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9034887 Dihydroorotate dehydrogenase as antifungal drug target and quinazolinone-based inhibitors thereof  
A method of identifying an antifungal agent which targets a DHODH protein (alias PyrE, dihydroorotate dehydrogenase, EC: 1.3.99.11) of a fungus comprising contacting a candidate substance with a...
9012215 Methods for identifying leukemia stem cells and distinguishing them from normal hematopietic stem cells in patients with acute myeloid leukemia: uses in diagnosis, treatment, and research  
Using the methods of the present invention, intermediate (int) levels of aldehyde dehydrogenase (ALDH) activity reliably distinguished leukemic CD34+CD38− cells capable of engrafting...
8999661 Compositions for detecting cell death and methods of use thereof  
The invention provides compounds and methods of their use in the detection of apoptosis and necrosis both in vitro and in vivo. Also provided are compounds and methods of their use in selective...
8999662 Method for producing dry reagent, dry reagent, and analysis tool using same  
Provided is a dry reagent that allows measuring with good precision, in accordance with a transmission method that utilizes light of the ultraviolet region, increases or decreases of a...
8999691 Glucose dehydrogenase  
Disclosed is a modified glucose dehydrogenases that has dramatically increased productivity in Escherichia coli and dramatically increased thermal stability, which is obtained by introducing...
8969060 Modified glucose dehydrogenase  
The purpose of the present invention is to provide an FAD-conjugated glucose dehydrogenase that is hard to be inhibited by the inhibitors such as 1,10-phenanthroline. The present invention relates...
8951720 Markers for transformed epithelium and potential targets for therapy of cancer of the gingivo buccal complex  
Systematic comparisons of samples of adjacent clinically non malignant and tumor tissue from cancer of the gingivo buccal complex obtained during surgical resection of the tumor revealed...
8945864 Method of determining 1,5-anhydroglucitol, and reagent composition for determining 1,5-anhydroglucitol  
The object of the present invention is to provide a method of determining 1,5-anhydroglucitol, including using (a) a protein which consists of the amino acid sequence of SEQ ID NO: 2; (b) a...
8945824 Method of determining hypoxia  
A method of determining hypoxia in fetal scalp blood sampled during labor comprises the determination of total lactate dehydrogenase (LDH) in plasma obtained from the sample. The method can...
8945359 Flavin-binding glucose dehydrogenase  
The invention provides a flavin-binding glucose dehydrogenase exhibiting reduced fluctuation of activity depending on temperature environment, and a method for measuring glucose concentration...
8921065 Reagent composition for electrochemical biosensors  
A reagent composition containing GDH-PQQ as an enzyme-co-factor and screen-printed on working and counter electrodes of electrochemical biosensors, maintains activity of the enzyme reagents by...
8921061 Reagent materials and associated test elements  
Reagent materials and associated test elements are provided. In one embodiment, a test element having dual functionality includes a first coenzyme-dependent enzyme or a substrate for the first...
8883438 Method for diagnosing cell proliferation disorders having a neoactive mutation at residue 97 of isocitrate dehydrogenase 1  
Methods and compositions for treating and evaluating subjects having a neoactive mutation at residue 97 of IDH1 or 137 of IDH2.
8871520 Uracil-specific fluorescence detection reaction and method for examining dihydropyrimidine dehydrogenase deficiency  
The invention provides a method of detecting uracil. The method comprises reacting uracil with a compound represented by the formula (I) in the presence of an oxidant and a base to produce a...
8852874 Anti-amyloid β activity of intravenous immunoglobulin (IVIG) in vitro  
The present invention relates to a cell-based in vitro screening assay for identifying and selecting therapeutic agents that inhibit amyloid β-induced cytotoxicity.
8852582 Compositions comprising glutathione reductase and oxidized glutathione  
Compositions comprising Glutathione Reductase (GSSG-r) and Oxidized Glutathione (GSSG) or pharmaceutically acceptable salts thereof for pharmaceutical use as antiviral and antibacterial agents and...
