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7595183 |
Cathepsins L-like cysteine protease derived from northern shrimp (Pandalus eous)
The object of the present invention is to find and produce cathepsin L having high activity under neutral to alkaline conditions and at a low temperature range. The present inventors succeeded in...
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7544795 |
Recombinant hexose oxidase, a method of producing same and use of such enzyme
A method of producing hexose oxidase by recombinant DNA technology, recombinant hexose oxidase and the use of such enzyme, in particular in the manufacturing of food products such as doughs and...
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7507573 |
Modification of protein glycosylation in methylotrophic yeast
The present invention relates to methods and genetically engineered methylotrophic yeast strains for producing glycoproteins with mammalian-like glycosylation. The present invention also relates to...
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7501275 |
Yeast transformation system
Disclosed are methods for obtaining expression of polypeptides in organisms employing alternative codon systems, and polynucleotides for use therein.
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7479389 |
ARG1, ARG2, ARG3, HIS1, HIS2, HIS5, HIS6 genes and methods for stable genetic integration
Novel genes encoding P. pastoris ARG1, ARG2, ARG3, HIS1, HIS2, HIS5 and HIS6 are disclosed. A method for inactivating alternately at least two biosynthetic pathways in a methylotrophic yeast is...
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7479386 |
HXHV virus, nucleic material, peptide material and uses
Isolated HXHV virus having the following characteristics:
(i) a DNA genome which is at least partially single-stranded, (ii) the said genome comprises one reading frame (ORF) encoding one...
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7476726 |
Method of producing and purifying endostatin protein
The present invention provides a method for recombinant production, recovery and purification of endostatin protein. This method may be employed for large scale recovery and purification of...
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7465577 |
Methods for reducing or eliminating α-mannosidase resistant glycans for the production of glycoproteins
The present invention provides methods to reduce or eliminate α-mannosidase resistant glycans on glycoproteins in yeast. The reduction or elimination of α-mannosidase resistant glycans on...
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7429469 |
Enzyme gene participating in the synthesis of polyester and process for producing polyester using the same
This invention relates to a method of producing polyesters resulting from homopolymerization or copolymerization of a 3-hydroxyalkanoic acid(s) and having biodegradability and good physical...
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7422873 |
Mutant carotenoid ketolase
CrtW carotenoid ketolases are provided useful for the production of astaxanthin. The ketolases genes of the present invention exhibit improved ketolase activity when converting cyclic hydroxylated...
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7393671 |
Mutant carotenoid ketolases
CrtW carotenoid ketolases are provided that are useful for the production of astaxanthin and other cyclic ketocarotenoids. The mutant ketolase genes of the present invention encode polypeptides...
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7393667 |
Stereoselective reduction process for the preparation of pyrrolotriazine compounds
The invention relates to a process for the enzymatic, stereoselective reduction of ketone compounds to provide chiral alcohols, for example the compound of formula Ib:
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7368274 |
Expression of recombinant proteinase K from Tritirachium album in yeast
The invention concerns a method for the expression of a gene coding for a soluble proteinase K in yeast e.g. in Pichia pastoris with subsequent secretion into the culture medium. In addition a...
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7335501 |
Phytases and methods for producing these phytases
The present invention relates to novel phytases, in particular, of fungal origin, and also to their respective methods of production. The present invention relates more particularly to novel...
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7312063 |
Overexpression of phytase genes in yeast systems
The present invention relates to a method of producing a heterologous protein or polypeptide having phytase activity in a yeast system. The invention also provides proteins having phytase activity...
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7291493 |
Microbially expressed xylanases and their use as feed additives and other uses
The present invention relates to codon-optimized xylanase coding sequences and the expression of xylanases in microbes and yeast. The invention further relates to using multiple copies of the...
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7259007 |
Methods for eliminating mannosylphosphorylation of glycans in the production of glycoproteins
The present invention relates to the elimination of mannosylphosphorylation on the glycans of glycoproteins in the yeast genus Pichia . The elimination of mannosylphosphorylated glycoproteins...
