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3956069 Enzymatic assays for glucose, creatine phosphokinase or plasma ammonia  
Enzymatic assays for determining glucose, creatine phosphokinase or plasma ammonia, wherein nicotinamide adenine dinucleotide is reduced or the reduced form of nicotinamide adenine dinucleotide is...
3953296 Enzyme recovery by ultrafiltration in enzymatic analysis  
A method and device for producing low-molecular products, especially for determining the concentration of low-molecular biological substances, by means of enzyme reaction, characterized by the...
3950133 Reagent formulations for assaying biological specimens and methods of preparing and using same  
A solid, water-soluble substantially anhydrous, storage-stable reagent formulation for use in conducting a clinical diagnostic test on a biological specimen is provided. The reagent formulation...
3948731 Method and apparatus for measuring reactant concentrations and quantities  
A method and apparatus is provided for determining the concentration or quantity of substrate molecules by monitoring directly the concentration and/or the quantity of vaporous byproduct produced...
3941659 Blood alcohol analyzer  
A continuous-flow method and apparatus for the determination of alcohol in a biological fluid such as blood is disclosed. A packed column containing the enzyme alcohol dehydrogenase physically...
3936357 Method and device for determining the concentration of a substance in a fluid  
A diagnostic test device comprising an absorbent medium adapted to receive and retain a measured amount of fluid containing the substance to be tested and reagents adapted to contact said fluid to...
3935074 Antibody steric hindrance immunoassay with two antibodies  
A novel immunoassay is provided, as well as particular reagents, for determining the presence of a ligand. A Reagent is employed having at least two epitopes, one of the epitopes being common with...
3932221 Immunological isozyme determination method  
This invention relates to a process, to a diagnostic agent employed therein and to the use thereof, for the organ-specific and/or disease-specific diagnosis of the isozyme pattern of an enzyme...
3929580 Creatine phosphokinase test indicator  
A diagnostic test indicator is prepared for the detection and determination of the concentration of creatine phosphokinase in sera comprising three superimposed layers the upper of which has...
3929581 Quantitative determination of blood ammonia  
Blood ammonia is quantitatively determined by contacting a sample suspected of containing blood ammonia, with glutamate dehydrogenase, α-ketoglutarate, and, as a coenzyme in the reduced state,...
3926736 Enzymatic ethanol assay  
This invention provides an improved enzymatic assay for ethanol in body fluids, whereby a single substance acts simultaneously as a buffer and as a trapping agent for one of the products of the...
3925162 Method for simultaneous determination of enzymatic activities of enzymes  
A method for the simultaneous determination of enzymatic activities of a plurality of enzymes in a single reaction medium which comprises adding a substrate of each of the enzymes to be determined...
3915647 Device for determining the concentration of a substance in a fluid  
A diagnostic test device which includes a cavity adapted to receive a fluid containing a substance to be tested, reagents adapted to contact said fluid and react with said substance to form a...
3910824 Interferon assay  
The antiviral activity of agents such as interferon, adamantanamine and 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide is determined by measurement of the intracellular enzymes released upon...
3907644 Creatinine amidohydrolase composition and process for the determination of creatinine  
Creatinine is determined by use of a novel enzyme, creatinine amidohydrolase, which converts the creatinine in a creatinine-containing sample to creatine, the latter being determined in...
3905871 Lactam conjugates to enzymes  
Novel biological assay method for determining the presence of a specific organic material by employing a modified enzyme for amplification. By employing receptors specific for one or a group of...
3891507 Organ function test cards  
A combination of solid and dried diagnostic test indicators in the form of spot deposits are grouped on a diagnostic test card for purposes of profiling or monitoring a specific organ by way of...
3883250 Method of optically measuring the absorption of light having a specific wavelength by a sample, by adjusting the output of a detector responsive to light having wavelengths longer than the specific wavelength to a zero level  
A method of optically measuring absorption of light having a specific wavelength of a sample by adjusting the output of a detector in response to light having wavelengths longer than the specific...
3881992 Optical rate measurement method  
A method for clinical analysis is provided by combining a reagent with a sample composition and causing an enzymatic reaction thereof, projecting a light beam at the composition as the reaction...
3876375 Biological composition for use as a reference control in diagnostic analysis  
Preparation of stable aqueous-containing biological compositions capable of use as liquid human reference serums in diagnostic analysis using sequential multichannel automated analyzers having...
3876502 Reagent formulations for assaying urea nitrogen in biological specimens and methods of preparing and using same  
A solid, water-soluble substantially anhydrous, storage-stable reagent formulation for use in conducting a clinical diagnostic test on a biological specimen is provided. The reagent formulation...
3875011 Enzyme immunoassays with glucose-6-phosphate dehydrogenase  
Novel conjugated enzyme compositions are provided for use in homogeneous enzyme immunoassays. A wide variety of haptenic compounds, particularly drugs of abuse, and drugs used in repetitive...
3875001 Fermentative production of L-histidine  
Mutant strains of Brevibacterium flavum, Brevibacterium lactofermentum, and Corynebacterium acetoacidophilum which resist 2-thiazole alanine and require arginine, methionine, tryptophan, leucine,...
