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7635582 |
Process for the production of triacylglycerols
The present invention relates to the isolation, identification and characterization of nucleotide sequences encoding an enzyme catalysing the transfer of fatty acids from phospholipids to...
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7622275 |
Aequorin as a growth marker in yeast
A yeast cell containing constitutively expressed aequorin and methods of using the cells in growth and toxicity assays are disclosed.
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7618774 |
Materials and methods for identifying genes and/or agents that alter replicative lifespan
Recombinant materials, including DNA constructs, expression vectors, and host cells, and methods of identifying an environmental stimulus or a gene that alters the lifespan of an organism are...
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7611854 |
Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of α-factor, transporters of a-factor, pheromone receptors, etc.) and a...
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RE40940 |
Yeast promoter and use thereof
The present invention concerns DNA sequences from the K. lactis PGK gene having transcriptional promoter activity. to expression vectors comprising these sequences and to their use for the...
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7601533 |
Reverse two-hybrid systems
Disclosed are methods for identifying molecular interactions (e.g., protein/protein, protein/DNA, protein/RNA, or RNA/RNA interactions). All of the methods within the invention employ...
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7601805 |
Photoprotein with improved bioluminescence
Disclosed is a photoprotein with improved luminescent activity, the use thereof as calcium indicator and in cell-based assays for the detection and measurement of intracellular calcium.
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7598066 |
Gene encoding vitamin b6 phosphate phosphatase and use thereof
Disclosed is an isolated DNA encoding vitamin B 6 phosphate phosphatase selected from the group consisting of: (a) a DNA sequence represented in SEQ ID NO:9; (b) a DNA sequence which encodes a...
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7588914 |
Bacterial Bcl-2 domain-containing polypeptides, encoding nucleic acid molecules, and related methods
The invention provides isolated Bcl-2 domain-containing polypeptides from Mycobacterial species, including M. tuberculosis, M. avium, M. bovis, M. leprae and M. smegmatis, and from Streptomyces...
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7588931 |
High arachidonic acid producing strains of Yarrowia lipolytica
Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 10% arachidonic acid (ARA, an ω-6 polyunsaturated fatty acid) in the total oil fraction are...
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7582449 |
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies...
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7582458 |
Fermentation processes and compositions
The present invention provides improved fermentation processes, including for use in an ethanol production process. The improved fermentation processes include applying at least one fatty acid...
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7582457 |
Method for the production of 1,3-propanediol by recombinant organisms comprising genes for coenzyme B12 synthesis
Recombinant organisms are provided comprising genes encoding cob(II)alamin reductase, cob(I)alamin adenosyltransferase, glycerol dehydratase and 1,3-propanediol oxidoreductase activities useful for...
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7579146 |
Nucleic acid cloning
The present invention provides an improved system for linking nucleic acids to one another. In particular, the present invention provides techniques for producing DNA product molecules that may be...
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7579168 |
Human Dickkopf-related nucleic acid molecules
Novel Dkk and Dkk-related polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Dkk and Dkk-related proteins, the invention further provides...
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7575892 |
Expression vector encoding a triterpene hydroxylase polypeptide
Soyasapogenol B is biosynthesized via two steps of hydroxylation reaction of its precursor β-amyrin. However, the gene of the hydroxylase concerned in this reaction has not been revealed....
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7572602 |
Nucleic acid encoding endolysin fusion protein
The invention concerns a recombinant nucleic acid molecule encoding an antimicrobial fusion peptidoglycan endopeptidase. The recombinant nucleic acid molecule according to the invention is formed...
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7569360 |
γ-glutamylcysteine producing yeast
A yeast which harbors a mutant glutathione synthetase having one or both of mutations selected from the group consisting of a mutation to replace a threonine residue at the position 47 with an...
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7569351 |
P53 dependent apoptosis-associated gene and protein
A novel apoptosis-associated gene p53AIPI is isolated by screening for a gene the expression of which is induced by p53. Since the protein encoded by this gene has an activity of inducing...
