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7279309 |
Process for manufacture of Nematode-extracted Anticoagulant Protein (NAP)
The present invention provides a process for manufacture of purified Nematode-extracted Anticoagulant Proteins (NAPs), wherein the NAP manufactured by the claimed process method is a NAP drug...
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7259007 |
Methods for eliminating mannosylphosphorylation of glycans in the production of glycoproteins
The present invention relates to the elimination of mannosylphosphorylation on the glycans of glycoproteins in the yeast genus Pichia . The elimination of mannosylphosphorylated glycoproteins...
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7252985 |
Carotenoid ketolases
Novel CrtW carotenoid ketolase are provided that are useful for the production of ketocarotenoids. The ketolases genes of the present invention exhibit low homology in comparison to other CrtW...
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7229789 |
Methods and compositions for extracting proteins from cells
A process is disclosed for releasing proteins from cells and/or inactivating viruses. In the process, a host cell containing a protein of interest is contacted with a solution of an effective...
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7109005 |
Process for the simultaneous production of xylitol and ethanol
Effective processes are provided for the production of xylitol and ethanol and other products from solutions derived from lignocellulose-containing material in biomass. The solutions can be...
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7078191 |
Composition and method for the detection of diseases associated with amyloid-like fibril or protein aggregate formation
The present invention relates to novel compositions useful for elucidating the onset or progress of diseases such as Huntington's disease, that are associated with the formation of fibrils or...
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7067298 |
Compositions and methods of using a synthetic Dnase I
Compositions and method for making and using a synthetic bovine DNase I are disclosed. More particularly, the sbDNase I of the present invention is a versatile enzyme that cleaves DNA...
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7029873 |
Nucleic acids to PRO1387 polypeptides
The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid...
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7009045 |
Transformation systems for flavinogenic yeast
This invention is directed to the transformation of the flavinogenic yeasts, Pichia guilliermondii and Candida famata , and mutants thereof, by electroporation (electrotransformation) and by...
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6987005 |
DNA encoding SNORF33 receptor
This invention provides isolated nucleic acids encoding mammalian SNORF33 receptors, purified mammalian SNORF33 receptors, vectors comprising nucleic acid encoding mammalian SNORF33 receptors,...
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6984726 |
Recombinant major allergen of the pollen of Artemisia vulgaris (mugwort)
The invention relates to DNA molecules which code for the allergen Art v 1 or isoforms thereof, the sequence of the allergen, a method for the production of an Art v 1 molecule, a vector and a...
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6902912 |
Process for producing glutathione
There is disclosed a fermentation process for producing glutathione which comprises (a) the obtainment of a biomass pre-culture by pre-cultivating, in aerobic conditions, a strain of a glutathione...
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6884602 |
Expression of alkaline phosphatase in yeast
This invention involves a process for selecting and producing eukaryotic alkaline phosphatase in yeast. Yeast cells are subjected to multiple transformations using a vector comprising a first...
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6846657 |
Process for the simultaneous production of xylitol and ethanol
The invention relates to a process for the simultaneous production of xylitol and ethanol from a hydrolyzed lignocellulose-containing material starting. The starting material is fermented with a...
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6821752 |
Methods and compositions for extracting proteins from cells
The present invention relates to a process of releasing a protein, recombinant or otherwise, from a cell. The process of the present invention involves contacting a host cell containing a protein...
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6734164 |
Process for the stabilization of proteins in complex mixtures during their storage in aqueous solvents
The present invention relates to a process for the storage of proteins in an aqueous solution. The addition of cysteine delays the temporal decrease in the effective concentration of the protein....
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6730499 |
Promoter for the Pichia pastoris formaldehyde dehydrogenase gene FLD1
The present invention provides formaldehyde dehydrogenase genes (FLD) from methylotrophic yeasts. The FLD structural genes confer resistance to formaldehyde and are therefore useful as a selectable...
