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5780256 Method and composition for quantitative determination of ammonia, α-amino acid, or α-keto acid  
The present invention is directed to a method for the quantitative determination of ammonia, an α-amino acid and an α-keto acid corresponding to the α-amino acid, or a chemical substance producing...
5776715 Biosensors for detecting nitrate or nitrite ions  
A biosensor for detecting nitrate or nitrite ions is provided containing a nitrate reductase or nitrite reductase for nitrate or nitrite ions, respectively, a co-factor such as NADPH, a...
5770391 Reagents and methods for use in bioluminescence  
The subject invention pertains to a combination of enzyme activities comprising an ATP-degrading enzyme and one or more enzymes capable of degrading substances, other than ATP, that are substrates...
5766874 Kit containing d-arabinitol dehydrogenase and NAD+ for determining d-arabinitol  
A D-arabinitol dehydrogenase enzyme is prepared that is capable of catalyzing the oxidation of D-arabinitol and substantially incapable of catalyzing the oxidation of D-mannitol and is...
5759796 Method for the determination of lactic acid in organic materials of alimentary interest and biosensor for putting this method into effect  
A method is described for the determination of lactic acid in organic materials of alimentary interest that involves reacting, in a buffered aqueous medium, a sample of the said materials, or a...
5753453 Stable single liquid reagent for the determination of carbon dioxide in serum  
A stable single reagent for the determination of carbon dioxide in serum is provided as an aqueous solution of diagnostically amounts and NADH and/or NADPH, and a stabilizing system therefore...
5750360 Method for quantitatively measuring apoptosis  
The invention encompasses methods of detecting and/or quantifying ε(γ-glutamyl)lysine isodipeptide by catalytically releasing lysine, then measuring free lysine.
5719036 Quantitative determination method for potassium ions  
The present invention relates to a method for quantitatively determining potassium ions in a sample using a glycerol dehydrogenase, which method is characterized by pretreating said sample with a...
5710011 Mediators to oxidoreductase enzymes  
Half-sandwich complexes of transition metals having a single π-ligand with delocalised π bonding are of use in mediating electron transfer between an electrode and a redox protein, for example an...
5707820 Reagent and assay methods including a phenazine-containing indicator  
A new reagent and methods for measuring the concentration of (or detecting the presence of) an analyte in a sample. The reagent includes a phenazine-containing compound and an enzyme. The...
5705356 Reagent for invitro diagnostic determination of bicarbonate  
The invention provides a reagent for enzymatic determination of serum bicarbonate levels in a patient wherein the degree of oxidation of a coenzyme is measured and said reagent is stabilized...
5686260 Method and composition for the enzymic determination of aspartame  
The invention relates to a method and a composition for the enzymic determination of aspartame in aqueous solutions. The method is carried out such that the sample solution is incubated...
5679532 Serum ferritin as a predictor of the acute respiratory distress syndrome  
The invention relates to the discovery that serum ferritin concentrations are elevated in patients at risk for the development of Acute Respiratory Distress Syndrome (ARDS) and who subsequently...
5656449 Neutral unsymmetrical cyanine dyes  
The invention describes the preparation and use of fluorescent stains for nucleic acids derived from neutral unsymmetrical cyanine dyes comprising a substituted benzazolium ring system linked to a...
5656448 Dipstick immunoassay device  
The invention pertains to dipstick immunoassay devices. The device comprises a base member and a single, combined sample contact zone and test zone, wherein the test zone incorporates the use of...
5654152 Method of measuring enzyme activity by using a column having an immobilized substrate  
Enzyme activity is measured promptly with a high accuracy by introducing an enzyme, the activity of which is to be measured, into a column comprising a hollow tube packed with a filler comprising...
5639629 Method of using LDH as a predictor of the adult respiratory distress syndrome in septic patients  
At the initial diagnosis of sepsis (6-24 h before the development of ARDS), serum lactate dehydrogenase (LDH) activity level is increased in septic patients who subsequently develop ARDS compared...
