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8501917 Anti c-Met antibody and uses thereof  
An anti c-Met antibody or antigen-binding fragment thereof comprising a heavy-chain variable region having heavy-chain complementarity determining region (CDR) amino acid sequences of SEQ ID NOs:...
8501089 Methods of disinfecting packages in aseptic packaging using antimicrobial peracid compositions with selected catalase enzymes  
The present invention relates to specially selected catalase enzymes and their use in reducing hydrogen peroxide in applications, and particularly in aseptic packaging applications.
8501448 Family 44 xyloglucanases  
The present invention relates to xyloglucanases belonging to family 44 of glycosyl hydrolases and having a relative xyloglucanase activity of at least 30% between pH 5 and pH 8 are derived from the...
8501455 3-hydroxypropionic acid and other organic compounds  
Methods and materials related to producing 3-HP as well as other organic compounds are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, and methods and materials for...
8501449 Recombinant elastase proteins and methods of manufacturing and use thereof  
The present invention relates to methods for the manufacture, purification, formulation, and use of biologically active recombinant elastase proteins. Described are recombinant methods for...
8501452 Modified 13-hydroperoxide lyases and uses thereof  
Fatty acid 13-hydroperoxide lyase proteins which have been modified with respect to a previously described guava 13-hydroperoxide lyase and the nucleic acid sequences encoding these proteins. Also,...
8501450 Hepatitis C virus variants  
The present invention relates to HCV variants, particularly variants that are resistant to a protease inhibitors such as VX-950. Also provided are methods and compositions related to the HCV...
8497109 Polypeptides having cellobiohydrolase II activity and polynucleotides encoding same  
The present invention relates to polypeptides having cellobiohydrolase II activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to...
8497102 Mutant methylglyoxal synthase (MGS) for the production of a biochemical by fermentation  
The present invention concerns a method for the production of a biochemical selected among lactic acid, acetol and 1,2-propanediol, comprising culturing a microorganism modified for an improved...
8497098 Biochemical synthesis of 1,4-butanediamine  
The invention relates to a process for biochemical synthesis of 1,4-butanediamine in a microorganism having an increased level of an ornithine decarboxylase activity (increased ODC activity) as...
8497094 Prevention and treatment of complement-associated eye conditions  
The invention concerns the prevention and treatment of complement-associated eye conditions, such as choroidal neovascularization (CNV) and age-related macular degeneration (AMD), by administration...
8492531 Nucleic acids encoding humanized anti-CD40 antibodies  
Provided are humanized anti-CD40 antibodies and antigen-binding fragments and methods for treating disease characterized by expression of CD40 antigen.
8492127 Bacillus coagulans strains and their applications in L-lactic acid production  
The invention is concerned with the strains of B. coagulans for lactic acid production and the related methods, in which the carbon sources are pentose or hexose or the agricultural or industrial...
8492605 Microbial derived isoprene and methods for making the same  
A method for producing isoprene comprising an aqueous medium including genetically modified host cells capable of producing isoprene, where the resulting isoprene composition is processed through...
8492133 MIR-21 promoter driven targeted cancer therapy  
The invention provides a nucleic acid construct comprising a promoter sequence derived from microRNA-21 (miR-21) linked to a nucleic acid sequence encoding an anti-cancer agent, an example of which...
8492130 FAD-conjugated glucose dehydrogenase gene  
An object of the present invention is to provide: a novel gene (polynucleotide) encoding an FAD-conjugated glucose dehydrogenase having excellent properties that it has excellent reactivity to...
8492343 Protein scaffold library based on kringle domain structure and uses thereof  
There are provided a Kringle domain structure, comprising: inducing artificial mutations at amino acid residues except for conserved amino acid residues that are important to maintain the...
8492114 Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes  
A genetically modified organism comprising: at least one nucleic acid sequence and/or at least one recombinant nucleic acid isolated from Alicyclobacillus acidocaldarius and encoding a polypeptide...
8486687 Sporulation-deficient thermophilic microorganisms for the production of ethanol  
A thermophilic microorganism comprising a modification that prevents sporulation, wherein the modification inactivates the native spo0A gene.
8486683 Beta-glucosidase enzymes  
Provided are modified beta-glucosidase enzymes, derived from the Trichoderma reesei Cel3A beta-glucosidase, that exhibit improvements in one or more kinetic parameters (KG, KG2, kcat) comprising...
8486686 Large scale microbial culture method  
A new culture method for producing high levels of a metabolite, such as succinic acid uses oxygen rich culture without pH adjustment to increase the biomass, acclimation in under oxygen lean...
8486646 Methods of using a G protein-coupled receptor to identify peptide YY (PYY) secretagogues  
The present invention relates to methods of using GPR119 receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY, such as conditions...
8486661 Polynucleotides encoding antibodies against sclerostin and uses therefor  
The present invention relates to antibodies against sclerostin and compositions and methods of use for said antibodies to treat a pathological disorder that is mediated by sclerostin or disease...
8486662 DNA encoding antibody molecules having specificity for human IL-6  
The invention relates to antibody molecules having specificity for antigenic determinants of IL-6, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.
8486667 EGVII endoglucanase and nucleic acids encoding the same  
The present invention provides a novel endoglucanase nucleic acid sequence, designated egl7, and the corresponding EGVII amino acid sequence. The invention also provides expression vectors and host...
8481307 Modified fluorescent proteins and methods for using same  
Nucleic acid molecules encoding improved fluorescent mutants of the mKate2 protein, variants and derivatives thereof are provided, as well as proteins and peptides encoded by these nucleic acids....
8481052 Avirulent Salmonella gallinarum variants and pharmaceutical composition using the same  
The present invention relates to avirulent Salmonella gallinarum variants by inactivating virulence gene clusters of Salmonella gallinarum (SG), a main pathogen of avian salmonellosis, and various...
8481287 Method, vector and system for expressing polypeptides  
Disclosed herein are methods and systems for expressing a polypeptide in a Rhodospirillum species. The methods include introducing an expression vector having a nucleic acid sequence encoding the...
RE44359 Nucleic acid molecules encoding anti-P-selectin antibodies  
This invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do not bind...
8481288 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Polynucleotides encoding antibodies that bind both IL-17A and IL-17F
 
