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7371847 |
Yeast-origin promoter and vector and expression system using the same
The present invention provides a DNA fragment having a cold-inducible promoter function of yeast, which has high activity in a low temperature range, by identifying a DNA fragment, which exists in...
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7371559 |
Peptides and related molecules that modulate nerve growth factor activity
The present invention relates to certain biologically active peptides and polypeptides which can be used as therapeutics or prophylactics against diseases or disorders linked to NGF as the...
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7371546 |
Glucoamylase variants
The invention relates to a variant of a parental fungal glucoamylase, which exhibits improved thermal stability and/or increased specific activity using saccharide substrates.
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7364901 |
Recombinant Stokesia epoxygenase gene
A chimeric gene comprising an isolated nucleic acid molecule encoding a delta 12-fatty acid epoxygenase enzyme and transgenic plants containing the chimeric gene are described. Expression of the...
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7364883 |
Process for producing poly-unsaturated fatty acids by oleaginous yeasts
The present invention is directed to a process of producing novel fatty acids in oleaginous yeast by producing oleaginous yeast by introducing into the yeast genes coding for enzymes selected from...
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7355025 |
Marker molecules associated with lung tumors
The present invention relates to nucleic acids and polypeptides associated with lung cancer. The invention is more specifically related to a nucleic acids and the polypeptides transcribed thereof,...
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7354761 |
Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs...
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7354752 |
Acid-stable alpha amylases having granular starch hydrolyzing activity and enzyme compositions
The present invention relates to an acid-stable alpha amylase (asAA) derived from a strain of Aspergillus kawachi, which has granular starch hydrolyzing (GSH) activity, the heterologous...
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7354739 |
TML polynucleotides
The present invention is directed to polynucleotides, peptides, variants, and uses thereof for a novel peptide fragment designated TML peptides. Binding of the peptide fragment has been shown in...
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7348469 |
Plant farnesyltransferases
This invention relates to an isolated nucleic acid fragment encoding a farnesyltransferase subunit. The invention also relates to the construction of a chimeric gene encoding all or a portion of...
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7348172 |
Method and DNA constructs for increasing the production level of carbohydrate degrading enzymes in filamentous fungi
The invention is related to a method and DNA constructs for obtaining in a filamentous fungus host a higher production level of a carbohydrate degrading (CD) enzyme, having in its original state a...
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7348170 |
Fungus-origin lysyl oxidases
Lysyl oxidase derived from filamentous fungi and a DNA encoding thereof are provided. Lysyl oxidase including a protein described in of the following (a) or (b): (a) a protein having an amino acid...
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7344861 |
Secreted proteins and polynucleotides encoding them
Novel polynucleotides and the proteins encoded thereby are disclosed.
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7338792 |
Process for the preparation of D-pantothenic acid and/or salts thereof
The invention provides a process for the preparation of D-pantothenic acid and/or salts thereof or feedstuffs additives comprising these by fermentation of microorganisms of the Bacillus group,...
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7335505 |
Materials and methods relating to protein aggregation in neurodegenerative disease
The present invention provides methods of proteolytically converting a precursor protein (e.g. tau) to a product fragment (e.g., a 12 kd fragment) in a stable cell line, wherein the precursor...
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7335501 |
Phytases and methods for producing these phytases
The present invention relates to novel phytases, in particular, of fungal origin, and also to their respective methods of production. The present invention relates more particularly to novel...
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7332593 |
Variants of TRAF2 which act as an inhibitor of TNF-alpha (TNFα) signaling pathway
The present invention relates to variants of TRAF2 which demonstrate the ability to inhibit the TNF α signaling pathway. In particular, applicants have isolated a splice variant of TRAF2 referred...
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7332324 |
Attenuated vaccine useful for immunizations against Coccidioides spp. infections
A Coccidioides spp. fungus that is attenuated by the loss of endosporulation potential of the fungus wherein said fungus does not replicate when transformed into the parasitic phase.
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7332319 |
Heterologous alpha amylase expression in Aspergillus
The present invention relates to the co-expression and production of a heterologous alpha amylase and an endogenous glucoamylase in an Aspergillus strain and enzyme compositions including the same.
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7332302 |
Polynucleotides encoding leukocyte adhesion inhibitor-1 (LAI-1)
There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human chemokine beta-11 (Ck beta-11) polypeptide and a human leukocyte adhesion inhibitor-1...
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7323325 |
Shrimp alkaline phosphatase
The present invention relates to a nucleic acid molecule comprising a nucleotide sequence as set forth in SEQ ID Nos. 1 or 20 or having at least 55% sequence identify therewith and/or capable of...
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7317099 |
Polynucleotides encoding stem cell growth factor-like polypeptides
The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like...
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7317003 |
Small peptides having anti-angiogenic and endothelial cell inhibition activity
The present invention provides peptides having potent anti-angiogenic activity and endothelial cell proliferation inhibition activity. The peptides can be administered as pharmaceutical...
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7314747 |
SMRT co-repressors, transcriptional co-repressors that interact with nuclear hormone receptors
The present invention relates to isolated polynucleotides encoding a family of silencing mediators of retinoic acid and thyroid hormone receptor (SMRT) isoforms, including vertebrate and...
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7312066 |
Nucleic acid molecules encoding NRC interacting factor-1 (NIF-1)
The present invention relates to isolated human and rat nucleic acid molecules encoding a protein or polypeptide that modulates transcriptional activation in a cell with or without collaboration...
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7309597 |
Alanine 2,3-Aminomutase
Alanine 2,3-aminomutase sequences are disclosed, as are cells having alanine 2,3-aminomutase activity and methods of selecting for such cells. Methods for producing beta-alanine, pantothenate,...
