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7598067 |
PDEs and uses thereof
The present invention provides isolated full-length nucleic acid molecules encoding the novel PDE protein of the invention, and methods for uses thereof. The nucleic acid molecules of the invention...
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7598065 |
S-adenosylmethionine-6-N-lysine-methyltransferase from Neurospora crassa, a gene encoding the same, a vector and host cell containing the same, and method for producing trimethyllysine using the host cell
Provided is S-adenosylmethionine-6-N-lysine-methyl-transferase obtained from Neurospora crassa , a polynucleotide encoding the same, a vector and host cell containing the polynucleotide, and a...
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7598063 |
Process for producing ethanol by using recombinant coryneform bacterium
The present invention provides a process for highly efficiently producing ethanol at a high productivity consisting of using a coryneform bacterium which has been transformed by a DNA containing a...
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7595184 |
Nitrile hydratase variant
The amino acid sequence of a mutant which is obtained by introducing a novel mutation into a Pseudonocardia thermophila JCM3095-derived nitrile hydratase consisting of two types of heterogeneous...
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7595178 |
Process for the preparation of amides
A novel biotechnological process for the preparation of nitrites, starting from amides, is described. Microorganisms of the genus Amycolatopsis, Actinomadura or Rhodococcus are employed for...
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7595185 |
Cytotoxin-based biological containment
Method of conditionally controlling the survivability of a recombinant cell population and of containing such cells to an environment or containing replicons to a host cell is based on the use of...
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7595182 |
Endoglucanase STCE and cellulase preparation containing the same
A novel endoglucanase derived from Staphylotrichum coccosporum , a polynucleotide encoding the endoglucanase, and a cellulase preparation containing the endoglucanase are disclosed. The...
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7595186 |
Cytotoxin-based biological containment
Method of conditionally controlling the survivability of a recombinant cell population and of containing such cells to an environment or containing replicons to a host cell is based on the use of...
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7595183 |
Cathepsins L-like cysteine protease derived from northern shrimp (Pandalus eous)
The object of the present invention is to find and produce cathepsin L having high activity under neutral to alkaline conditions and at a low temperature range. The present inventors succeeded in...
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7595375 |
Fluorescent protein
The present invention provides a fluorescent protein having an amino acid sequence of the green fluorescent protein, the yellow fluorescent protein or mutants thereof wherein the 46th phenylalanine...
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7595175 |
Polyketides and their synthesis
Biosyntheses of compounds whereof at least portions are polyketides produced by means of polyketide synthase (PKS) enzyme complexes are carried out after specific alterations have been made within...
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7595156 |
Genes for synthesis of FR-008 polyketides
The present invention relates to the base sequence of whole genes involved in the biosynthesis of FR-008 polyketides derived from Streptomyces sp. FR-008. This base sequence comprises genes...
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7592011 |
Genes and proteins, and their use
A protein from Group B Streptococcus is shown to be an outer surface protein and is a useful target for antimicrobial therapy.
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7592166 |
Enone reductase gene and microbial production of levodione
Disclosed is an isolated DNA comprising a nucleotide sequence coding for an enzyme having enone reductase activity wherein the enzyme is characterized by the following physico-chemical properties:...
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7592439 |
Method for making monoclonal antibodies and cross-reactive antibodies obtainable by the method
A method of making monoclonal antibodies according to a mixed antigen immunization protocol is described. In addition, antibodies obtainable by the method are disclosed which specifically...
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7592434 |
Pectate lyases, nucleic encoding them and methods for making and using them
The invention is directed to polypeptides having pectate lyase (pectinase) activity, polynucleotides encoding the polypeptides, and methods for making and using these polynucleotides and...
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7592156 |
Synthetic dog/human chimeric C-C chemokine receptor 2B
Disclosed herein are polynucleotides encoding a chimeric C—C chemokine receptor 2B, the encoded polypeptides thereof, and methods of making and using said polynucleotides and polypeptides.
