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9040269 Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof  
A recombinant micro-organism producing resveratrol by a pathway in which phenylalanine ammonia lyase (PAL) produces trans-cinnamic acid from phenylalanine, cinnamate 4-hydroxylase (C4H) produces...
9040266 Cell-based systems for production of methyl formate  
Disclosed is a process in which a recombinant organism, such as a yeast, expressing a heterologous S-adenosylmethionine (SAM)-dependent methyl halide transferase (MHT) protein is combined with a...
9034608 Polypeptides with permease activity  
The invention relates to a polypeptide having a mutation at one or more position corresponding to T219 of SEQ ID NO: 55, wherein the polypeptide has at least 50% sequence identity with SEQ ID NO:...
9034599 Polynucleotides encoding monomeric variants of the tetrameric eqFP611  
DNA encoding a monomeric variant of red fluorescent protein eqFP611 comprising an amino acid sequence selected from the group consisting of SEQ ID No. 1, SEQ ID No. 3 and SEQ ID No. 5. DNA...
9029122 Long chain omega-3 and omega-6 polyunsaturated fatty acid biosynthesis by expression of acyl-CoA lysophospholipid acyltransferases  
Methods for increasing C18 to C20 elongation conversion efficiency and/or Δ4 desaturation conversion efficiency in long-chain polyunsaturated fatty acid [“LC-PUFA”]-producing recombinant...
9023626 Methods for the synthesis of fatty diacids by the metathesis of unsaturated diacids obtained by fermentation of natural fatty acids  
The invention relates to a method for the synthesis of diacids of general formula ROOC—(CH2)n—(CH═CH)a—(CH2)mCOOR1 in which n and m are identical or different and each represent an integer such...
9017989 Means for reducing acetoin buildup in alcoholic fermentation media  
The invention relates to yeasts expressing the gene BDH1 coding for Bdh1p, characterized in that they catalyze, in an alcoholic fermentation medium, the reduction of acetoin into 2,3-butanediol by...
9017984 Enhanced production of fatty acid derivatives  
Genetically engineered microorganisms that produce fatty alcohols from a sugar source by way of the fatty acid biosynthetic pathway, as well as methods of their use are provided.
9005939 Protoilludene synthase  
The present invention relates to an isolated, recombinant or synthetic polynucleotide encoding a polypeptide with protoilludene synthase activity and comprising a sequence selected from the group...
8999691 Glucose dehydrogenase  
Disclosed is a modified glucose dehydrogenases that has dramatically increased productivity in Escherichia coli and dramatically increased thermal stability, which is obtained by introducing...
8993275 Polypeptides having cellobiohydrolase activity and polynucleotides encoding same  
The present invention relates to isolated polypeptides having cellobiohydrolase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs,...
8993305 Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene  
The invention provides for methods for the production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in cells via the heterologous expression of phosphoketolase enzymes.
8993743 Chimeric surface active proteins  
The present invention relates to a nucleic acid molecule encoding a chimeric protein having the biochemical activity of a surface active protein, wherein said chimeric protein comprises: (a) an...
8986950 Method of producing a low molecular weight organic compound in a cell  
A method of producing a low molecular weight organic compound (e.g. a plant or bacteria secondary metabolite) in increased yields involving use of a microorganism cell, which comprises a gene...
8986948 Prokaryotic xylose isomerase for the construction of xylose fermenting yeasts  
The present invention relates to the use of nucleic acid molecules coding for a bacterial xylose isomerase (XI), preferably coming from Clostridium phytofermentans, for reaction/metabolization,...
8980634 Reverse genetics of negative-strand RNA viruses in yeast  
The present invention relates to a methodology for the generation of infectious ribonucleoparticles (RNPs) of negative-strand RNA viruses, and in particular of non-segmented negative-strand RNA...
8969005 Gene targets associated with amyotrophic lateral sclerosis and methods of use thereof  
Compositions and methods for diagnosis and treatment of ALS are provided.
8969065 Enhanced pyruvate to acetolactate conversion in yeast  
A high flux in conversion of pyruvate to acetolactate was achieved in yeast through expression of acetolactate synthase in the cytosol in conjunction with reduction in pyruvate decarboxylase...
8962289 Strains of Saccharomyces cerevisiae  
A method for producing a strain of Saccharomyces cerevisiae with introduced genes coding for xylose reductase, xylitol dehydrogenase and xylulokinase and with improved ethanol production, improved...
8961977 Antigenic mimics of discontinuous epitopes of pathogen recognized by broadly neutralizing antibodies  
The present invention relates to an anti-idiotypic polypeptide scaffold that includes two or more peptide sequences that mimic a discontinuous epitope of a pathogen that is recognized by or...
8961988 Compositions and methods for the treatment or prevention of hepatitis B virus infection  
Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well...
8956851 Methods for the improvement of product yield and production in a microorganism through the addition of alternate electron acceptors  
The present invention provides for novel metabolic pathways to reduce or eliminate glycerol production and increase product formation. More specifically, the invention provides for a recombinant...
8956850 Enhanced pyruvate to acetolactate conversion in yeast  
A high flux in conversion of pyruvate to acetolactate was achieved in yeast through expression of acetolactate synthase in the cytosol in conjunction with reduction in pyruvate decarboxylase...
8951937 Identification and use of bacterial [2Fe-2S] dihydroxy-acid dehydratases  
A group of bacterial dihydroxy-acid dehydratases having a [2Fe-2S] cluster was discovered. Bacterial [2Fe-2S] DHADs were expressed as heterologous proteins in bacteria and yeast cells, providing...
