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7425324 |
Antagonists of MCP proteins
Novel antagonists of MCP proteins, in particular of MCP-1 protein, can be obtained by generating MCP mutants whose GAG binding site, located at the N-terminal of MCP proteins, is eliminated...
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7422873 |
Mutant carotenoid ketolase
CrtW carotenoid ketolases are provided useful for the production of astaxanthin. The ketolases genes of the present invention exhibit improved ketolase activity when converting cyclic hydroxylated...
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7422754 |
Neisseria meningitidis compounds and anti-infection applications thereof
The invention provides novel Neisseria meningitides (Nm) polypeptides and polynucleotides which cover the Nm genetic diversity, and which correspond to polypeptide of Nm outer membrane and/or...
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7422880 |
Method for producing an l-amino acid using a bacterium of the enterobacteriaceae family having a pathway of glycogen biosynthesis disrupted
There is provided a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to the genus Escherichia or Pantoea , having the...
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7422898 |
Nucleic acid encoding monkey Gpr103
There are provided non-human primate and rat GPR103 genes and proteins and a compound evaluation method employing the genes or proteins. There are also provided highly useful novel ligands for...
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7422890 |
Therapeutic and prophylactic agents and methods of using the same
A phospholipase A 2 inhibitor protein designated “Phospholipase Inhibitor from Python” (PIP)—formerly designated “Python Antitoxic Factor” (PAF)—is given by SEQ ID NO:2. The partial...
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7422884 |
Feedback-resistant mevalonate kinases
The present invention relates to modified mevalonate kinases that are less sensitive to feedback inhibition, and to polynucleotides encoding them. The invention further pertains to vectors...
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7419813 |
Fructosyl peptide oxidase
The present invention has an object of providing a novel fructosyl peptide oxidase having superior physicochemical properties such as stability that is useful as an enzyme for clinical diagnosis,...
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7419815 |
Inhibitors of plant peptide deformylase for use as broad-spectrum herbicides and methods for identifying the same
The invention relates to a method of identifying herbicides and to the use of inhibitors of plant peptide deformylase as broad spectrum herbicides.
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7419814 |
Mammalian sphingosine kinase type 2 isoforms, cloning, expression and methods of use thereof
Methods for detecting agents or drugs which inhibit or promote an activity of sphingosine kinase type 2 isoform involving providing a recombinant DNA construct into a cell such that sphingosine...
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7419672 |
Genes and proteins, and their use
According to the present invention, a series of genes are identified in Group B Streptococcus, the products of which may be associated with the outer surface of the organism. The genes, or...
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7419791 |
Methods of screening compounds using a T1R3 hetero-oligomeric taste receptor
Newly identified mammalian taste-cell-specific G protein-coupled receptors which function as hetero-oligomeric complexes in the sweet taste transduction pathway, and the genes and cDNA encoding...
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7419810 |
Arginine repressor deficient strain of coryneform bacterium and method for producing L-arginine
L-Arginine is produced by culturing a coryneform bacterium in which an arginine repressor involved in L-arginine biosynthesis is deleted by disrupting a gene coding for the repressor, and which has...
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7419824 |
BASB006 polypeptides from Neisseria meningitidis and immunogenic compositions thereof
The invention provides BASB006 polypeptides and polynucleotides encoding BASB006 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic,...
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7420038 |
Compositions for controlling hair growth
FP-1 is a protein that is specifically expressed in the follicular papilla of the hair follicle. The nucleic acid and amino acid sequences of FP-1, as well as antibodies that specifically bind FP-1...
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7416859 |
Rhodococcus cloning and expression vectors
A plasmid has been isolated from Rhodococcus erythropolis strain AN12 comprising a unique replication protein. The replication protein may be used in a variety of cloning and expression vectors...
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7416872 |
Taxoid oxygenases and their uses
Oxygenase enzymes and the use of such enzymes to produce paclitaxel (Taxol™), related taxoids, as well as intermediates in the Taxol biosynthetic pathway are disclosed. Also disclosed are nucleic...
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7417131 |
Modified green fluorescent proteins and methods for using same
The present invention provides nucleic acid molecules encoding mutant fluorescent proteins as well as proteins encoded by these nucleic acids. In addition, host-cells, stable cell lines and...
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7416849 |
HBM variants that modulate bone mass and lipid levels
The present invention relates to methods and materials used to express an HBM-like polypeptide derived from HBM, LRP5 or LRP6 in animal cells and transgenic animals. The present invention also...
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7416881 |
Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor
Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of α-factor, transporters of a-factor, pheromone receptors, etc.) and a...
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7416877 |
Receptor that causes cell death and recombinant production thereof
Isolated apoptosis inducing receptors, DNAs encoding such receptors, and pharmaceutical compositions made therefrom, are disclosed. The isolated receptors can be used to regulate an immune...
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7416878 |
Immunogenic compositions including rough phenotype Brucella host strains and complementation DNA fragments
Live attenuated vaccines against brucellosis and infection by other diseases are described. It has been discovered that trans complementation of the Brucella wboA gene can be used to maintain an...
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7416866 |
Process for the overexpression of dehydrogenases
A process for the overexpression of dehydrogenases, especially for the overexpression of Δ 1 -dehydrogenases, in particular for the overexpression of 3-keto steroid-Δ 1 -dehydrogenases, as well...
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7416875 |
Cytotoxic ribonuclease variants
This invention relates to altered forms of members of the RNase A superfamily. An RNase A can be modified to be cytotoxic by altering its amino acid sequence so that it is not bound easily by the...