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7592509 |
Isolated DNA sequences and polypeptides inducing multiple resistance of plants to phytopathogens and pests
The invention relates to isolated DNA sequences encoding MF3 polypeptides that induce multiple resistance in plants toward a variety of viral and microbial infections and against pests and a method...
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7592437 |
Genes involved in intestinal inflammatory diseases and use thereof
The invention concerns genes involved in inflammatory and/or immune diseases and some cancers, in particular intestinal cryptogenic inflammatory diseases, and proteins coded by said genes. The...
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7592165 |
Process for the enzymatic preparation of an amide from a nitrile
Disclosed herein are cyanide-tolerant nitrile hydratases especially from Pseudomonas putida or Pseudomonas marginalis strains which exhibit increased cyanide tolerance. Also disclosed are...
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7592140 |
2′, 5′-oligoadenylate phosphodiesterase
Polypeptides having 2′,5′-oligoadenylate phosphodiesterase activity, antibodies against the polypeptides, polynucleotides coding for the polypeptides, recombinant plasmid DNAs into which the...
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7588930 |
Compositions and methods for enhancing the immunogenicity of antigens
The present invention includes compositions, methods and kits for enhancing the immunogenicity of an antigen via fusion to a Listerial protein. The present invention further encompasses Listeria ...
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7588926 |
Proteases
The invention relates to a novel class of serine proteases of peptidase family S2A or S1E that are stable in the presence of copper (Cu2+) and/or inhibited by copper only to a limited extent....
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7588901 |
Modulation of angiogenesis through targeting of arginyl transferase (ATE1)
The invention provides methods and compositions for modulating angiogenesis in a subject. The methods of modulating angiogenesis in a subject include administering to the subject a modulator of...
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7588914 |
Bacterial Bcl-2 domain-containing polypeptides, encoding nucleic acid molecules, and related methods
The invention provides isolated Bcl-2 domain-containing polypeptides from Mycobacterial species, including M. tuberculosis, M. avium, M. bovis, M. leprae and M. smegmatis, and from Streptomyces...
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7588920 |
Nucleic acid and amino acid sequences relating to Staphylococcus epidermidis for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Staphylococcus epidermidis that are useful in diagnosis and therapy of pathological conditions; antibodies...
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7588934 |
Gene encoding fumarate hydratase C and use thereof
A nucleotide sequence encoding a fumarate hydratase C and a method for preparing succinic acid using the same, more particularly, a fumarate hydratase C having the activity of converting malate to...
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7588933 |
Nucleotide sequences for detecting enterohaemorrhagic Escherichia coli (EHEC)
The invention concerns nucleic sequences of plasmid origin, present in bacteria of the group enterohemorrhagic Escherichia coli (EHEC), the use of said sequences for searching for EHEC, in...
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7588758 |
COX-2 function and wound healing
The invention relates to compositions and methods for enhancing bone healing, bone formation and wound healing. More specifically, it relates to the use of cyclooxygenase 2 (COX-2) following bone...
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7588927 |
Composition and methods relating to SENP1—a sentrin-specific protease
The invention relates to a novel protease, called SENP1, which is active against sentrin-modified proteins in vivo. The invention more specifically relates to the genomic and amino acid sequences...
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7588900 |
Mammalian sweet and amino acid heterodimeric taste receptors
The present invention provides isolated nucleic acid and amino acid sequences of sweet or amino acid taste receptors comprising two heterologous G-protein coupled receptor polypeptides from the T1R...
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7588916 |
T1R taste receptors and genes encoding same
Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in...
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7585961 |
Nucleic acid encoding human antibodies specific for interleukin 15 (IL-15)
Isolated human monoclonal antibodies which specifically bind to IL-15 (e.g., human IL-15), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced...
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7585654 |
Nucleic acid encoding cysteinized ribonuclease to which a targeting moiety can be conjugated
A nucleic acid encodes a cysteinized RNase to which a targeting moiety can be conjugated.
