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7943356 Alcohol dehydrogenase for the stereoselective production of hydroxy compounds  
The invention relates to a DNA sequence encoding an NADP-dependent alcohol dehydrogenase, to a vector containing at least one copy of the DNA sequence and to prokaryotic or eukaryotic host cells...
7939309 Glucose dehydrogenase polypeptides and related polynucleotides  
The present invention is directed to glucose dehydrogenase (GDH) polypeptides that have enhanced GDH activity and/or thermostability relative to the backbone wild-type glucose dehydrogenase...
7919268 Reducing sample turbidity in measurement of enzymatic activity in cell lysates  
Disclosed are methods and kits for measuring enzyme activity in which the turbidity of a sample caused by cell components is minimized by particular additives. The methods include the steps of...
7914663 Structure, porous body, sensor, process of structure and detecting method for specimen  
A mesoporous silica structure having a plurality of mesopores includes a dendritic framework having mesopores. 90% or more of the mesopores observable in a 500 nm×500 nm area pass through the...
7867728 Determining the concentration of analytes in sample by direct mediation of enzymes  
The glucose content of blood can be determined by contacting a blood sample with a test strip containing a glucose dehydrogenase dependent on PQQ (or derivatives or isomers) thereof as a...
7867729 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 molecules and uses therefor  
The invention provides isolated nucleic acids molecules, designated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules. The invention also...
7833397 Amino-acid biosensor, Fischer-ratio biosensor and health information management system  
Disclosed is a biosensor capable of measuring a total concentration of plural types of amino acids. An amino-acid biosensor (200) for measuring a total concentration of a plurality of specific...
7829316 Process for production of succinic acid  
Disclosed is a process for production of succinic acid, which comprises the step of reacting a bacterium which has been modified so as to increase the expression of a sucE1 gene or a product...
7824881 Glucose level measuring method and glucose sensor utilizing glucose dehydrogenase  
The present invention relates to a technique for measuring a glucose level by utilizing a reaction system containing an enzyme and an electron carrier. In accordance with the glucose level...
7816075 Methods and compositions using stearoyl-CoA desaturase to identify triglyceride reducing therapeutic agents  
The use of screening assays based on the role of human stearoyl-CoA desaturase-1 (“hSCD1”) in human diseases, disorders or conditions relating to serum levels of triglyceride, VLDL, HDL, LDL,...
7816111 Glucose dehydrogenase polypeptides and related polynucleotides  
The present invention is directed to glucose dehydrogenase (GDH) polypeptides that have enhanced GDH activity and/or thermostability relative to the backbone wild-type glucose dehydrogenase...
7785771 Assay for determination of free D-galactose and/or L-arabinose  
The invention provides an assay kit for the measurement of free D-galactose and/or L-arabinose in a sample, the kit comprising galactose mutarotase and (3-galactose dehydrogenase. The kit may...
7776575 Mutant glucose dehydrogenase  
A mutant glucose dehydrogenase having the amino acid sequence of SEQ ID NO: 3 or an amino acid sequence of SEQ ID NO: 3 including substitution, deletion, insertion or addition of one or more amino...
7741069 Mesoporous material having dendritic skeleton containing immobilized glucose dehydrogenase  
A porous material containing mesopores with immobilized glucose dehydrogenase is provided. The pore size is at least 10 nm.
7732179 Mutants of pyrroloquinoline quinone dependent soluble glucose dehydrogenase  
A mutant of PQQ-dependent soluble glucose dehydrogenase (s-GDH; EC 1.1.5.2) is provided with improved specificity for glucose as compared to maltose, having a substitution of threonine at position...
7645599 Methods for producing optically active alcohols  
A method for producing optically active alcohols is provided. Optically active alcohols are useful intermediates in pharmaceutical production. The method of the present invention enables simple...
7608437 Method of constructing amino acid producing bacterial strains, and method of preparing amino acids by fermentation with the constructed amino acid producing bacterial strains  
A method of producing coryneform bacteria having an improved amino acid or nucleic acid-productivity comprises the steps of introducing a mutation in a promoter sequence of amino acid- or nucleic...