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6699691 |
Alcohol oxidase 1 regulatory nucleotide sequences for heterologous gene expression in yeast
Polynucleotides that comprise regulatory regions of the yeast alcohol oxidase 1 promoter are provided. Isolated polynucleotides, recombinant polynucleotides, vectors, expression cassettes and...
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6692735 |
Variant of C6 β-chemokine leukotactin-1(shLkn-1) with enhanced biological activity
The present invention relates to a variant of Lkn-1(shLkn-1) with enhanced biological activity, which is a truncated form of Lkn-1, a process for preparing a recombinant shLkn-1 by employing...
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6638735 |
Plasmid for gene expression in pichia ciferrii and transformation method using the same
Expression cassettes for transforming Pichia ciferrii and their use are disclosed. The present invention relates to expression cassettes containing Pichia ciferrii ribosomal DNA fragment, CYH r...
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6500425 |
Inhibiting plant pathogens with an antagonistic microorganism(s)
The present invention is drawn to biological control of plant pathogens (e.g. either preharvest or postharvest diseases) on agricultural commodities (such as fruits, vegetables, cereals, grains,...
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6498029 |
Pentose fermentation of normally toxic lignocellulose prehydrolysate with strain of Pichia stipitis yeast using air
Strains of the yeast Pichia stipitis NPw9 (ATCC PTA-3717) useful for the production of ethanol using oxygen for growth while fermenting normally toxic lignocellulosic prehydrolysates.
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6489147 |
Gene for adenylate cyclase and its use
A gene which contains the nucleotide sequence shown in SEQ ID NO:1 from nucleotide 671 to nucleotide 6295 or a nucleotide sequence which can be obtained therefrom by substitution, insertion or...
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6423310 |
Biological coating with a protective and curative effect for the control of postharvest decay
Novel methods and compositions are provided for the biocontrol of plant diseases by use of a biological coating that confers both a protective and a curative effect for the control of postharvest...
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6342375 |
Modified methylotrophic Pichia pastoris yeast which secretes human growth hormone
In the present system an adequate expression system for the production and secretion of biologically active human growth hormone (HGH) in its natural form in which a methylotrophic yeast such as ...
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6316245 |
Mutant cells of Pichia
The present invention relates to a fermentation process to have a high productivity with a novel mutant of Pichia sp., more specifically, for preparing erythritol under optimal fermentation...
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6204012 |
Protein production process
A method for producing a protein by culturing a cell capable of expressing the protein and which contains a methylotrophic yeast promoter for an enzyme of the methanol metabolic pathway controlling...
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6204006 |
Microbial strains producing sphingolipid bases
Microbial strains capable of producing enhanced levels of sphingosine, dihydrosphingosine, phytosphingosine and/or derivatives thereof are disclosed. Additionally, there are disclosed methods based...
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6194169 |
Enhanced expression of human platelet-derived growth factor in Pichia pastoris
Enhanced yields of the platelet-derived growth factor (PDGF) B-chain are obtained using the Pichia pastoris yeast system. Yields of both wild-type and mutant human proteins are enhanced when the...
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6184018 |
β-glucosidase coding sequences and protein from orpinomyces PC-2
Provided is a novel β-glucosidase from Orpinomyces sp. PC2, nucleotide sequences encoding the mature protein and the precursor protein, and methods for recombinant production of this β-glucosidase.
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6171828 |
Method for culturing microorganisms having a methanol metabolic pathway
The present invention discloses a method for culturing microorganisms having a methanol metabolic pathway in which an expression unit is introduced that comprises a target gene linked downstream...
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6121034 |
Coniothyrium minitans xylanase gene Cxy1
The nucleotide sequence of a novel xylanase gene obtained from the soilborne fungus Coniothyrium minitans, and denoted cxy1, is provided. The amino acid sequence of the encoded xylanase enzyme,...
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6107057 |
Pichia secretory leader for protein expression
Polynucleotides, vectors, and host cells comprising a polynucleotide having a fragment of a leader sequence and a second nucleotide sequence that encodes a polypeptide heterologous to the leader...
