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7320884 |
Fermentation process
A process for forming a color and odor stable polycarboxylic acid or polyhydroxy acid is provided. The process is carried out by fermenting a mixture containing a substrate which can be converted...
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7297513 |
Gene encoding glutathione synthetase from Candida utilis
A gene encoding glutathione synthetase from Candida utilis is provided and food containing γ-glutamylcysteine cysteine or cystenylglycine is produced by cultivating Candida utilis modified by...
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7267976 |
Acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts
Two acyltransferases are provided, suitable for use in the manufacture of microbial oils enriched in omega fatty acids in oleaginous yeast (e.g., Yarrowia lipolytica ). Specifically, the genes...
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7262038 |
Simplified eukaryotic nitrate reductase
The invention provides modification to the polynucleotide coding sequence for Pichia angusta NAD (P)H: nitrate reductase [YNaR1; GenBank accession number Z49110], which has Enzyme Commission...
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7256033 |
Delta-8 desaturase and its use in making polyunsaturated fatty acids
Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding a delta-8 desaturase along with a method of making long chain polyunsaturated fatty acids (PUFAs) using...
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7244833 |
Recombinant human albumin fusion proteins with long-lasting biological effects
Compositions, kits and methods are provided for promoting general health or for prevention or treatment of diseases by using novel recombinant fusion proteins of human serum albumin (HSA) and...
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7241613 |
Identification of Candida cell surface proteins and their uses
The invention provides for novel polypeptides of Candida species found on the cell wall of the Candida organism. The invention further provides for methods of using these polypeptides, the...
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7238482 |
Production of polyunsaturated fatty acids in oleaginous yeasts
The present invention relates to methods for the production of ω-3 and/or ω-6 fatty acids in oleaginous yeast. Thus, desaturases and elongases able to catalyze the conversion of linoleic acid...
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7217538 |
CaESS1: a Candida albicans gene, methods for making and using, and targeting it or its expression products for antifungal applications
Disclosed and claimed is the CaESS1 gene, portions thereof such as primers or probes, expression products therefrom, and methods for using the gene, and expression products; for instance, for...
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7214491 |
Δ-12 desaturase gene suitable for altering levels of polyunsaturated fatty acids in oleaginous yeasts
The present invention relates to a Δ12 fatty acid desaturase able to catalyze the conversion of oleic acid to linoleic acid (LA; 18:2). Nucleic acid sequences encoding the desaturase, nucleic acid...
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7192762 |
Mortierella alpina glycerol-3-phosphate o-acyltransferase for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms
Glycerol-3-phosphate o-acyltransferase (GPAT) participates in the first step of oil biosynthesis and is expected to play a key role in altering the quantity of long-chain polyunsaturated fatty...
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7163819 |
Bacterial hemoglobin genes and their use to increase carotenoid production
Genes encoding bacterial oxygen binding proteins are provided. Recombinant expression of at least one of the present bacterial hemoglobin genes increased the growth characteristics and/or...
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7141410 |
Methods and materials for the production of organic products in cells of Candida species
The present invention relates to biocatalysts that are cells, optimally of the Crabtree-negative phenotype, comprising expression vectors encoding genes heterologous to the cell that enable...
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7129067 |
Method for producing lactone
This invention relates to a method for producing a lactone comprising culturing Candida sorbophila in a medium containing at least one selected from the group consisting of a hydroxy fatty acid,...
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7091031 |
Carotenoid hydroxylase enzymes
A novel CrtZ carotenoid hydroxylase, isolated from Brevundimonas vesicularis DC263, is provided that is useful for the production of hydroxylated carotenoids. Additionally, a previously...
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7070970 |
Elongase genes and uses thereof
The subject invention relates to the identification of four genes involved in the elongation of polyunsaturated acids (i.e., “elongases”) and to uses thereof. Two of these genes are also...
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7070952 |
Genes encoding carotenoid compounds
Genes have been isolated from Pectobacterium cypripedii encoding geranylgeranyl pyrophosphate (GGPP) synthase (CrtE), phytoene synthase (CrtB), phytoene desaturase (Crtl), lycopene cyclase...
