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8168442 |
Cartridge for conducting a chemical reaction
A cartridge for conducting a chemical reaction includes a body having at least one flow path formed therein. The cartridge also includes a reaction vessel extending from the body for holding a...
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8158405 |
Process for concentrating and processing fluid samples
A method of treating a liquid sample having microbiological target species therein to concentrate the species and collect lysate is disclosed. The liquid sample comprises non-target microbiological...
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8043496 |
System for extracting oil from algae
A method and apparatus for extracting oil from algae comprises a disruptor (125) having a plurality of deflectors (220 and 225) against which a mixture of algae and water (100) is forcibly impacted...
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8003369 |
Bacteriolytic agent
The present invention is a bacteriolytic agent containing a cationic surfactant (A) of which a counteranion is an acid having a pKa (25° C.) of 0 to 10. As the counterion, a carboxylate anion is ...
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7919436 |
Sequences for differential diagnostic of Ehrlichia ruminantium and use thereof
The invention provides genes that are unique either to Ehrlichia ruminantium strain Gardel or to Ehrlichia ruminantium strain Welgevonden, or allelic couples which are present in both strains but...
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7914994 |
Method for separating an analyte from a sample
An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an...
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7892811 |
Controlled lysis of bacteria
The present invention relates to the simple, gentle, and efficient extraction of biological material from Escherichia coli (E. coli). The use of E. coli in research laboratories depends on the...
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7858357 |
Immunization with bacterial ghost-based vaccines
Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain,...
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7857957 |
Integrated portable biological detection system
We have performed separation of bacterial and cancer cells from peripheral human blood in microfabricated electronic chips by dielectrophoresis. The isolated cells were examined by staining the...
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7829323 |
Mixing devices for chemical lysis of cells
The invention relates to flow-through devices for mixing fluids and uses thereof for mixing and for lysing cells to release biological compounds of interest. The invention particularly encompasses...
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7745181 |
Process for producing yeast-derived glucan
It is an object of the invention to provide a process for easily producing a glucan, which assures a high degree of safety and which does not generate an oxidation off-flavor, without using a...
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7687039 |
Methods and systems for modulating acoustic energy delivery
The present invention provides systems, methods, and devices for using acoustic energy.
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7659063 |
High throughput assay system
The present invention relates to compositions, apparatus and methods useful for concurrently performing multiple, high throughput, biological or chemical assays, using repeated arrays of probes. A...
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7645593 |
Kit for enumerating mammalian cell micronuclei
The present invention relates a method for the enumeration of mammalian cell micronuclei, while distinguishing micronuclei from the chromatin of dead and dying cells. The method utilizes...
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7611840 |
Method and device for the treatment of biological samples
A device for sample tissue disruption and/or cell lysis comprising: a piezoelectric material; and at least a second material in contact with the piezoelectric material; and wherein the second...
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7585617 |
Method and device for thermal conditioning of a cell
The invention relates to methods and agents for thermal conditioning of a biological cell, methods and uses of said agents for releasing and insulating ingredients outside the biological cell, and...
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7569346 |
Method for separating analyte from a sample
An analyte is separated from a fluid sample by introducing the sample into a cartridge having a sample port and a first flow path extending from the sample port. The first flow path includes an...
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7560228 |
Solid-phase nucleic acid isolation
The present invention provides a method of isolating nucleic acid from a sample of cells, said method comprising: (a) binding cells in said sample in a solid support to isolate cells from the...
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7553647 |
Microfluidic differential extraction cartridge
A differential extraction system is directed to a microfluidic-based integrated cartridge to automate differential extraction of specific cell types within a mixed sample. The integrated cartridge...
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7544493 |
Method for the purification of an N-terminal fragment of hepatocyte growth factor
A method for the production of the N-terminal four kringle-containing fragment of hepatocyte growth factor (NK4) by expression of a nucleic acid encoding said NK4 in a microbial host cell,...
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7541166 |
Sonication to selectively lyse different cell types
A sonication apparatus is directed to a microfluidic-based system to automate differential extraction of specific cell types within a mixed sample. The microfluidic-based system includes a...
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7541039 |
Immunization with bacterial ghost-based vaccines
Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain,...
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7531308 |
Process for the reduction of endotoxins in a plasmid preparation using a carbohydrate non-ionic detergent with silica chromatography
The present invention provides methods for the reduction of endotoxins in a plasmid preparation using a carbohydrate non-ionic detergent with silica chromatography.
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7527734 |
Rapid non-equilibrium decompression of microorganism-containing waste streams
A process for treating a microorganism-containing stream includes the steps of passing the stream through a chamber, pressurizing the stream in the chamber to a pressure greater than 14.7 p.s.i.g.,...
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7494771 |
Universal method and composition for the rapid lysis of cells for the release of nucleic acids and their detection
This invention describes a rapid (10 to 15 minutes), simple, flexible and efficient method of nucleic acids extraction for nucleic acid testing assays. This method has the following basic steps: i)...
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7488596 |
Microfluidic device comprising electrolysis device for cell lysis and method for electrochemically lysing cells using the same
Provided are a microfluidic device including an electrolysis device for cell lysis which includes an anode chamber, a cathode chamber and a separator, in which the separator is installed between...
