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7611840 |
Method and device for the treatment of biological samples
A device for sample tissue disruption and/or cell lysis comprising: a piezoelectric material; and at least a second material in contact with the piezoelectric material; and wherein the second...
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7598064 |
Microfluidic device comprising electrolysis device for cell lysis and method for electrochemically lysing cells using the same
Provided are a microfluidic device including an electrolysis device for cell lysis which includes an anode chamber, a cathode chamber and a separator, in which the separator is installed between...
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7585617 |
Method and device for thermal conditioning of a cell
The invention relates to methods and agents for thermal conditioning of a biological cell, methods and uses of said agents for releasing and insulating ingredients outside the biological cell, and...
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7569346 |
Method for separating analyte from a sample
An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an...
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7560228 |
Solid-phase nucleic acid isolation
The present invention provides a method of isolating nucleic acid from a sample of cells, said method comprising: (a) binding cells in said sample in a solid support to isolate cells from the...
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7553647 |
Microfluidic differential extraction cartridge
A differential extraction system is directed to a microfluidic-based integrated cartridge to automate differential extraction of specific cell types within a mixed sample. The integrated cartridge...
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7544493 |
Method for the purification of an N-terminal fragment of hepatocyte growth factor
A method for the production of the N-terminal four kringle-containing fragment of hepatocyte growth factor (NK4) by expression of a nucleic acid encoding said NK4 in a microbial host cell,...
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7541039 |
Immunization with bacterial ghost-based vaccines
Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain,...
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7541166 |
Sonication to selectively lyse different cell types
A sonication apparatus is directed to a microfluidic-based system to automate differential extraction of specific cell types within a mixed sample. The microfluidic-based system includes a...
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7531308 |
Process for the reduction of endotoxins in a plasmid preparation using a carbohydrate non-ionic detergent with silica chromatography
The present invention provides methods for the reduction of endotoxins in a plasmid preparation using a carbohydrate non-ionic detergent with silica chromatography.
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7527734 |
Rapid non-equilibrium decompression of microorganism-containing waste streams
A process for treating a microorganism-containing stream includes the steps of passing the stream through a chamber, pressurizing the stream in the chamber to a pressure greater than 14.7 p.s.i.g.,...
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7494771 |
Universal method and composition for the rapid lysis of cells for the release of nucleic acids and their detection
This invention describes a rapid (10 to 15 minutes), simple, flexible and efficient method of nucleic acids extraction for nucleic acid testing assays. This method has the following basic steps: i)...
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7488596 |
Microfluidic device comprising electrolysis device for cell lysis and method for electrochemically lysing cells using the same
Provided are a microfluidic device including an electrolysis device for cell lysis which includes an anode chamber, a cathode chamber and a separator, in which the separator is installed between...
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7425439 |
Method for dissociation of cells
Disclosed is a method for the dissociation of cells. Cells are processed under conditions of pH, temperature, and shear to thereby yield a mixture of cell wall ghosts and cytoplasm. Preferably, the...
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7422868 |
Microbial ATP extraction and detection system
The present invention is directed to compositions and methods for single-step extraction and detection of ATP levels from microbial cells. The disclosed compositions are formulated to efficiently...
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7238522 |
Devices and methods for biomaterial production
An apparatus and a method for isolating a biologic product, such as plasmid DNA, from cells. The method involves lysing cells in a controlled manner separate insoluble components from a fluid...
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7129344 |
Nucleic acid isolation
A method for isolating plasmids DNA from a DNA containing material which comprises plasmid DNA and genomic DNA, comprising extracting the plasmid DNA into a water-immiscible organic solvent, a...
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7078061 |
Methods, compositions and kits for biomarker extraction
The present invention is directed to methods for extracting markers from biological samples, and to systems, devices, kits and reagents for use in such methods. The invention is also to methods,...
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7067639 |
Method to provide bacterial ghosts provided with antigens
Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain,...
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6987002 |
Composition for detecting β-1,3-glucan
The present invention relates to a composition for detecting an infinitesimal quantity of β-1,3-glucan, a preparation method thereof and a diagnostic kit detecting β-1,3-glucan. The composition...
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6951746 |
Method of manufacturing polyamine composition
After yeast somatic components are digested with nuclease or hydrolyzed with alkali, polyamine is recovered to obtain a polyamine composition in volume efficiently at a high recovery rate from...
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6942169 |
Micromachined lysing device and method for performing cell lysis
A method and device for performing lysing on a cell-containing fluid, in which the fluid flows through a vibrating micromachined tube to physically rupture the cell walls (mechanical lysis), and/or...
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6939696 |
Cell disruption method using sonication
The present invention relates to a method for disrupting cells by subjecting the cells to ultrasonic energy in the absence of beads. The present invention also relates to the enhancement of cell...
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6881541 |
Method for analyzing a fluid sample
A method for extracting nucleic acid from a fluid sample comprises the steps of introducing the sample into a cartridge having a sample flow path and a lysing chamber in the sample flow path. The...
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6872399 |
Dermatomycosis vaccine
The present invention relates to the preparation of universal inactivated vaccines and their use in preparing compositions for the prophylaxis and therapy of dermatomycosis. Vaccines according to...
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6861230 |
Antibiotic sensitivity testing
The use of an assay for adenylate kinase in an in vitro test for the effect of external conditions on the growth characteristics of bacterial cells. Such tests in particular include tests for the...
