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8183030 |
Use of cell surface displays in yeast cell catalyst supports
Methods and compositions for providing novel catalyst supports are included herein. In one embodiment, included herein are yeast cell supports including one or more receptor proteins uniformly...
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8183013 |
Method for production of protein having non-natural type amino acid integrated therein
This invention provides a method for producing proteins into which non-natural amino acids have been incorporated at desired positions involving the use of either prokaryote-derived or...
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8183036 |
Luciferase biosensor
A modified beetle luciferase protein which is an environmentally sensitive reporter protein is provided.
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8178331 |
Recombinant yeast with improved ethanol tolerance and related methods of use
The present invention provides isolated Elo1 and Mig3 nucleic acid sequences capable of conferring increased ethanol tolerance on recombinant yeast and methods of using same in biofuel production,...
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8178090 |
Recombinant hexose oxidase
Use of a preparation as an antimicrobial agent or as an anti-oxidant; wherein said preparation comprises a polypeptide having hexose oxidase activity, the polypeptide being in a substantially pure...
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8173405 |
Nerolidol, terpene, and terpene deriviative synthesis
According to one embodiment, the description relates to a method of nerolidol production. The method includes culturing a yeast strain lacking functional squalene synthase and overproducing HMG CoA...
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8173410 |
Isoprene synthase variants for improved microbial production of isoprene
The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention...
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8173782 |
Fusion protein comprising growth hormone and growth hormone receptor
Agents which bind to cell surface receptors; methods to manufacture such agents; therapeutic compositions comprising such agents; and screening methods to identify novel agents.
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8168426 |
Multiple inducible gene regulation system
The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions...
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8163871 |
Enzymatic reactions in the presence of keto acids
Conversion in vitro of X-Gly to X-alpha-hydroxy-Gly or X-NH2 (X being a peptide or any other compound having a carbonyl group capable of forming a covalent bond with glycine) is accomplished...
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8158384 |
Methods for reducing or eliminating α-mannosidase resistant glycans in the production of glycoproteins
The present invention provides methods to reduce or eliminate α-mannosidase resistant glycans on glycoproteins in yeast. The reduction or elimination of α-mannosidase resistant glycans on g...
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8158404 |
Reduced by-product accumulation for improved production of isobutanol
The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In...
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8158392 |
Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant...
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8153415 |
Reduced by-product accumulation for improved production of isobutanol
The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In...
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8143049 |
Modified beta-glucosidases with improved stability
Provided are modified beta-glucosidase enzymes, derived from the Trichoderma reesei Cel3A beta-glucosidase, that exhibit improved stability at low pH, low pH and high aeration, low pH and high...
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8137953 |
Lactic acid-producing yeast cells having nonfunctional L- or D-lactate:ferricytochrome C oxidoreductase cells
Yeast cells having an exogenous lactate dehydrogenase gene ae modified by reducing L- or D-lactate:ferricytochrome c oxidoreductase activity in the cell. This leads to reduced consumption of...
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8133715 |
Reduced by-product accumulation for improved production of isobutanol
The present invention relates to recombinant microorganisms comprising biosynthetic pathways and methods of using said recombinant microorganisms to produce various beneficial metabolites. In...
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8129511 |
Modified amylases, nucleic acids encoding those amylases and uses thereof
This invention relates to nucleic acids encoding amylase polypeptides, the encoded polypeptides and uses thereof. The amylases of the present invention have been engineered to have more beneficial...
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8129598 |
DNA recombination in eukaryotic cells by the bacteriophage PHIC31 recombination system
This invention provides methods for obtaining specific and stable integration of nucleic acids into eukaryotic cells. The invention makes use of site-specific recombination systems that use...
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8124375 |
Geraniol synthase, methods of production and uses thereof
The present invention relates to novel type of monoterpene synthase, a key enzyme in the production of the monoterpene aroma compound geraniol. More specifically, the present invention relates to...
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8124379 |
Signal peptide for producing a polypeptide
The present invention relates to a method for producing a polypeptide comprising using a signal peptide, to nucleic acid constructs comprising a first nucleotide sequence encoding the signal...
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8119172 |
Microorganism for biological detoxification of mycotoxins, namely ochratoxins and/or zearalenons, as well as method and use thereof
A microorganism for the biological inactivation or detoxification of mycotoxins, in particular ochratoxins, which is selected from bacteria and/or yeasts, which cleaves the phenylalanine group of...
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8119390 |
Methods and compositions for concentrating secreted recombinant proteins
Methods and compositions are described that relate to obtaining concentrated preparations of secreted recombinant proteins. These proteins are expressed in the form of fusion proteins with a...
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8119404 |
Inhibitor of apoptosis proteins and nucleic acids and methods for making and using them
The invention provides polypeptides comprising inhibitor of apoptosis protein (IAP) family members, such as BmIAP initially derived from Bombyx mori BmN cells, and nucleic acids encoding them, and...
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8114648 |
In vivo incorporation of unnatural amino acids
The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
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8114974 |
Engineered microorganisms with enhanced fermentation activity
Provided herein are genetically modified microorganisms that have enhanced fermentation activity, and methods for making and using such microorganisms.
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8110389 |
Family 6 cellulase with decreased inactivation by lignin
A modified Trichoderma reesei Family 6 (TrCel6A) cellulase enzyme comprising amino acid substitutions at one or more positions selected from the group consisting of 129, 322, 363 and 410 of SEQ ID...
