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9040020 Muteins of hNGAL and related proteins with affinity for a given target  
The present invention relates to novel muteins derived from human lipocalin 2 (hNGAL) and related proteins that bind a given non-natural ligand with detectable affinity. The invention also related...
9029142 Recombinant vectors and hosts comprising human glucokinase encoding gene  
Gene encoding human glucokinase mutant is provided. The gene has the nucleotide sequence chosen from the nucleotide sequence listed as SEQ ID NO:2 and the nucleotide sequence wherein the ORF...
9029136 Alpha (1,2) fucosyltransferases suitable for use in the production of fucosylated oligosaccharides  
The invention provides compositions and methods for engineering E. coli or other host production bacterial strains to produce fucosylated oligosaccharides, and the use thereof in the prevention or...
9023627 Systems and methods for biotransformation of carbon dioxide into higher carbon compounds  
Systems, compounds and methods for the conversion of C1 carbon compounds to higher carbon compounds useful for the generation of commodity compounds.
9023608 Modified glucose dehydrogenase  
The present invention relates to glucose dehydrogenase [NAD(P)+GDH] using nicotinamide adenine dinucleotide or nicotinamide adenine dinucleotide phosphate as a coenzyme, in which the thermal...
9017980 Variant forms of urate oxidase and use thereof  
Genetically modified proteins with uricolytic activity are described. Proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated...
9012195 Non-cytotoxic protein conjugates  
The present invention is directed to non-cytotoxic protein conjugates for inhibition or reduction of exocytic fusion in a nociceptive sensory afferent cell. The protein conjugates comprise: (i) a...
9005953 Recombinant microorganism having butanol production capacity and butanol production method  
This invention relates to a recombinant microorganism having improved butanol production capacity and butanol production with the use of such recombinant microorganism with good efficiency. In...
9005939 Protoilludene synthase  
The present invention relates to an isolated, recombinant or synthetic polynucleotide encoding a polypeptide with protoilludene synthase activity and comprising a sequence selected from the group...
8999682 Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms  
Disclosed are the uses of specific genes of the mevalonate and isoprenoid biosynthetic pathways, and of inactive gene sites (the pseudogene) to (1) enhance biosynthesis of isopentenyl diphosphate,...
8999691 Glucose dehydrogenase  
Disclosed is a modified glucose dehydrogenases that has dramatically increased productivity in Escherichia coli and dramatically increased thermal stability, which is obtained by introducing...
8999343 Antibodies that bind myostatin, compositions and methods  
Myostatin antagonists, including myostatin binding antibodies, are disclosed. Also disclosed are nucleic acids encoding and cells including myostatin antagonists; methods of production; and...
8993305 Utilization of phosphoketolase in the production of mevalonate, isoprenoid precursors, and isoprene  
The invention provides for methods for the production of mevalonate, isoprene, isoprenoid precursor molecules, and/or isoprenoids in cells via the heterologous expression of phosphoketolase enzymes.
8993743 Chimeric surface active proteins  
The present invention relates to a nucleic acid molecule encoding a chimeric protein having the biochemical activity of a surface active protein, wherein said chimeric protein comprises: (a) an...
8993276 Chimeric enzymes with improved cellulase activities  
Nucleic acid molecules encoding chimeric cellulase polypeptides that exhibit improved cellulase activities are disclosed herein. The chimeric cellulase polypeptides encoded by these nucleic acids...
8993285 Organisms for the production of isopropanol, n-butanol, and isobutanol  
A non-naturally occurring microbial organism having an isopropanol pathway includes at least one exogenous nucleic acid encoding an isopropanol pathway enzyme. The pathway includes an enzyme...
8986965 Production of monoterpenes  
The present invention relates to methods for producing monoterpenes, particularly tricyclene, by culturing microbial organisms that express a terpene synthase and optionally a prenyl transferase.
8975059 Polypeptides having endoglucanase activity and polynucleotides encoding same  
The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs,...
8975048 Multimeric oxidoreductases  
Described herein are multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate. The complexes comprise a dehydrogenase subunit and a cytochrome C...
8975045 Mutant RpsA gene and method for producing L-amino acid  
A method for efficiently producing an L-amino acid utilizing a bacterium belonging to the family Enterobacteriaceae from a fatty acid or an alcohol such as glycerol as a raw material is provided....
8975049 Biofuel production by recombinant microorganisms  
Provided herein are metabolically-modified microorganisms useful for producing biofuels. More specifically, provided herein are methods of producing high alcohols including isobutanol, 1-butanol,...
8969054 Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors  
The invention provides a non-naturally occurring microbial biocatalyst including a microbial organism having a 4-hydroxybutanoic acid (4-HB) biosynthetic pathway having at least one exogenous...
8969521 General method for designing self-assembling protein nanomaterials  
Methods and systems for computationally designing self-assembling polypeptides are disclosed. A representation of a docked configuration of a symmetric protein architecture can be determined by a...
8962294 Perhydrolase variant providing improved specific activity  
An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a...