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7414122 |
Nucleic acids encoding B7-Like molecules and uses thereof
The present invention provides B7-Like (B7-L) polypeptides and nucleic acid molecules encoding the same. The invention also provides selective binding agents, vectors, host cells, and methods for...
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7413875 |
ESTs and encoded human proteins
The sequences of 5′ ESTs and consensus contigated 5′ESTs derived from mRNAs encoding secreted proteins are disclosed. The 5′ ESTs and consensus contigated 5′ESTs may be to obtain cDNAs and...
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7413877 |
Bacterial expression of bowman-birk protease inhibitors and variants thereof
The present invention provides compositions and methods related to the expression of Bowman-Birk protease inhibitors and variants thereof in bacterial species. The present invention further...
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7414119 |
Aldolases, nucleic acids encoding them and methods for making and using them
The invention provides novel aldolases, nucleic acids encoding them and methods for making and using them, including chemoenzymatic processes for making β,δ-dihydroxyheptanoic acid side chains...
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7413876 |
Expression of G protein coupled receptors in yeast
Disclosed is a transformed yeast cell containing a first heterologous DNA sequence which codes for a mammalian G protein-coupled receptor and a second heterologous DNA sequence which codes for a...
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7413888 |
Variants of beta-glucosidases
The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842...
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7411057 |
Nucleic acids encoding human monoclonal antibodies to CTLA-4
In accordance with the present invention, there are provided fully human monoclonal antibodies against human cytotoxic T-lymphocyte antigen 4 (CTLA-4). Nucelotide sequences encoding and amino acid...
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7410776 |
Polypeptides, their production and use
This invention relates to a novel polypeptide involving in the modulation of central nervous system function, circulatory function, immune function, gastrointestinal function, metabolic function,...
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7410765 |
System for protease mediated protein expression
The present invention provides methods and materials that can be used to detect, examine and exploit protease mediated protein expression. An illustrative embodiment of the invention is a...
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7410648 |
Polypeptides of Moraxella (Branhamella) catarrhalis
The present invention relates to polypeptides, more particularly polypeptides of Moraxella ( Branhamella ) catarrhalis which may be used to prevent, diagnose and/or treat Moraxella (...
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7410638 |
Bacterial strains, genes and enzymes for control of bacterial diseases by quenching quorum-sensing signals
The present invention relates to isolated nucleic acid molecules encoding an autoinducer inactivation protein, wherein the encoded protein comprises an amino acid sequence selected from the group...
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7410786 |
Sulfated fucogalactan digesting enzyme gene
A gene encoding a polypeptide having an activity of digesting sulfated fucogalactan which is useful in sugar chain engineering reagents, analyzing the structures of sulfated fucose-containing...
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7410781 |
IL-4/IL-13 specific polypeptides and therapeutic uses thereof
Polypeptides and multimeric polypeptides capable of binding interleukin-4 (IL-4) and interluekin-13 (IL-13) which are useful therapeutically in methods of treating IL-4 and IL-13-related conditions...
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7410789 |
Process for the fermentative production of S-adenosylmethionine
A microorganism strain secreting S-adenosylmethionine having increased activity of the cmr (mdfA) gene product is provided.
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7410788 |
Compositions and methods for production of disulfide bond containing proteins in host cells
The invention provides composition and methods for producing proteins of interest which comprise at least one disulfide bond, include proteins which in their mature form do not contain disulfide...
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7410796 |
Proteinase inhibitor, precursor thereof and genetic sequences encoding same
The present invention relates generally to proteinase inhibitors, a precursor thereof and to genetic sequences encoding same. More particularly, the present invention relates to a nucleic acid...
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7410777 |
Non-endogenous, constitutively activated human G protein-coupled receptors
Disclosed herein are constitutively activated, non-endogenous versions of endogenous human G protein-coupled receptors comprising (a) the following amino acid sequence region (C-terminus to...
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7411054 |
25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 molecules and uses therefor
The invention provides isolated nucleic acids molecules, designated 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 nucleic acid molecules. The invention also...
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7407785 |
Human DNase I hyperactive variants
The present invention relates to amino acid sequence variants of human DNase I that have increased DNA-hydrolytic activity. The invention provides nucleic acid sequences encoding such hyperactive...
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7407777 |
IL-2 transmembrane construct
Compounds, genetic constructs, and cancer treatment methods are provided. Expression vectors were designed to express fusion genes including hIL-2 with a Fcε-γ transmembrane anchor derived from a...
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7407791 |
Production of secreted polypeptides
Described herein are methods and compositions for the production and secretion of polypeptides. Included herein is the use of interrupting peptide transport activity for an increase in polypeptide...
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7407677 |
Enzymes having alpha amylase activity and methods of use thereof
The invention relates to alpha amylases and to polynucleotides encoding the alpha amylases. In addition methods of designing new alpha amylases and methods of use thereof are also provided. The...
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7407788 |
BGL7 beta-glucosidase and nucleic acids encoding the same
The present invention provides a novel β-glucosidase nucleic acid sequence, designated bgl7, and the corresponding BGL7 amino acid sequence. The invention also provides expression vectors and host...
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7407783 |
Fructosylamine oxidase
The present invention provides a fructosylamine oxidase which is obtainable by culturing Fusarium proliferatum , and purifying two types of fructosylamine oxidase (FAO) with different substrate...
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7407804 |
Human genes relating to respiratory diseases and obesity
This invention relates to isolated nucleic acids comprising genes of human chromosome 12q23-qter and the proteins encoded by these genes. Expression vectors and host cells containing such genes or...
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7407780 |
Process for producing glycerol in recombinant bacterial host cells
The invention provides methods for producing products comprising improved host cells genetically engineered to have uncoupled productive and catabolic pathways. In particular, the present invention...
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