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8524476 Bacterium producing a product of a reaction catalyzed by a protein having 2-oxoglutarate-dependent enzyme activity and a method for manufacturing the product  
A method for manufacturing a product of a reaction catalyzed by a protein having 2-oxoglutarate-dependent enzyme activity such as (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof using a...
8524252 Temperature sensitive vaccine strain of Mycoplasma hyopneumoniae and uses thereof  
The present invention relates to a Mycoplasma hyopneumoniae vaccine strain comprising a mutation in at least one of the genes listed or as deposited with the National Measurements Institute...
8524484 Immunogenic minicells and methods of use  
The disclosed invention relates to immunogenic minicells cells (anucleated) and their use to induce an immune response from a subject.
8518678 Strain comprising increased expression of a CFA coding region for butanol production  
Screening of fatty acid fed bacteria which are not natural butanol producers identified increased membrane cyclopropane fatty acid as providing improved butanol tolerance. Increasing expression of...
8518679 Complementation of the Trichoderma reesei secretome limiting microbiological contaminations within the context of industrial processes  
The present invention describes the use of a genetically improved Trichoderma reesei strain allowing to limit microbiological contaminations during an industrial process. The genetic strain...
8512989 Highly stable beta-class carbonic anhydrases useful in carbon capture systems  
The present disclosure relates to β-class carbonic anhydrase polypeptides having improved properties including increased thermostability and/or stability in the presence of amine compounds, ...
8512995 DNA encoding polypeptide involved in biosynthesis of herboxidiene  
The nucleotide sequence of a DNA involved in the biosynthesis of herboxidiene was determined. Utilizing this DNA, herboxidiene and analogues thereof can be efficiently produced.
8512988 Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway  
The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGPPS) enzyme in cells and the production of terpenoids.
8513175 Alpha-amylase mutants  
The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative...
8513493 Hemipteran and coleopteran active toxin proteins from Bacillus thuringiensis  
A novel Bacillus thuringiensis crystal protein exhibiting insect inhibitory activity is disclosed. Growth of Lygus insects is significantly inhibited by providing the novel crystal protein in Lygus...
8507235 Isoprene production using the DXP and MVA pathway  
The invention provides for methods for producing isoprene from cultured cells using various components of the DXP pathway and MVA pathway, or components associated with the DXP pathway and MVA...
8507241 Cloning, expression and use of acid lysophospholipases  
The invention relates to a DNA sequence that encodes a polypeptide with lysophospholipase activity and was isolated from Aspergillus and sequences derived therefrom, polypeptides with...
8507227 Method of producing sialylated oligosaccharides  
The present invention relates to a method for the large scale in vivo synthesis of sialylated oligosaccharides, culturing a microorganism in a culture medium, optionally comprising an exogenous...
8507250 Methods and genetically engineered micro-organisms for the combined production of PDO, BDO and PHP by fermentation  
The present invention relates to genetically engineered micro-organisms for the combined production of 1,3-propanediol (PDO), 2,3-butanediol (BDO), and polyhydroxypropionic acid (PHP) by...
8507249 Bacterial virulence factors and uses thereof  
The invention relates to, in part, secreted proteins of bacterial pathogens and methods for their use. More specifically, the invention provides in part several new common secreted proteins for A/E...
8506969 Efficient cell culture system for hepatitis C virus genotype 7a  
Genotype 7a has been identified recently, thus not much is known about the biology of this new, major HCV genotype. The present inventors developed hepatitis C virus 7a/2a intergenotypic...
8507217 Ethanol yield and reduction of biomass accumulation in the recombinant strain of Saccharomyces cerevisiae overexpressing atpase  
A new approach for increase of ethanol yield during alcoholic fermentation via decrease of biomass accumulation by using ATP degrading enzymes is described. The part of the Saccharomyces cerevisiae...
8507244 Variants of bacillus sp. TS-23 alpha-amylase with altered properties  
Variants of Bacillus sp. TS-23 strain alpha-amylases exhibit improved enzymatic performance, including increased thermostability, reduced calcium dependence, increased washing/cleaning performance,...
8507248 Genetically engineered biological indicator  
The disclosed technology relates to a genetically engineered biological indicator, comprising: at least one test organism and at least one reporter gene suitable for producing an indicator enzyme,...
8501917 Anti c-Met antibody and uses thereof  
An anti c-Met antibody or antigen-binding fragment thereof comprising a heavy-chain variable region having heavy-chain complementarity determining region (CDR) amino acid sequences of SEQ ID NOs:...
8501089 Methods of disinfecting packages in aseptic packaging using antimicrobial peracid compositions with selected catalase enzymes  
The present invention relates to specially selected catalase enzymes and their use in reducing hydrogen peroxide in applications, and particularly in aseptic packaging applications.
8501448 Family 44 xyloglucanases  
The present invention relates to xyloglucanases belonging to family 44 of glycosyl hydrolases and having a relative xyloglucanase activity of at least 30% between pH 5 and pH 8 are derived from the...
8501455 3-hydroxypropionic acid and other organic compounds  
Methods and materials related to producing 3-HP as well as other organic compounds are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, and methods and materials for...
8501449 Recombinant elastase proteins and methods of manufacturing and use thereof  
The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for...
8501452 Modified 13-hydroperoxide lyases and uses thereof  
Fatty acid 13-hydroperoxide lyase proteins which have been modified with respect to a previously described guava 13-hydroperoxide lyase and the nucleic acid sequences encoding these proteins. Also,...
