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5679532 |
Serum ferritin as a predictor of the acute respiratory distress syndrome
The invention relates to the discovery that serum ferritin concentrations are elevated in patients at risk for the development of Acute Respiratory Distress Syndrome (ARDS) and who subsequently...
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5656449 |
Neutral unsymmetrical cyanine dyes
The invention describes the preparation and use of fluorescent stains for nucleic acids derived from neutral unsymmetrical cyanine dyes comprising a substituted benzazolium ring system linked to a...
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5656448 |
Dipstick immunoassay device
The invention pertains to dipstick immunoassay devices. The device comprises a base member and a single, combined sample contact zone and test zone, wherein the test zone incorporates the use of...
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5654152 |
Method of measuring enzyme activity by using a column having an immobilized substrate
Enzyme activity is measured promptly with a high accuracy by introducing an enzyme, the activity of which is to be measured, into a column comprising a hollow tube packed with a filler comprising a...
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5639629 |
Method of using LDH as a predictor of the adult respiratory distress syndrome in septic patients
At the initial diagnosis of sepsis (6-24 h before the development of ARDS), serum lactate dehydrogenase (LDH) activity level is increased in septic patients who subsequently develop ARDS compared...
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5637450 |
Decontaminated serum and method of production therefor
Decontaminated biological material, particularly liquids, and a method for decontaminating biological material, wherein serum is employed in cell structures for cultivating human and animal cells...
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5635366 |
Predictive assay for the outcome of IVF
The present invention provides a method for predicting the outcome of IVF which comprises: (i) determining the level of 11β-hydroxysteroid dehydrogenase (11β-HSD) in a biological sample from a...
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5633143 |
Method for the quantitative determination of D-3-hydroxybutyric acid and acetoacetic acid, and analytical reagent therefor
Disclosed is a method for the quantitative determination of D-3-hydroxybutyric acid and acetoacetic acid, which comprises reacting a biological sample containing D-3-hydroxybutyric acid and...
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5624597 |
Reagent compositions for analytical testing
The present invention provides lyophilized reagent spheres comprising reagents suitable for analysis of biological samples, in particular analysis of blood samples in centrifugal analyzers. Also...
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5624812 |
Method for measuring carbon dioxide and reagent therefor
A method for measuring carbon dioxide, comprising the steps of: (1) reacting bicarbonate ion in a sample with phosphoenolpyruvate carboxylase derived from an acetic acid bacterium in the presence...
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5618686 |
Method of measuring the total ketone body and a sample reagent
A method of measuring the total ketone body in a sample comprising converting acetoacetic acid in the sample to 3-hydroxybutyric acid in advance and subsequently converting the whole...
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5614374 |
Glycerol dehydrogenase, process for its production and its use
Pyrroloquinoline quinone-dependent glycerol dehydrogenase is provided which requires no surfactant for its solubilization and stabilization. The glycerol dehydrogenase has the following properties:...
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5614375 |
Method and test kit for the rapid detection of biotoxic contaminants
The invention provides a method for the rapid detection of biotoxic contaants in a test material comprising combining a sample of the test material with activated spores essentially devoid of...
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5610026 |
Agent for the determination of peroxidase activity, a process for its preparation and its use
An agent for the detection of peroxidase or of pseudoperoxidase activity, and its preparation and its use are described. The agent contains a tetraalkylbenzidine, a peroxide and buffer substances....
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5607838 |
Method for determination of α-amylase activity
A method for determining α-amylase activity which involves bringing a sample into contact with an α-glucosidase in the presence of an α-amylase substrate and optically determining a liberated...
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5605795 |
Assays using chemiluminescent, enzymatically cleavable substituted 1,2-dioxetanes and kits therefor
Dioxetane compounds reactable with an enzyme to release optically detectable eneregy are disclosed. These compounds have the formula: ##STR1## wherein T is a cycloalkyl group or a fused...
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5601981 |
Methods for determining and agents for modulating cellular redox potential and genotoxic states
Methods for determining the genotoxic or carcinogenic status of a subject by analyzing the cellular redox potential of a test specimen where an increased risk of, or presence of, genotoxic injury...