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7309595 |
Protein hydrolysates enriched in peptides having a carboxy terminal proline residue
The present invention provides An isolated polypeptide which has proline specific endoprotease activity, selected from the group consisting of:(a) a polypeptide which has an amino acid sequence...
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7307159 |
Heparin/heparosan synthase from P. multocida and methods of making and using same
The presently claimed and disclosed invention relates, in general, to dual action heparin synthases and, more particularly, to dual action heparin synthases obtained from Pasteurella multocida ....
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7307158 |
Selection marker gene
It is intended to provide a selection marker gene with the use of auxotrophy as an indication which is usable in transforming a fungus. Namely, a selection marker comprising a quinolinate...
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7306932 |
Coryneform bacteria with altered glucokinase activity in the production of L-lysine
The invention relates to alleles of the glk gene from coryneform bacteria coding for glucokinases, and to processes for the production of L-lysine by fermentation using bacteria containing such...
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7303890 |
Proteins, genes encoding them and method of using the same
The present invention provides, as a gene encoding an antigen recognized by a G-CSF inducing antibody, a gene encoding any one of the following proteins: (a) a protein having an amino acid sequence...
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7300772 |
BMP products
Purified BMP-2 and BMP-4 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue...
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7291493 |
Microbially expressed xylanases and their use as feed additives and other uses
The present invention relates to codon-optimized xylanase coding sequences and the expression of xylanases in microbes and yeast. The invention further relates to using multiple copies of the...
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7288400 |
Nucleic acids encoding esterases and methods of making and using them
The invention relates to esterases and to polynucleotides encoding the esterases. In addition methods of designing new esterase method of use thereof are also provided. The esterases have increased...
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7288387 |
Genes of strain DC413 encoding enzymes involved in biosynthesis of carotenoid compounds
A carotenogenic biosynthetic gene cluster has been isolated from Panteoa stewartii strain DC413, wherein the genetic organization of the cluster is crtE-idi-crtX-crtY-crtI-crtB-crtZ. The genes...
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7285409 |
Isolated gum operon from Xyllela fastidiosa, isolated nucleic acid molecules therefrom, and uses thereof
This invention relates to the isolation and characterization of an operon from the organism Xylella fastidiosa . This operon, referred to as the XfGUM operon, contains 9 genes, and is involved in...
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7285407 |
Genes of cell wall-degrading enzymes derived from aspergillus, and method for the production the enzymes
The purpose of the present invention is to isolate a gene encoding novel exo-, or endo-β-1,3-glucanase, to obtain a microorganism having an enhanced expression of said gene and to degrade...
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7285389 |
Protein, gene encoding the same, and method of utilization thereof
The present invention provides, as a gene encoding an antigen recognized by G-CSF-inducing antibodies, a gene encoding:
(a) a protein having the amino acid sequence listed as SEQ ID NO:2 of...
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7282365 |
Rhesus HER2/neu, nucleotides encoding same, and uses thereof
Polynucleotides encoding rhesus monkey HER2/neu have been isolated, cloned and sequenced. The gene encoding the HER2/neu is commonly associated with the development of epithelial-derived human...
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7282356 |
D-aminoacylase mutants
The present invention provides mutant D-aminoacylases and use thereof. The mutant D-aminoacylases are hard to be inhibited by the substrate and, comprise the amino acid sequences of the...
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7279564 |
Expression in filamentous fungi of protease inhibitors and variants thereof
Described herein are protease inhibitors, variants thereof and methods for their production.
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7279308 |
Polynucleotides encoding polypeptides having aminopeptidase activity
The present invention relates to isolated polypeptides having aminopeptidase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid...
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7276605 |
Method for producing recombinant trypsin
The present invention concerns a method for producing recombinant trypsin from porcine pancreas in Pichia pastoris which is soluble and secreted into the culture medium, whereby expression at pH...
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7273746 |
Diacylglycerol acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms
Acyltransferases are provided, suitable for use in the manufacture of microbial oils enriched in omega fatty acids in oleaginous yeast (e.g., Yarrowia lipolytica ). Specifically, genes encoding...
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7270989 |
Method of producing non-bovine chymosin and use hereof
A method of recombinantly producing a non-bovine pre-prochymosin, prochymosin or chymosin derived from ruminant species including deer species, buffalo species, antelope species, giraffe species,...
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7267976 |
Acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts
Two acyltransferases are provided, suitable for use in the manufacture of microbial oils enriched in omega fatty acids in oleaginous yeast (e.g., Yarrowia lipolytica ). Specifically, the genes...
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7264946 |
Thermoanaerobacter brockii alcohol dehydrogenase promoter for expression of heterologous proteins
The present invention discloses the isolation and use of a specific bacterial promoter region suitable for use in constructs for the high level production of heterologous proteins. This promoter is...
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7262038 |
Simplified eukaryotic nitrate reductase
The invention provides modification to the polynucleotide coding sequence for Pichia angusta NAD (P)H: nitrate reductase [YNaR1; GenBank accession number Z49110], which has Enzyme Commission...
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7262027 |
Polypeptide and DNA immunization against Coccidioides spp. infections
The present invention provides compositions of novel polypeptides and polynucleotides encoding the polypeptides, which polypeptides are useful for generating an immunological response in an...
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7262026 |
Hematopoietic stem cell proliferation regulators and polynucleotides encoding the same
By analyzing hematopoietic stem cell proliferation regulators produced by stroma cells, a cDNA library is constructed and novel hematopoiesis-associated genes are isolated. Genes encoding the...
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