8809013 Stable NAD/NADH derivatives  
The present invention provides for stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives of formula (I), enzyme complexes of...
8802403 Method of preparation of a compound using a genetically modified homolactic thermophilic bacilli  
Disclosed herein is a genetic modification of moderately thermophilic Bacillus species that are facultative anaerobic and homolactic. The method includes introducing DNA cloned in a...
8748113 Methods for detecting and monitoring circulating cancer stem cells  
Provided herein are compositions, methods, and kits useful for detecting whether a subject has or is likely to develop a cancer and for monitoring, staging and examining a cancer patient. Also...
8728754 Use of proteins isolated from Pseudomonas to control molluscs  
Provided herein are proteins derived from Pseudomonas sp., particularly Pseudomonas protegens, compositions comprising said proteins and their use in controlling molluscidal activity.
8703458 Method comprising co-crosslinking polyaniline, polymer acid and redox enzyme to produce polymeric matrix  
A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble...
8623654 Stabilizing agent for control material, control material containing the stabilizing agent, and measurement kit comprising the control material  
An object of the present invention is to provide a control material which can be preferably employed in detection of 1,5-anhydro-D-glucitol and glycoalbumin, which are employed as excellent...
8618293 Redox mediators  
The present invention relates to ruthenium and osmium complexes of Formula [M(A)w(B)x(C)y]m(Xz)n, per se and the use of ruthenium and osmium complexes of Formula I as redox mediators in...
8580547 Variants of PQQ-dependent glucose dehydrogenase having improved substrate specificity  
The invention relates to novel PQQ-dependent soluble glucose dehydrogenases (sPQQGDH) which have an increased substrate specificity compared with the wild type, and also to methods for production...
8574882 Thermostable 1,5-anhydroglucitol dehydrogenase, and method for measurement of 1,5-anhydroglucitol by using the same  
A protein comprising an amino acid sequence having at least one mutation selected from a Gly-4 to Ala mutation, a Glu-6 to His mutation, a Ser-14 to Thr mutation, an Ala-37 to Thr or Arg mutation,...
8563317 Apparatus for detecting gamma hydroxybutyrate, ketamines and related drugs in beverages  
Apparatus for detecting the presence of foreign substances in a beverage. The apparatus for detecting the presence of Gamma-hydroxybutyrate or other drugs in a beverage comprises apparatus wherein...
8541242 Device and method for detection of analytes  
The present invention provides assays and devices for detection of substances in liquid samples. The assays and devices utilize passive diffusion between a porous material and a porous membrane...
8497084 15-PGDH in colon cancer  
The disclosure provides, among other things, a method of decreasing resistance to the chemopreventive properties of non-steroidal anti-inflammatory agents, e.g., celecoxib, particularly in the...
8486654 Compositions and methods for measuring 3,6-L-AHG transferase activity and 3,6-L-AHG  
Provided herein are a composition for measuring 3,6-anhydro-L-galactose (3,6-L-AHG) transferase activity by reduction of NADP to NADPH, and a method of measuring 3,6-L-AHG transferase activity...
8481294 Mutant formate dehydrogenase, gene encoding the same, and method for producing NADH  
Durability of formate dehydrogenase is improved with the use of formate dehydrogenase exhibiting high specific activity that is unpredictable from conventional findings. A specific amino acid...
8476051 Thermostable alcohol dehydrogenase derived from Thermococcus guaymasensis  
An alcohol dehydrogenase (ADH) from hyperthermophilic archaeon Thermococcus guaymasensis was purified to homogeneity and was found to be a homotetramer with a subunit size of 40±1 kDa. The gene...
8476034 Methods and compositions for assaying homocysteine  
This invention relates generally to the field of homocysteine detection. In particular, the invention provides a method for determining homocysteine presence or concentration in samples, which...