7604969 Mutant glucose dehydrogenase  
A mutant glucose dehydrogenase having an improved substrate specificity to glucose, which is a protein comprising the amino acid sequence depicted in SEQ ID NO:3 or an amino acid sequence having...
7598063 Process for producing ethanol by using recombinant coryneform bacterium  
The present invention provides a process for highly efficiently producing ethanol at a high productivity consisting of using a coryneform bacterium which has been transformed by a DNA containing a...
7585400 Chip for electrochemical immunoassay  
The present invention provides a chip 100 that enables an immunoassay with high accuracy and without requiring a high volatile reagent. The chip 100 includes a chip substrate 20, a reagent mixture...
7582460 3-phosphoglycerate dehydrogenase variants whose inhibition by L-serine is reduced, and genes encoding them  
A 3-phosphoglycerate dehydrogenase (PGD) which exhibits a susceptibility to inhibition by serine which is reduced a as compared with that of an Escherichia coli wild-type PGD and which possesses...
7575884 Test piece for measuring high-density lipoprotein (HDL) cholesterol  
The present invention relates to a test piece having a simple structure, by which HDL cholesterol can be measured easily using a small amount of specimen. A reagent layer (2) is formed on a...
7560239 Homogeneous enzyme immunoassay for simultaneous detection of multiple analytes  
Methods and kits are provided for the simultaneous detection of multiple analytes, i.e. to the determination of whether one or more of a plurality of analytes is present in a sample, particularly...
7553615 Compounds, methods, complexes, apparatuses and uses relating to stabile forms of NAD/NADH  
The invention concerns stable nicotinamide adenine dinucleotide (NAD/NADH) and nicotinamide adenine dinucleotide phosphate (NADP/NADPH) derivatives, enzyme complexes of these derivatives and their...
7547441 PAI-2 conjugates for the treatment and imaging of cancer  
A method is described for detecting, visualizing, or treating cells, particularly cancerous cells, that express a uPA/uPAR complex. The method employs a PAI-2 conjugate molecule that comprises...
7547524 Genetically engineered pyrroloquinoline quinone dependent glucose dehydrogenase comprising an amino acid insertion  
The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH) comprising an amino acid insertion between positions 428 and...
7524872 Method and composition for treating cancer using cellular organelle crystallizing agents  
This invention provides a method for treating cancer in mammals through cellular-organelle-crystallization-induced-death (herein defined as “Cocid”), a method for treating cancer using cellular...
7517664 Inactivated enzyme variants and associated process and reagent system  
The present invention relates to oxidoreductase apoenzyme variants which are enzymatically inactive but have coenzyme-binding properties. Further, the present invention relates to DNA sequences...
7507551 Multiple quantification method for cholesterol in low-density lipoproteins  
The present invention is intended to provide a method for simultaneously measuring cholesterol in low density lipoprotein and total cholesterol as test components in blood. Specifically, a method...
7491542 Test device for determining the concentration of LDL-cholesterol in a sample  
The present invention provides a test device for determining the concentration of LDL-cholesterol in a sample. The test device has a continuous solid surface with at least one reaction area on the...
7488602 Method for detecting and compensating an underdosage of test strips  
The invention concerns a method for detecting an underdosage of an analytical test element and optionally for compensating the underdosage. The invention also concerns an analytical system and a...
7485705 Water-soluble tetrazolium compounds  
The purpose of the present invention is to provide a water-soluble tetrazolium compound that will form a water-soluble formazan exhibiting long-wavelength absorption and is stable in aqueous...
7479383 Modified pyrroloquinoline quinone (PQQ) dependent glucose dehydrogenase excellent in substrate specificity  
PQQGDH having an improved substrate specificity or having an improved specific activity in an assay system using ferricyanide ion as a mediator is provided. Modified PQQGDH having the enhanced...