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5589348 |
In situ nicotinamide coenzyme generating system for enzyme based clinical chemistry assays
The invention relates to an improved enzymatic method for determining the concentration of an analyte in a sample body fluid. The improvement comprises a coupled enzyme reaction scheme comprising...
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5589347 |
Multilayer analysis elements for the determination of total cholesterol
A multilayer analysis element for determination of total cholesterol is prepared having a light-transmissive water-impermeable support, at least one hydrophilic polymer layer on said support and a...
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5589349 |
Method for enzymatic analysis and reagant therefor
A method of enzymatic analysis utilizing a color-development signal amplification system associated with enzymatic cycling of NAD-NADH interconversion in the presence of dehydrogenase and its...
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5587296 |
Reagent for assaying glucose
A reagent for assaying glucose, which comprises a first liquid reagent having a pH of 7.5 to 9.5 and containing at least either glucokinase or hexokinase, glucose 6-phosphate dehydrogenase, and...
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5583006 |
Stabilizing tetrazolium salts in a reagent
A stable reagent for assaying an analyte from a fluid sample which includes an enzyme, a mediator, a tetrazolium salt and an oxidizing agent selected from the group consisting of sodium chlorate,...
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5571685 |
Morphinone reductase for the preparation of hydromorphone and hydrocodone
A morphinone reductase enzyme and related process provide for the preparation of hydromorphone from morphinone and hydrocodone from neopinone or codeinone. The enzyme has no significant activity...
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5567605 |
Assay for D-allose using a NAD cofactor coupled D-allose dehydrogenase
A D-allose specific dehydrogenase has been isolated which can be used with NAD as a cofactor in a sensitive, specific, quantitative assay for D-allose in aqueous media. A qualitative, color-based...
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5552297 |
Lead detection method and reggents utilizing aminolevulinic acid dehydratase and tertiary phosphines
A method and kit for simplifying and improving the sensitivity and accuracy of a lead assay for a sample solution suspected of containing lead determines the extent of a reaction between a...
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5545519 |
Electrolytic analytical methods
Enzyme electrodes having the enzyme enclosed within liposomes supported on, or in a membrane and immobilized therein are provided. The liposomes may be made using lipids and conveniently by...
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5543299 |
Extender containing polymer compositions and uses thereof
The invention relates to polymeric compositions useful in analyte determination. The compositions contain a polymer, a reagent system for analyte determination, and an extender. The last component...
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5543295 |
Chemiluminescent 3--(Substituted adamant--2'--Ylidene) 1,2--Dioxetanes
Enzymatically clearable chemiluminescent 1,2-dioxetane compounds capable of producing light energy when decomposed, substantially stable at room temperature before a bond by which an enzymatically...
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5543298 |
Method for assaying the sod activity by using a self-oxidizable compound necessary for its implementation, self-oxidizable compounds and preparation thereof
The method for assaying the SOD (super oxide dismutase) activity in liquid medium is based on the activation of self-oxidization, by SOD activity, of a reactive agent having the general formula (I)...
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5529906 |
Analytical system or kit for phosphatase
A system or kit for analysis of phosphatase comprising a reagent I containing NADP or NADPH as a main component, and a reagent II containing components for color-development signal amplification...
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5527509 |
Colorimetric enzymic analysis
A colorimetric enzymic analytical test element comprises a support and a plurality of reaction zones incorporating a dried enzyme composition, dyestuff and reagent adapted to provide a substantial...
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5525481 |
Enzymatic Reagents for ethanol assay containing diamino compounds
An enzymatic assay assemblage for ethanol determination is provided. A diamino compound acts as a buffer and a trapping agent for a product of the enzymatic reaction. Long stability of the assay...
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5514538 |
Bicarbonate assay and phosphoenolpyruvate carboxylase enzyme from hyphomicrobium
Phosphoenolpyruvate carboxylase (PEPC) characterized by a specific activity of at least 40 units/mg; and/or by no more than 50% loss of activity after 60 days in 167 mM Tricine/HCl buffer, pH 8.0,...