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8110670 |
Enhanced production of fatty acid derivatives
Genetically engineered cells and microorganisms are provided that produce products from the fatty acid biosynthetic pathway (fatty acid derivatives), as well as methods of their use. The products...
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8105827 |
Protein expression systems
Disclosed are recombinant non-insect host cells and use of activation of CMV or SV40 promoters by IE1, IE2 and the enhancer hr of the baculovirus in non-insect host cells for expression...
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8105825 |
Multiple inducible gene regulation system
The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions...
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8101399 |
Artemisinic epoxide and methods for producing same
The present invention provides artemisinic epoxide, and methods of synthesizing artemisinic epoxide in a genetically modified host cell. The present invention further provides methods for producing...
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8097440 |
Engineered microorganisms capable of producing target compounds under anaerobic conditions
The present invention is generally provides recombinant microorganisms comprising engineered metabolic pathways capable of producing C3-C5 alcohols under aerobic and anaerobic conditions. The...
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8093031 |
Heparanases and splice variants thereof, polynucleotides encoding them and uses thereof
The invention relates to novel heparanases, heparanase splice variants, and to polynucleotides encoding them. Particularly, the invention relates to Spalax heparanases, and to Spalax and human...
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8080389 |
Auto-inducible sodium phosphate symporter promoter from Pichia pastoris and method for producing recombinant protein using it
Disclosed herein are a Pichia pastoris-derived auto-inducible NPS promoter; a recombinant expression vector carrying the promoter and a nucleotide sequence, the sequence being operably linked to...
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8071341 |
Synthesis of long-chain polyunsaturated fatty acids by recombinant cells
The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant...
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8071355 |
Polyhydroxyalkanoate production by coenzyme A-dependent aldehyde dehydrogenase pathways
Organisms are provided containing genes encoding one or more enzymes, Coenzyme-A-dependent aldehyde dehydrogenase, acyl-CoA transferase, acyl-CoA synthetase, β-ketothiolase, acetoacetyl-CoA ...
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8071357 |
Yeast and method of producing L-lactic acid
Yeast includes an introduced gene coding a Homo sapiens- or frog-derived L-lactate dehydrogenase. It is possible to produce lactic acid, which has a variety of applications, efficiently and more...
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8071298 |
Increased ethanol production from xylose
Methods and compositions for the production of ethanol from lignocellulosic starting materials are provided herein. Embodiments of the invention provide methods of manipulating the carbon flux of a...
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8071358 |
Methods of increasing dihydroxy acid dehydratase activity to improve production of fuels, chemicals, and amino acids
The present invention is directed to recombinant microorganisms comprising one or more dihydroxyacid dehydratase (DHAD)-requiring biosynthetic pathways and methods of using said recombinant...
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8067530 |
Scytovirin domain 1 related polypeptides
A scytovirin domain 1 (SD1) polypeptide, a nucleic acid encoding the polypeptide, and related fusion proteins, conjugates, isolated cells, vectors, and antibodies, as well as a method of inhibiting...
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8063194 |
Specific arabinose transporter from the yeast Pichia stipitis, and uses thereof
The present invention relates to a polypeptide which has a novel specific arabinose transporter function as well as to nucleic acids coding therefore. The invention further relates to host cells,...
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8053224 |
Glucose-induced inactivation/degradation-resistant transporter gene and use thereof
The present invention relates to a glucose-induced inactivation/degradation resistant transporter gene and use thereof, and more particularly to a brewery yeast having excellent assimilability of...
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8048667 |
Hybrid alpha-glucoside transporter
The present invention relates to alpha-glucoside transporters which can promote assimilation of maltose/maltotriose contained in wort, etc., and so on. Especially in relation to glucose-induced...
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8043638 |
Mutant ILV5 gene and use thereof
The present invention relates to a mutant acetohydroxy-acid reductoisomerase gene (mutant ILV5 gene) and use thereof, in particular, a brewery yeast for producing alcoholic beverages with superior...
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8034591 |
Xylose-fermenting yeast engineered to increase flux of the pentose phosphate pathway
The present invention relates to further genetic modifications in eukaryotic host cells that have been transformed to express a xylose isomerase that confers the host cell the ability of...
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8034607 |
Methods of enhanced heterologous protein secretion
A method of enhancing heterologous protein secretion in a yeast cell is disclosed. In one embodiment, the method comprising the steps of engineering a yeast cell to overexpress at last one gene...
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8030045 |
Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production
The present disclosure provides novel beta-alanine/alpha ketoglutarate aminotransferase nucleic acid and protein sequences having increased biological activity. Also provided are cells containing...
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8026083 |
Yarrowia lipolytica and Pichia pastoris HAC1 nucleic acids
Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered...
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8026089 |
Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids
The present invention relates to mutant Δ8 desaturase genes, which have the ability to convert eicosadienoic acid [20:2 ω-6, EDA] to dihomo-γ-linolenic acid [20:3, DGLA] and/or eicosatrienoic ac...
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8017376 |
Methods of increasing dihydroxy acid dehydratase activity to improve production of fuels, chemicals, and amino acids
The present invention is directed to recombinant microorganisms comprising one or more dihydroxyacid dehydratase (DHAD)-requiring biosynthetic pathways and methods of using said recombinant...
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