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6121010 Methods and assays useful in the treatment of alcohol dependence or alcohol abuse  
A method for the treatment of alcohol abuse using daidzin and compounds analogous to daidzin is disclosed. Also disclosed is a method for screening compounds having antidipsotropic activity.
6121009 Electrochemical analyte measurement system  
A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow "one-point" in vivo calibration, i.e., to...
6114134 Method for assaying biological specimens for substances contained in the components thereof and reagent to be used in this method  
A method for assaying biological specimens for substances contained in the components of each specimen by the use of one or more kinds of calixarenes; and a reagent comprising one or more kinds of...
6077660 Diagnostic assay requiring a small sample of biological fluid  
An article and a method for monitoring the concentration of glucose in blood. In one aspect, the invention involves an article comprising a multiple-layer element utilizing reagents capable of...
6068989 Method and dry analytical element for determination of bicarbonate ion in liquid  
This invention provides a reagent composition for the determination of bicarbonate ion capable of measuring in a wide determination range in visible light region which comprises a combined...
6046018 Highly sensitive method for assaying chiro-inositol and compositions for the assay  
The present invention relates to an assay method of chiroinositol which comprises reacting a specimen containing chiroinositol with 1) a dehydrogenase, which catalyses at least reversible reaction...
6046017 Rapid and sensitive assay for homocysteine  
Methods and kits for assaying homocysteine in biological samples utilizing enzymatic reactions are provided. One method utilizes the enzymes methionine synthase and serine hydroxymethyltransferase...
6043048 Rapid inducible beta-lactamase screen test  
In an assay for determination of beta-lactam antibiotic resistance in a target bacterial strain, the strain is grown in the presence of both a beta-lactamese inducing antibiotic and a beta-lactam...
6043047 Sample-collecting and assay device for use in the detection of biological material  
An assay device comprises a tube, a removable top part and a bottom part, wherein an elongate member with a swab at its distal end is mounted on the top part, the top part includes a compartment...
6043043 Method for the determination of hemoglobin adducts  
Disclosed is an improvement to the method of determining the concentration of a hemoglobin adduct in a blood sample by the steps of assaying the blood sample for the total amount of hemoglobin,...
6020148 In vitro method for eye and skin irritation testing  
A technique for in vitro testing of ocular and dermal irritants is disclosed. The process involves the topical application of liquid, solid granular or gel-like materials (e.g. cosmetics) to a...
6017769 Non-enzymatic methods of generating chemiluminescence from acridan alkenes  
Methods of generating chemiluminescence rapidly without the use of enzymes are provided. The methods utilize chemiluminescent compounds comprising an acridan ring bearing an exocyclic double bond...
5972637 Determining the organic content of a fluid  
The organic content of a fluid is determined by: (a) reacting a sample of a fluid containing organic matter (such as viable biomass or soluble or insoluble organic compounds) with excess oxidizing...
5965379 Method for measuring endogenous cytokines  
The present invention relates to methods for measuring endogenous cytokines in blood. The method accurately measures the cytokines in the blood in the presence of substances that bind the...
5958715 Method for quantitative measurement of an enzyme linked immunosorbent assay  
Method of quantitative analysis of an enzyme linked immuno assay comprising the steps of forming an antigen--antibody complex between an antigen present in a sample to be tested and an enzyme...
5932434 Method for identifying weeds resistant to inhibitors of acetolactate synthase  
Resistance of given plant tissue to an inhibitor of acetolactate synthase is identified by (a) combining in an aqueous medium a sample of the plant tissue, the inhibitor of acetolactate synthase,...
5925534 Method for measuring LDL-cholesterol  
The amount of cholesterol in low density lipoproteins in a sample can be measured by contacting the sample with one or more reagent solutions to carry out the reaction in the presence of a...
5919644 Method for assaying sulfate-conjugated bile acid and therefore  
In a method of quantifying sulfate-conjugated bile acid in a sample with bile acid sulfate sulfatase and a reductive system indicator, an...
5916757 Specific binding assay using enzyme inhibitor and anti-inhibitor antibodies  
Specific binding ligands can be detected with an assay which utilizes an immobilized receptor for the ligand, an immobilized reporter enzyme, an inhibitor antibody and a a water-soluble conjugate...
5912139 Test strip  
A test strip which comprises a carrier, a dehydrogenase, diaphorase, a fluorescent chromogen, and NAD or NADP. The test strip provides high sensitivity and high accuracy measurement, and have...
5888755 Method of determining the amount of cholesterol in a high-density lipoprotein  
Provided is a method of determining the amount of cholesterol in high-density lipoprotein (HDL), which comprises reacting an HDL-containing sample with cholesterol esterase and cholesterol oxidase...
5885767 Methods and compositions for quantitating L-homocysteine and/or l-methionine in a solution  
A method for quantitating L-homocysteine and/or L-methionine in a solution involves contacting a solution containing L-homocysteine and/or L-methionine with a reagent comprising methionine...
5882878 INHA crystals and three dimensional structure  
This invention relates to InhA enzyme crystals and to the use of said crystals to determine the three dimensional structure of InhA enzyme. This invention is further directed to a method of...
5879902 Diagnostic methods and kits for the evaluation of the sympathetic nervous system function  
The present invention relates to an in vitro diagnostic method for the determination of specific dopamine-β-hydroxylase activity for the evaluation of the sympathetic nervous system function of a...
5876956 Methods for identification or purification of cells containing an enzymatic intracellular marker  
Production of a stem cell enriched cell composition using essentially non-toxic methodology comprising contacting a cell mixture with a cell-permeable, fluorescent non-polar compound that reacts...
