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7449178 |
Attenuated gram negative bacteria
Disclosed and claimed are a mutant of a gram negative bacterium, wherein said bacterium has at least one mutation in a nucleotide sequence which codes for a polypeptide having an identity which is...
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7449317 |
Phytase enzymes, nucleic acid sequences encoding phytase enzymes and vectors and host cells incorporating same
DNA is provided which encodes an enzyme having phytase activity isolated from Penicillium, Fusarium, Humicola and Emericella . Also provided for is a method of isolating DNA encoding an enzyme...
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7449188 |
Recombinant oligometric protein complexes with enhanced immunogenic potential
The present invention relates to a chimeric protein comprising an antigen and an oligomerisation domain. The present invention relates further to recombinant oligomeric protein complexes comprising...
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7449310 |
Recombinant Fusobacterium necrophorum leukotoxin vaccine and preparation thereof
The F. necrophorum gene expressing leukotoxin was sequenced and cloned. The leukotoxin open reading frame (lktA) is part of a multi-gene operon containing 9,726 bp, and encoding a protein...
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7446241 |
Transcription factors, DNA and methods for introduction of value-added seed traits and stress tolerance
Abscisic acid-inducible gene expression in different plant tissues is enhanced synergistically by the co-expression of a B3-domain transcription factor and various bZIP-domain transcription...
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7445922 |
Zygomycetes-derived endoglucanase enzyme lacking cellulose-binding domain
This invention relates to a protein that is a Zygomycetes -derived endoglucanase lacking the cellulose-binding domain and exhibits endoglucanase activity, and a method for using the same. This...
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7446183 |
Fusion protein comprising growth hormone and growth hormone receptor
This invention relates to agents which bind to cell surface receptors; methods to manufacture said agents; therapeutic compositions comprising said agents; and screening methods to identify novel...
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7445915 |
Mutant isopropylmalate isomerase
The present invention provides a polypeptide comprising an amino acid sequence in which at least one amino acid is deleted, substituted or added in an amino acid sequence of isopropylmalate...
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7445921 |
Transglycosylation method and protein having transglycosylation activity
The present invention provides a transglycosylation method and a protein catalyzing a transglycosylation reaction. A reaction of transferring a galactosylβ1→3N-acetylgalactosaminyl group from a...
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7445920 |
Member of the lysyl oxidase gene family
The present invention relates to a novel lysyl oxidase genes, termed EER-7. The invention relates to the protein and nucleic acids encoding the protein. The invention further relates to an assay...
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7445917 |
Process for producing glycolic acid from formaldehyde and hydrogen cyanide
A process is provided for producing glycolic acid from formaldehyde and hydrogen cyanide. More specifically, heat-treated formaldehyde and hydrogen cyanide are reacted to produce glycolonitrile...
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7442535 |
Fusion protein incorporating a cysteinized ribonuclease
A fusion protein contains a cysteinized variant of an RNase disclosed in U.S. Pat. No. 6,239,257 B1.
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7442766 |
Pfu replication accessory factors and methods of use
This invention provides isolated polynucleotides that encode replication accessory factors. The invention also provides novel DNA replication accessory factors, which have been isolated and...
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7442540 |
Polynucleotide encoding coleopteran-toxic polypeptide
Disclosed are novel insecticidal polypeptides, and compositions comprising these polypeptides, peptide fragments thereof, and antibodies specific therefor. Also disclosed are vectors, transformed...
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7442532 |
Essential fungal CaYLR100w polypeptides, and methods of use
The present invention provides essential fungal polynucleotides and their encoded polypeptides, homologues thereof and their uses. Additionally, the invention provides methods for the...
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7439061 |
DNA encoding the novel mammalian protein, Ire1p
A novel polynucleotide encoding a mammalian bifunctional protein kinase\endoribonuclease referred to herein as hIre1p, is provided. hIre1p is expressed in the endoplasmic reticulum (ER) and...
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7439034 |
Alginases, systems containing alginases and methods of cloning, purifying and/or utilizing alginases
The present invention relates to cell wall degradative systems, in particular to systems containing enzymes that bind to and/or depolymerize cellulose. These systems have a number of applications.