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7425439 |
Method for dissociation of cells
Disclosed is a method for the dissociation of cells. Cells are processed under conditions of pH, temperature, and shear to thereby yield a mixture of cell wall ghosts and cytoplasm. Preferably, the...
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7422868 |
Microbial ATP extraction and detection system
The present invention is directed to compositions and methods for single-step extraction and detection of ATP levels from microbial cells. The disclosed compositions are formulated to efficiently...
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7238522 |
Devices and methods for biomaterial production
An apparatus and a method for isolating a biologic product, such as plasmid DNA, from cells. The method involves lysing cells in a controlled manner separate insoluble components from a fluid...
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7129344 |
Nucleic acid isolation
A method for isolating plasmids DNA from a DNA containing material which comprises plasmid DNA and genomic DNA, comprising extracting the plasmid DNA into a water-immiscible organic solvent, a...
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7078061 |
Methods, compositions and kits for biomarker extraction
The present invention is directed to methods for extracting markers from biological samples, and to systems, devices, kits and reagents for use in such methods. The invention is also to methods,...
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7067639 |
Method to provide bacterial ghosts provided with antigens
Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain,...
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6987002 |
Composition for detecting β-1,3-glucan
The present invention relates to a composition for detecting an infinitesimal quantity of β-1,3-glucan, a preparation method thereof and a diagnostic kit detecting β-1,3-glucan. The composition o...
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6951746 |
Method of manufacturing polyamine composition
After yeast somatic components are digested with nuclease or hydrolyzed with alkali, polyamine is recovered to obtain a polyamine composition in volume efficiently at a high recovery rate from...
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6942169 |
Micromachined lysing device and method for performing cell lysis
A method and device for performing lysing on a cell-containing fluid, in which the fluid flows through a vibrating micromachined tube to physically rupture the cell walls (mechanical lysis), and/or...
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6939696 |
Cell disruption method using sonication
The present invention relates to a method for disrupting cells by subjecting the cells to ultrasonic energy in the absence of beads. The present invention also relates to the enhancement of cell...
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6881541 |
Method for analyzing a fluid sample
A method for extracting nucleic acid from a fluid sample comprises the steps of introducing the sample into a cartridge having a sample flow path and a lysing chamber in the sample flow path. The...
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6872399 |
Dermatomycosis vaccine
The present invention relates to the preparation of universal inactivated vaccines and their use in preparing compositions for the prophylaxis and therapy of dermatomycosis. Vaccines according to...
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6861230 |
Antibiotic sensitivity testing
The use of an assay for adenylate kinase in an in vitro test for the effect of external conditions on the growth characteristics of bacterial cells. Such tests in particular include tests for the...
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6833251 |
Bacteria detection using immobilized enzyme substrates
Methods of detecting bacteria including the use of an immobilized enzyme substrate are provided.
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6800476 |
Regulated expression of PKC and/or SRB1/psa1 in yeast
The present invention relates to yeast cells containing the SRB1/PSA1 gene and/or the PKC1 gene or functional derivatives thereof operatively linked to a heterologous inducible promoter and also to...
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6780612 |
Methods for the propagation of lytic organisms
The present invention provides a method for the propagation of lytic organisms which comprises the infection of the cells of a stable cell line within a hollow fibre bioreactor with a lytic...
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6759230 |
Microbe, microbial exopolysaccharide, and uses thereof
A novel microorganism producing a nontoxic, non-antigenic exopolysaccharide is taught. The exopolysaccharide has neutral sugars migrating at the same rate as mannose, fucose, fructose and...
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6730781 |
Purification of plasmid DNA of pharmaceutical quality
The invention is directed to a process for purifying double-stranded DNA, comprising using ceramic hydroxyapatite column chromatography. The invention is also directed to a purified recombinant...
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6722062 |
Capsular polysaccharides from enterococci
The present invention is directed to a method for purifying polysaccharides capable of inducing the production of high titers of opsonic antibodies that kill strains of enterococcal bacteria. In...
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6706498 |
Method for isolating DNA
The invention describes a method for the isolation of components from samples, particularly large molecular weight DNA from biological samples. The method involves the application of controlled...
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6699711 |
Device and method for selective exposure of a biological sample to sound waves
A device and method are disclosed for selective exposure of a biological sample, preferably biological cell material, to sound waves. The device is provided with a receptacle for the sample, in...
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6699706 |
Cell lysis method using a vortex mixer
Cell lysis may be brought about by contacting a suspension of cells with a lysis reagent such as sodium hydroxide solution; subsequent treatment enables organic molecules such as plasmid DNA to be...
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6673349 |
Method of inactivating microorganisms
This invention provides methods of inactivating a microorganism and preparing a vaccine including the step of applying to said microorganism a cross-linking agent simultaneously with a separate...
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6664078 |
Method for the isolation of ccc plasmid DNA
The present invention relates to the production of biomass for the isolation of ccc plasmid DNA comprising culturing a bacterial transformant in a bioreactor containing an antibiotic-free batch...
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