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7049058 |
Methods for suppressing the induction of nitric oxide synthase in a cell
Disclosed are methods for suppressing the induction of inducible nitric oxide synthase in a cell comprising contacting said cell with an effective amount of at least one induction suppressor of...
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7001738 |
Method for assaying protein nitrosylation
Many of the effects of nitric oxide are mediated by the direct modification of cysteine residues resulting in an adduct called a nitrosothiol. A method to detect proteins which contain...
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6989274 |
Polyaspartic acid concentration determination by fluorometry
The present invention relates to a method of performing concentration determinations of aqueous solutions of polyaspartic acid and/or salts thereof.
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6986998 |
Method of analyzing components in biological samples
There is provided a method for a selective assay of component, particularly cholesterol, in very low-density lipoprotein (VLDL) which is one of serum lipoproteins. In the assay, an enzymatic...
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6974665 |
In situ screening to optimize variables in organic reactions
A biphasic process for rapid screening of organic reactions comprising monitoring relative rates of parallel organic reactions. The screening process is suitable to determine the efficacy of...
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6962805 |
Method of constructing amino acid producing bacterial strains, and method of preparing amino acids by fermentation with the constructed amino acid producing bacterial strains
A method of producing coryneform bacteria having improved amino acid or nucleic acid productivity comprising the steps of introducing a mutation in a promoter sequence of amino acid- or nucleic...
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6939682 |
Test piece for assaying high density lipoprotein (HDL) cholesterol
The present invention relates to a test piece having a simple structure, by which HDL cholesterol can be measured easily using a small amount of specimen. A reagent layer ( 2 ) is formed on a...
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6939685 |
Stabilized tetrazolium phenazine reagent compositions and methods for using the same
Stabilized tetrazolium dye-phenazine reagent compositions and methods for their use in the measurement of an analyte in a sample are provided. The subject reagent compositions include: (1) a...
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6916626 |
Detection of Candida
The present invention relates to a method and a means of diagnosing Candida infection. In particular, the present invention relates to a method of diagnosing Candida infection comprising the...
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6916641 |
(R)-2-hydroxy-3-phenylpropionate (d-phenyllactate) dehydrogenase and gene encoding the same
An objective of the present invention is to provide a D-phenyllactic acid dehydrogenase. Another objective of the present invention is to provide a gene which encodes the D-phenyllactic acid...
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6872574 |
Proteomic analysis
The present invention provides methods for analyzing proteomes, as cells or lysates. The analysis is based on the use of probes that have specificity to the active form of proteins, particularly...
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6867012 |
Determination method of biological component and reagent kit used therefor
The present invention provides novel glutathione-dependent formaldehyde dehydrogenase that makes possible quantitative measurement of formaldehyde by cycling reaction, and a determination method of...
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6852502 |
Electrochemiluminescent enzyme biosensors
Electrochemiluminescent enzymes, their preparation and use as biosensors are disclosed. Specifically, two appendages are covalently attached to a desired dehydrogenase enzyme; (1) a nicotinamide...
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6849421 |
Assays for compounds modulating human serine protease C-E
Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease C-E. The deduced amino acid sequence, and it alignment with other well-characterized...
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6838276 |
Isolated nucleic acids encoding methylenetetrahydrofolate dehydrogenase enzymes
This invention relates to an isolated nucleic acid fragment encoding a tetrahydrofolate metabolism enzyme. The invention also relates to the construction of a chimeric gene encoding all or a...
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6825029 |
Nucletoide sequences which code for the opcA gene
The present invention relates to polynucleotides that encode proteins having OpcA enzymatic activity. These polynucleotides can be used for increasing lysine biosynthesis in Coryneform glutamicum.
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6821746 |
Methods of screening for FabK antagonists and agonists
The invention provides methods for identifying agonists and antagonists of FabK polypeptides.
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6811998 |
Conjugates of uncompetitive inhibitors of inosine monophosphate dehydrogenase
The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The...
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6811990 |
Methods and compositions for coupled luminescent assays
The present invention provides a set of methods and compositions for homogeneous coupled luminescent assays of cytotoxicity and/or proliferation of cells, as well as for enzymatic activity. In both...
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6803185 |
Method to measure acyl-coenzyme a esters
The invention provides a method for measuring an acyl coenzyme A (acyl CoA) ester or esters in a sample, comprising the steps of: a) forming a reaction mixture comprising the sample to be tested...
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6797467 |
Compositions and methods for determining interactions of mitochondrial components, and for identifying agents that alter such interactions
Compositions and methods are provided for identifying agents that alter mitochondrial membrane permeability transition. The screening methods generally detect agents that alter the interaction...
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6794157 |
Methods for fractional quatification of cholesterol in lipoproteins and quantification reagents
The present invention provides a method for the quantitative determination of cholesterol in low density lipoproteins and a reagent kit for use therein. The present invention also provides a method...
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6764828 |
Method for quantitatively determining LDL cholesterols
A method for quantitatively determining LDL cholesterol, including the steps of adding to serum a surfactant selected from among polyoxyethylenealkylene phenyl ethers and polyoxyethylenealkylene...
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6762035 |
Method and test strips for the measurement of fat loss during weight loss programs
A method for monitoring the progress of fat loss in a patient during a weight loss program which comprises, contacting a body fluid sample from said patient with a solid test strip to provide a...
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6753174 |
Isolated human lactate dehydrogenase proteins
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically...
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6737247 |
Imaging of enzymatic activity
The invention features methods of detecting enzymatic activity (e.g., in a magnetic resonance image). In general, the methods include: (1) providing a monomeric substrate (e.g., a substrate that is...