5637450 Decontaminated serum and method of production therefor  
Decontaminated biological material, particularly liquids, and a method for decontaminating biological material, wherein serum is employed in cell structures for cultivating human and animal cells...
5635366 Predictive assay for the outcome of IVF  
The present invention provides a method for predicting the outcome of IVF which comprises: (i) determining the level of 11β-hydroxysteroid dehydrogenase (11β-HSD) in a biological sample from a...
5633143 Method for the quantitative determination of D-3-hydroxybutyric acid and acetoacetic acid, and analytical reagent therefor  
Disclosed is a method for the quantitative determination of D-3-hydroxybutyric acid and acetoacetic acid, which comprises reacting a biological sample containing D-3-hydroxybutyric acid and...
5624812 Method for measuring carbon dioxide and reagent therefor  
A method for measuring carbon dioxide, comprising the steps of: (1) reacting bicarbonate ion in a sample with phosphoenolpyruvate carboxylase derived from an acetic acid bacterium in the presence...
5624597 Reagent compositions for analytical testing  
The present invention provides lyophilized reagent spheres comprising reagents suitable for analysis of biological samples, in particular analysis of blood samples in centrifugal analyzers. Also...
5618686 Method of measuring the total ketone body and a sample reagent  
A method of measuring the total ketone body in a sample comprising converting acetoacetic acid in the sample to 3-hydroxybutyric acid in advance and subsequently converting the whole...
5614375 Method and test kit for the rapid detection of biotoxic contaminants  
The invention provides a method for the rapid detection of biotoxic contaants in a test material comprising combining a sample of the test material with activated spores essentially devoid of...
5614374 Glycerol dehydrogenase, process for its production and its use  
Pyrroloquinoline quinone-dependent glycerol dehydrogenase is provided which requires no surfactant for its solubilization and stabilization. The glycerol dehydrogenase has the following...
5610026 Agent for the determination of peroxidase activity, a process for its preparation and its use  
An agent for the detection of peroxidase or of pseudoperoxidase activity, and its preparation and its use are described. The agent contains a tetraalkylbenzidine, a peroxide and buffer substances....
5607838 Method for determination of α-amylase activity  
A method for determining α-amylase activity which involves bringing a sample into contact with an α-glucosidase in the presence of an α-amylase substrate and optically determining a liberated...
5605795 Assays using chemiluminescent, enzymatically cleavable substituted 1,2-dioxetanes and kits therefor  
Dioxetane compounds reactable with an enzyme to release optically detectable eneregy are disclosed. These compounds have the formula: ##STR1## wherein T is a cycloalkyl group or a fused...
5601981 Methods for determining and agents for modulating cellular redox potential and genotoxic states  
Methods for determining the genotoxic or carcinogenic status of a subject by analyzing the cellular redox potential of a test specimen where an increased risk of, or presence of, genotoxic injury...
5589347 Multilayer analysis elements for the determination of total cholesterol  
A multilayer analysis element for determination of total cholesterol is prepared having a light-transmissive water-impermeable support, at least one hydrophilic polymer layer on said support and a...
5589349 Method for enzymatic analysis and reagant therefor  
A method of enzymatic analysis utilizing a color-development signal amplification system associated with enzymatic cycling of NAD-NADH interconversion in the presence of dehydrogenase and its...
5589348 In situ nicotinamide coenzyme generating system for enzyme based clinical chemistry assays  
The invention relates to an improved enzymatic method for determining the concentration of an analyte in a sample body fluid. The improvement comprises a coupled enzyme reaction scheme comprising...
5587296 Reagent for assaying glucose  
A reagent for assaying glucose, which comprises a first liquid reagent having a pH of 7.5 to 9.5 and containing at least either glucokinase or hexokinase, glucose 6-phosphate dehydrogenase, and...
