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8183012 |
Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs...
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8183436 |
Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics
Isolated polynucleotides and polypeptides encoded thereby are described, together with the use of those products for making transgenic plants.
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8183013 |
Method for production of protein having non-natural type amino acid integrated therein
This invention provides a method for producing proteins into which non-natural amino acids have been incorporated at desired positions involving the use of either prokaryote-derived or...
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8183017 |
Method of producing L-lysine
The ability and speed with which a coryneform bacterium can produce L-lysine are improved when the coryneform bacterium contains an aspartokinase in which feedback inhibition by L-lysine and...
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8183014 |
High affinity antibodies to human IL-6 receptor
A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less, is provided. In...
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8183027 |
Methods and compositions for the recombinant biosynthesis of N-Alkanes
The present disclosure identifies methods and compositions for modifying photoautotrophic organisms as hosts, such that the organisms efficiently convert carbon dioxide and light into n-alkanes,...
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8183354 |
Virus coat protein/receptor chimeras and methods of use
The invention relates to chimeric molecules comprising a virus coat sequence and a receptor sequence that can inter-act with each other to form a complex that is capable of binding a co-receptor....
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8183028 |
Methods and compositions for producing olefins
Compositions and methods for producing olefins are described herein. The olefins can be used to produced biofuels.
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8178328 |
Fermentive production of four carbon alcohols
Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium...
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8178346 |
GPCR expression vector
The present invention provides expression vectors that facilitate high levels of expression of GPCR proteins. Encompassed by the invention are methods and compositions for recombinant cell lines...
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8178310 |
Babesia microti genomic clones containing novel antigens useful in the diagnosis of Babesios
Disclosed are the cloning and expression of novel antigens in Babesia microti. The recombinant polypeptides are highly immunogenic. The polypeptides of the present invention provide the basis of a...
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8178335 |
Intracellular production of a nuclease
Methods and compositions are provided that relate to obtaining a recombinant DNA and RNA cleaving nuclease. This involves the over-expression of a fusion protein between maltose-binding protein and...
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8178090 |
Recombinant hexose oxidase
Use of a preparation as an antimicrobial agent or as an anti-oxidant; wherein said preparation comprises a polypeptide having hexose oxidase activity, the polypeptide being in a substantially pure...
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8178301 |
Mutant SepRS, and method for site-specific introduction of phosphoserine into protein using the same
A mutant SepRS which is suitable for a site-specific introduction of phosphoserine into a protein is prepared by analyzing the structure and functions of a phosphoseryl-tRNA synthetase (SepRS)...
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8178337 |
Lactobacillus acidophilus nucleic acid sequences encoding carbohydrate utilization-related proteins and uses therefor
Carbohydrate utilization-related and multidrug transporter nucleic acids and polypeptides, and fragments and variants thereof, are disclosed in the current invention. In addition, carbohydrate...
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8173396 |
Methods for reducing gluconoylation of proteins
The present invention relates to methods of preventing glyconoylation of polypeptides produced in micororganisms.
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8173870 |
Fatty acid desaturases from primula
The invention relates generally to methods and compositions concerning desaturase enzymes that modulate the number and location of double bonds in long chain poly-unsaturated fatty acids...
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8173410 |
Isoprene synthase variants for improved microbial production of isoprene
The present invention provides methods and compositions comprising at least one isoprene synthase enzyme with improved catalytic activity and/or solubility. In particular, the present invention...
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8173402 |
Modified yeasts and uses thereof, in particular for producing steroid derivatives
The present invention relates to novel yeast strains, methods and genetic constructs for their preparation, and their use for the synthesis or modification of steroidal compounds. More...
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8173408 |
Recombinant carrier molecule for expression, delivery and purification of target polypeptides
Recombinant carrier molecules having amino acid sequences from thermostable enzymes and methods of use for expression, recovery and delivery of foreign sequences (peptides and polypeptides)...
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8173392 |
In vivo incorporation of unnatural amino acids
The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids.
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8173378 |
Methods of using an alpha-1-adrenergic receptor having altered ligand affinity
A modified G-protein-coupled receptor (GPCR), having modified ligand affinity is provided by binding a G-protein-coupled receptor to a polypeptide consisting of an amino acid sequence of SEQ ID NO:...
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8173782 |
Fusion protein comprising growth hormone and growth hormone receptor
Agents which bind to cell surface receptors; methods to manufacture such agents; therapeutic compositions comprising such agents; and screening methods to identify novel agents.
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8173787 |
Plant wall degradative compounds and systems
The present invention relates to cell wall degradative systems, in particular to systems containing enzymes that bind to and/or depolymerize cellulose. These systems have a number of applications.
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8168865 |
Polypeptides having endoglucanase activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs,...
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8168421 |
Microbial vaccine and vaccine vector
The present invention includes cold-adapted, acid-fast bacterium for use as a vaccine and a vaccine vector. In preferred embodiments, the cold-adapted, acid-fast bacterium is a Mycobacteria, for...
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8168434 |
Process for chromosomal integration and DNA sequence replacement in Clostridia
The present invention is related to a new method for replacing or deleting DNA sequences in Clostridia, with high efficiency, easy to perform and applicable at an industrial level. This method is...
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8168422 |
Microorganism producing inosine and method of producing inosine using the same
The present invention relates to a microorganism producing inosine, which is one of purine nucleoside, an important material for 5′-inosinic acid synthesis, and method for producing inosine using t...