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7256034 |
Inhibitor of cell proliferation and methods of use thereof
An chimerical polypeptide that arrests proliferating cells in mitosis is provided. In general the polypeptide has an N-terminal transit peptide, such as HIV-1 Tat, and a C-terminal cell-cycle...
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7252933 |
Protein glycosylation modification in methylotrophic yeast
The present invention provides genetically engineered strains of methylotrophic yeast including Pichia and especially Pichia pastoris capable of producing proteins with reduced or modified...
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7250502 |
Formaldehyde dehydrogenase genes from methylotrophic yeasts
The present invention provides formaldehyde dehydrogenase genes (FLD) from methylotrophic yeasts. The FLD structural genes confer resistance to formaldehyde and are therefore useful as a selectable...
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7244833 |
Recombinant human albumin fusion proteins with long-lasting biological effects
Compositions, kits and methods are provided for promoting general health or for prevention or treatment of diseases by using novel recombinant fusion proteins of human serum albumin (HSA) and...
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7202072 |
Production of weakly active or inactive mutants of alkaline phosphatase and their expression in yeast
The invention concerns a method for the recombinant production or expression of eukaryotic alkaline phosphatase mutants in yeast cells wherein the specifically introduced mutations result in a...
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7198921 |
Process for producing protein with reduction of acidic sugar chain and glycoprotein produced thereby
The present invention intends to find out a gene participating in addition of mannose phosphate to a sugar chain of a glycoprotein originating in a yeast belonging to the genus Pichia and provide...
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7195903 |
Methods for the treatment of thrombosis
A fibrinolytically active metalloproteinase polypeptide (called “novel acting thrombolytic”) which is useful for blood clot lysis in vivo and methods and materials for its production by...
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7135323 |
Microbially expressed thermotolerant phytase for animal feed
The invention provides methods for making and using thermotolerant phytases, e.g., a method of using a thermotolerant phytase in feed and food processing and feed or food products comprising a...
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7091032 |
Expression of a human insulin precursor in P. pastoris
Methylotrophic recombinant yeast strain producing human insulin precursor, the strain comprising, in its genome, a copy of a first DNA construction and a second DNA construction, wherein the...
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7091031 |
Carotenoid hydroxylase enzymes
A novel CrtZ carotenoid hydroxylase, isolated from Brevundimonas vesicularis DC263, is provided that is useful for the production of hydroxylated carotenoids. Additionally, a previously...
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7070952 |
Genes encoding carotenoid compounds
Genes have been isolated from Pectobacterium cypripedii encoding geranylgeranyl pyrophosphate (GGPP) synthase (CrtE), phytoene synthase (CrtB), phytoene desaturase (Crtl), lycopene cyclase...
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7070970 |
Elongase genes and uses thereof
The subject invention relates to the identification of four genes involved in the elongation of polyunsaturated acids (i.e., “elongases”) and to uses thereof. Two of these genes are also...
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7067300 |
Process for the biological production of 1,3-propanediol with high titer
The present invention provides an improved method for the biological production of 1,3-propanediol from a fermentable carbon source in a single microorganism. In one aspect of the present...
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7060810 |
Regulation of human eosinophil serine protease 1-like enzyme
A human eosinophil serine protease 1-like enzyme, cDNA, and reagents that regulate the enzyme can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not...
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7033788 |
Protein derived from Agkistrodon saxatilis emelianov and process preparing the same
The present invention relates to Saxatilin, a protein derived from the venom of a Korean snake, Agkistrodon saxatilis emelianov , a process for preparing Saxatilin, and pharmaceutical application...
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7018829 |
Metabolically engineered microbial cell with an altered metabolite production
A recombinant microbial cell comprises at least one increased expressible enzyme activity controlling anabolic metabolism of ammonia as a nutrient source, the increased enzyme activity being an...