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6720164 |
Method of determining substrate, and biosensor
A method of quantifying a substrate, by which the substrate contained in various samples can be conveniently and quickly quantified without resort to any troublesome pretreatments, and a biosensor....
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6716596 |
Agents for replacement of NAD&plus /NADH system in enzymatic reactions
Novel agents acting as co-factors for replacement of NAD(P) + /NAD(P)H co-enzyme systems in enzymatic oxido-reductive reactions. Agents mimicking the action of NAD(P) + /NAD(P)H system in enzymatic...
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6703216 |
Methods, compositions and apparatuses for detection of gamma-hydroxybutyric acid (GHB)
Methods, compositions and articles of manufacture for assaying a sample for a GHB source are provided. A sample suspected of containing a GHB source is contacted with a first oxidoreductase...
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6696266 |
Method for assaying ammonia using an NAD-based cycling reaction system
A method for assaying ammonia and/or ammonium ions contained in a liquid sample which comprises subjecting the sample to a reaction at least in the presence of an NAD synthetase, deamidated NAD,...
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6673560 |
Measurement of hydride using chemiluminescent acridinium compounds and applications thereof
The present invention discloses a method for the measurement of hydride using a chemiluminescent compound. The preferred chemiluminescent molecule is an acridinium compound. The source of hydride...
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6664070 |
Washing solution for solid-phase immunometric methods which contains stabilizers for the labeling system, and the use thereof
A washing solution for solid-phase immunometric methods which contains stabilizers for the labeling system, and the use thereof
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6656702 |
Biosensor containing glucose dehydrogenase
A biosensor that enables rapid and simple quantitation of a substrate with high accuracy and demonstrates an excellent preservation characteristic by best retaining enzyme activity is disclosed....
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6653094 |
Indicators of altered mitochondrial function in predictive methods for determining risk of type 2 diabetes mellitus
The present invention relates to improved diagnostic methods for early detection of a risk for developing type 2 diabetes mellitus in humans, and screening assays for therapeutic agents useful in...
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6632600 |
Altered thermostability of enzymes
Provided is a method of screening gene libraries derived from a mixed population of organisms for a bioactivity or biomolecule of interest. The mixed population of organisms can be a cultured...
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6627759 |
Method of isolating stem cells
The present invention relates, in general, to stem cells, and in particular, to a method of isolating stem cells and to reagents suitable for use in such a method. The invention further relates to...
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6617123 |
Method for detection of 4-hydroxybutyric acid and its precursor(s) in fluids
A method for determining the presence or amount of gamma-hydroxybutyrate or precursors in a sample, said method comprising contacting said sample with an indicator which specifically binds to...
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6613555 |
32142, 21481, 25964, 21686, novel human dehydrogenase molecules and uses therefor
The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense...
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6586199 |
Stabilized tetrazolium reagent compositions and methods for using the same
Stabilized tetrazolium dye reagent compositions and methods for their use in the measurement of an analyte in a sample are provided. The subject reagent compositions include a tetrazolium dye...
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6576461 |
Electrochemical affinity assay
An electrochemical affinity assay system for detection of ligand—ligand receptor binding.
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6562563 |
Compositions and mehtods for determining interactions of mitochondrial components, and for identifying agents that alter such interactions
Compositions and methods are provided for identifying agents that alter mitochondrial membrane permeability transition. The screening methods generally detect agents that alter the interaction...
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6545006 |
Process for obtaining L-dihydroorotic acid and use thereof
The invention relates to a process for obtaining L-dihydroorotic acid by chromatography on an anionic exchange material in a base water mixture under a pressure from about 1.1 MPa to about 40 MPa....
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6544756 |
Sorbitol dehydrogenase, microorganism for producing same, process for the production thereof, method for the measurement of sorbitol and reagent for the quantitative determination therefor
A novel sorbitol dehydrogenase having excellent substrate affinity and substrate specificity which can be used to measure D-sorbitol which occurs in human erythrocytes and serum in a slight amount...
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6541216 |
Amperometric biosensor test strip
A reagent and method for determining the levels of 3-hydroxybutyric acid in a sample are provided. The reagent comprises a ferricyanide salt, a catalytic amount of a first enzyme operative to...
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6541195 |
Correction of genetic defects using chemical chaperones
A method of improving a phenotypic defect in a cell that contains a conformationally defective target protein wherein the conformational defect causes the phenotype defect, comprising contacting a...
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6541215 |
Quantitative determination method of mannose and reagent therefor
Disclosed are a method for quantitatively determining mannose, which comprises reacting mannose in a specimen with an enzyme which is capable of oxidizing the mannose by dehydrogenation, in the...
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6528277 |
Indicator systems for determination of sterilization
This invention relates to a container and method for detecting a specific environmental parameter or combination of parameters, or for determining the effectiveness of a sterilization procedure....
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6524808 |
Enzyme inhibition immunoassay
The present invention provides a method for the measurement of an analyte in biological samples whereby an uncompetitive inhibitor is coupled to a ligand and utilized in a homogeneous assay. The...
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6511800 |
Methods of treating nitric oxide and cytokine mediated disorders
The current invention discloses novel methods for the inhibition of inducible nitric oxide synthesis (iNOS) and the production of NO. Methods of inhibiting the induction of proinflammatory...
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6503743 |
Isolated nucleic acid encoding a human lactate dehydrogenase and uses thereof
The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the secreted peptides of the present invention. The present invention specifically...
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