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8168608 |
Promoter and plasmid system for genetic engineering
This invention provides a series of low-copy number plasmids comprising restriction endonuclease recognition sites useful for cloning at least three different genes or operons, each flanked by a...
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8168409 |
Compositions and methods relating to anti-IGF-1 receptor antibodies
The present invention provides compositions and methods relating to or derived from anti-IGF-1R antibodies. In particular embodiments, the invention provides fully human, humanized, or chimeric...
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8168752 |
T cell proteins and nucleotides encoding the same
The present invention relates to mouse and human J12 polynucleotides, polypeptide and anti J12 antibody molecules. The J12 is a cytokine that is preferentially expressed in Th2 cells. The...
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8163529 |
Nicking endonuclease methods and compositions
A nicking endonuclease is described which has an amino acid sequence with at least 70% identity to SEQ ID NO:6 and comprising a mutation at least one of an arginine or glutamic acid corresponding...
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8163871 |
Enzymatic reactions in the presence of keto acids
Conversion in vitro of X-Gly to X-alpha-hydroxy-Gly or X-NH2 (X being a peptide or any other compound having a carbonyl group capable of forming a covalent bond with glycine) is accomplished...
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8163285 |
Nogo-A binding molecules and pharmaceutical use thereof
The present invention provides a binding molecule which is capable of binding to the human NogoA polypeptide or human NiG with a dissociation constant<1000 nM, a polynucleotide encoding such...
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8163879 |
Fusion molecules and IL-15 variants
The instant invention provides soluble fusion protein complexes and IL-15 variants that have therapeutic and diagnostic use, and methods for making the such proteins. The instant invention...
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8163525 |
Method of expressing long-chain prenyl diphosphate synthase
The present disclosure describes a method of producing a long-chain prenyl diphosphate synthase (in particular decaprenyl diphosphate synthase and solanesyl diphosphate synthase) using a gene and a...
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8163532 |
Microorganisms with a reactivation system for cob(I)alamin-dependent methionine synthase
The present invention relates to microorganisms and methods for producing methionine by reactivation of the MetH enzyme.
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8163520 |
Nucleic acids encoding a chimeric polypeptide comprising IL-7 and HGF-beta chain and methods of use
The present invention relates to a single-chain or chimeric polypeptide comprising a cytokine and a growth factor linked by at least one amino acid residue, and wherein the chimeric polypeptide...
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8158371 |
Assay for antibodies to Mycobacterium paratuberculosis
A method of detecting an immune response to a paratuberculosis-specific antigen, comprising incubating a sample from a subject with the paratuberculosis-specific antigen and detecting the presence...
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8158389 |
Products and methods for in vivo secretion of monatin
Products and methods for the in vivo production of monatin sweetener are provided. The products include microorganisms that are genetically modified to secrete or to improve secretion of monatin;...
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8158769 |
Members of the capsaicin/vanilloid receptor family of proteins and uses thereof
The invention provides isolated nucleic acids molecules, designated hVR-1, hVR-2, and rVR-2 nucleic acid molecules, which encode novel members of the Capsaicin/Vanilloid receptor family. The...
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8158766 |
Genes with ES cell-specific expression
The present invention relates to a probe for selecting ES cells, which characteristically contains one of DNAs having base sequences depicted in SEQ ID Nos; 1, 2, 3, 4, 5, 6, 7 and 8, or DNAs...
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8158394 |
Genetically stable plasmid expressing PDH and FDH enzymes
Bi-cistronic plasmids used for the expression of formate dehydrogenase (FDH) and modified phenylalanine dehydrogenase (PDHmod) are provided.
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8158383 |
Methods of generating protein variants
The present invention provides methods of designing and generating polypeptide variants that have altered properties compared to a parent polypeptide. The present invention further provides a...
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8158387 |
Method for cell surface display of target proteins using FadL of E. coli
The present invention relates to an expression vector which can effectively express target proteins or peptides on the surface of cells using an outer membrane protein (FadL) of E. coli as a...
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8158395 |
Polypeptides having C4 dicarboxylic acid transporter activity and polynucleotides encoding same
The present invention relates to isolated polypeptides having C4-dicarboxylic acid transporter activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic...
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8153392 |
Method(s) of preventing, arresting, reversing and treatment of atherosclerosis
A method of detecting, diagnosing and prognosticating atherosclerosis by measuring the activities of Δ6 and Δ5 desaturases is described. It is suggested that enhancing the activities of Δ6 and Δ5...
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8153399 |
Methods and compositions for inactivating glutamine synthetase gene expression
Disclosed herein are methods and compositions for inactivating a glutamine synthetase (GS) gene, using fusion proteins comprising a zinc finger protein and a cleavage domain or cleavage...
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8153129 |
Antibodies against human cytimegalovirus (HCMV)
The present invention provides novel antibody sequences that bind human cytomegalovirus (hCMV) and neutralize hCMV infection. The novel sequences can be used for the medical management of hCMV...
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8153774 |
Human T1R2 taste receptor nucleic acids and cells containing these nucleic acids
Newly identified mammalian taste-cell-specific G protein-coupled receptors, and the genes and cDNA encoding said receptors are described. Specifically, T1R G protein-coupled receptors active in...
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