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6613555 32142, 21481, 25964, 21686, novel human dehydrogenase molecules and uses therefor  
The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense...
6586199 Stabilized tetrazolium reagent compositions and methods for using the same  
Stabilized tetrazolium dye reagent compositions and methods for their use in the measurement of an analyte in a sample are provided. The subject reagent compositions include a tetrazolium dye...
6576461 Electrochemical affinity assay  
An electrochemical affinity assay system for detection of ligand—ligand receptor binding.
6562563 Compositions and mehtods for determining interactions of mitochondrial components, and for identifying agents that alter such interactions  
Compositions and methods are provided for identifying agents that alter mitochondrial membrane permeability transition. The screening methods generally detect agents that alter the interaction...
6544756 Sorbitol dehydrogenase, microorganism for producing same, process for the production thereof, method for the measurement of sorbitol and reagent for the quantitative determination therefor  
A novel sorbitol dehydrogenase having excellent substrate affinity and substrate specificity which can be used to measure D-sorbitol which occurs in human erythrocytes and serum in a slight amount...
6545006 Process for obtaining L-dihydroorotic acid and use thereof  
The invention relates to a process for obtaining L-dihydroorotic acid by chromatography on an anionic exchange material in a base water mixture under a pressure from about 1.1 MPa to about 40 MPa....
6541195 Correction of genetic defects using chemical chaperones  
A method of improving a phenotypic defect in a cell that contains a conformationally defective target protein wherein the conformational defect causes the phenotype defect, comprising contacting a...
6541216 Amperometric biosensor test strip  
A reagent and method for determining the levels of 3-hydroxybutyric acid in a sample are provided. The reagent comprises a ferricyanide salt, a catalytic amount of a first enzyme operative to...
6541215 Quantitative determination method of mannose and reagent therefor  
Disclosed are a method for quantitatively determining mannose, which comprises reacting mannose in a specimen with an enzyme which is capable of oxidizing the mannose by dehydrogenation, in the...
6528277 Indicator systems for determination of sterilization  
This invention relates to a container and method for detecting a specific environmental parameter or combination of parameters, or for determining the effectiveness of a sterilization procedure....
6524808 Enzyme inhibition immunoassay  
The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The...
6511800 Methods of treating nitric oxide and cytokine mediated disorders  
The current invention discloses novel methods for the inhibition of inducible nitric oxide synthesis (iNOS) and the production of NO. Methods of inhibiting the induction of proinflammatory...
6503722 Diagnostic tests and kits for Clostridium difficile  
This invention provides methods, compositions, and kits for detecting the presence of toxigenic strains of C. difficile in a biological sample. One embodiment provides methods for C. difficile...
6503743 Isolated nucleic acid encoding a human lactate dehydrogenase and uses thereof  
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention...
6500633 Method of detecting carcinomas  
The present invention relates to methods of detecting carcinomas by measuring the level of a glycero compound, such as glycerol-3-phosphate, in a plasma, serum, or urine specimen from a patient....
6495352 Sol-gel method for encapsulating molecules  
A method for encapsulating organic molecules, and in particular, biomolecules using sol-gel chemistry. A silica sol is prepared from an aqueous alkali metal silicate solution, such as a mixture of...
6489135 Determination of biological characteristics of embryos fertilized in vitro by assaying for bioactive lipids in culture media  
The present invention provides methods for determining various biological characteristics of in vitro fertilized embryos, including overall embryo health, implantability, and increased likelihood...
6485927 Method for quantitatively determining bicarbonate ion in liquid and dry analysis device  
This invention provides a method for the determination of bicarbonate ion existing in liquid using phosphenolpyruvate carboxylase and malate dehydrogenase as conjugate enzyme wherein thioNAD(P)H...
6475750 Glucose biosensor  
A biosensor (10) has a hydrogel (30) in a rigid and referably biocompatible enclosure (20). The hydrogel (30) includes an immobilized glucose-binding molecule such as concanavalin A (Con A) and an...
