AcclaimIP-ad

Match Document Document Title
7244581 Glucose dehydrogenase  
Disclosed is a modified glucose dehydrogenase having pyrroloquinoline quinone as a coenzyme, wherein one or more amino acid residues in a region of amino acid 349-377 of water-soluble PQQGDH...
7238483 Method for detecting catalytic activity  
This invention has as its object a method for detecting catalytic activity of a sample, characterized in that it comprises: the incubation of a substrate (S) with the sample that may have the...
7236236 Methods for detecting malaria parasites and reagent kits therefor  
Methods for detecting a malaria parasite are described that include: releasing the malaria parasite by allowing an erythrocyte in a specimen to undergo hemolysis; staining the released malaria...
7235672 Probe, assay and kits for detecting 11β-hydroxysteroid dehydrogenase and modulators thereof  
A probe, kit comprising the probe, and methods for using the probe are provided where the probe comprises: whereinDM is a detectable marker; andL is a straight or branched chain moiety providing...
7208301 Method for producing 6-0-α-D-glucopyranosyl-D-sorbitol  
This invention concerns a method for enzymatic preparation of 6-O-α-D-glucopyranosyl-D-sorbitol (1,6-GPS) from isomaltulose. It is specified that the isomaltulose is put into an aqueous reaction...
7202069 (R)-2-octanol dehydrogenases, methods for producing the enzymes, DNA encoding the enzymes, and methods for producing alcohols using the enzymes  
This invention provides (R)-2-octanol dehydrogenase that catalyzes oxidation-reduction reaction using NAD+ (NADH) as a coenzyme and the genes that encodes them. The enzymes of this invention can...
7198905 Method of screening methods prediabetic state and screening reagent  
The present invention provides a screening method by which a prediabetic state can be more accurately determined and many test samples can be treated without physical burden on patients, and a...
7198955 Method and apparatus for measurement of blood substitutes  
A method is disclosed whereby the concentration of a blood substitute, such as cross-linked hemoglobin, in a serum or plasma specimen is rapidly and accurately identified and quantified. The...
7192727 Reagent for measuring alanine aminotransferase activity  
A reagent for measuring an alanine aminotransferase activity comprising L-alanine, 2-oxoglutaric acid, lactate dehydrogenase, and reduced nicotinamide adenine dinucleotide, characterized by...
7186534 Potent inhibitors of human 9-cis retinol dehydrogenase  
The cDNA sequence of the human 9-cis-retinol dehydrogenase enzyme is disclosed.
7148007 Method for evaluating immunotoxicity of test substance  
The present invention discloses a method of evaluating the immunotoxicity of a hydrophobic test substance, comprising (1) culturing immunocompetent cells in a culture system containing a...
7122333 Method and reagent for visually measuring ATP  
The object of the invention is to provide a handy type visually determinable ATP measuring reagent which can be easily handled and has good measuring sensitivity. The invention is an ATP measuring...
7105128 Dry analytical element using water-soluble indicator for colorimetry  
This invention relates to a dry analytical element using a water-soluble indicator which improves measuring accuracy, which comprises a water-impermeable support, a water-permeable layer and a...
7052861 Graphitic nanotubes in luminescence assays  
Graphitic nanotubes, which include tubular fullerenes (commonly called “buckytubes”) and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated...
7049058 Methods for suppressing the induction of nitric oxide synthase in a cell  
Disclosed are methods for suppressing the induction of inducible nitric oxide synthase in a cell comprising contacting said cell with an effective amount of at least one induction suppressor of...
7001738 Method for assaying protein nitrosylation  
Many of the effects of nitric oxide are mediated by the direct modification of cysteine residues resulting in an adduct called a nitrosothiol. A method to detect proteins which contain...
6989274 Polyaspartic acid concentration determination by fluorometry  
The present invention relates to a method of performing concentration determinations of aqueous solutions of polyaspartic acid and/or salts thereof.
6986998 Method of analyzing components in biological samples  
There is provided a method for a selective assay of component, particularly cholesterol, in very low-density lipoprotein (VLDL) which is one of serum lipoproteins. In the assay, an enzymatic...
6974665 In situ screening to optimize variables in organic reactions  
A biphasic process for rapid screening of organic reactions comprising monitoring relative rates of parallel organic reactions. The screening process is suitable to determine the efficacy of...
6939685 Stabilized tetrazolium phenazine reagent compositions and methods for using the same  
Stabilized tetrazolium dye-phenazine reagent compositions and methods for their use in the measurement of an analyte in a sample are provided. The subject reagent compositions include: (1) a...
6939682 Test piece for assaying high density lipoprotein (HDL) cholesterol  
The present invention relates to a test piece having a simple structure, by which HDL cholesterol can be measured easily using a small amount of specimen. A reagent layer (2) is formed on a...
6916626 Detection of Candida  
The present invention relates to a method and a means of diagnosing Candida infection. In particular, the present invention relates to a method of diagnosing Candida infection comprising the steps...
6916641 (R)-2-hydroxy-3-phenylpropionate (d-phenyllactate) dehydrogenase and gene encoding the same  
An objective of the present invention is to provide a D-phenyllactic acid dehydrogenase. Another objective of the present invention is to provide a gene which encodes the D-phenyllactic acid...
6872574 Proteomic analysis  
The present invention provides methods for analyzing proteomes, as cells or lysates. The analysis is based on the use of probes that have specificity to the active form of proteins, particularly...
