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7378261 |
Method for preparing para-hydroxystyrene by biocatalytic decarboxylation of para-hydroxycinnamic acid in a biphasic reaction medium
A biocatalytic method for preparing para-hydroxystyrene from para-hydroxycinnamic acid is described. The method uses an enzyme source having para-hydroxycinnamic acid decarboxylase activity to...
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7371548 |
Avermectin aglycon synthase genes
The present invention relates to an isolated DNA which comprises a DNA sequence encoding avermectin aglycon synthase domains that corresponds to multifunctional enzyme proteins involved in the...
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7344869 |
Isolated DNA comprising one or more genes specific for 5S clavam biosynthesis, vectors comprising such DNA and Streptomyces hosts capable of improved clavulanic acid production
Novel bacterial genes, microorganisms and processes for improving the manufacture of 5R clavams, eg. clavulanic acid.
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7341861 |
Non-ribosomal peptide synthetases and associated biosynthetic genes
The present invention describes the identification of novel non-ribosomal peptide synthetases and associated biosynthetic genes from Streptomyces hygroscopicus . The present invention further...
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7335501 |
Phytases and methods for producing these phytases
The present invention relates to novel phytases, in particular, of fungal origin, and also to their respective methods of production. The present invention relates more particularly to novel...
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7329521 |
Transglutaminase-producing strain
It is intended to provide a strain capable of producing transglutaminase at a high efficiency; and a process for producing transglutaminase by using this strain. A structural gene from ...
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7326782 |
Metabolic engineering of viomycin biosynthesis
The invention provides a nucleic acid molecule comprising at least a functional fragment of the viomycin biosynthetic gene cluster, functional proteins encoded by the cluster, expression cassettes...
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7309599 |
Aerobic fermentation method
A method and apparatus for effectively aerating large-scale cultures of microorganisms is disclosed.
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7291490 |
Nucleic acid fragment encoding an NRPS for the biosynthesis of anthramycin
Genes and proteins involved in the biosynthesis of benzodiazepines by microorganisms, including the genes and proteins forming the biosynthetic loci for the benzodiazepine anthramycin from ...
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7285406 |
Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from Comamonas testosteroni 5-MGAM-4D and recombinant organisms expressing those enzymes useful for the production of amides and acids
The invention relates to the isolation, sequencing, and recombinant expression of genes encoding either a nitrile hydratase (NHase) or amidase (Am) from Comamonas testosteroni 5-MGAM-4D, where...
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7282356 |
D-aminoacylase mutants
The present invention provides mutant D-aminoacylases and use thereof. The mutant D-aminoacylases are hard to be inhibited by the substrate and, comprise the amino acid sequences of the...
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7259004 |
Endophytic streptomycetes from higher plants with biological activity
The present invention relates to isolated strains of a Streptomyces spp. which are endophytes of dicotyledonous plants and to methods for selecting such strains. The present invention also...
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7247455 |
Streptococcus pyogenes DNase B leader peptide and methods for its use
The gene for Streptococcus pyogenes DNase B has been cloned and vectors incorporating the cloned DNA have been used to transform Escherichia coli, allowing efficient and rapid production of the...
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7227010 |
Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy
Botulinum neurotoxins, the most potent of all toxins, induce lethal neuromuscular paralysis by inhibiting exocytosis at the neuromuscular junction. The light chains (LC) of these dichain...
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7223590 |
Process for preparing pravastatin sodium
The present invention relates to a process for preparing pravastatin sodium. More specifically, in the process for preparing pravastatin sodium by adding a precursor of the pravastatin to a...
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7217511 |
Methods of increasing antibiotic production in Streptomyces by deletion of the scbA gene
Methods are provided for increasing and altering the timing of antibiotic production in Streptomyces species, particularly S. coelicolor and S. lividans , by functionally deleting the S....
