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8183013 |
Method for production of protein having non-natural type amino acid integrated therein
This invention provides a method for producing proteins into which non-natural amino acids have been incorporated at desired positions involving the use of either prokaryote-derived or...
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8183016 |
Synthesis method of aromatic amino acids
A method for synthesizing aromatic amino acids according to one aspect of the present invention includes processes of: (a) of preparing a thermostable a Thermus thermophilus aspartate...
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8183036 |
Luciferase biosensor
A modified beetle luciferase protein which is an environmentally sensitive reporter protein is provided.
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8183029 |
Replicable expression vector for bacterial expression of a mammalian polypeptide
Refractile particles containing a heterologous polypeptide as an insoluble aggregate are recovered from bacterial periplasm. The process involves culturing bacterial cells so as to express nucleic...
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8178338 |
Inducible expression vectors and methods of use thereof
The present invention provides nucleic acids that include a promoter that is inducible by a transcriptional activator protein; and a nucleotide sequence that encodes the transcriptional activator...
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8178340 |
Human specific Escherichia coli strains
The present invention relates to human specific Escherichia coli strains.
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8178327 |
Microorganisms for the production of 1,4-butanediol
The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed...
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8178334 |
Variant form of urate oxidase and use thereof
The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for...
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8178090 |
Recombinant hexose oxidase
Use of a preparation as an antimicrobial agent or as an anti-oxidant; wherein said preparation comprises a polypeptide having hexose oxidase activity, the polypeptide being in a substantially pure...
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8178319 |
Peptides and uses thereof
The present invention relates to monovalent fucose-binding peptides. The peptides may be recombinantly produced or chemically synthesized. Preferably the peptides are derived from a lectin, in...
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8178339 |
Reduced genome E. coli
Reduced genome strains of E. coli MG1655 are described. In various embodiments, the strains have one or more of equal or improved growth rate, transformation efficiency, protein expression, DNA...
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8173364 |
Methods and composition for the production of orthogonal tRNA-aminoacyl tRNA synthetase pairs
This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs...
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8173410 |
Isoprene synthase variants for improved microbial production of isoprene
The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention...
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8173397 |
Folded recombinant catalytic fragments of multidomain serine proteases, preparation and uses thereof
The invention relates to unglycosylated folded C-terminal fragments of a multidomain serine protease of the complement cascade obtainable by expression in a bacterial host, wherein said serine...
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8168411 |
Highly thermostable fluorescent proteins
Thermostable fluorescent proteins (TSFPs), methods for generating these and other stability-enhanced proteins, polynucleotides encoding such proteins, and assays and method for using the TSFPs and...
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8163525 |
Method of expressing long-chain prenyl diphosphate synthase
The present disclosure describes a method of producing a long-chain prenyl diphosphate synthase (in particular decaprenyl diphosphate synthase and solanesyl diphosphate synthase) using a gene and a...
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8158382 |
UBP1 protease mutant and its coding sequence, their applications and heterogonous protein expression system
Invention relates to novel and improved UBP1 protease mutants with a substitution at position (754), a deletion of amino-acids at position (1-54) and at least a portion of the amino-acids found at...
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8158387 |
Method for cell surface display of target proteins using FadL of E. coli
The present invention relates to an expression vector which can effectively express target proteins or peptides on the surface of cells using an outer membrane protein (FadL) of E. coli as a...
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8153397 |
Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy
The present invention relates to the construction, expression, and purification of synthetic or recombinant light chain (LC) botulinum neurotoxin genes from all botulinum neurotoxin serotypes. The...
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8153412 |
Variants of Bacillus sp. TS-23 alpha-amylase with altered properties
Variants of Bacillus sp. TS-23 strain alpha-amylases exhibit improved enzymatic performance, including increased themostability, reduced calcium dependence, increased washing/cleaning performance,...
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8148105 |
Scaleable manufacturing process for cysteine endoprotease B, isoform 2
Methods are provided for the production of gram to kilogram quantities of pro-EP-B2 (proenzyme form of EP-B2) in a lyophilized form. The methods include scalable fermentation, refolding and...
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8148137 |
Mutant microorganism having improved production ability of branched amino acid and method for preparing branched amino acid using the same
The present invention relates to mutant microorganisms having improved productivity of branched-chain amino acids, and a method for producing branched-chain amino acids using the mutant...
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8143044 |
Crystal structure of the influenza virus polymerase PAC-PB1N complex and uses thereof
Provided are the expression method of influenza virus polymerase PAc-PB1N complex, the co-crystallization method of the complex and the three-dimendional structure of the crystal of PAc-PB1N...
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8129156 |
Microorganisms for the production of 1,4-butanediol
The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO) pathway comprising at least one exogenous nucleic acid encoding a BDO pathway enzyme expressed...
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8129148 |
Process for preparation of chondroitin fraction
Provided are a method for producing a fraction containing more than 50% of CH represented by the general formula (1), which comprises at least the step of allowing a glucuronic acid donor, an...