5583006 Stabilizing tetrazolium salts in a reagent  
A stable reagent for assaying an analyte from a fluid sample which includes an enzyme, a mediator, a tetrazolium salt and an oxidizing agent selected from the group consisting of sodium chlorate,...
5571685 Morphinone reductase for the preparation of hydromorphone and hydrocodone  
A morphinone reductase enzyme and related process provide for the preparation of hydromorphone from morphinone and hydrocodone from neopinone or codeinone. The enzyme has no significant activity...
5567605 Assay for D-allose using a NAD cofactor coupled D-allose dehydrogenase  
A D-allose specific dehydrogenase has been isolated which can be used with NAD as a cofactor in a sensitive, specific, quantitative assay for D-allose in aqueous media. A qualitative, color-based...
5552297 Lead detection method and reggents utilizing aminolevulinic acid dehydratase and tertiary phosphines  
A method and kit for simplifying and improving the sensitivity and accuracy of a lead assay for a sample solution suspected of containing lead determines the extent of a reaction between a...
5545519 Electrolytic analytical methods  
Enzyme electrodes having the enzyme enclosed within liposomes supported on, or in a membrane and immobilized therein are provided. The liposomes may be made using lipids and conveniently by...
5543298 Method for assaying the sod activity by using a self-oxidizable compound necessary for its implementation, self-oxidizable compounds and preparation thereof  
The method for assaying the SOD (super oxide dismutase) activity in liquid medium is based on the activation of self-oxidization, by SOD activity, of a reactive agent having the general formula...
5543299 Extender containing polymer compositions and uses thereof  
The invention relates to polymeric compositions useful in analyte determination. The compositions contain a polymer, a reagent system for analyte determination, and an extender. The last component...
5543295 Chemiluminescent 3--(Substituted adamant--2'--Ylidene) 1,2--Dioxetanes  
Enzymatically clearable chemiluminescent 1,2-dioxetane compounds capable of producing light energy when decomposed, substantially stable at room temperature before a bond by which an enzymatically...
5529906 Analytical system or kit for phosphatase  
A system or kit for analysis of phosphatase comprising a reagent I containing NADP or NADPH as a main component, and a reagent II containing components for color-development signal amplification...
5527509 Colorimetric enzymic analysis  
A colorimetric enzymic analytical test element comprises a support and a plurality of reaction zones incorporating a dried enzyme composition, dyestuff and reagent adapted to provide a substantial...
5525481 Enzymatic Reagents for ethanol assay containing diamino compounds  
An enzymatic assay assemblage for ethanol determination is provided. A diamino compound acts as a buffer and a trapping agent for a product of the enzymatic reaction. Long stability of the assay...
5514538 Bicarbonate assay and phosphoenolpyruvate carboxylase enzyme from hyphomicrobium  
Phosphoenolpyruvate carboxylase (PEPC) characterized by a specific activity of at least 40 units/mg; and/or by no more than 50% loss of activity after 60 days in 167 mM Tricine/HCl buffer, pH 8.0,...
5510245 Composition and method of assaying for ketone bodies  
A composition, test device and method of determining the presence or concentration of ketone bodies, and specifically D-β-hydroxybutyrate, in a test sample are disclosed. The test device includes...
5510244 Apparatus and method for assaying optical isomers  
A method, apparatus and kit for assaying the L- and D-optical isomers and optionally the oxidation product derived from a L- (or D-) optical isomer.
5506113 Measuring composition  
A measuring composition for use in determination of glucose, ATP, phosphotransferases such as creatine phosphokinase, and glucosidases is disclosed. The composition is comprised of glucokinase,...
5501958 Determination of potassium ions in fluids  
A process and a reagent for the determination of ions in fluids, wherein the influence of these ions on the activity of an enzyme is measured. The ions for example are sodium, potassium, calcium,...
5501961 Method for detection of a physiological abnormality  
There is disclosed a method for the determination of a physiological abnormality in a human or animal subject, which method includes determining ion flux across the membrane of epithelial cells...