5874229 Method for avoiding influence of hemoglobin  
A method for avoiding influence of hemoglobin, in which the influence is caused by the changes with time in the absorption wavelength of hemoglobin when light absorption of a color reaction of a...
5874078 Reagent composition of glutamate dehydrogenase from pseudomonas  
A novel glutamate dehydrogenase derived from the genus Pseudomonas which is specific to L-glutamic acid, requires NAD+ and NADH as coenzymes, does not act on NADP+ and NADPH, is with an optimum pH...
5871949 Method of quantitative assay for 1,5-anhydroglucitol and reagent for quantitative assay  
Using a 1,5-anhydroglucitol dehydrogenase capable of acting on 1,5-anhydroglucitol and directly catalyzing a reducing chromophoric agent in the absence of an electron carrier, the...
5871948 Alkaline reagent solution for eliminating ammonia in an assay  
The invention relates to an ammonia elimination reagent for use in an enzymatic assay of a biological substance which produces ammonia as the reaction product. The reagent is an alkaline solution...
5866353 Electro chemical biosensor containing diazacyanine mediator for co-enzyme regeneration  
A variety of diazacyanine mediators that are soluble in aqueous media and which do not inhibit enzymatic activity are provided for use on the surface of a working electrode of a electrochemical...
5866349 Method for determination of glucose in whole blood and cuvette and photometer for carrying out said method  
A sample of whole blood is contacted with a reagent which by chemical reaction with glucose in the sample brings about a detectable dye concentration change (10) the size of which is determined as...
5861269 Methods for removing interferences due to endogenous dehydrogenases in enzyme assays  
The present invention is an improvement in a method using a reporter dehydrogenase for detecting the presence of an analyte in a sample in which endogenous dehydrogenases present in the sample...
5858691 Method and agent for the simultaneous colorimetric and electrochemical measurement of an analyte  
The invention concerns a method for the simultaneous colorimetric and electrochemical measurement of an analyte using an oxidizing enzyme and a chromogen A that accepts electrons from the enzyme...
5858644 Analysis of analytes in biological fluids  
A method for detecting an analyte in a sample uses both the specificity of an enzymatic reaction and the separation power of capillary electrophoresis. In general, the method comprises: (1)...
5856156 Microbial cholesterol dehydrogenase, process for its production and use  
Oxygen-independent cholesterol-converting enzyme obtainable from Actinomycetes or Basidiomycetes which utilizes artificial electron acceptors as well as a method and reagent for the determination...
5846734 Mammalian adipogenic factors  
Mammalian adipogenic factors, including purified proteins or glycoproteins, capable of inducing the adipose differentiation of adipogenic cells are disclosed, as are antibodies to such proteins,...
5834227 Kit for assaying creatine kinase  
A reagent for assaying creatine kinase, which contains glucokinase or hexokinase, glucose-6-phosphate dehydrogenase, adenosine 5'-diphosphate, creatine phosphate, oxidized nicotinamide adenine...
5834225 Method, device and test kit for capacitation of sperm  
A method, medical device (10) and test kit for capacitation of sperm for fertilizing eggs in vitro or in vivo, is described. The sperm is particularly from lower mammals, such as domestic animals...
5830673 Bioassay of selenium  
The invention relates to a plasmid carrying a selenium-specifying DNA seqce of the E. coli fdhF gene upstream of the E. coli lac'Z gene which permits the incorporation of selenocystein into...
5817467 Method for quantitatively determining creatinine kinase and a reagent therefor  
The object of the invention is to provide a reagent for quantitatively determining creatine kinase with improved storability in liquid form as well as a method for quantitatively determining...
5814472 Measurement of LDL-cholesterol  
Cholesterol in low density lipoproteins can be measured specifically and precisely by optically measuring a reaction product of a living sample with cholesterol oxidase or cholesterol...
5804047 Enzyme-immobilized electrode, composition for preparation of the same and electrically conductive enzyme  
An enzyme sensor system capable of quantitatively determining a particular component contained in a biological sample in a rapid and easy manner is disclosed. More particularly, an electrically...
5804403 Stable aqueous reagent containing NAD  
A stable aqueous NAD reagent useful in the measurement of analytes in biological fluids, particularly ethanol and lactate. For the determination of alcohol, the reagent contains alcohol...
5804402 Reagent  
This invention relates to a reagent for enzymatic determination of an analyte concentration in a patient wherein the degree of oxidation of a coenzyme is measured, characterized in that said...
5800979 Gas chromatography/mass spectrometric determination of folic acid coenzymes  
A method for determination of in vivo concentrations in a body fluid of one or more folate co-enzymes is provided including the steps of (a) combining a known amount of at least one folate...
5801006 Use of NADPH and NADH analogs in the measurement of enzyme activities and metabolites  
Kits and methods for measuring enzyme activities and metabolites using NADH and NADPH analogs are disclosed. The analogs have extended stability in aqueous solutions and can used as replacements...
5789186 Marker for cerebral apoplexy  
A sample is treated with a phosphoglyceric acid mutase (PGAM) inhibitor (polythionic acid (salt) such as potassium tetrathionate) to inactivate the M-type isozyme activity and the B-type PGAM is...
5783382 Method for storing liquid diagnostic reagents  
Disclosed is a method for stably storing a liquid diagnostic reagent, comprising air-hermetically keeping the liquid diagnostic reagent in a closed container in the presence of a disoxidant...
5780254 Method for detection of herbicides  
This invention relates to novel screening methods for identifying compounds that specifically inhibit a metabolic target site or pathway in plants. Enzymes which are specifically affected by the...
5780253 Screening method for detection of herbicides  
This invention relates to novel screening methods for identifying compounds that specifically inhibit a biosynthetic pathway in plants. Enzymes which are specifically affected by the novel...