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7094569 |
Hair follicle growth factor proteins
The present invention relates to novel hair follicle growth factor (HFGF) proteins, genes encoding HFGFs, methods for preparing HFGF proteins and therapeutic uses of HFGF proteins. The HFGF...
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7094531 |
Nucleic acid sequencing
Provided is a method for sequencing DNA, which comprises: (a) obtaining a target DNA population comprising one or more single-stranded DNAs to be sequenced, each of which is present in a unique...
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7090998 |
Method for producing target substance by fermentation
In a method for producing a target substance utilizing a microorganism, which comprises culturing a γ-proteobacterium in a medium to produce and accumulate the target substance in the medium or...
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7083794 |
Recombinant vaccines comprising immunogenic attenuated bacteria having RpoS positive phenotype
Attenuated immunogenic bacteria having an RpoS + phenotype, in particular, Salmonella enterica serotype Typhi having an RpoS + phenotype and methods therefor are disclosed. The Salmonella ...
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7078220 |
Highly transformable bacterial cells and methods for producing the same
The invention provided herein includes novel gram negative bacteria cells containing the Hte mutation. Other aspects of the invention include methods for rendering gram negative bacterial cells...
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7078191 |
Composition and method for the detection of diseases associated with amyloid-like fibril or protein aggregate formation
The present invention relates to novel compositions useful for elucidating the onset or progress of diseases such as Huntington's disease, that are associated with the formation of fibrils or...
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7070944 |
System for screening fatty acid transport inhibitors, methods of use and modulators identified thereby
Methods for identifying modulators of fatty acid transport and/or uptake, comprising contacting, under conditions favorable for fatty acid uptake, a putative modulator, e.g., an inhibitor with a...
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7067300 |
Process for the biological production of 1,3-propanediol with high titer
The present invention provides an improved method for the biological production of 1,3-propanediol from a fermentable carbon source in a single microorganism. In one aspect of the present...
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7067289 |
Method for producing histidine by fermentation with E. coli
The present invention provides a method for producing an amino acid selected from the group consisting of L-alanine, L-valine, L-leucine, L-isoleucine, L-methionine, L-phenylalanine, L-proline,...
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7060436 |
Nucleic acid accessible hybridization sites
The present invention relates to methods and compositions for analyzing nucleic acids, and in particular, methods and compositions for detection and characterization of nucleic acid sequences and...
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7052884 |
L-arginine producing Escherichia coli and method of producing L-arginine
Arginine can be efficiently produced by cultivating Escherichia coli which has an ability to produce arginine and an ability to utilize acetate in a culture medium to produce and accumulate...
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7053196 |
Ketogulonigenium endogenous plasmids
The present invention relates, in general, to a genus of bacteria known as Ketogulonigenium. The present invention further relates to transformed Ketogulonigenium, and methods of transforming ...
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7053197 |
Ketogulonigenium endogenous plasmids
The present invention relates, in general, to a genus of bacteria known as Ketogulonigenium . The present invention further relates to transformed Ketogulonigenium , and methods of transforming ...
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7048915 |
Composition for cell-free protein synthesis
The present invention provides a composition for cell-free protein synthesis, which is superior in storage stability in a freeze-dried state, more particularly a freeze-dryable or freeze-dried...
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7045324 |
Tocopherol associated protein and uses thereof
The present invention provides a novel tocopherol associated protein (TAP-38) DNA/protein with a 76 nucleotide base deletion resulting in a 25 amino acid deletion, followed by 90 novel nucleotides...
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7045320 |
Methods for producing L-amino acids
A bacterium belonging to the genus Escherichia having an ability to produce an L-amino acid is cultured in a medium containing fructose as a main carbon source, preferably a medium containing a...
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7033772 |
Methods of identifying inhibitors of fatty acid transport proteins (FATP)
A family of fatty acid transport proteins (FATPs) mediate transport of long chain fatty acids (LCFAs) across cell membranes into cells. These proteins exhibit different expression patterns among...
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7030233 |
Ketogulonigenium endogeneous plasmids
The present invention relates, in general, to a genus of bacteria known as Ketogulonigenium . The present invention further relates to transformed Ketogulonigenium , and methods of transforming ...
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7018629 |
Probiotic compositions for the treatment of inflammatory bowel disease
Pharmaceutical compositions of probiotic E. coli strains and uses thereof for treating inflammatory bowel disease.
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7008651 |
E. coli extract for protein synthesis
There is now a market for kits containing the necessary components for performing protein synthesis reactions using template DNA of the experimenter. One category of existing system for performing...
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7001721 |
Nucleic acid sequence identification
Disclosed are methods for determining the presence or absence of a target nucleic acid (e.g. DNA) sequence in a sample nucleic acid, the method comprising: (a) exposing the sample to a detection...
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6998231 |
Typing and diagnosis of spongiform encephalopathy
The present invention relates to a method for typing a sample of a prion or spongiform encephalopathy disease, a kit suitable for use in such a typing method, a method for identifying infection in...
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6994960 |
Nucleic acid diagnostics based on mass spectrometry or mass separation and base specific cleavage
A method of detecting a mutation or a difference of one or more nucleotides between a nucleic acid molecule to be tested and a reference nucleic acid molecule, said method comprising subjecting the...
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6989265 |
Bacteria with reduced genome
The present invention provides a bacterium having a genome that is genetically engineered to be at least 2 to 14% smaller than the genome of its native parent strain. A bacterium with a smaller...
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6986985 |
Process for producing multiple nucleic acid copies in vivo using a protein-nucleic acid construct
This invention provides in vitro processes for producing copies of specific nucleic acids using protein-nucleic acid constructs which are part of conjugates which are introduced into cells....
