diseases, disorders or conditions relating to serum levels of triglyceride, VLDL, HDL, LDL, tot...
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7816111 |
Glucose dehydrogenase polypeptides and related polynucleotides
The present invention is directed to glucose dehydrogenase (GDH) polypeptides that have enhanced GDH activity and/or thermostability relative to the backbone wild-type glucose dehydrogenase...
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7785771 |
Assay for determination of free D-galactose and/or L-arabinose
The invention provides an assay kit for the measurement of free D-galactose and/or L-arabinose in a sample, the kit comprising galactose mutarotase and (3-galactose dehydrogenase. The kit may...
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7776575 |
Mutant glucose dehydrogenase
A mutant glucose dehydrogenase having the amino acid sequence of SEQ ID NO: 3 or an amino acid sequence of SEQ ID NO: 3 including substitution, deletion, insertion or addition of one or more amino...
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7741069 |
Mesoporous material having dendritic skeleton containing immobilized glucose dehydrogenase
A porous material containing mesopores with immobilized glucose dehydrogenase is provided. The pore size is at least 10 nm.
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7732179 |
Mutants of pyrroloquinoline quinone dependent soluble glucose dehydrogenase
A mutant of PQQ-dependent soluble glucose dehydrogenase (s-GDH; EC 1.1.5.2) is provided with improved specificity for glucose as compared to maltose, having a substitution of threonine at position...
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7645599 |
Methods for producing optically active alcohols
A method for producing optically active alcohols is provided. Optically active alcohols are useful intermediates in pharmaceutical production. The method of the present invention enables simple and...
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7608437 |
Method of constructing amino acid producing bacterial strains, and method of preparing amino acids by fermentation with the constructed amino acid producing bacterial strains
A method of producing coryneform bacteria having an improved amino acid or nucleic acid-productivity comprises the steps of introducing a mutation in a promoter sequence of amino acid- or nucleic...
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7604969 |
Mutant glucose dehydrogenase
A mutant glucose dehydrogenase having an improved substrate specificity to glucose, which is a protein comprising the amino acid sequence depicted in SEQ ID NO:3 or an amino acid sequence having...
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7598063 |
Process for producing ethanol by using recombinant coryneform bacterium
The present invention provides a process for highly efficiently producing ethanol at a high productivity consisting of using a coryneform bacterium which has been transformed by a DNA containing a...
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7585400 |
Chip for electrochemical immunoassay
The present invention provides a chip 100 that enables an immunoassay with high accuracy and without requiring a high volatile reagent. The chip 100 includes a chip substrate 20, a reagent mixture...
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7582460 |
3-phosphoglycerate dehydrogenase variants whose inhibition by L-serine is reduced, and genes encoding them
A 3-phosphoglycerate dehydrogenase (PGD) which exhibits a susceptibility to inhibition by serine which is reduced a as compared with that of an Escherichia coli wild-type PGD and which possesses an...
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7575884 |
Test piece for measuring high-density lipoprotein (HDL) cholesterol
The present invention relates to a test piece having a simple structure, by which HDL cholesterol can be measured easily using a small amount of specimen. A reagent layer (2) is formed on a support...
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7560239 |
Homogeneous enzyme immunoassay for simultaneous detection of multiple analytes
Methods and kits are provided for the simultaneous detection of multiple analytes, i.e. to the determination of whether one or more of a plurality of analytes is present in a sample, particularly...
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7553615 |
Compounds, methods, complexes, apparatuses and uses relating to stabile forms of NAD/NADH
The invention concerns stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives, enzyme complexes of these derivatives and their...
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7547524 |
Genetically engineered pyrroloquinoline quinone dependent glucose dehydrogenase comprising an amino acid insertion
The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH) comprising an amino acid insertion between positions 428 and...
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7547441 |
PAI-2 conjugates for the treatment and imaging of cancer
A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises...
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7524872 |
Method and composition for treating cancer using cellular organelle crystallizing agents
This invention provides a method for treating cancer in mammals through cellular-organelle-crystallization-induced-death (herein defined as “Cocid”), a method for treating cancer using cellular org...