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7063958 |
Nucleic acids db, the receptor for leptin
The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In...
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7033814 |
Methods for preparing yeast with improved biotin productivity using integrating plasmids encoding biotin synthase
Methods for preparing yeast with improved biotin productivity using integrating plasmids encoding biotin synthase. The yeast is transformed by an integrating plasmid, which includes a Candida...
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7001757 |
Protein
This invention relates to polynucleotides, polypeptides encoded by these polynucleotides, to the production of such polynucleotides and polypeptides, and to the uses of such polynucleotides and...
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6955890 |
Method for the identification and treatment of pathogenic microorganisms infections by inhibiting one or more enzymes in an essential metabolic pathway
A method for the identification and treatment of pathogenic microorganism infections by inhibiting one or more enzymes in a metabolic pathway by inhibiting the conversion of substrate to produce...
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6929941 |
Chimeric cell-targeting pathogenic organism and method of therapeutic use
The invention chimeric organism comprises a chimeric surface integrin-like fusion protein in which the I domain has been replaced by an antibody fragment that binds a disease-associated antigen on...
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6929928 |
Genes encoding carotenoid compounds
A unique carotenogenic biosynthetic gene cluster has been isolated from Panteoa agglomerans strain DC404, wherein the genetic organization of the cluster is crtE-idi-crtY-crtI-crtB-crtZ. The...
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6908992 |
Methanotrophic carbon metabolism pathway genes and enzymes
Genes have been isolated from a Methylomonas sp encoding enzymes in the carbon flux pathway. The genes encode a 2-keto-3-deoxy-6-phosphogluconate (KDPGA) and a fructose bisphosphate aldolase...
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6828092 |
In vivo assays for modulators of sterol biosynthesis
A method for the identification of agents which modulate sterol biosynthesis which method comprises contacting a test compound with a host cell comprising a DNA sequence which controls expression...
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6824996 |
Production of ascorbic acid
The present invention provides for the production of ASA from yeast capable of producing ASA from KLG. The present invention provides methods for the production of ASA as well as recombinant yeast...
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6803225 |
Protein glycosylation modification in Pichia pastoris
The present invention provides genetically engineered strains of Pichia capable of producing proteins with reduced glycosylation. In particular, the genetically engineered strains of the present...
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6803191 |
Candida albicans two-component hybrid kinase gene, CaNik1, and use thereof
A Candida albicans gene, CaNik1, is involved in phenotypic switching which is significant because of a direct correlation between the switching and the level of virulence of the organism. A...
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6783985 |
Gene disruption methodologies for drug target discovery
The present invention provides methods and compositions that enable the experimental determination as to whether any gene in the genome of a diploid pathogenic organism is essential, and whether it...
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6723540 |
Manufacture of xylitol using recombinant microbial hosts
Novel methods for the synthesis of xylitol are described.
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6720151 |
Therapeutic agents that inhibit the tup1 pathway
A gene previously identified in the context of controlling filamentous growth in C. albicans , TUP1, plays a central role in the regulation of phenotype switching in Candida cells. Accordingly,...
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6699658 |
Yeast cell surface display of proteins and uses thereof
The present invention provides a genetic method for tethering polypeptides to the yeast cell wall in a form accessible for binding to macromolecules. Combining this method with...
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6682916 |
Chlorohydroxyacetone derivative and process for producing optically active chloropropanediol derivative from the same
A process for efficiently preparing an optically active chloropropanediol derivative, especially (S)-1-benzyloxy-3-chloro-2-propanol, which has a high optical purity and is useful as an...
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6670148 |
Compositions comprising bioactive peptides prepared without formation of native disulfide bonds
A method of preparing a bioactive polypeptide in a stable, inactivated form, the method comprising the step of treating the polypeptide with ozonated water in order to oxidize and/or stabilize the...
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6660491 |
Process for producing dietary sterol fatty acid esters
A process for enzymatically producing, from a vegetable oil deodorizer distillate, a dietary sterol fatty acid ester superior in flavor qualities (e.g., color, odor and taste) and safety and...