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7214527 |
Compositions and methods for hydroxylating epothilones
Isolated nucleic acid sequences and polypeptides encoded thereby for epothilone B hydroxylase and mutants and variants thereof and a ferredoxin located downstream from the epothilone B hydroxylase...
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7208303 |
Bacterial nitric oxide synthases and uses thereof
The present invention relates to isolated nucleic acid molecules encoding nitric oxide synthases. The isolated nucleic acid molecules and their encoded protein or polypeptides are useful in methods...
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7202077 |
Methods for enhancing the translation and expression of recombinant proteins
The increased use of nucleotide sequence data mining techniques has amplified the demand for efficient methods of producing recombinant proteins in prokaryotic cells. A strategy is provided for...
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7202059 |
Fusion proteins capable of being secreted into a fermentation medium
Fusion protein including a fusion part and a protein of interest, the combination of the two proteins leading to the fusion protein being secreted into a supernatant of a bacterial host with the...
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7189549 |
Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthase and accessory proteins, and uses thereof
The invention relates to recombinant polyketide synthase enzymes, polyketide modifying proteins, and other proteins involved in polyketide biosynthesis or function. The invention provides domains...
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7179628 |
Transglutaminase
A DNA molecule encoding transglutaminase, a transglutaminase, an expression vector containing the DNA molecule, and a cell containing the expression vector.
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7112425 |
Polynucleotides and polypeptides coded by said polynucleotides involved in the synthesis of diketopiperazine derivatives
The invention concerns novel isolated natural or synthetic polynucleotides and polypeptides coded by said polynucleotides, involved in the synthesis of diketopiperazine derivatives, vectors...
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7109019 |
Gene cluster for production of the enediyne antitumor antibiotic C-1027
This invention provides nucleic acid sequences and characterization of the gene cluster responsible for the biosynthesis of the enediyne C-1027 (produced by Streptomyces globisporus ). The pathway...
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7108998 |
Nucleic acid fragment encoding an NRPS for the biosynthesis of anthramycin
Genes and proteins involved in the biosynthesis of benzodiazepines by microorganisms, including the genes and proteins forming the biosynthetic loci for the benzodiazepine anthramycin from ...
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7091031 |
Carotenoid hydroxylase enzymes
A novel CrtZ carotenoid hydroxylase, isolated from Brevundimonas vesicularis DC263, is provided that is useful for the production of hydroxylated carotenoids. Additionally, a previously...
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7070980 |
Midecamycin biosynthetic genes
The present invention provides an isolated polypeptide comprising a nucleotide sequence encoding a protein which is involved in midecamycin biosynthesis, wherein the protein contains an amino acid...
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7070952 |
Genes encoding carotenoid compounds
Genes have been isolated from Pectobacterium cypripedii encoding geranylgeranyl pyrophosphate (GGPP) synthase (CrtE), phytoene synthase (CrtB), phytoene desaturase (Crtl), lycopene cyclase...
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7063958 |
Nucleic acids db, the receptor for leptin
The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In...
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7049111 |
Process for producing HMG-CoA reductase inhibitor
The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus , which has an activity of hydroxylating a compound represented by the formula (I-a):
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7018808 |
Polyketides and their synthesis and use
The rapamycin gene cluster is an example of a gene cluster which includes a gene (rapL) leading to the formation of a precursor compound (pipecolic acid, in this case) which is required for...
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7001747 |
Nucleic acid molecules encoding modified polyketide synthases containing polylinkers and uses thereof
Nucleic acid molecules encoding at least part of a Type I polyketide synthase, and having a polylinker with multiple restriction enzyme sites in place of one or more PKS genes encoding enzymes...
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6969611 |
Methods to prepare cells comprising heterologous polyketide synthase expression systems
Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described...
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6964865 |
Host cells comprising Streptomyces clavuligerus chromosomal DNA fragments encoding enzymes for β-lactam antibiotic biosynthesis
DNA sequences obtained from S. clavuligerus ATCC 27064, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more...