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7563595 |
Nucleic acids encoding functional splice variants of the α7 nicotinic acetylcholine receptor subunit and methods for producing the encoded proteins
The present invention concerns a novel α7 nicotinic receptor subunit isoform, α7-2. The α7-2 isoform contributes to novel acetylcholine receptors (AChRs) with pharmacological and biophysical...
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7563586 |
Method of identifying a modulator of a voltage-gated sodium channel using cells expressing Nav1.8 and p11
The present invention provides a method of identifying a modulator of a voltage gated sodium channel (VGSC), which method comprises bringing into contact a VGSC, a p11 peptide and a test compound...
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7563879 |
Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof
The present invetion relates to a novel isolated leafhopper ecdysone receptor polypeptide. The invention also realtes to an isolated nucleic acid encoding the leafhopper ecdysone receptor...
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7556938 |
Nucleic acids encoding potassium channel interactors
The invention provides isolated nucleic acids molecules, designated PCIP nucleic acid molecules, which encode proteins that bind potassium channels and modulate potassium channel mediated...
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7556949 |
Δ17 desaturase and its use in making polyunsaturated fatty acids
The present invention relates to Δ17 desaturases, which have the ability to convert ω-6 fatty acids into their ω-3 counterparts (i.e., conversion of arachidonic acid [20:4, ARA] to...
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7556929 |
Compositions and methods for screening anti-cancer agents in yeast
Methods and kits for identifying novel anti-tumor agents are provided.
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7550286 |
Docosahexaenoic acid producing strains of Yarrowia lipolytica
An engineered strain of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 5.6% docosahexaenoic acid acid (DHA, an w-3 polyunsaturated fatty acid) in the total oil...
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7544795 |
Recombinant hexose oxidase, a method of producing same and use of such enzyme
A method of producing hexose oxidase by recombinant DNA technology, recombinant hexose oxidase and the use of such enzyme, in particular in the manufacturing of food products such as doughs and...
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7544859 |
Elongase gene and method for producing multiple-unsaturated fatty acids
The invention relates to novel elongase genes with the sequences stated in sequence SEQ ID NO:1, SEQ ID NO: 3, SEQ ID NO: 5 and SEQ ID NO: 7 or their homologs, derivatives or analogs, to a gene...
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7541432 |
L-glutamate-gated chloride channel proteins from Rhipicephalus sanguineus
The present invention relates in part to isolated nucleic acid molecules (polynucleotides) which encode Rhipicephalus sanguineus glutamate gated chloride channels. The present invention also...
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7534597 |
Methods and materials for the production of L-lactic acid in yeast
Recombinant yeast are provided having, in one aspect, multiple exogenous LDH genes integrated into the genome, while leaving native PDC genes intact. In a second aspect, recombinant yeast are...
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7531345 |
Mutations for enhanced tyrosine production
The present invention provides cells genetically engineered to express mutated chorismate mutase/prephenate dehydrogenase (CM/PDH), the nucleic acid coding for each mutated CM/PDH and similar...
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7531347 |
Methods and compositions for synthesis of long chain polyunsaturated fatty acids
The present invention relates to fatty acid desaturases able to catalyze the conversion of oleic acid to linoleic acid, linoleic acid to γ-linolenic acid, or of alpha-linolenic acid to stearidonic...
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7524646 |
Method for diversifying the chemical composition of proteins produced in vivo by genetically disabling the editing function of their aminoacyl tRNA synthetases
The present invention is directed to a method to diversify the chemical composition of proteins produced in vivo comprising the step of disabling, particularly by mutagenesis, the editing function...
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7521059 |
Kennel cough vaccine
Improved, low cost vaccines for administration to living subjects such as mammals and birds are provided, which include killed recombinantly modified microorganisms (whole cell recombinant bacterin...