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6645755 |
VECTOR MODIFIED BY SEQUENCE CODING FOR A SEQUENCE OF AMINO ACIDS CONTAINED IN A MAMMALIAN PROTEIN HAVING THE BIOLOGICAL ACTIVITY OF A MEMBRANE RECEPTOR, EXPRESSION OF THIS SEQUENCE IN TRANSFORMED UNICELLULAR CULTURES BY MEANS OF THIS VECTOR, PROCEDURE FOR STUDYING LIGANDS RECOGNIZING THESE RECEPTORS
The invention relates to a vector capable of being replicated in cultures of unicellular organisms, this vector containing a gene coding for a eukaryotic protein having the biological activity of a...
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6620611 |
Solid-chemical composition for sustained release of organic substrates and complex inorganic phosphates for bioremediation
A slow-release solid chemical composition for environmental bioremediation is provided. The composition comprises a source of soluble organic substrates which include sugars, soluble organic...
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6610514 |
Yeast vector and method of producing proteins using the same
An object of the present invention is to provide a vector which can be integrated into a yeast chromosome in a high number of copies. Another object of the present invention is to provide a...
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6582944 |
Production of ethanol from xylose
This invention relates to recombinant-DNA-technology. Specifically this invention relates to new recombinant yeast strains transformed with xylose reductase and/or xylitol dehydrogenase enzyme...
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6562595 |
Dominant selectable marker for gene transformation and disruption in yeasts
The present invention provides a novel dominant selectable marker system in yeast that is based on an aminoglycoside, nourseothricin (NST). This compound possesses a powerful antifungal activity...
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6555353 |
Methanotrophic carbon metabolism pathway genes and enzymes
Genes have been isolated from a Methylomonas sp encoding enzymes in the carbon flux pathway. The genes encode a 2-keto-3-deoxy-6-phosphogluconate (KDPGA) and a fructose bisphosphate aldolase...
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6528290 |
Candida magnoliae producing mannitol and fermentation method for producing mannitol
The present Invention is to provide a novel strain, Candida magnoliae (KCCM-10252) producing mannitol isolated from the fermentation sludge collected from a xylitol manufacturing company, and...
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6475768 |
Xylose isomerase with improved properties
The present invention relates to novel nucleic acid sequences which, upon expression in a procaryotic or eucaryotic cell, code for a polypeptide having an elevated specific xylose isomerase...
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6428984 |
Method for obtaining recombinant hbsag
The present invention relates to a method for recovering recombinant HBsAg, wherein recombinant methylotrophic yeast cells which are capable of expressing HBsAg are disrupted using a high pressure...
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6423510 |
Candida boidini dihydroxyacetone synthase promoter
This invention relates to a promoter for dihydroxyacetone synthase gene from Candida boidinii ; an expression cassette or vector comprising the promoter and a heterologous gene; a transformant...
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6413754 |
Kinase activating dependent cyclin protein kinases, and their uses
The invention concerns the family of protein-kinases having the following common characteristics: they are devoid of the consensus pattern GxGx(Y/F)GxV; they have a dependent non-cyclin CAK...
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H002022 |
Inositolphosphoryl ceramide (IPC) synthase genes from fungi
The invention provides isolated nucleic acid compounds encoding IPC synthase or subunit thereof from fungal cells. Also provided are vectors and transformed heterologous host cells for expressing...
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6376222 |
Riboflavin production
The present invention provides a transformed yeast strain containing a DNA sequence transcriptionally linked to a promoter functional in such yeast cells, which when expressed in a suitable host...
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6346411 |
DNA encoding—candida albicans integrin-like protein
An isolated and purified DNA molecule encoding Candida albicans protein with integrin-like motifs, the protein itself, antibodies thereto, and methods of use, are provided.
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6331420 |
Cytochrome P450 monooxygenase and NADPH cytochrome P450 oxidoreductase genes and proteins related to the omega hydroxylase complex of Candida tropicalis and methods relating thereto
Novel genes have been isolated which encode cytochrome P450 and NADPH reductase enzymes of the ω-hydroxylase complex of C. tropicalis 20336. Vectors including these genes, transfected host cells...
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