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7439050 |
Corynebacterium glutamicum genes encoding diaminopimelate epimerase
Isolated nucleic acid molecules, designated MP nucleic acid molecules, which encode novel MP proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic...
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7439045 |
pH controlled fermentation process for pseudomonic acid production
An improved fermentation process for preparing pseudomonic acid A (mupirocin) is disclosed. The metabolically controlled fermentation process provides culturing a Pseudomonas sp. strain in a...
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7439053 |
Transformed Shigella
A method for modifying a wild strain of an entero-invasive Shigella to produce a modified strain of Shigella that can be used for making a vaccine against the wild strain of Shigella . The...
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7439224 |
Indications of mannan-binding lectin (MBL) in the treatment of immuno-compromised individuals
The present invention relates to the use of a composition comprising at least one mannan-binding lectin (MBL) subunit, or at least one mannan-binding lectin (MBL) oligomer comprising the at least...
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7439044 |
High viscosity xanthan polymer preparations
Increasing the molecular length of xanthan polymer makes a higher viscosity xanthan composition. Xanthan with higher specific viscosity characteristics provides more viscosity at equivalent...
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7438912 |
S.agalactiae antigens I + II
The present invention discloses isolated nucleic acid molecules encoding a hyperimmune serum reactive antigen or a fragment thereof as well as hyperimmune serum reactive antigens or fragments...
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7439039 |
Assays for novel serotonin transporter (SERT) blockers
The serotonin transporter (SERT) is a target of various therapeutic agents used in the treatment of neurological and neurodegenerative disorders. The present invention provides novel forms of SERT...
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7439049 |
Nucleic acid molecules coding for a dextran-saccharase catalysing the synthesis of dextran with α 1,2 osidic sidechains
The invention relates to an isolated polypeptide with an glycosyl transferase enzymatic activity for producing dextrans with α(1→2) sidechains, comprising at least one region for bonding to...
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7435571 |
Microbial production of COQ10
The present Invention relates to enzymes involved in the Synthesis of Coenzyme Q-10, i.e., decaprenyl diphosphate (DPP) synthase and 4-hydroxybenzoate polyprenyltransferase, to isolated DNA...
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7435556 |
Method for increasing the ratio of p-hydroxybenzoic acid ester glucoside to total p-hydroxybenzoic acid glucose conjugates in p-hydroxybenzoic acid-producing microorganisms and green plant cells
This invention pertains to a method for increasing the ratio of the pHBA ester glucoside to total pHBA glucose conjugates in pHBA-producing microorganisms and green plant cells using nucleic acid...
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7435808 |
Polynucleotides encoding novel adiponectin receptor variant, AdipoR2v2
The present invention provides novel polynucleotides encoding human AdipoR2v1 polypeptides, mouse AdipoR2v1 polypeptides, human AdipoR3 polypeptides, human AdipoR2v2 polypeptides, human AdipoR3v1...
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7435574 |
NADH oxidase from Lactobacillus
The present invention is directed to a new NADH oxidase from Lactobacillus , nucleic acids encoding the NADH oxidase, methods of producing the NADH oxidase, as well as there use in producing...
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7435434 |
Phage resistant bacteria
The invention relates to an S thermophilus bacterium which is resistant to attack by at least one bacteriophage, a method of production of the bacterium and a composition which comprises the...
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7432079 |
Plant virus coat fusion proteins with GDF8 epitopes and vaccines thereof
The invention provides a fusion protein comprising a plant virus coat protein and a GDF8 peptide domain, or antigenic fragment of the GDF8 peptide domain. Plant virus vectors expressing the fusion...
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7432089 |
DNA encoding favin-adenine-dinucleotide-dependent-D-erythronate-4-phosphate-de-hydrogenase, pdxR, and microbial production of vitamin B6
The present invention relates to a DNA encoding a novel flavin adenine dinucleotide (FAD)-dependent D-erythronate 4-phosphate (EN4P) dehydrogenase originated from Sinorhizobium meliloti , which is...