3867259 LACTATE DEHYDROGENASE TEST MATERIAL  
A diagnostic test indicator for the determination of the concentration of lactate dehydrogenase in sera comprising a bibulous material which has contained therein the dried residue resulting from...
3862009 DETERMINATION OF TRIGLYCERIDES  
Triglycerides are determined by enzymatic saponification with lipase and measurement of the liberated glycerol by carrying out the saponification in the presence of carboxylesterase and an alkali...
3862012 QUANTITATIVE DETERMINATION OF URIC ACID  
Uric acid is determined by contacting a sample suspected of containing uric acid with a phosphate buffer, an NADH solution, ethanol, alcohol dehydrogenase and catalase in the presence of air to...
3862010 METHOD OF HEAT FRACTIONATING LDH INTO ISOENZYME COMPONENTS  
A method of effectively heat fractionating lactic acid dehydrogenase-containing samples into their isoenzyme components to determine abnormal LDH activity for diagnostic purposes is disclosed...
3819488 DIAGNOSTIC COMPOSITIONS FOR GLUTAMIC OXALIC TRANSAMINASE (GOT) AND GLUTAMIC PYRUVIC TRANSAMINASE (GPT) DETERMINATIONS  
Stable, lyophilized diagnostic compositions are disclosed effective in determining glutamic oxalic transaminase (GOT) and glutamic pyruvic transaminase (GPT) comprising malate dehydrogenase (for...
3819487 STABLE NADH COMPOSITIONS  
Storage stable reduced nicotinamide-adenine-dinucleotide (NADH) compositions, which do not form dehydrogenase inhibitors of prolonged time periods, are produced by forming a dilute aqueous...
3791933 RAPID METHODS FOR ASSAY OF ENZYME SUBSTRATES AND METABOLITES  
Method and apparatus for quantitating the amounts of enzyme substrates and metabolites present in biological fluids using spot test techniques. The tests utilize both fixed, preselected color...
3791931 REAGENT AND METHOD FOR DETERMINATION OF LACTATE DEHYDROGENASE  
Lactate dehydrogenase is quickly and reliably determined by means of a color test by contacting the test composition with the reagent comprising serum albumin, pig's heart diaphorase and...
3732147 COLORIMETRIC DETERMINATION OF DEHYDROGENASES  
Test composition and method for assaying dehydrogenase enzymes in test fluids which comprises contacting the fluid with a test reagent comprising a coenzyme, a substrate for the dehydrogenase...
3663374 METHOD AND APPARATUS FOR QUANTITATING ENZYME ACTIVITY  
Method and apparatus for quantitating enzyme activity in blood and other fluids, using a spot test technique. The test utilizes enzyme standards freeze-dried in absorbent discs held under a...
3655516 UREA ASSAY PROCESS AND COMPOSITION  
Assay of urea is provided by spectrophotometric measurement of a test solution containing the urea to be assayed together with ATP: urea amido-lyase and adenosine triphosphate as co-substrate for...
3627645 METHOD AND REAGENTS FOR THE DETERMINATION OF NICOTINE ADENINE DINUCLEOTIDE PHOSPHATE AND OF GLUTATHIONE  
The level of nicotine adenine dinucleotide phosphate (NADP) or of glutathione in a given sample is determined spectrophotometrically to extremely low levels, the method employed in testing for...
3616257 REAGENT FOR ASSAYING THYROMIMETRIC COMPOUNDS  
Thyromimetric compounds are assayed by determining the decrease in conversion of inosine-5'-monophosphate to xanthine-5'-phosphate by inosine-5'-monophosphate dehydrogenase. The rate of conversion...
3551296 REAGENT AND METHOD FOR ASSAYING MALATE DEHYDROGENASE  
3539453 REAGENT AND METHOD FOR ASSAYING LACTATE DEHYDROGENASE  
3528888 REAGENT AND METHOD FOR ASSAYING ALPHA-HYDROXYBUTYRATE DEHYDROGENASE  
3527331 REAGENT FOR ASSAYING ALDOLASE  
3527674 REAGENT MATERIAL AND METHOD FOR UREA ASSAY  
3509026 METHOD OF AND APPARATUS FOR INDICATING THE SENSITIVITY OF MICROORGANISMS TO ANTIBIOTICS  
3509025 METHOD AND AGENT FOR THE ENZYMATIC DETERMINATION OF GLUCOSE  
3506544 METHOD OF DETERMINING MICROBIAL POPULATIONS,ENZYME ACTIVITIES,AND SUBSTRATE CONCENTRATIONS BY ELECTROCHEMICAL ANALYSIS  
3493467 REVERSIBLE BIOCHEMICAL REACTION EMPLOYING A TRAPPING AGENT  
3493466 METHOD AND PREPARATION FOR CLINICAL DIAGNOSIS  
3490874 COLORIMETRIC METHOD FOR THE QUANTITATIVE DETERMINATION OF OXALACETIC ACID  
3490875 PHOTOELECTRIC MEASURING SYSTEM INCLUDING TWO CONTROLLED RADIATION ATTENUATORS  
3783105 APPARATUS FOR ASSAYING ENZYME ACTIVITY  
3728226 BLOOD SERUM ANALYTICAL CONTROL STANDARD