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7390646 |
Bacterial vectors and methods of use thereof
The present invention provides a live, attenuated, invasive bacterium that infects a mammalian host cell, and releases exogenous RNA into the cytoplasm of the host cell. The present invention...
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7390645 |
Lactose repressor proteins with increased operator DNA binding affinity
The present invention provides altered lac repressor proteins that recognize the lactose operator with increased affinity and have either normal or enhanced ligand responsivity. For example, the...
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7390633 |
Methods for preparing low molecular weight heparin with modified heparinase III
The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of...
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7387893 |
Vectors, cells and processes for pyrimidine deoxyribonucleosides production
Novel DNA constructs and host cells comprising the same are disclosed. DNA constructs comprise a transcription unit (e.g. operon) comprising DNA sequences encoding for ribonucleotide reductase and...
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7378263 |
In vivo site-specific incorporation of N-acetyl-galactosamine amino acids in eubacteria
Methods and compositions for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid having a N-acetylgalactosamine moiety into a...
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7378261 |
Method for preparing para-hydroxystyrene by biocatalytic decarboxylation of para-hydroxycinnamic acid in a biphasic reaction medium
A biocatalytic method for preparing para-hydroxystyrene from para-hydroxycinnamic acid is described. The method uses an enzyme source having para-hydroxycinnamic acid decarboxylase activity to...
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7378257 |
Bacterial superantigen vaccines
The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an...
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7375205 |
Elongase genes and uses thereof
The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated fatty acids (i.e., “elongases”) and to uses thereof. At least two of these...
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7371839 |
Alkaline proteases
The present invention relates to alkaline proteases having high specific activity and strong oxidant resistance. The present invention also relates to alkaline proteases having excellent detergency...
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7371559 |
Peptides and related molecules that modulate nerve growth factor activity
The present invention relates to certain biologically active peptides and polypeptides which can be used as therapeutics or prophylactics against diseases or disorders linked to NGF as the...
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7371558 |
Process for the biological production of 1,3-propanediol with high yield
The present invention provides a microorganism useful for biologically producing 1,3-propanediol from a fermentable carbon source at higher yield than was previously known. The complexity of the...
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7368277 |
Method for assay of antibodies and antibody assay device
The invention relates to a technology by which antibodies directed to sources of infection in body fluids can be assayed with high accuracy, expediency and specificity. More particularly, the...
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7368271 |
Polypeptides having alpha-glucosidase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having alpha-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid...
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7361487 |
Enzyme fusion proteins and their use
Cellulase fusion proteins comprising an endoglucanase core region and a heterologous cellulose binding domain are described. The fusion proteins may be produced by recombinant techniques using...
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7358069 |
Vector constructs
Improved vector constructs useful in the expression of double-stranded RNA are provided. The constructs are particularly useful for expression of double-stranded RNA in vitro and in vivo.
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7354761 |
Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs...
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7354746 |
Method for producing optically active IHOG and monatin
The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for...
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7351566 |
27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552, and 65577 molecules and uses therefor
The invention provides isolated nucleic acids molecules, designated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules. The invention also...
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7351564 |
SQS gene
The present invention relates to a gene useful in a process to increase the microbial production of carotenoids. The carotenoids astaxanthin is distributed in a wide variety of organisms such as...
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7351560 |
Glycerol-3-phosphate phosphatase and glycerol-3-phosphate dehydrogenase from Candida albicans, genes encoding the same, vector and host cell containing the genes, and method for producing glycerol using the host cell
Provided are a polypeptide having glycerol-3-phosphate dehydrogenase activity and a 80% or more homology to an amino acid sequence as set forth in SEQ ID NO: 1 and a polypeptide having...
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7348421 |
Methods for production of p-hydroxybenzoate in bacteria
This invention relates to the isolation of a novel tonB operon from Pseudomonas putida . These genes are useful to render the cells more sensitive to antibiotics, toluene, pHBA, aromatic...
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7348161 |
Macrolide efflux genetic assembly
Macrolide resistance associated with macrolide efflux (mef) in Streptococcus pneumoniae has been defined with respect to the genetic structure and dissemination of a novel mefE-containing...
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7344874 |
L-glutamic acid-producing microorganism and a method for producing L-glutamic acid
L-Glutamic acid is produced by culturing a microorganism in which an expression of L-glutamic acid-export gene, a yhfK gene, is enhanced or overexpressed, in a medium to produce and cause...
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7344856 |
Method of controlling cleavage by OmpT protease
Methods of using OmpT protease are provided. In particular, the invention provides for a method of controlling cleavage of a polypeptide by OmpT protease comprising, converting a sequence site...
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7341861 |
Non-ribosomal peptide synthetases and associated biosynthetic genes
The present invention describes the identification of novel non-ribosomal peptide synthetases and associated biosynthetic genes from Streptomyces hygroscopicus . The present invention further...
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7335505 |
Materials and methods relating to protein aggregation in neurodegenerative disease
The present invention provides methods of proteolytically converting a precursor protein (e.g. tau) to a product fragment (e.g., a 12 kd fragment) in a stable cell line, wherein the precursor...
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7335501 |
Phytases and methods for producing these phytases
The present invention relates to novel phytases, in particular, of fungal origin, and also to their respective methods of production. The present invention relates more particularly to novel...
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7332312 |
Carbonyl reductase, gene thereof and use of the same
The present invention provides a novel polypeptide forming (R)-2-chloro-1-(3′-chlorophenyl)ethanol, a polynucleotide coding for said polypeptide, and use of the same. The present invention...