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5510244 |
Apparatus and method for assaying optical isomers
A method, apparatus and kit for assaying the L- and D-optical isomers and optionally the oxidation product derived from a L- (or D-) optical isomer.
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5510245 |
Composition and method of assaying for ketone bodies
A composition, test device and method of determining the presence or concentration of ketone bodies, and specifically D-β-hydroxybutyrate, in a test sample are disclosed. The test device includes...
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5506113 |
Measuring composition
A measuring composition for use in determination of glucose, ATP, phosphotransferases such as creatine phosphokinase, and glucosidases is disclosed. The composition is comprised of glucokinase,...
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5501958 |
Determination of potassium ions in fluids
A process and a reagent for the determination of ions in fluids, wherein the influence of these ions on the activity of an enzyme is measured. The ions for example are sodium, potassium, calcium,...
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5501961 |
Method for detection of a physiological abnormality
There is disclosed a method for the determination of a physiological abnormality in a human or animal subject, which method includes determining ion flux across the membrane of epithelial cells...
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5492815 |
Method of determining glucose-6-phosphate and composition therefor
A method is provided for determining glucose-6-phosphate, including the step of dehydrogenating glucose-6-phosphate and NAD or NADP in the presence of glucose-6-phosphate dehydrogenase to produce...
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5486459 |
Biologically relevant methods for the rapid determination of sterility
The invention is directed to biological processes and apparatus for determining the efficacy of a sterilization cycle based upon the recovery of activity of interactive enzyme systems comprising...
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5484708 |
Method for the colorimetric determination of an analyte with a PQQ-dependent dehydrogenase
The invention concerns a method for the colorimetric determination of an analyte by means of enzymatic oxidation with a PQQ-dependent dehydrogenase in the presence of an electron acceptor from the...
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5480777 |
Kinetic enzyme assay for determining the CO.sub.2 content of body fluids using PEP carboxylase with inhibitor
An improved kinetic assay is provided for spectrophotometrically determining the dissolved carbon dioxide (CO 2 ) content of a body fluid (e.g., blood, plasma or serum), wherein at about pH 8.0 the...
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5474907 |
Multilayer analytical element for salicylate assay
A multilayer analytical element for measuring salicylate is disclosed. The element has a support. The support is coated with the following layers, top down to the support: a) a spreading layer, b)...
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5462858 |
Dry multilayer analytical elements for assaying transaminases
A dry multilayer analytical element for assaying transaminases wherein the analytical element comprises: a) a transaminase substrate; b) reagents that generate pyruvate in the presence of a...
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5460948 |
Assay of salicylates or reduced pyridine nucleotides
A method for the estimation of a salicylate in a sample is characterized by enzymatically converting the salicylate to a catechol by the action of a salicylate mono-oxygenase enzyme on the...
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5459032 |
Method of conducting a non-instrumental test to determine catalyst presence
A method and apparatus for performing an enzyme spot test without traditional instrumentation is disclosed. The method utilizes various reagents to allow the visual determination of the presence of...
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5453360 |
Oxidative coupling dye for spectrophotometric quantitive analysis of analytes
A dye couple, comprising 3-methyl-2-benzothiazolinone hydrazone (MBTH) and 8-anilino-l-naphthalenesulfonate (ANS), is used as an indicator in a reaction cascade producing a strong oxidizing agent,...
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5449609 |
Methods for screening for neurotoxicity using a clonal human teratocarcinoma cell line
Methods for screening for excitotoxic effects of an agent on neurons of the central nervous system are provided by the present invention.
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5447847 |
Quantitative determination of pyruvic acid and quantitative analysis for component of living body making use of such determination
Disclosed herein is a quantitative determination of pyruvic acid, which comprises reacting oxidized nicotinamide adenine dinucleotide, a pyruvate dehydrogenase complex and coenzyme A to a specimen...
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5445943 |
Method for the colorimetric determination of an analyte by means of benzyl alcohol dehydrogenase and a chromogenic redox indicator
The invention concerns a method for the colorimetric determination of NADH by means of enzymatic oxidation with benzyl alcohol dehydrogenase whereby an aromatic nitrosoaniline compound of the...
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