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6960453 |
Hybrid polyketide synthases combining heterologous loading and extender modules
A hybrid type I polyketide synthase gene typically containing a starter module and a plurality of heterologous extender modules is used to synthesize novel polyketides. It is preferably under the...
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6939691 |
E. coli and Streptomyces host cells that contain MatBC genes or E. coli host cells that contain pcc genes useful for enhanced polyketide production
The use of enzymes that catalyze the production of starter and extender units for polyketides in E. coli and Streptomyces is described; these enzymes include malonyl CoA decarboxylase (MatA),...
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6929928 |
Genes encoding carotenoid compounds
A unique carotenogenic biosynthetic gene cluster has been isolated from Panteoa agglomerans strain DC404, wherein the genetic organization of the cluster is crtE-idi-crtY-crtI-crtB-crtZ. The...
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6927286 |
Bleomycin gene cluster components and their uses
This invention provides detailed sequence analysis and characterization of the gene cluster responsible for the synthesis of bleomycin in Streptomyces verticillus . The bleomycin gene cluster...
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6908992 |
Methanotrophic carbon metabolism pathway genes and enzymes
Genes have been isolated from a Methylomonas sp encoding enzymes in the carbon flux pathway. The genes encode a 2-keto-3-deoxy-6-phosphogluconate (KDPGA) and a fructose bisphosphate aldolase...
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6902913 |
Recombinant narbonolide polyketide synthase
Recombinant DNA compounds that encode all or a portion of the narbonolide polyketide synthase are used to express recombinant polyketide synthase genes in host cells for the production of...
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6872526 |
High throughput screening for novel Bioactivities
Disclosed is a process for identifying clones having a specified activity of interest, which process comprises (i) generating one or more expression libraries derived from nucleic acid directly...
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6869773 |
Process for the manufacture of carotenoids and biologically useful materials thereof
A process is provided for producing a carotenoid, which process includes cultivating a recombinant organism having a gene for one or more active oxygen species-quenching factor(s) that is...
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6767533 |
Use of a substance binding with the peripheral benzodiazepin receptor for treating skin stress
A composition containing a peripheral benzodiazepine receptor ligand for topical use in the treatment of cutaneous stress.
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6746870 |
DNA recombination in eukaryotic cells by the bacteriophage PHIC31 recombination system
This invention provides methods for obtaining specific and stable integration of nucleic acids into eukaryotic cells. The invention makes use of site-specific recombination systems that use...
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6727083 |
Protein capable of catalyzing transamination stereoselectively, gene encoding said protein and use thereof
DNA encoding a novel protein from Mycobacterium aurum SC-S423 capable of converting acetophenone to an optically active 1-phenylethlamine in the presence of a racemic mixture of sec-butylamine is...
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6709859 |
Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression
DNA sequences obtained from S. clavuligerus ATCC 27064, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more...
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6696295 |
Transducing phages
The present invention is directed to isolated transducing phages, methods of isolating transducing phages, and methods of using transducing phages including, for instance, transferring at least one...
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6670168 |
Recombinant Streptomyces hygroscopicus host cells that produce 17-desmethylrapamycin
Recombinant host cells that produce rapamycin analogues are constructed by deleting or modifying rapamycin biosynthetic gene cluster genes and are useful in the production of compounds used as...
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6638503 |
STREPTOMYCES MEGASPORUS SD5, PROCESS FOR THE ISOLATION THEREOF, NOVEL FIBRINOLYTIC ENZYME PREPARED THEREFROM, PROCESS FOR THE PRODUCTION OF SAID ENZYME AND METHOD OF TREATMENT OF THROMBOLYTIC DISORDERS USING SAID ENZYME
The present invention relates to a novel microorganism Streptomyces megasporus SD5. The present invention also relates to a process for the isolation of said Streptomyces megasporus SD5. The...
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6632673 |
Directing the ratio of B2:B1 avermectins in Streptomyces avermitilis host cells
The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of...
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