8440422 Method for measuring phosphoric acid  
In measuring phosphoric acid by the use of an enzyme cycling system using a dehydrogenase together with a thio-NADP, a thio-NAD, a reduced thio-NADP or a reduced thio-NAD as a coenzyme, phosphoric...
8440068 Amino-acid biosensor, fischer-ratio biosensor and health information management system  
Disclosed is a biosensor capable of measuring a total concentration of plural types of amino acids. An amino-acid biosensor (200) for measuring a total concentration of a plurality of specific...
8426156 Method for assaying plasma enzymes in whole blood  
The present invention relates to a method for assaying catalytic plasma enzymes, such as transaminases and NADH-dependent enzymes, in a sample of whole blood, by measuring, in a microfluidic...
8426213 Hydrogen peroxide droplet-based assays  
The present invention relates to providing improved hydrogen peroxide assays, as well as droplet actuators for conducting such assays. The droplet actuators of the invention may be used to conduct...
8383361 Method for determining analyte concentration in biological fluid using electrochemical sensor  
A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble...
8354245 Method of assaying glucose-6-phosphate dehydrogenase on a chromatographic test strip  
A lateral flow chromatographic assay format for the performance of rapid enzyme-driven assays is described. A combination of components necessary to elicit a specific enzyme reaction, which are...
8343726 Device and method for detection of analytes  
The present invention provides assays and devices for detection of substances in liquid samples. The assays and devices utilize passive diffusion between a porous material and a porous membrane...
8309329 Process for production of 5′-guanylic acid  
By reacting inosinic acid (IMP) with a bacterium which has been modified so that IMP dehydrogenase activity and 5′-guanylic acid (GMP) synthetase activity are enhanced, GMP is produced.
8288119 PGDS as modifiers of the PTEN pathway and methods of use  
Human PGD genes are identified as modulators of the PTEN pathway, and thus are therapeutic targets for disorders associated with defective PTEN function. Methods for identifying modulators of...
8277636 Glucose sensor and glucose level measuring apparatus  
The present invention relates to a glucose sensor (2) including an electrode (32) which includes a conductive component and glucose dehydrogenase immobilized to the conductive component. As the...
8206944 Dry stick device construction and method for determining an analyte in a sample using said dry stick device  
A novel dry stick device construction for the determination of an analyte in a sample is provided. The device comprises: (i) optionally a solid support, (ii) at least one reagent pad comprising a...
8183004 Determination of short-chain SRL alcohol dehydrogenase (DHRS4) as a biomarker for inflammations and infections  
The present invention relates to the use of short-chain SRL alcohol dehydrogenase (DHRS4, SEQ ID NO: 1) and peptides thereof as humoral biomarkers for the diagnostic detection and prognosis of the...
8178311 Multiple quantification of cholesterol in low density lipoprotein  
The present invention is intended to provide a method for simultaneously measuring cholesterol in low density lipoprotein and total cholesterol as test components in blood. Specifically, a method...
8080385 Crosslinked adduct of polyaniline and polymer acid containing redox enzyme for electrochemical sensor  
A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble...
8012725 Method for the production of optically-active alcohols  
The present invention relates to enzymic processes for preparing S-butan-2-ol; and to enzymes for carrying out said processes; to nucleic acid sequences coding for said enzymes, to expression...
8008037 Matrix composition with alkylphenazine quaternary salt and a nitrosoaniline  
A chemistry matrix for use in determining the concentration of an analyte in a biological fluid includes a glucose dehydrogenase, nicotinamide adenine dinucleotide, an alkylphenazine quaternary...
7964382 DNA encoding a protein having D-lactate dehydrogenase activity and uses thereof  
This invention provides a polynucleotide that encodes a protein having lactate dehydrogenase activity and such protein that can be used for producing D-lactic acid. This polynucleotide has the...
7964372 Size self-limiting compositions and test devices for measuring analytes in biological fluids  
A test strip or electrochemical sensor for measuring the amount of an analyte in a biological fluid, e.g. the glucose content of whole blood, includes a size self-limiting reagent formulation...