6461830 Determining existence of preeclampsia in pregnancies by measuring levels of glycerophosphatidyl compounds, glycerophosphatidycholine, lysophospholipids and lysophosphatidylcholine  
The present invention relates generally to methods for detecting preeclampsia in pregnancies. The present invention comprises the steps of obtaining a sample specimen from a patient, assaying the...
6448023 Enzyme method for detecting sphingosine-1-phosphate (S1P)  
The present invention relates to non-radioactive enzymatic methods for detecting Sphingosine-1-Phosphate (S1P) in biological fluids. The present invention further relates to a method of detecting...
6440688 Enzymatic cofactor cycling using soluble pyridine nucleotide transhydrogenase  
The present invention pertains to an enzymatic reaction involving a pyridine nucleotide cofactor, wherein an enzyme is used that has a sequence of greater than 70% identity to SEQ ID NO: 2 and is...
6428972 Biochemical method to measure niacin status in a biological sample  
The invention relates to assay or determining intercellular niacin status in solid tissues. One extracts intracellular pyredine nucleotides, cycles these, in the presence of agents which reduce...
6426204 Method for detecting candida infection  
A D-arabinitol dehydrogenase enzyme is disclosed. The enzyme is capable of catalyzing the oxidation of D-arabinitol and substantially incapable of catalyzing the oxidation of D-mannitol and is...
6423518 Design and production of mutant 2,5-diketo-D-gluconic acid reductase enzymes with altered cofactor dependency  
Methods for producing mutant 2,5-diketo-D-gluconic acid reductase enzymes with altered cofactor dependency are provided. Also provided are mutant 2,5-diketo-D-gluconic acid reductase enzymes with...
6420128 Test strips for detecting the presence of a reduced cofactor in a sample and method for using the same  
Test strips and methods for their use in the detection of an analyte in a sample are provided. The subject test strips are characterized by at least including a water soluble tetrazolium salt on a...
6406878 Methods for identifying enzyme inhibitors  
A method for identifying an inhibitor of dehydroquinate synthase (DHQS) and/or dehydroquinase (DQ), which method comprises: i) contacting a test substance with DHQS and a substrate for DHQS and...
6395502 Method and means for modulating PGE synthase activity  
Isolated PGE synthase, provided from encoding nucleic acid. Methods of production and use. Assays for modulators, especially inhibitors, of PGE synthase activity.
6387648 Method for adjusting and disinfecting liquids  
A Method for regulating the disinfection of a liquid includes a number of stages. At one stage of the said disinfection (stage 2), the activity of at least one enzyme is measured by bringing the...
6380380 Use of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucliotide phosphate (NADP) analogs to measure enzyme activities metabolites and substrates  
Kits and methods for measuring enzyme activities and metabolites using NAD analogs and NADP analogs are disclosed. The analogs can be used as replacements for NAD and NADP cofactors in analytical...
6372463 Mutations in nucleic acid molecules encoding 11-CIS retinol dehydrogenase, the mutated proteins, and uses thereof  
The invention relates to mutations in the gene encoding 11-cis retinal dehyrogenase. The mutations in the gene and in the resulting encoded protein are correlated to ocular disorders, such as...
6352847 Ammonia elimination liquid reagent  
The invention provides an ammonia elimination reagent in solution, comprising a thermo-resistant isocitrate dehydrogenase with prominent stability under conditions at high alkaline pHs. For...
6350601 Enzyme composition for use as a clinical diagnostic reagent  
Disclosed is a stabilized enzyme composition for use in clinical examination, comprising: (a) an enzyme component comprising at least two enzymes selected from the group consisting of alkaline...
6340597 Electrochemical biosensors and process for their preparation  
The present invention concerns new electrochemical biosensors for the determination of analytes concentration in sample solutions or suspensions, based on composite transducers containing an...
