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7625756 |
Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells
A method for producing human-like glycoproteins by expressing a Class 2 α-mannosidase having a substrate specificity for Manα1,3 and Manα1,6 glycosidic linkages in a lower eukaryote is...
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7625569 |
Yeast-based therapeutic for chronic hepatitis C infection
Disclosed are compositions, including vaccines, and methods for vaccinating an animal against hepatitis C virus (HCV) and for treating or preventing hepatitis C viral infection in an animal. The...
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7622564 |
Prostate stem cell antigen (PSCA) variants and subsequences thereof
PSCA and its encoded protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table...
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7608452 |
Polynucleotides encoding cytokine receptor zcytor19
Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used...
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7601805 |
Photoprotein with improved bioluminescence
Disclosed is a photoprotein with improved luminescent activity, the use thereof as calcium indicator and in cell-based assays for the detection and measurement of intracellular calcium.
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7601529 |
Pectate lyase variants
The present invention relates to pectate lyase variants exhibiting alterations relative to a parent enzyme exhibiting pectate lyase activity as its major enzymatic activity; to a method of...
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7601516 |
Heterodimeric follicle stimulating hormone-Fc (FSH-Fc) fusion proteins for the treatment of infertility
The invention provides novel heterodimeric fusion proteins comprising a first polypeptide including an alpha subunit of FSH (αFSH) linked directly or indirectly to a binding partner of neonatal Fc...
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7592439 |
Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method
A method of making monoclonal antibodies according to a mixed antigen immunization protocol is described. In addition, antibodies obtainable by the method are disclosed which specifically...
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7588934 |
Gene encoding fumarate hydratase C and use thereof
A nucleotide sequence encoding a fumarate hydratase C and a method for preparing succinic acid using the same, more particularly, a fumarate hydratase C having the activity of converting malate to...
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7588931 |
High arachidonic acid producing strains of Yarrowia lipolytica
Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 10% arachidonic acid (ARA, an ω-6 polyunsaturated fatty acid) in the total oil fraction are...
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7588901 |
Modulation of angiogenesis through targeting of arginyl transferase (ATE1)
The invention provides methods and compositions for modulating angiogenesis in a subject. The methods of modulating angiogenesis in a subject include administering to the subject a modulator of...
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7579171 |
Ascorbic acid production from yeast
Herein is disclosed a method of generating ascorbic acid from yeast. In one embodiment, the yeast is a Zygosaccharomyces spp. or a Kluyveromyces spp. growing in a medium comprising an ascorbic...
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7575892 |
Expression vector encoding a triterpene hydroxylase polypeptide
Soyasapogenol B is biosynthesized via two steps of hydroxylation reaction of its precursor β-amyrin. However, the gene of the hydroxylase concerned in this reaction has not been revealed....
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7575881 |
Modulation of nitric oxide signaling through signaling through specific regulation by arginylation and the N-end rule pathway
Screening assays that allow for the identification of agents that modulate the activity of the arginylation branch of the N-end rule pathway are provided. Also provided are method of using an agent...
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7572899 |
Compositions and methods for increasing bone mineralization
Nucleic acids relating to human TGF-β binding proteins are disclosed. Also disclosed are assays for selecting molecules for increasing bone mineralization and methods for utilizing such molecules.
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7572602 |
Nucleic acid encoding endolysin fusion protein
The invention concerns a recombinant nucleic acid molecule encoding an antimicrobial fusion peptidoglycan endopeptidase. The recombinant nucleic acid molecule according to the invention is formed...
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7569386 |
Chondroitin synthase gene and methods of making and using same
The present invention relates to a chondroitin synthase gene and methods of making and using same. In more particular, but not by way of limitation, the present invention relates to a chondroitin...
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7569351 |
P53 dependent apoptosis-associated gene and protein
A novel apoptosis-associated gene p53AIPI is isolated by screening for a gene the expression of which is induced by p53. Since the protein encoded by this gene has an activity of inducing...
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7563879 |
Leafhopper ecdysone receptor nucleic acids, polypeptides, and uses thereof
The present invetion relates to a novel isolated leafhopper ecdysone receptor polypeptide. The invention also realtes to an isolated nucleic acid encoding the leafhopper ecdysone receptor...
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7563612 |
Recombinant bifunctional protein of human lutropin receptor and human chorionic gonadotropin B-subunit and uses thereof
The present invention relates to a chimeric nucleic acid molecule encoding a fusion protein having a human lutropin hormone-receptor domain and a human chorionic gonadotropin-β subunit domain, the...
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7556949 |
Δ17 desaturase and its use in making polyunsaturated fatty acids
The present invention relates to Δ17 desaturases, which have the ability to convert ω-6 fatty acids into their ω-3 counterparts (i.e., conversion of arachidonic acid [20:4, ARA] to...
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7556929 |
Compositions and methods for screening anti-cancer agents in yeast
Methods and kits for identifying novel anti-tumor agents are provided.
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7553659 |
CHD5 encoding nucleic acids, polypeptides, antibodies and methods of use thereof
Nucleic acid sequences encoding chromodomain helicase DNA-binding (CHD) proteins, CHD proteins, and antibodies thereto and methods of use thereof are disclosed.
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7553640 |
Saponin-decomposing enzyme, gene thereof and large-scale production system for producing soyasapogenol B
The present invention provides a protein having saponin-decomposing activity, more specifically a protein which can decompose a glycoside having soyasapogenol B as an aglycone to produce...
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7553635 |
Process for production of cephalosporin C
The present invention relates to isolated nucleic acid molecules which code for a new protein from Acremonium chrysogenum , to vectors which comprise such a nucleic acid molecule, to Acremonium...