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7432100 |
Variant aldolase and processes for producing an optically active IHOG and an optically active monatin using the same
The present invention relates to variant aldolase enzymes that are modified so as to produce IHOG (4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid: IHOG), a process for producing an optically...
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7432077 |
High-affinity choline transporter
The present invention provides a protein having high-affinity choline transporter activity which is important physiologically, a gene encoding the protein, and a method of screening a material...
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7432095 |
Formate dehydrogenase tolerant to halogen compounds and process for producing the same
The invention provides a formate dehydrogenase having high specific activity, small Km values for formate and NAD, broad temperature and pH ranges of stability, broad temperature and pH ranges for...
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7432096 |
Glucose dehydrogenase and production thereof
The invention relates to novel PQQ-dependent soluble glucose dehydrogenases (sPQQGDH) from Acinetobacter and to a process for their preparation by overexpression in suitable microbial expression...
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7432350 |
Recombinant biotin carboxylase domains for identification of Acetyle CoA carboxylase inhibitors
A peptide comprising an Acetyl CoA carboxylase (ACCase) having a deleted biotin binding domain, having a deleted carboxy transferase domain, and having a functional biotin carboxylase (BC) domain...
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7431927 |
TNFα-neutralizing antibodies
The invention provides monoclonal antibodies that neutralize TNFα activity. The monoclonal antibodies may be rabbit monoclonal antibodies or monoclonal antibodies having CDR regions derived from...
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7432090 |
Blocking sporulation by inhibiting SpoIIE
We have shown that the control of solventogenesis and sporulation can be genetically uncoupled in C. acetobutylicum . In strain 824(pASspo), the absence of SpoIIE causes sporulation to be blocked...
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7432246 |
Sir2 products and activities
A novel compound, 2′/3′-O-acetyl-ADP-ribose, is provided. The compound is a mixture of the 2′ and 3′ regioisomers of O-acetyl-ADP ribose, and is formed nonenzymatically from...
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7432097 |
Phytases, nucleic acids encoding them and methods of making and using them
In one aspect, the invention provides a purified and modified phytase enzyme from Escherichia coli K12 appA phytase. The enzyme has phytase activity and improved thermal tolerance as compared...
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7432053 |
Fluorescent protein from Aequorea coerulscens and methods for using the same
The present invention provides nucleic acid compositions encoding a novel colorless GFP-like protein, acGFP, from Aequorea coerulscens and fluorescent and non-fluorescent mutants and derivatives...
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7429484 |
Nucleic acid molecules encoding osteogenic proteins
Disclosed are 1) osteogenic devices comprising a matrix containing osteogenic protein and methods of inducing endochondral bone growth in mammals using the devices; 2) amino acid sequence data,...
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7429474 |
2-O sulfatase compositions and methods of analyzing therewith
The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode...
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7427487 |
Constitutively active CXCR3 G protein-coupled chemokine receptor and modulators thereof for the treatment of inflammatory disorders
The invention disclosed in this patent document relates to transmembrane receptors, particularly to a human G protein-coupled receptor, more particularly to a CXC chemokine receptor subtype 3...
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7427492 |
Polynucleotides encoding human tumor necrosis factor receptor-like2
The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice...
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7427658 |
Chicken anemia virus mutants and vaccines and uses based on the viral proteins VP1, VP2 and VP3 or sequences of that virus coding therefor
The coding information for three putative chicken anemia virus proteins (VP1, VP2, VP3) was inserted into a baculovirus vector and expressed in insect cells. Only lysates of insect cells which have...
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7425429 |
Method for the identification of tissue-specific regulatory sequences
The invention relates to a method for the identification of regulatory sequences in genomes of micro-organisms, isolated ex vivo from infected tissues. The invention further relates to promoters in...
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7425667 |
Methods to produce desired proteins in plants
Fusion proteins that comprise at least one subunit of glutelin and a desired protein permit enhanced production of the desired protein in a useable form in plants. Such fusion proteins may be used...
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7425436 |
Covalent tethering of functional groups to proteins and substrates therefor
A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase...
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