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6833251 |
Bacteria detection using immobilized enzyme substrates
Methods of detecting bacteria including the use of an immobilized enzyme substrate are provided.
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6800476 |
Regulated expression of PKC and/or SRB1/psa1 in yeast
The present invention relates to yeast cells containing the SRB1/PSA1 gene and/or the PKC1 gene or functional derivatives thereof operatively linked to a heterologous inducible promoter and also to...
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6780612 |
Methods for the propagation of lytic organisms
The present invention provides a method for the propagation of lytic organisms which comprises the infection of the cells of a stable cell line within a hollow fibre bioreactor with a lytic...
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6759230 |
Microbe, microbial exopolysaccharide, and uses thereof
A novel microorganism producing a nontoxic, non-antigenic exopolysaccharide is taught. The exopolysaccharide has neutral sugars migrating at the same rate as mannose, fucose, fructose and...
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6730781 |
Purification of plasmid DNA of pharmaceutical quality
The invention is directed to a process for purifying double-stranded DNA, comprising using ceramic hydroxyapatite column chromatography. The invention is also directed to a purified recombinant...
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6722062 |
Capsular polysaccharides from enterococci
The present invention is directed to a method for purifying polysaccharides capable of inducing the production of high titers of opsonic antibodies that kill strains of enterococcal bacteria. In...
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6706498 |
Method for isolating DNA
The invention describes a method for the isolation of components from samples, particularly large molecular weight DNA from biological samples. The method involves the application of controlled...
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6699711 |
Device and method for selective exposure of a biological sample to sound waves
A device and method are disclosed for selective exposure of a biological sample, preferably biological cell material, to sound waves. The device is provided with a receptacle for the sample, in...
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6699706 |
Cell lysis method using a vortex mixer
Cell lysis may be brought about by contacting a suspension of cells with a lysis reagent such as sodium hydroxide solution; subsequent treatment enables organic molecules such as plasmid DNA to be...
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6673349 |
Method of inactivating microorganisms
This invention provides methods of inactivating a microorganism and preparing a vaccine including the step of applying to said microorganism a cross-linking agent simultaneously with a separate...
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6664078 |
Method for the isolation of ccc plasmid DNA
The present invention relates to the production of biomass for the isolation of ccc plasmid DNA comprising culturing a bacterial transformant in a bioreactor containing an antibiotic-free batch...
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6664094 |
Neisserial vaccine free of immunologically functional PIII or class 4 proteins
This invention relates to mutants of Neisseria useful for vaccine preparation. Specifically this invention relates to mutants of Neisseria containing mutations in a major outer membrane protein...
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6660489 |
ATP extraction method
A method for extracting ATP from a biological sample is disclosed. The method involves introducing a cationic extractant and an anionic substance and then extracting ATP. The method may be used to...
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6632662 |
Device and method for the lysis of micro-organisms
The invention concerns a device for lysis ( 1 ) of micro-organism to release at least one intracellular biological constituent, comprising a container ( 2 ) wherein are present a biological sample,...
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6589785 |
Disrupting cells and/or tissue in solid state in presence of solid denaturing substance
A method for disrupting frozen cells and/or tissue in a solid, frozen state in the presence of a solid denaturing substance is provided. The method comprises providing frozen cells and/or tissue in...
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6465201 |
Method for rapidly detecting and enumerating microorganisms in mammalian cell preparations using ATP bioluminescence
A method for rapidly detecting and enumerating microorganisms, having a level of microbial ATP, in the presence of mammalian cell preparations, comprising the steps of: providing a mammalian cell...
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6455287 |
Mechanical disruption of bacterial cells for plasmid recovery
The recovery yields of intact plasmids from bacterial cells mechanically disrupted by various methods were measured. Bacterial cell disruption through bead milling and microfluidization were found...
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6448047 |
Sample processing to release nucleic acids for direct detection
The present invention describes compositions and methods for releasing nucleic acids from cells in a form that is suitable for labeling/capture, amplification, or detection in a single reagent...
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6444448 |
Production of β-glucan-mannan preparations by autolysis of cells under certain pH, temperature and time conditions
There is provided a method of production of an immunostimulatory β-glucan-mannan preparation, comprising the step of autolysis of cells of a microorganism at a pH of 5 to 6 and a temperature of 35...
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6423519 |
Compositions and methods for inhibiting fungal growth
The present invention relates to compositions and methods for inhibiting fungal growth. In particular, the present invention relates to methods for use as anti-fungal agents of inhibitors, and...
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6406880 |
Betaines as adjuvants to susceptibility testing and antimicrobial therapy
The present invention is related to methods and compositions for susceptibility testing of bacteria containing mycolic acid structures using betaine-like detergents, and inducing the susceptibility...
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6391541 |
Apparatus for analyzing a fluid sample
A cartridge for separating a desired analyte from a fluid sample has a sample flow path and a lysing chamber in the sample flow path. The lysing chamber contains at least one filter for capturing...
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6376245 |
Associations of antagonistic prokaryotes with eukaryotes
The invention provides a process for protecting whole eukaryotes or parts thereof from an invasive attack from an invasive agent which comprises, selecting a prokaryotic bacterium which is capable...
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6344349 |
Process and system for electrical extraction of intracellular matter from biological matter
A process and system for electrical extraction of intracellular matter from biological matter, and intracellular matter products formed thereby, based on preparing a mixture of biological matter...
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