6326159 Receptors for immune complexes  
Receptors are disclosed that are antibodies that exhibit a binding affinity for an immune complex of a monoepitopic antigen and an antibody for such antigen that is substantially greater than the...
6309852 Method and reagent for quantitative determination of 1,5-anhydroglucitol  
The present invention provides a simple method for the determination of a specific component, e.g. 1,5-anhydroglucitol (1,5-AG) in a sample containing glucose, and a reagent and a reagent kit...
6306618 Homocysteine desulphurase from the protozoan trichomonas vaginalis  
The present invention relates to an assay for determining homocysteine, cysteine, O-acetyl-L-serine and/or methionine levels in a biological sample using an enzyme that catalyzes the degradation...
6274138 Human mitochondrial malate dehydrogenase  
The invention provides a human mitochondrial malate dehydrogenase (MT-MDH) and polynucleotides which identify and encode MT-MDH. The invention also provides expression vectors, host cells,...
6268166 Method of quantitative assay for 1,5-anhydroglucitol  
There is provided an enzymatic method of rapid quantitative assay for 1,5-anhydroglucitol which is also applicable to an automated analysis device. The enzymatic method of quantitative assay for...
6268167 Methods for determining an analyte in a plasma or serum sample which may be contaminated with interfering substances resulting from hemolysis  
In order to analyze a medical sample while avoiding error contributions due to hemolysis, prior to the main reaction for a component present in the sample, a pre-reaction is produced and measured...
6255063 Disease conditions by measuring lysophosphatidic acid  
The present invention is an enzymatic method and diagnostic kits for detecting and quantifying the presence of one or more lysophospholids in a sample of bodily fluid taken from a test subject....
6248553 Enzyme method for detecting lysophospholipids and phospholipids and for detecting and correlating conditions associated with altered levels of lysophospholipids  
The present invention is an enzymatic method and diagnostic kits for detecting and quantifying the presence of one or more lysophospholids in a sample of bodily fluid taken from a test subject....
6242208 LDH1 assay  
By a process comprising inhibiting LDH2, LDH3, LDH4 and LDH5 in a sample with a protease in the presence of a protein-denaturating agent and then determining LDH1 remaining uninhibited, LDH1 in...
6232060 Assay system for anti-stress agents  
Methods and compositions are provided for screening compounds for anti-stress activity. A rat hepatoma-derived cell line is employed, which is particularly responsive to mitochondrial function...
6214612 Cholesterol sensor containing electrodes, cholesterol dehydrogenase, nicotinamide adenine dinucleotide and oxidized electron mediator  
A cholesterol sensor for quantitative determination of cholesterol is provided containing an electrode system and a reaction reagent system. The electrode system contains a measuring electrode...
6190918 Analyte detection device and process  
The present invention provides a device and a process for detecting an analyte in a biological fluid. The device comprises a separating matrix for separating analyte from the fluid and means for...
6162615 Stabilized coenzyme solutions and their use thereof for the determination of dehydrogenases or the substrate thereof in an alkaline medium  
Stabilized aqueous coenzyme solutions which contain up to ca. 60 mM of a heavy metal salt and optionally a complexing agent in a defined ratio to the heavy metal salt as well as their use for the...
6153398 Method to identify specific inhibitors of IMP dehydrogenase  
This invention relates to methods to identify specific inhibitors of the purine nucleotide synthesis enzyme, IMP dehydrogenase (IMPDH). IMPDH is an essential enzyme found in all free-living...
6143537 Method for stabilizing analyte structure using antibodies or antibody fragments thereof  
A method for stabilizing analyses with antibodies and antibody fragments comprises dissolving the analyte in a liquid to form a solution, adding analyte-specific antibodies, fragments of such...
6130054 Test strip for creatine kinase activity measurement  
Test strips by which creatine kinase activity can be quantitatively measured at a high sensitivity within a broad measuring range and which have excellent storage stability. Particularly, test...