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7517972 |
Nucleic acid sequences encoding a bitter taste receptor, T2R76
Isolated nucleic acids encoding T2R76 polypeptides, recombinantly expressed T2R76 polypeptides, heterologous expression systems for recombinant expression of T2R76 polypeptides, assay methods...
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7517671 |
Methods and compositions for concentrating secreted recombinant protein
Methods and compositions are described that relate to obtaining concentrated preparations of secreted recombinant proteins. These proteins are expressed in the form of fusion proteins with a...
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7504236 |
Method to increase carotenoid production in a microbial host cell by down-regulating glycogen synthase
A method to increase carotenoid production in carotenogenic microbial host cells is provided by down-regulating or disrupting glycogen synthesis. Disruption of glycogen synthase activity in a...
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7504227 |
Drug targets for the treatment of neurodegenerative disorders
Methods of screening candidate agents to identify potential therapeutic agents for the treatment of a neurodegenerative disease, such as Huntington's Disease and Parkinson's Disease and methods for...
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7501268 |
Methods of producing prenyl alcohols
A method of producing a prenyl alcohol, comprising creating a recombinant by transferring into a host a recombinant DNA for expression or a DNA for genomic integration each comprising a prenyl...
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7498306 |
Peptides binding to the phosphatase 2A protein
The invention relates to novel synthetic or natural E4orf4 or Bcl-2 peptides particularly useful in antitumoral, antiviral and antiparasitic treatments, said peptides being less than 30 amino acids...
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7491798 |
Scytovirins and related conjugates, fusion proteins, nucleic acids, vectors, host cells, compositions, antibodies and methods of using scytovirins
An isolated or purified antiviral protein of SEQ ID NO: 1, nucleic acids encoding the antiviral protein, cells comprising the nucleic acids, and methods of inhibiting viral infection comprising...
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7485713 |
Polypeptides comprising growth hormone receptor extracellular domain and glycosylphosphatidylinositol
The present invention relates to polypeptides which comprise a receptor binding domain of a cytokine and a domain which includes a signal sequence for the attachment of glycosylphosphatidylinositol...
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7485426 |
Method and kits for preparing multicomponent nucleic acid constructs
The invention provides a highly efficient, rapid, and cost effective method of linking nucleic acid components in a predetermined order to produce a nucleic acid multicomponent construct. The...
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7485449 |
Nucleic acids encoding sodium channel scn3a alpha subunits
The present invention relates to epilepsy. More particularly, the present invention relates to idiopathic generalized epilepsy (IGE) and to the identification of three genes mapping to chromosome...
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7482157 |
Monacolin K biosynthesis genes
Cholesterol inhibitor produced by Monascus , monacolin k, is a secondary metabolite of polyketides. The invention provides probes specific to monacolin k biosynthesis gene cluster. BAC clones...
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7482144 |
Method for the production of xylitol
The invention relates to a method for the production of xylitol, the method comprising
(a1) providing (i) a microorganism having xylanolytic activity, and (ii) a microorganism capable of...
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7470532 |
Mortierella alpina C16/18 fatty acid elongase
The present invention relates to a fungal C 16/18 fatty acid elongase that is able to catalyze the conversion of palmitate (16:0) to stearic acid (18:0). Specifically, the nucleotide sequence of a...
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7465459 |
Piroplasmid vaccine
The invention relates to a Piroplasmid protein or an immunogenic fragment of the protein, and to a nucleic acid encoding the Piroplasmid protein or the immunogenic fragment. Furthermore, the...
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7465564 |
Production of γ-linolenic acid in oleaginous yeast
The present invention relates to methods for the production of γ-linolenic acid (GLA) in oleaginous yeast. Thus, Δ12 and Δ6 desaturases able to catalyze the conversion of oleic acid to GLA have...
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7465571 |
Endoglucanases
In one aspect, the invention provides a purified thermostable enzyme derived from the archael bacterium AEPII 1a. In one aspect, the enzyme has a molecular weight of about 60.9 kilodaltons and has...
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