7452505 Method for analyzing blood test sample and dry analytical element and analytical kit utilizing the method  
Objects of the present invention are to provide a method for analyzing a blood test sample containing blood platelet collected from a human body to detect presence of an analyte in the test...
7442496 Methods and kits for diagnosis of schizophrenia  
The present invention provides methods and kits for the diagnosis of schizophrenia, which employ mitochondrial complex I as a peripheral biological marker for schizophrenia. In one embodiment, the...
7425302 Dry chemistry, lateral flow-reconstituted chromatographic enzyme-driven assays  
A lateral flow chromatographic assay format for the performance of rapid enzyme-driven assays is described. A combination of components necessary to elicit a specific enzyme reaction, which are...
7416866 Process for the overexpression of dehydrogenases  
A process for the overexpression of dehydrogenases, especially for the overexpression of Δ1-dehydrogenases, in particular for the overexpression of 3-keto steroid-Δ1-dehydrogenases, as well as for...
7402387 Methods and compositions for detecting dihydropyrimidine dehydrogenase splicing mutations  
The present invention provides compositions, methods, and kits for the detection of genetic polymorphisms or mutations of the dihydropyrimidine dehydrogenase deficiency (DPDD). The polymorphisms...
7381540 Composition for measuring glucose having improved substrate specificity  
The present invention relates to a method for lowering activity with respect to maltose in glucose measurement comprising a step of reacting modified pyrroloquinoline quinone dependent glucose...
7348135 Assay for detecting changes in mitochondrial membrane permeability and method of using same  
An assay for assessing the permeability of mitochondrial membranes is provided. The assay is based on enzymatic reactions that produce a detectable signal in the presence of intra-mitochondrial...
7341830 Method and reagent system having a non-regenerative enzyme-coenzyme complex  
The invention relates to a method and reagent system for detecting an analyte in a sample by means of an enzymatic reaction, involving the use of an enzyme-coenzyme complex as a stoichiometric...
7341846 Method of measuring glucose concentration and glucose sensor with the use of glucose dehydrogenase  
The present invention relates to a technique for measuring a glucose level by utilizing a reaction system containing an enzyme and an electron carrier. In accordance with the glucose level...
7335483 Method of pretreatment of sample for quantitating cholesterol and method for quantitating cholesterol in specific lipoproteins by using the same  
A method of a pretreatment of a sample for quantitating cholesterol characterized by, before measuring cholesterol contained in specific lipoproteins, treating the sample containing lipoproteins...
7329518 Enzyme for producing optically active pyridineethanol derivatives  
The present invention relates to a method of producing an optically active pyridineethanol derivative. More particularly, it relates to a method of producing an optically active polycyclic...
7300769 Stabilized coenzyme solutions for determining dehydrogenase activity  
Stabilized aqueous solution of a coenzyme for hydrogen-transferring enzymes characterized in that the solution contains NAD, NADP or a derivative thereof in an oxidized or reduced form and one or...
7291256 Mediator stabilized reagent compositions and methods for their use in electrochemical analyte detection assays  
Mediator stabilized reagent compositions and methods for their use in electrochemical analyte determination assays are provided. The subject reagent compositions include an enzyme, a redox...
7282348 Kit for measuring cytotoxicity of a test agent  
Disclosed are a method and a corresponding kit for determining the cytotoxicity of a test agent. The method includes the steps of adding a pre-determined amount of the test agent to a vessel...
7279302 Methods for identifying herbicidal compounds  
The invention concerns novel enzymes having an arogenate dehydrogenase activity, in particular arogenate dehydrogenase enzymes of plants, and the genes encoding said enzymes. The inventive...
7270977 Polypeptides for identifying fungicidally active compounds  
The invention relates to polypeptides from phytopathogenic fungi with the biological activity of an inosine monophosphate dehydrogenase, to nucleic acids encoding them, to the use of the...
7252931 NMR-solve method for rapid identification of bi-ligand drug candidates  
Methods for rapidly identifying drug candidates that can bind to an enzyme at both a common ligand site and a specificity ligand site, resulting in high affinity binding. The bi-ligand drug...