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6998260 |
Recombinant proteolytic tryptases, active site mutants thereof, and methods of making same
Disclosed is a method of expressing enzymatically-active, recombinant proteolytic tryptase in a eukaryotic host cell, expression constructs which drive the production of enzymatically-active...
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6962795 |
Neutrophil inhibitors
Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Also provided are recombinant Neutrophil...
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6929928 |
Genes encoding carotenoid compounds
A unique carotenogenic biosynthetic gene cluster has been isolated from Panteoa agglomerans strain DC404, wherein the genetic organization of the cluster is crtE-idi-crtY-crtI-crtB-crtZ. The...
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6908992 |
Methanotrophic carbon metabolism pathway genes and enzymes
Genes have been isolated from a Methylomonas sp encoding enzymes in the carbon flux pathway. The genes encode a 2-keto-3-deoxy-6-phosphogluconate (KDPGA) and a fructose bisphosphate aldolase...
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6893849 |
Fermentation process for production of xylitol from Pichia sp
The present invention deals with an improved fermentation process for the production of xylitol from Pichia sp. and the said process is submerged fermentation for the production of xylitol using...
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6803225 |
Protein glycosylation modification in Pichia pastoris
The present invention provides genetically engineered strains of Pichia capable of producing proteins with reduced glycosylation. In particular, the genetically engineered strains of the present...
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6723536 |
Method of producing and purifying angiostatin
The present invention provides a method for recombinant production, recovery and purification of angiostatin protein. This method may be employed for large scale recovery and purification of...
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6723540 |
Manufacture of xylitol using recombinant microbial hosts
Novel methods for the synthesis of xylitol are described.
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6699658 |
Yeast cell surface display of proteins and uses thereof
The present invention provides a genetic method for tethering polypeptides to the yeast cell wall in a form accessible for binding to macromolecules. Combining this method with...
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6638735 |
Plasmid for gene expression in pichia ciferrii and transformation method using the same
Expression cassettes for transforming Pichia ciferrii and their use are disclosed. The present invention relates to expression cassettes containing Pichia ciferrii ribosomal DNA fragment, CYH r...
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6617145 |
DNA molecules encoding fibrinolytically active polypeptide
A fibrinolytically active metalloproteinase polypeptide (called “novel acting thrombolytic”) which is useful for blood clot lysis in vivo and methods and materials for its production by...
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6613547 |
Pichia methanolica glyceraldehyde-3-phosphate dehydrogenase 1 promoter and terminator
Transcription promoter and terminator sequences from the Pichia methanolica glyceraldehyde-3-phosphate dehydrogenase 1 gene (GAP1 gene) are disclosed. The sequences are useful within DNA...
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6582944 |
Production of ethanol from xylose
This invention relates to recombinant-DNA-technology. Specifically this invention relates to new recombinant yeast strains transformed with xylose reductase and/or xylitol dehydrogenase enzyme...
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6555353 |
Methanotrophic carbon metabolism pathway genes and enzymes
Genes have been isolated from a Methylomonas sp encoding enzymes in the carbon flux pathway. The genes encode a 2-keto-3-deoxy-6-phosphogluconate (KDPGA) and a fructose bisphosphate aldolase...
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6475768 |
Xylose isomerase with improved properties
The present invention relates to novel nucleic acid sequences which, upon expression in a procaryotic or eucaryotic cell, code for a polypeptide having an elevated specific xylose isomerase...
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6451557 |
Method for producing, in yeast, a hydroxylated triple helical protein, and yeast host cells useful in said method
A method for producing a hydroxylated triple helical protein is disclosed, as well as a yeast host cell used in the method. The method comprises culturing a yeast host cell comprising: (1) a first...
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6440720 |
Pichia methanolica glyceraldehyde-3-phosphate dehydrogenase 2 promoter and terminator
Transcription promoter and terminator sequences from the Pichia methanolica glyceraldehyde-3-phosphate dehydrogenase 2 gene (GAP2 gene) are disclosed. The sequences are useful within DNA...
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