6867012 Determination method of biological component and reagent kit used therefor  
The present invention provides novel glutathione-dependent formaldehyde dehydrogenase that makes possible quantitative measurement of formaldehyde by cycling reaction, and a determination method...
6852502 Electrochemiluminescent enzyme biosensors  
Electrochemiluminescent enzymes, their preparation and use as biosensors are disclosed. Specifically, two appendages are covalently attached to a desired dehydrogenase enzyme; (1) a nicotinamide...
6849421 Assays for compounds modulating human serine protease C-E  
Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease C-E. The deduced amino acid sequence, and it alignment with other...
6838276 Isolated nucleic acids encoding methylenetetrahydrofolate dehydrogenase enzymes  
This invention relates to an isolated nucleic acid fragment encoding a tetrahydrofolate metabolism enzyme. The invention also relates to the construction of a chimeric gene encoding all or a...
6825029 Nucletoide sequences which code for the opcA gene  
The present invention relates to polynucleotides that encode proteins having OpcA enzymatic activity. These polynucleotides can be used for increasing lysine biosynthesis in Coryneform glutamicum.
6821746 Methods of screening for FabK antagonists and agonists  
The invention provides methods for identifying agonists and antagonists of FabK polypeptides.
6811990 Methods and compositions for coupled luminescent assays  
The present invention provides a set of methods and compositions for homogeneous coupled luminescent assays of cytotoxicity and/or proliferation of cells, as well as for enzymatic activity. In...
6811998 Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase  
The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The...
6803185 Method to measure acyl-coenzyme a esters  
The invention provides a method for measuring an acyl coenzyme A (acyl CoA) ester or esters in a sample, comprising the steps of: a) forming a reaction mixture comprising the sample to be tested...
6797467 Compositions and methods for determining interactions of mitochondrial components, and for identifying agents that alter such interactions  
Compositions and methods are provided for identifying agents that alter mitochondrial membrane permeability transition. The screening methods generally detect agents that alter the interaction...
6794157 Methods for fractional quatification of cholesterol in lipoproteins and quantification reagents  
The present invention provides a method for the quantitative determination of cholesterol in low density lipoproteins and a reagent kit for use therein. The present invention also provides a...
6764828 Method for quantitatively determining LDL cholesterols  
A method for quantitatively determining LDL cholesterol, including the steps of adding to serum a surfactant selected from among polyoxyethylenealkylene phenyl ethers and polyoxyethylenealkylene...
6762035 Method and test strips for the measurement of fat loss during weight loss programs  
A method for monitoring the progress of fat loss in a patient during a weight loss program which comprises, contacting a body fluid sample from said patient with a solid test strip to provide a...
6753174 Isolated human lactate dehydrogenase proteins  
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention...
6737247 Imaging of enzymatic activity  
The invention features methods of detecting enzymatic activity (e.g., in a magnetic resonance image). In general, the methods include: (1) providing a monomeric substrate (e.g., a substrate that...
6720164 Method of determining substrate, and biosensor  
A method of quantifying a substrate, by which the substrate contained in various samples can be conveniently and quickly quantified without resort to any troublesome pretreatments, and a...
6716596 Agents for replacement of NAD&plus /NADH system in enzymatic reactions  
Novel agents acting as co-factors for replacement of NAD(P)+/NAD(P)H co-enzyme systems in enzymatic oxido-reductive reactions. Agents mimicking the action of NAD(P)+/NAD(P)H system in enzymatic...
6703216 Methods, compositions and apparatuses for detection of gamma-hydroxybutyric acid (GHB)  
Methods, compositions and articles of manufacture for assaying a sample for a GHB source are provided. A sample suspected of containing a GHB source is contacted with a first oxidoreductase...
6696266 Method for assaying ammonia using an NAD-based cycling reaction system  
A method for assaying ammonia and/or ammonium ions contained in a liquid sample which comprises subjecting the sample to a reaction at least in the presence of an NAD synthetase, deamidated NAD,...
6673560 Measurement of hydride using chemiluminescent acridinium compounds and applications thereof  
The present invention discloses a method for the measurement of hydride using a chemiluminescent compound. The preferred chemiluminescent molecule is an acridinium compound. The source of hydride...
6664070 Washing solution for solid-phase immunometric methods which contains stabilizers for the labeling system, and the use thereof  
A washing solution for solid-phase immunometric methods which contains stabilizers for the labeling system, and the use thereof
6656702 Biosensor containing glucose dehydrogenase  
A biosensor that enables rapid and simple quantitation of a substrate with high accuracy and demonstrates an excellent preservation characteristic by best retaining enzyme activity is disclosed....
6653094 Indicators of altered mitochondrial function in predictive methods for determining risk of type 2 diabetes mellitus  
The present invention relates to improved diagnostic methods for early detection of a risk for developing type 2 diabetes mellitus in humans, and screening assays for therapeutic agents useful in...
6632600 Altered thermostability of enzymes  
Provided is a method of screening gene libraries derived from a mixed population of organisms for a bioactivity or biomolecule of interest. The mixed population of organisms can be a cultured...
6627759 Method of isolating stem cells  
The present invention relates, in general, to stem cells, and in particular, to a method of isolating stem cells and to reagents suitable for use in such a method. The invention further relates to...
6617123 Method for detection of 4-hydroxybutyric acid and its precursor(s) in fluids  
A method for determining the presence or amount of gamma-hydroxybutyrate or precursors in a sample, said method comprising contacting said sample with an indicator which specifically binds to...