8501450 Hepatitis C virus variants  
The present invention relates to HCV variants, particularly variants that are resistant to a protease inhibitors such as VX-950. Also provided are methods and compositions related to the HCV...
8497109 Polypeptides having cellobiohydrolase II activity and polynucleotides encoding same  
The present invention relates to polypeptides having cellobiohydrolase II activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to...
8497102 Mutant methylglyoxal synthase (MGS) for the production of a biochemical by fermentation  
The present invention concerns a method for the production of a biochemical selected among lactic acid, acetol and 1,2-propanediol, comprising culturing a microorganism modified for an improved...
8497098 Biochemical synthesis of 1,4-butanediamine  
The invention relates to a process for biochemical synthesis of 1,4-butanediamine in a microorganism having an increased level of an ornithine decarboxylase activity (increased ODC activity) as...
8497094 Prevention and treatment of complement-associated eye conditions  
The invention concerns the prevention and treatment of complement-associated eye conditions, such as choroidal neovascularization (CNV) and age-related macular degeneration (AMD), by administration...
8492531 Nucleic acids encoding humanized anti-CD40 antibodies  
Provided are humanized anti-CD40 antibodies and antigen-binding fragments and methods for treating disease characterized by expression of CD40 antigen.
8492127 Bacillus coagulans strains and their applications in L-lactic acid production  
The invention is concerned with the strains of B. coagulans for lactic acid production and the related methods, in which the carbon sources are pentose or hexose or the agricultural or industrial...
8492605 Microbial derived isoprene and methods for making the same  
A method for producing isoprene comprising an aqueous medium including genetically modified host cells capable of producing isoprene, where the resulting isoprene composition is processed through...
8492133 MIR-21 promoter driven targeted cancer therapy  
The invention provides a nucleic acid construct comprising a promoter sequence derived from microRNA-21 (miR-21) linked to a nucleic acid sequence encoding an anti-cancer agent, an example of which...
8492130 FAD-conjugated glucose dehydrogenase gene  
An object of the present invention is to provide: a novel gene (polynucleotide) encoding an FAD-conjugated glucose dehydrogenase having excellent properties that it has excellent reactivity to...
8492343 Protein scaffold library based on kringle domain structure and uses thereof  
There are provided a Kringle domain structure, comprising: inducing artificial mutations at amino acid residues except for conserved amino acid residues that are important to maintain the...
8492114 Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes  
A genetically modified organism comprising: at least one nucleic acid sequence and/or at least one recombinant nucleic acid isolated from Alicyclobacillus acidocaldarius and encoding a polypeptide...
8486687 Sporulation-deficient thermophilic microorganisms for the production of ethanol  
A thermophilic microorganism comprising a modification that prevents sporulation, wherein the modification inactivates the native spo0A gene.
8486683 Beta-glucosidase enzymes  
Provided are modified beta-glucosidase enzymes, derived from the Trichoderma reesei Cel3A beta-glucosidase, that exhibit improvements in one or more kinetic parameters (KG, KG2, kcat) comprising...
8486686 Large scale microbial culture method  
A new culture method for producing high levels of a metabolite, such as succinic acid uses oxygen rich culture without pH adjustment to increase the biomass, acclimation in under oxygen lean...
8486646 Methods of using a G protein-coupled receptor to identify peptide YY (PYY) secretagogues  
The present invention relates to methods of using GPR119 receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY, such as conditions...
8486661 Polynucleotides encoding antibodies against sclerostin and uses therefor  
The present invention relates to antibodies against sclerostin and compositions and methods of use for said antibodies to treat a pathological disorder that is mediated by sclerostin or disease...
8486662 DNA encoding antibody molecules having specificity for human IL-6  
The invention relates to antibody molecules having specificity for antigenic determinants of IL-6, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
8486667 EGVII endoglucanase and nucleic acids encoding the same  
The present invention provides a novel endoglucanase nucleic acid sequence, designated egl7, and the corresponding EGVII amino acid sequence. The invention also provides expression vectors and host...
8481307 Modified fluorescent proteins and methods for using same  
Nucleic acid molecules encoding improved fluorescent mutants of the mKate2 protein, variants and derivatives thereof are provided, as well as proteins and peptides encoded by these nucleic acids....
8481052 Avirulent Salmonella gallinarum variants and pharmaceutical composition using the same  
The present invention relates to avirulent Salmonella gallinarum variants by inactivating virulence gene clusters of Salmonella gallinarum (SG), a main pathogen of avian salmonellosis, and various...
8481287 Method, vector and system for expressing polypeptides  
Disclosed herein are methods and systems for expressing a polypeptide in a Rhodospirillum species. The methods include introducing an expression vector having a nucleic acid sequence encoding the...
RE44359 Nucleic acid molecules encoding anti-P-selectin antibodies  
This invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do not bind...
8481288 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Polynucleotides encoding antibodies that bind both IL-17A and IL-17F
 
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A and IL-17F. IL-17A and IL-17F are cytokines that are involved in inflammatory...
8481293 Mutant microorganisms having a high ability to produce putrescine and method for producing putrescine using the same  
Provided are mutant microorganisms having the ability to produce a high concentration of putrescine wherein gene(s) involved in the putrescine degradation or utilization pathway is inactivated or...