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7517664 |
Inactivated enzyme variants and associated process and reagent system
The present invention relates to oxidoreductase apoenzyme variants which are enzymatically inactive but have coenzyme-binding properties. Further, the present invention relates to DNA sequences...
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7507551 |
Multiple quantification method for cholesterol in low-density lipoproteins
The present invention is intended to provide a method for simultaneously measuring cholesterol in low density lipoprotein and total cholesterol as test components in blood. Specifically, a method...
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7491542 |
Test device for determining the concentration of LDL-cholesterol in a sample
The present invention provides a test device for determining the concentration of LDL-cholesterol in a sample. The test device has a continuous solid surface with at least one reaction area on the...
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7488602 |
Method for detecting and compensating an underdosage of test strips
The invention concerns a method for detecting an underdosage of an analytical test element and optionally for compensating the underdosage. The invention also concerns an analytical system and a...
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7485705 |
Water-soluble tetrazolium compounds
The purpose of the present invention is to provide a water-soluble tetrazolium compound that will form a water-soluble formazan exhibiting long-wavelength absorption and is stable in aqueous...
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7479383 |
Modified pyrroloquinoline quinone (PQQ) dependent glucose dehydrogenase excellent in substrate specificity
PQQGDH having an improved substrate specificity or having an improved specific activity in an assay system using ferricyanide ion as a mediator is provided. Modified PQQGDH having the enhanced...
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7452505 |
Method for analyzing blood test sample and dry analytical element and analytical kit utilizing the method
Objects of the present invention are to provide a method for analyzing a blood test sample containing blood platelet collected from a human body to detect presence of an analyte in the test sample,...
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7442496 |
Methods and kits for diagnosis of schizophrenia
The present invention provides methods and kits for the diagnosis of schizophrenia, which employ mitochondrial complex I as a peripheral biological marker for schizophrenia. In one embodiment, the...
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7425302 |
Dry chemistry, lateral flow-reconstituted chromatographic enzyme-driven assays
A lateral flow chromatographic assay format for the performance of rapid enzyme-driven assays is described. A combination of components necessary to elicit a specific enzyme reaction, which are...
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7416866 |
Process for the overexpression of dehydrogenases
A process for the overexpression of dehydrogenases, especially for the overexpression of Δ1-dehydrogenases, in particular for the overexpression of 3-keto steroid-Δ1-dehydrogenases, as well as f...
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7402387 |
Methods and compositions for detecting dihydropyrimidine dehydrogenase splicing mutations
The present invention provides compositions, methods, and kits for the detection of genetic polymorphisms or mutations of the dihydropyrimidine dehydrogenase deficiency (DPDD). The polymorphisms or...
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7381540 |
Composition for measuring glucose having improved substrate specificity
The present invention relates to a method for lowering activity with respect to maltose in glucose measurement comprising a step of reacting modified pyrroloquinoline quinone dependent glucose...
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7348135 |
Assay for detecting changes in mitochondrial membrane permeability and method of using same
An assay for assessing the permeability of mitochondrial membranes is provided. The assay is based on enzymatic reactions that produce a detectable signal in the presence of intra-mitochondrial...
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7341830 |
Method and reagent system having a non-regenerative enzyme-coenzyme complex
The invention relates to a method and reagent system for detecting an analyte in a sample by means of an enzymatic reaction, involving the use of an enzyme-coenzyme complex as a stoichiometric...
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7341846 |
Method of measuring glucose concentration and glucose sensor with the use of glucose dehydrogenase
The present invention relates to a technique for measuring a glucose level by utilizing a reaction system containing an enzyme and an electron carrier. In accordance with the glucose level...
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7335483 |
Method of pretreatment of sample for quantitating cholesterol and method for quantitating cholesterol in specific lipoproteins by using the same
A method of a pretreatment of a sample for quantitating cholesterol characterized by, before measuring cholesterol contained in specific lipoproteins, treating the sample containing lipoproteins...
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