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8124375 |
Geraniol synthase, methods of production and uses thereof
The present invention relates to novel type of monoterpene synthase, a key enzyme in the production of the monoterpene aroma compound geraniol. More specifically, the present invention relates to...
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8124407 |
Circular nucleic acid vectors, and methods for making and using the same
Circular nucleic acid vectors that provide for persistently high levels of protein expression are provided. The circular vectors of the subject invention are characterized by being devoid of...
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8124381 |
Process and materials for production of glucosamine and N-acetylglucosamine
A biosynthetic method for producing glucosamine and N-acetylglucosamine is disclosed. Such a method includes the fermentation of a genetically modified microorganism to produce glucosamine and/or...
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8119386 |
Proteases and variants thereof
The present invention relates to isolated proteases of the RP-II type and variants of RP-II proteases exhibiting improved properties in comparison to the parent RP-II protease, DNA constructs and...
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8114627 |
Genetically programmed expression of selectively sulfated proteins in eubacteria
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid sulfotyrosine into proteins produced in eubacterial host cells such...
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8114639 |
Method for producing an L-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of the sfmACDFH-fimZ cluster or the fimZ gene
The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which...
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8114628 |
Expanding the eukaryotic genetic code
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include...
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8114652 |
Genetically programmed expression of selectively sulfated proteins in eubacteria
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid sulfotyrosine into proteins produced in eubacterial host cells such...
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RE43166 |
Gene encoding chondroitinase ABC and uses therefor
Nucleic acid sequences coding for the chondroitinase ABC gene and isolated chondroitinase ABE protein produced in a host cell transformed with a nucleic acid vector directing the expression of a...
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8101378 |
Dual expression vector system and screening methods
The present invention features vectors that contain a promoter effective for expression in bacterial cells and a promoter effective for expression in insect cells. The dual promoter system allows...
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8101394 |
Recombinantly modified plasmin
Polynucleotides and polypeptides relating to a recombinantly-modified plasmin(ogen) molecule are provided. The plasmin(ogen) molecule has a single kringle domain N-terminal to the activation site...
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8101386 |
Escherichia coli strains which over-produce L-threonine and processes for the production of L-threonine by fermentation
The present invention relates to the fields of microbiology and microbial genetics. More specifically, the invention relates to novel bacteria strains and processes employing these strains for the...
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8088607 |
Microorganisms for the production of adipic acid and other compounds
The invention provides a non-naturally occurring microbial organism having an adipate, 6-aminocaproic acid or caprolactam pathway. The microbial organism contains at least one exogenous nucleic...
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8080397 |
Biocatalystic synthesis of quinic acid and conversion to hydroquinone by recombinant microbes
A bioengineered synthesis scheme for the production of quinic acid from a carbon source is provided. Methods of producing quinic acid from a carbon source based on the synthesis scheme as well as...
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8080402 |
Surface expression method of peptides P5 and Anal3 using the gene encoding poly-gamma-glutamate synthetase
The present invention relates to a method for expressing each of peptide antibiotics P5 3 and Anal3 35 having amphiphilicity and showing antibacterial, antifungal and anticancer activities 61, 63,...
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8071339 |
Mutant phosphoribosylpyrophosphate synthetase and method for producing L-histidine
The present invention relates to a mutant bacterial PRPP synthetase which is resistant to feedback by purine nucleotides, and a method for producing L-histidine using the bacterium of the...
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8067202 |
Bacterial superantigen vaccines
The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an...
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8067214 |
Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors
The invention provides a non-naturally occurring microbial organism having 4-hydroxybutanoic acid (4-HB) and 1,4-butanediol (1,4-BDO) biosynthetic pathways. The pathways include exogenous nucleic...
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8062865 |
Expression control using antibody expression optimisation sequences
The present invention provides a dicistronic message for producing an antibody molecule, in which the upstream cistron contains DNA coding for the light chain of the antibody and the downstream...
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8048624 |
Compositions and methods for 3-hydroxypropionate bio-production from biomass
Methods of obtaining mutant nucleic acid sequences that demonstrate elevated oxaloacetate α-decarboxylase activity are provided. Compositions, such as genetically modified microorganisms that ...
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8039687 |
Method for screening genomic DNA fragments
The present invention provides a method for selecting genomic DNA fragments which are useful for providing a plant with an agriculturally advantageous improvement. The method of the present...
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8039434 |
Method for producing human insulin-like growth factor I
A method is provided for producing hIGF-I with high purity and yield. This is a method for producing human insulin-like growth factor I, having a step of removing modified human insulin-like growth...
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8034907 |
Polynucleotides encoding soluble, stable forms of human double minute 2 polypeptides
The present invention discloses modified Hdm2 proteins that are soluble. In addition, the present invention discloses nucleic acids that encode the modified Hdm2 proteins of the present invention....
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8030036 |
Method for producing L-lysine or L-threonine
A bacterium belonging to the genus Escherichia which has an ability to produce L-lysine or L-threonine and which is modified so that a malic enzyme does not function normally in a cell, and a...
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8030028 |
Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of...
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