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6987176 |
Combinant polypeptide for use in the manufacture of vaccines against Campylobacter induced diarrhea and to reduce colonization
This invention comprises a recombinant protein comprising the maltose binding protein (MBP) of Escherichia coli fused to amino acids 5–337 of the FlaA flagellin of Campylobacter coli VC167...
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6982147 |
Apparatus for assaying biopolymer binding by means of multiple measurements under varied conditions
An apparatus for assaying specific binding of a probe to a target, includes: a sample support; a light source; an optical train; a light detector; an electricity source; an electrical property...
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6969587 |
Detection of nucleic acid heteroduplex molecules by anion-exchange chromatography
The present invention describes a method for separating or partially separating heteroduplex and homoduplex DNA molecules in a mixture. In the method, the mixture is applied to an anion-exchange...
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6964847 |
Derivative nucleic acids and uses thereof
The invention features a method for multiplexed analysis of a plurality of target nucleic acid sequences in a sample. The method provides a derivative nucleic acid for each target sequence analyzed...
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6962795 |
Neutrophil inhibitors
Compositions enriched for Neutrophil Inhibitory Factor which inhibit neutrophil activity including adhesion to vascular endothelial cells are provided. Also provided are recombinant Neutrophil...
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6960464 |
Methods for lyophilizing competent cells
This invention relates to a method for producing cells which are competent for transformation and which may be stably stored for extended periods of time at various temperatures. The method...
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6958215 |
Methods and compositions for inhibition of RNA splicing
A method of inhibiting the self-splicing of a Group I intron is disclosed. The method uses an oligonucleotide having a sequence essentially identical to a guide sequence found in the 5′ flanking...
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6949383 |
Mutagenesis method
This application provides a method for mutagenesis of a gene, which comprises introducing much more point mutations into one strand of double-stranded genomic DNA of cell or organism individual...
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6942996 |
Isolated polynucleotide from Corynebacterium encoding a homocysteine methyltransferase
An isolated polynucleotide comprising a polynucleotide sequence selected from the group consisting of
a) polynucleotide which is at least 70% identical to a polynucleotide that codes for a...
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6924109 |
High-throughput transcriptome and functional validation analysis
Methods for correlating genes and gene function are provided. Such methods generally involve selecting a candidate gene that appears to be correlated with a particular cellular state or activity...
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6923972 |
Methods for use of genetically modified tumor-targeted bacteria with reduced virulence
The present invention is directed to mutant Salmonella sp. having a genetically modified msbB gene in which the mutant Salmonella is capable of targeting solid tumors. The present invention...
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6924107 |
Four dimensional biochip design for high throughput applications and methods of using the four dimensional biochip
The present invention provides a 4D biochip containing m 3D biochips having n capillaries, wherein the n capillaries each contain a biological factor, and methods for preparing and using the 4D...
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6921640 |
Process for labeling a ribonucleic acid
The present invention relates to a process for labeling a synthetic or natural ribonucleic acid (RNA). It also relates to RNA fragments, which have been labeled by fragmenting the RNA to free a...
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6919175 |
System for releasing and isolating nucleic acids
A procedure for the release and isolation of nucleic acids from biological compartments of a sample always uses an instrument that can hold one or more sample processsing vessels, maintain the...
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6916613 |
Compositions, methods, kits and apparatus for determining the presence or absence of target molecules
The present invention is directed to methods, compositions, kits and apparatus to identify and detect the presence or absence of target analytes. The embodiments of the present invention have...
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6916646 |
Enterobacteriaceae fermentation strains
Methods are provided for preparing improved fermentation strains of the family Enterobacteriaceae which comprise the steps of eliminating the cryptic plasmid from the progenitor strain thereby...
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6913880 |
Method for determining transcription factor activity and its technical uses
Certain transcription factors (enhancer binding proteins) significantly increase transcription rates from genes by nicking a single DNA strand in the vicinity of their DNA binding sites, thereby...
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6905823 |
Cellular arrays and methods of detecting and using genetic disorder markers
A method is disclosed for rapid molecular profiling of tissue or other cellular specimens by placing a donor specimen in an assigned location in a recipient array, providing copies of the array,...
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6905817 |
Ret-independent signaling pathway for GDNF
Methods for screening for agonists and antagonists of GPI-anchored independent intracellular signaling resulting in [Ca 2+ ] i elevation, ERK1, ERK2 and CREB phosphorylation, and Src family kinase...
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6905866 |
Sigma binding region of RNA polymerase and uses thereof
The invention provides cells expressing the sigma binding region of the β′ subunit of RNA polymerase and a method to identify inhibitors of the formation of holoenzyme from core RNA polymerase...
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6902906 |
Bacteria attenuated by a non-reverting mutation in each of the aroC, ompF and ompC genes, useful as vaccines
The invention provides a bacterium attenuated by a non-reverting mutation in each of the aroC gene, the ompF gene and the ompC gene. The bacterium is useful as a vaccine. The bacterium may, for...
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6893860 |
Microorganisms and methods for producing threonine
The present invention relates to methods and microorganisms for producing L-threonine. In particular, the present invention relates to the production of L-threonine using microorganisms, and ...
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6893821 |
Agents that modulate DNA-PK activity and methods of use thereof
The present invention provides methods for modulating cell death in a eukaryotic cell, and methods for reducing DNA damage in a eukaryotic cell. The methods generally comprise modulating a...
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6866847 |
Method of delivering a protein to poultry
A method of delivering a protein to domestic poultry by administering to the poultry by whole body spray an effective amount of a live avirulent derivative of an enteropathogenic bacterium that...
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6861247 |
Salmonella secreted proteins and uses thereof
Substantially pure Salmonella secreted proteins (Ssp), the sercetion of which is dependent upon the expession of PrgH; methods of diagnosing Salmonella infection; and live attenuated vaccine...
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