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7332309 |
Process for the preparation of L-amino acids using strains of the enterobacteriaceae family which contain an enhanced sucC or sucD gene
The invention relates to a process for the preparation of L-amino acids, in particular L-threonine, in which the following steps are carried out: a) fermentation of microorganisms of the...
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7332304 |
Process and materials for production of glucosamine and N-acetylglucosamine
A biosynthetic method for producing glucosamine and N-acetylglucosamine is disclosed. Such a method includes the fermentation of a genetically modified microorganism to produce glucosamine and/or...
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7329741 |
Polynucleotides that hybridize to DP-75 and their use
The present invention is a novel nucleic acid sequence which hybridizes to SEQ ID NO:6 or fragments thereof under stringent conditions, or fragments thereof. The invention also includes diagnostic...
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7329514 |
Process for producing n-acetylneuraminic acid
In the process for producing N-acetylneuraminic acid by using a microorganism having the ability to produce N-acetylneuraminic acid, the present invention provides economical and efficient process...
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7326548 |
Polypeptides having glucoamylase activity and polynucleotides encoding same
The present invention relates to polypeptides having glucoamylase activity and isolated polynucleotides encoding said polypeptides. The invention also relates to nucleic acid constructs, vectors,...
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7323558 |
Nucleic acids encoding dendritic cell transmembrane serine protease
Isolated Dendritic Cell Transmembrane Serine Proteases (DCTSPs), DNAs encoding such DCTSPs, and pharmaceutical and/or diagnostic compositions made therefrom, are disclosed. The isolated DCTSPs can...
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7320883 |
Process for producing coenzyme Q10
The invention aims at providing a process for producing coenzyme Q 10 efficiently in microorganisms by utilizing a coenzyme Q 10 side chain synthesis gene derived from a fungal species belonging...
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7320882 |
Process for L-amino acid production using enterobacteriaceae strain with enhanced ptsG expression
The invention relates to a process for the preparation of L-amino acids, in particular L-threonine, which comprises overexpressing a ptsG gene coding for the glucose-specific IIBC component of the...
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7319024 |
C. elegans p21-activated kinase (PAK) gene and associated loss-of-function phenotypes that facilitate screening for small molecule modulators of PAK activity in the nematode, caenorhabditis elegans
The invention refers to a novel C. elegans p21-activated kinase gene, the pak-3 gene, and associated loss-of-function phenotypes. These phenotypes can be used to elucidate PAK signaling pathways...
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7316924 |
Twin-arginine translocation in Bacillus
Described herein are methods to enhance protein secretion in a host cell. In preferred embodiment, the host cell is a gram-positive microorganism such as a Bacillus . In another preferred...
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7316916 |
DNA for encoding D-hydantoin hydrolases, DNA for encoding N-carbamyl-D-amino acid hydrolases, recombinant DNA containing the genes, cells transformed with the recombinant DNA, methods for producing proteins utilizing the transformed cells and methods for producing D-amino acids
DNA for encoding a protein having D-hydantoinase activity which has a base sequence represented by Sequence ID No. 1 in the Sequence Listing. DNA for encoding a protein having D-carbamylase...
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7314857 |
Synergistic antimicrobial compositions and methods of inhibiting biofilm formation
A synergistic antimicrobial composition for inhibiting biofilm formation includes an iron-sequestering glycoprotein, a cationic polypeptide and a chelating agent, or an iron-sequestering...
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7309600 |
Haemophilus influenzae sialyltransferase and methods of use thereof
The present invention is directed to sialytransferases, such as SiaA sialytransferases isolated from Haemophilus influenzae . Further provided herein are methods for producing sialylated...
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7306933 |
Method for producing L-lysine or L-threonine
A bacterium belonging to the genus Escherichia which has an ability to produce L-lysine or L-threonine and which is modified so that a malic enzyme does not function normally in a cell, and a...
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7303906 |
Competent bacteria
The present invention discloses that a bacterium having a genome that is genetically engineered to be at least 10% smaller than the genome of its native parent strain has better transformation...
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7303894 |
Detection of phenols using engineered bacteria
Detection of phenols using engineered bacteria. A biosensor can be created by placing a reporter gene under control of an inducible promoter. The reporter gene produces a signal when a cognate...
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7300786 |
Bacteria of the Enterobacteriaceae family having enhanced transaldolase activity
A method is provided for producing L-histidine using bacterium of the Enterobacteriaceae family, wherein the L-amino acid productivity of said bacterium is enhanced by enhancing an activity of the...
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7300776 |
L-amino acid-producing bacterium and a method for producing L-amino acid
An L-amino acid-producing strain of Escherichia coli is bred by modifying an Escherichia coli K12 strain or a derivative thereof so as to become resistant to L-valine and have an ability to...
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7291495 |
β-Secretase variant
The invention provides polynucleotides and polypeptides encoding an isolated amyloid inhibitor protein (APIP) and compositions thereof. The polypeptides of the subject invention can be used to...
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7291490 |
Nucleic acid fragment encoding an NRPS for the biosynthesis of anthramycin
Genes and proteins involved in the biosynthesis of benzodiazepines by microorganisms, including the genes and proteins forming the biosynthetic loci for the benzodiazepine anthramycin from ...
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7291486 |
Genetically modified cells and methods for converting (R)-methylmalonyl CoA to (S)-methylmalonyl CoA
Recombinant Escherichia coli host cells that comprise recombinant DNA expression vectors that drive expression of methylmalonyl CoA mutase from Propionibacterium shermanii or Streptomyces...
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7291482 |
Mutations affecting plasmid copy number
Mutations in chromosomal genes have been identified that affect plasmid copy number in plasmids that are anti-sense RNA regulated such as the pMB1-derived and p15A-derived plasmids.
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