8962284 Sulfur-containing amino acid-producing bacterium and method for producing sulfur-containing amino acid  
A novel technique for improving the production by bacteria of amino acids that contain sulfur has been developed, and thereby a sulfur-containing amino acid-producing bacterium, and a method for...
8962918 Polynucleotide sequence of fruit softening associated A-mannosidase and its uses for enhancing fruit shelf life  
The present invention provides isolated polynucleotide sequences encoding α-mannosidase. The present invention further provides DNA constructs comprising the polynucleotide sequence coding for...
8962296 Isoprene synthase and gene encoding the same, and method for producing isoprene monomer  
The present invention provides means useful for establishing an excellent isoprene monomer production system. Specifically, the present invention provides a polynucleotide of the following (a),...
8962272 Engineered bacteria produce succinate from sucrose  
Bacteria optimized to produce succinate and other feedstocks by growing on low cost carbon sources, such as sucrose.
8962285 Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane  
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides...
8956838 Carboxyl esterase polypeptides  
The present invention relates to a polynucleotide encoding an enzyme having carboxyl esterase [E.C. 2.1.1.1] activity.
8956843 Perhydrolase variant providing improved specific activity  
An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a...
8951937 Identification and use of bacterial [2Fe-2S] dihydroxy-acid dehydratases  
A group of bacterial dihydroxy-acid dehydratases having a [2Fe-2S] cluster was discovered. Bacterial [2Fe-2S] DHADs were expressed as heterologous proteins in bacteria and yeast cells, providing...
8951764 Production of isoprenoids under neutral pH conditions  
Embodiments of the present disclosure relate to a process for producing isoprenoid precursor molecules and/or isoprenoids from a starch substrate by saccharification and/or fermentation. The...
8945907 Genetically engineered recombinant Escherichia coli producing L-tryptophan having originally L-phenylalanine productivity, and method for producing L-tryptophan using the microorganism  
The present invention relates to a microorganism having L-tryptophan productivity and a method for producing L-tryptophan using the same. More precisely, the present invention relates to the...
8945872 Methods of purifying human recombinant growth and differentiation factor-5 (rhGDF-5) protein  
Expression vector systems are provided for increased production of a recombinant GDF-5 (rhGDF-5) protein. Also provided are transformed host cells that were engineered to produce and express high...
8945887 Whole cell biocatalyst  
The present invention relates to a method for producing a product of a reaction catalysed by a nitrilase, which method comprises the steps (i) providing a microorganism comprising said nitrilase...
8940509 Microorganisms and methods for the production of caprolactone  
The invention provides non-naturally occurring microbial organisms containing caprolactone pathways having at least one exogenous nucleic acid encoding a butadiene pathway enzyme expressed in a...
8940276 Human anti-alpha-synuclein antibodies  
Provided are human alpha-synuclein-specific autoantibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to...
8932834 Method for producing an L-amino acid in a cultured bacterium having reduced activity of the arginine succinyltransferase pathway  
A method for producing an L-amino acid which includes the steps of culturing a bacterium belonging to the family Enterobacteriaceae and having an L-amino acid producing ability in a medium to...
8932586 Modified forms of Pseudomonas exotoxin A  
Pseudomonas exotoxin A or “PE” is a 66 kD, highly potent, cytotoxic protein secreted by the bacterium Pseudomonas aeruginosa. Various forms of PE have been coupled to other proteins, such as...
8932836 Biocatalysts and methods for the synthesis of (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine  
The disclosure provides transaminase polypeptides capable of converting the substrate, 2-(3,4-dimethoxyphenethoxy)cyclohexanone to the trans diastereomer product...
8932845 Highly productive isopropyl alcohol-producing bacterium  
An isopropyl alcohol-producing Escherichia coli equipped with an isopropyl alcohol production system, having at least one enhanced enzyme activity selected from the group consisting of an enhanced...
8927231 Separatome-based protein expression and purification platform  
Provided is a separatome-based recombinant peptide, polypeptide, and protein expression and purification platform based on the juxtaposition of the binding properties of host cell genomic...
8927241 Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway  
The invention relates to the production of one or more terpenoids through microbial engineering, and relates to the manufacture of products comprising terpenoids.
8921525 Highly-functional mutant of humanized anti-EGFR antibody variable region  
[Problem] Disclosed is an antibody that exhibits excellent cytotoxicity and cell growth inhibition and that is based on an anti-human epithelial cell growth factor receptor (1) (Her1) antibody...
8916370 Isoprene synthase variants for improved microbial production of isoprene  
The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention...
8916361 Elongase gene and uses thereof  
The subject invention relates to the identification of a gene involved in the elongation of polyunsaturated fatty acids containing unsaturation at the carbon 9 position (i.e., “Δ9-elongase”) and...
8911978 Method for the preparation of hydroxy acids  
The present invention concerns a modified microorganism for the biological preparation of an hydroxy acid of formula (I) wherein the microorganism comprises a two-step metabolic pathway for the...
8906663 Nitrilases  
The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have...
8906666 Engineering resistance to aliphatic alcohols  
The present disclosure provides improved systems for the biological production of aliphatic alcohol compounds. In particular, the present disclosure provides biological systems that show improved...