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7550286 |
Docosahexaenoic acid producing strains of Yarrowia lipolytica
An engineered strain of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 5.6% docosahexaenoic acid acid (DHA, an w-3 polyunsaturated fatty acid) in the total oil...
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7544795 |
Recombinant hexose oxidase, a method of producing same and use of such enzyme
A method of producing hexose oxidase by recombinant DNA technology, recombinant hexose oxidase and the use of such enzyme, in particular in the manufacturing of food products such as doughs and...
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7531626 |
Tenebrio antifreeze proteins
A novel class of thermal hysteresis (antifreeze) proteins (THP) that have up to 100 times the specific activity of fish antifreeze proteins has been isolated and purified from the mealworm beetle, ...
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7527942 |
Transcription amplification system for molecular imaging
The present invention provides a transcription amplification system, comprising an effector nucleic acid molecule and a reporter molecule, which work together to produce a heterologous gene product...
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7524646 |
Method for diversifying the chemical composition of proteins produced in vivo by genetically disabling the editing function of their aminoacyl tRNA synthetases
The present invention is directed to a method to diversify the chemical composition of proteins produced in vivo comprising the step of disabling, particularly by mutagenesis, the editing function...
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7521230 |
Nucleic acid encoding a Brain Derived Tau Kinase polypeptide and methods of use thereof
The present invention provides materials and methods for treating Alzheimer's disease and other tau related neurodegenerative disorders. A tau kinase, Brain Derived Tau Kinase (BDTK) is provided....
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7507580 |
Ztnfr14, a tumor necrosis factor receptor
Novel tumor necrosis factor receptor (TNFR) polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods are disclosed. The polypeptides may be used for...
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7507573 |
Modification of protein glycosylation in methylotrophic yeast
The present invention relates to methods and genetically engineered methylotrophic yeast strains for producing glycoproteins with mammalian-like glycosylation. The present invention also relates to...
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7504236 |
Method to increase carotenoid production in a microbial host cell by down-regulating glycogen synthase
A method to increase carotenoid production in carotenogenic microbial host cells is provided by down-regulating or disrupting glycogen synthesis. Disruption of glycogen synthase activity in a...
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7485697 |
Soluble rage protein
The object of this invention is to elucidate the factors involved in the regulation of AGE (advanced glycation endproducts, which are produced in a living body accompanied with diabetes and aging)...
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7485415 |
Sequence analysis of the tetravalent rotavirus vaccine
Isolated nucleic acid molecules comprising a gene segment from a rhesus rotavirus (RRV) or from one of three rhesus: human reassortant viruses are disclosed, including isolated nucleic acid...
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7482157 |
Monacolin K biosynthesis genes
Cholesterol inhibitor produced by Monascus , monacolin k, is a secondary metabolite of polyketides. The invention provides probes specific to monacolin k biosynthesis gene cluster. BAC clones...
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7482144 |
Method for the production of xylitol
The invention relates to a method for the production of xylitol, the method comprising
(a1) providing (i) a microorganism having xylanolytic activity, and (ii) a microorganism capable of...
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7482008 |
Human T cell reactive feline protein (TRFP) isolated from house dust and uses therefor
A substantially pure, covalently linked human T cell reactive feline protein (TRFP) has been isolated from vacuum bag extract obtained by affinity purification of house dust collected from several...
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7470529 |
Chondroitin synthase and nucleic acid encoding the enzyme
A human-derived novel chondroitin synthase, which is an enzyme for synthesizing a fundamental backbone of chondroitin and has both glucuronic acid transferring activity and N-acetylgalactosamine...
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7468268 |
Nucleic acid molecules encoding osteoclastogenesis inhibitory factor proteins
A protein which inhibits osteoclast differentiation and/or maturation and a method for producing the protein. The protein is produced by human embryonic lung fibroblasts and has a molecular weight...
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7465571 |
Endoglucanases
In one aspect, the invention provides a purified thermostable enzyme derived from the archael bacterium AEPII 1a. In one aspect, the enzyme has a molecular weight of about 60.9 kilodaltons and has...
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7462482 |
Human smooth muscle myosin heavy chain
The invention provides novel compositions, methods, and uses of hSMMyHC polypeptides and polynucleotides.
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7462466 |
Porcine CD59 nucleic acids and cells containing the same
A graftable animal cell or tissue of a donor species for use in medicine expresses, or is capable of being caused to express, increased amounts of endogenous complement regulatory molecules for...
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7456269 |
Alzheimer's disease secretase, APP substrates thereof, and uses thereof
The present invention provides the enzyme and enzymatic procedures for cleaving the β secretase cleavage site of the APP protein and associated nucleic acids, peptides, vectors, cells and cell...
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7455990 |
Method of extracting recombinant hexose oxidase
A method is described for releasing a soluble or membrane associated intracellular protein of interest (POI) comprising the steps of: providing a cell comprising a soluble or membrane associated...
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7452706 |
Recombinant bacterial phytases and uses thereof
A purified recombinant phytase enzyme derived from Escherichia coli B. The enzyme has a molecular weight of about 47.1 kilodaltons and has phytase activity. The enzyme can be produced from native...
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7445922 |
Zygomycetes-derived endoglucanase enzyme lacking cellulose-binding domain
This invention relates to a protein that is a Zygomycetes -derived endoglucanase lacking the cellulose-binding domain and exhibits endoglucanase activity, and a method for using the same. This...
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7432246 |
Sir2 products and activities
A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from...
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7432102 |
Transformants producing substance pf1022 derivatives, methods for producing the same, and novel biosynthesis genes
An objective of the present invention is to provide a method for producing substance PF1022 derivatives, in particular PF1022-220 and PF1022-260, by a direct fermentation method, and a transformant...
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