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A and IL-17F. IL-17A and IL-17F are cytokines that are involved in inflammatory...
8481293 Mutant microorganisms having a high ability to produce putrescine and method for producing putrescine using the same  
Provided are mutant microorganisms having the ability to produce a high concentration of putrescine wherein gene(s) involved in the putrescine degradation or utilization pathway is inactivated or...
8481815 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Processes for producing polyunsaturated fatty acids in transgenic organisms
 
The present invention relates to polynucleotides from Ostreococcus lucimarinus which code for desaturases and elongases and which can be employed for the recombinant production of polyunsaturated...
8481296 Angiogenic tyrosyl t-RNA synthetase compositions and methods  
The present invention provides an isolated tyrosyl tRNA synthetase (TyrRS) polypeptide variant which comprises (a) a Rossmann fold region or a portion thereof, preferably including an α5 coil; and ...
8481053 Compositions and methods for treating of microbial infections  
The present invention relates to methods and compositions for treatment of microbial infections and for the enhancement of resistance to infection. The invention comprises administration of an...
8481816 ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***
Sweetpotato SRD1 cDNA and transgenic plants with high-numbered storage roots using the same
 
Disclosed herein are a sweetpotato SRD1 cDNA, a plant transformation vector carrying the same, and a transgenic plant comprising the vector. The thickening growth of storage roots of the transgenic...
8476053 Stabilized aqueous alpha-galactosidase composition and methods relating thereto  
The present invention provides an aqueous composition comprising a protein with enzymatic activity of alpha-galactosidase. The present invention further provides a method of stabilizing an aqueous...
8476042 Bacillus strain for increased protein production  
The present invention provides host cells that have been genetically manipulated to have an enhanced capacity to produce proteins of interest. In particular, the invention relates to modified...
8475807 Avian influenza virus live attenuated vaccine and uses thereof  
Described in this application are attenuated strains of avian influenza virus containing temperature sensitive mutations in addition to a genetic tag in the PB1 gene. The attenuated viruses are...
8470580 Method for the selection of recombination clones comprising a sequence encoding an antidote protein to a toxic molecule  
The present invention is related to a method for the selection of recombinant clones having integrated a gene of interest and a nucleotide sequence encoding a functional antidote protein to a toxic...
8470572 Ketoreductase polypeptides for the production of azetidinone  
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides...
8470758 Detergent compositions and methods of use for an alpha-amylase polypeptide of bacillus species 195  
Disclosed herein are compositions comprising an alpha-amylase enzyme obtained from Bacillus sp. no. 195, and methods of using the enzyme to clean surfaces and textiles. Also disclosed are variants...
8470566 Microorganisms and methods for conversion of syngas and other carbon sources to useful products  
A non-naturally occurring microbial organism having an isopropanol, 4-hydroxybutryate, or 1,4-butanediol pathway includes at least one exogenous nucleic acid encoding an isopropanol,...
8470993 Nucleic acid encoding antibody to human IL-22  
The present application provides human antibodies and antigen binding fragments thereof that specifically bind to the human interleukin-22 (IL-22). The antibodies can act as antagonists of IL-22...
8470581 Reduction of carbon dioxide emission during isoprene production by fermentation  
The present invention provides methods for increasing the amount of isoprene produced by cultured cells with only a minimal increase in carbon dioxide emitted, thereby resulting in process having a...
8470551 Surface expression vector for fusion protein of Myo-2 peptide multimer and myostatin, and microorganism transformed by thereof  
The present invention relates to a fusion protein in which a myostatin mature protein is fused to a multimer of myostatin-derived antigenic peptide Myo-2, a surface expression vector containing a...
8470545 Methods of modulating cold sensory perception via a cold- and menthol-sensitive receptor (CMR1)  
The present invention relates to regulation of cold sensation and pain. More particularly, the present invention is directed to nucleic acids encoding a member of the transient regulatory protein...
8470571 Delta-8 desaturase and its use in making polyunsaturated fatty acids  
Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding a delta-8 desaturase along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using...
8470576 Group of novel enantioselective microbial nitrile hydratases with broad substrate specificity  
The present invention provides a polynucleotide or a pair of polynucleotides encoding an enzyme having nitrile hydratase (NHase) [E.C. 4.2.1.84] activity. Furthermore, a vector and a host...
8470554 Prokaryotic expression of soluble, active Dkk  
Dickkopf (Dkk) proteins inhibit the canonical Wnt signaling pathway. Each of the members of the Dkk family has been previously cloned and expressed as a soluble protein in eukaryotic cells, while...
8465958 Polypeptides having endoglucanase activity and polynucleotides encoding same  
The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs,...