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7585648 |
Nucleic acids encoding neutralizing GDF8 epitope-based peptides and fusion proteins
The invention provides new, specific nucleic acids encoding antigenic peptides from the protein GDF8. The invention also provides nucleic acids encoding fusion proteins comprising the new peptides,...
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7585653 |
Oncokinase fusion polypeptides associated with hyperproliferative and related disorders, nucleic acids encoding the same and methods for detecting and identifying the same
Oncokinase fusion polypeptides associated with hyperproliferative disorders and the polynucleotides encoding for such fusion polypeptides are provided. The fusion polypeptides have a C-terminal...
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7585659 |
Carotene synthase gene and uses therefor
Described herein is a novel three domain gene from Schizochytrium , denoted carotene synthase, that encodes a protein with three different enzymatic activities: phytoene dehydrogenase (PD),...
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7585658 |
Staphylococcus aureus antigenic polypeptides and compositions
The invention relates to a method for the identification of antigenic polypeptides expressed by pathogenic microbes; vaccines comprising such polypeptides; recombinant methods to manufacture such...
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7585650 |
Alleles of the zwf gene from coryneform bacteria
The invention relates to mutants and alleles of the zwf gene of coryneform bacteria, which encode variants of the Zwf subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes...
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7585960 |
Nucleic acids encoding superagonistic anti-CD28 antibodies
The present invention relates to one or more nucleic acid(s) encoding a binding molecule specifically binding to a human CD28 molecule, comprising
(a) a nucleic acid sequence encoding a VH...
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7585646 |
Human GIL-19/AE289 polynucleotides and methods of producing the encoded polypeptides
Novel human GIL-19/AE289 protein is disclosed which shows a high degree of homology to interleukin-10 (IL-10). Polynucleotides encoding such protein are also enclosed.
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7585655 |
Nucleic acid encoding a fusion protein incorporating a cysteinized ribonuclease
A nucleic acid encodes a novel fusion protein. The fusion protein contains a cysteinized variant of an RNase disclosed in U.S. Pat. No. 6,239,257 B1.
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7582475 |
Vectors and methods for high throughput co-expression
The present invention includes vectors and methods for high throughput co-expression.
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7582445 |
Anti-interferon-α antibodies
Compositions of matter encoding or useful for expressing anti-interferon alpha antibodies are provided. Methods of using such compositions of matter for producing anti-interferon alpha antibodies...
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7582742 |
Method of treating or preventing an IL-1 related disease or condition
Methods of treating or preventing an IL-1 related disease or condition in a mammal comprising administering an effective amount of an IL-1β binding antibody or IL-1β binding fragment thereof. An...
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7582449 |
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies...
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7582743 |
Texturizing lactic bacteria
The invention relates to a novel strain of lactic bacteria comprising at least one sequence selected from a group consisting of nucleotide sequences SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3, SEQ ID...
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7582463 |
Non-reducing saccharide-forming enzyme, trehalose-releasing enzyme, and process for producing saccharides using the enzymes
A non-reducing saccharide-forming enzyme and a trehalose-releasing enzyme, which have an optimum temperature in a medium temperature range, i.e., a temperature of over 40 or 45° C. but below 60°...
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7582460 |
3-phosphoglycerate dehydrogenase variants whose inhibition by L-serine is reduced, and genes encoding them
A 3-phosphoglycerate dehydrogenase (PGD) which exhibits a susceptibility to inhibition by serine which is reduced a as compared with that of an Escherichia coli wild-type PGD and which possesses...
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7582731 |
Nucleic acid and amino acid sequences relating to Streptococcus pneumoniae for diagnostics and therapeutics
The invention provides isolated polypeptide and nucleic acid sequences derived from Streptococcus pneumoniae that are useful in diagnosis and therapy of pathological conditions; antibodies...
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