8951764 Production of isoprenoids under neutral pH conditions  
Embodiments of the present disclosure relate to a process for producing isoprenoid precursor molecules and/or isoprenoids from a starch substrate by saccharification and/or fermentation. The...
8951776 Engineered microbes and methods for microbial oil production  
Some aspects of this invention provide engineered microbes for oil production. Methods for microbe engineering and for use of engineered microbes are also provided herein. In some embodiments,...
8951762 Materials and methods for using an acyl—acyl carrier protein thioesterase and mutants and chimeras thereof in fatty acid synthesis  
A method of increasing production of fatty acids comprising introducing into a host cell or organism and expressing therein an acyl-acyl carrier protein (ACP) thioesterase (TE) from Bryantella...
8945855 Method for engineering proteases and protein kinases  
Provided are methods for protein engineering, such as engineering proteases or kinases. The methods may utilize yeast display and/or ER sequestration of proteins or substrates. In some aspects,...
8940876 Method for preparing recombinant glycoproteins with high sialic acid content  
The present disclosure relates to a method for preparing recombinant glycoproteins with high sialic acid content. More specifically, for UDP-GlcNAc 2-epimerase/ManNAc kinase (GNE/MNK) enzyme where...
8940511 Yeast strain for production of four carbon alcohols  
Yeast cells with a reduced general control response to amino acid starvation were found to have increased tolerance to butanol in the growth medium. The reduced response was engineered by genetic...
8940510 Spray dried microbes and methods of preparation and use  
The invention provides spray-dried preparations of microbes and methods of using those microbes.
8936929 Modified yeast strains exhibiting enhanced fermentation of lignocellulosic hydrolysates  
The present invention relates to novel xylose-fermenting yeast strains (for example, yeast of the genus Saccharomyces, e.g., S. cerevisiae) with an enhanced ability to ferment the xylose (and/or...
8932829 Recombinant alpha-fetoprotein and compositions thereof  
Disclosed are pharmaceutical and synergistic compositions comprising human recombinant alpha-fetoprotein expressed in eucaryotic cells for preparation of therapeutic agents for use in oncology,...
8932860 Retrons for gene targeting  
The invention provides methods and nucleic acid constructs that may be used to modify a nucleic acid of interest at a target locus within the genome of a host. In some aspects, the invention...
8926965 Nucleic acid encoding superoxide dismutase variants and methods of use thereof  
The present disclosure provides variant superoxide dismutase polypeptides, compositions comprising the polypeptides, and nucleic acids comprising nucleotide sequences encoding the polypeptides....
8916370 Isoprene synthase variants for improved microbial production of isoprene  
The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention...
8906650 Yarrowia esterase/lipase promoter regions for gene expression in yeast  
Promoter regions associated with the Yarrowia lipolytica esterase/lipase (EL1) gene are disclosed and have been found to be particularly effective for the expression of heterologous genes in...
8906393 Biofilm inhibiting composition  
Polysaccharide-containing extracts isolated from a host cell containing nucleotide sequences encoding genes pamA, pamB and pamC, wherein the extract is capable of inhibiting biofilm formation...
8895287 Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof  
A recombinant micro-organism producing resveratrol by a pathway in which phenylalanine ammonia lyase (PAL) produces trans-cinnamic acid from phenylalanine, cinnamate 4-hydroxylase (C4H) produces...
8889391 Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production  
The present disclosure provides novel beta-alanine/alpha ketoglutarate aminotransferase nucleic acid and protein sequences having increased biological activity. Also provided are cells containing...
8889397 Nucleotides for prevention and treatment of bacterial and fungal pathologies  
A selectively inducible, single-stranded DNA (ssDNA) expression library, a method for constructing a ssDNA expression library, a method for screening ssDNA using the expression library, and a...
8889381 Diterpene synthases and method for producing diterpenoids  
Provided herein are diterpene synthases (diTPS) and methods for producing diterpenoids. Also provided herein are nucleic acid sequences encoding diTPS, diTPS amino acid sequences, diTPS proteins,...
8883483 Combinatorial DNA library for producing modified N-glycans in lower eukaryotes  
The present invention relates to eukaryotic host cells having modified oligosaccharides which may be modified further by heterologous expression of a set of glycosyltransferases, sugar...
8883482 Methods for increasing homologous recombination of a nucleic acid sequence  
The present invention relates to methods for increasing homologous recombination of a nucleic acid sequence introduced into a host cell, comprising: (a) introducing into a population of...
8883445 Protein glycosylation modification in methylotrophic yeast  
The present invention provides genetically engineered strains of methylotrophic yeast including Pichia and especially Pichia pastoris capable of producing proteins with reduced or modified...
8877474 GH61 glycoside hydrolase protein variants and cofactors that enhance GH61 activity  
The present invention provides various GH61 protein variants comprising various amino acid substitutions. The GH61 protein variants have an improved ability to synergize with cellulase enzymes,...
8877915 Transcription regulatory factors for mannanases or cellulases, and genes for the transcription regulatory factor  
Disclosed are: transcription regulatory factors capable of regulating the transcription or expression of genes for mannanases or cellulases, as mentioned below; and others. Specifically disclosed...
8877205 Yeast-based therapeutic for chronic hepatitis B infection  
Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well...
8871488 Recombinant host cells comprising phosphoketolases  
The present invention is related to recombinant host cells comprising: (i) at least one deletion, mutation, and/or substitution in an endogenous gene encoding a polypeptide that converts pyruvate...
8865429 Increased oil content by increasing Yap1 transcription factor activity in oleaginous yeasts  
Transgenic oleaginous yeast having increased oil content comprising increased Yap1 transcription factor activity, wherein the increased oil content is compared to the oil content of a...