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6066469 |
Cloning, expression, and uses of human lactoferrin
Disclosed is human lactoferrin expressed using recombinant DNA, its method of production and purification.
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6051419 |
Genes which influence pichia proteolytic activity, and uses therefor
The isolation and characterization of genes involved in proteolytic processing in species of the genus Pichia is described. The availability of such genes has enabled the generation of strains of...
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6037149 |
DNA encoding human asthma associated factor 1
A C to T DNA variation at position 3365 in exon 5 of the human Asthma Associated Factor 1 (AAF1) produces the predicted amino acid substitution of a methionine for a threonine at codon 117 of AAF1....
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6001616 |
Process for preparing erythritol using novel cell of pichia
The present invention relates to a fermentation process to have a high productivity with a novel mutant of Pichia sp., more specifically, for preparing erythritol under optimal fermentation...
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5821038 |
Yeast with modified permeability
The present invention relates to a modified yeast wherein at least two of the genes controlling the cellular permeability of said yeast are modified, said modifications having an additive or...
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5756313 |
Albumin gene-containing plasmid, transformant carrying same, production of such transformant and production of albumin
A plasmid for a yeast host, the plasmid comprising in sequence: (1) a yeast derived promoter, (2) an albumin-encoding region placed under control of the yeast-derived promoter, (3) a transcription...
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5736383 |
Preparation of Pichia methanolica auxotrophic mutants
Methods for preparing Pichia methanolica cells having auxotrophic mutations are disclosed. The methods comprise the steps of (a) exposing P. methanolica cells to mutagenizing conditions, (b)...
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5707828 |
Expression of human serum albumin in Pichia pastoris
The present invention is directed to expression cassettes comprising a 5' regulatory region from at least one of the Pichia pastoris AOXI gene, p40 gene, DASI gene or HIS4 gene, operably linked to...
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5618706 |
Preparation of phytosphingosine derivative
The invention concerns a process for preparing tetraacetylphytospingosine (TAPS) using F-60-10 mating type strain of Pichia ciferrii. Such strain is subjected to mutagenesis and the high TAPS...
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5612198 |
Production of insulin-like growth factor-1 in methylotrophic yeast cells
Insulin-like growth factor-1 (IGF-1), a naturally occurring, relatively short, single chain polypeptide, is prepared by growing methylotrophic yeast transformants containing in their genome at...
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5580764 |
Process for microbial reduction producing 4(S)-hydroxy-6(S)methyl-thienopyran derivatives
A compound of formula ##STR1## in which X is hydrogen or a group of formula --SO 2 NH 2 is reduced to the trans (4S,6S) form of the corresponding alcohol by an enzyme reduction system.
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5238826 |
Process for manufacturing xylose
Process for manufacture of D-xylose characterized by the fact that: in a first step, syrup of D-xylulose is subjected to an enzymatic isomerization in M 3 providing a mixture of D-xylose and...
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5204261 |
Catalase-negative Pichia pastoris
A novel strain of P. pastoris and an alcohol oxidase free of catalase activity produced therefrom is provided.
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5041384 |
Pichia guilliermondii (Anamorph Candida guilliermondii) useful for the biological control of postharvest rots in fruits
The present invention is drawn to processes for biologically controlling postharvest disease in fruit using isolates of Pichia guilliermondii having the identifying characteristics of NRRL Y-18313,...
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4808537 |
Methanol inducible genes obtained from pichia and methods of use
A method for isolating and cloning methanol inducible genes from Pichia is taught. The regulatory regions are useful for the methanol regulated expression of heterologous genes.
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4795709 |
Solvent-induced autolysis of cells
A process to recover proteins, such as enzymes, from yeast cells, which comprises forming an admixture of yeast cells, water, and a minor effective amount of a polychloro aliphatic hydrocarbon, at...
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4707449 |
Pichia pastoris yeast strains of enhanced tryptophan content
Mutant Pichia pastoris yeasts which produce relatively high levels of tryptophan. These high tryptophan capability Pichia pastoris mutants, grown on such as methanol or glucose, produce improved...
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