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8679749 Red fluorescent proteins with enhanced bacterial expression, increased brightness and reduced aggregation  
Polynucleotides encoding variant polypeptides of DsRed are provided herein. The DsRed variants have increased bacterial expression, reduced aggregation, increased solubility, shifted emission...
8679800 Method for producing lactic acid from plant-derived raw material, and lactic-acid-producing bacterium  
The present invention provides: a lactic acid-producing Escherichia coli comprising at least one gene of a sucrose non-PTS gene group, including at least a sucrose hydrolase gene, provided that a...
8679813 Polypeptides having lipase activity and polynucleotides encoding same  
The present invention relates to polypeptide having lipase activity and which further has a RP of at least 0.8 and a BR of at least 1.1 at the test conditions given in the specification.
8679814 Protein and DNA sequence encoding a cold adapted xylanase  
A method of preparing a cold adapted xylanase by use of recombinant DNA techniques. A nucleic acid and corresponding amino acid sequences of a cold adapted xylanase, isolated from antarctic marine...
8679774 Lipolytic enzyme variants  
The substrate specificity of a lipolytic enzyme can be modified by making alterations to the amino acid sequence in a defined region of the lipolytic enzyme, so as to increase the level of a...
8679802 Methyl butenol synthase  
The present invention provides novels genes encoding methyl butenol (MBO) synthase, methy butenol synthases and their use in methyl butenol production.
8680248 Host cells comprising alpha 1,2 mannosidase and culture methods thereof  
Improved host cells and culture methods involving overexpression of MAN1C1 activity to improve protein production are provided.
8679799 Production of acid and solvent in microorganisms  
The invention relates to a method and means for the bioengineered fermentative production of solvents, in particular of butanol, acetone and ethanol, and of short-chained carboxylic acids such as...
8679822 Xylose utilization in recombinant zymomonas  
Xylose-utilizing Zymomonas strains studied were found to accumulate ribulose when grown in xylose-containing media. Engineering these strains to increase ribose-5-phosphate isomerase activity led...
8679493 Immunoglobulin Fc polypeptides  
Methods and compositions involving polypeptides having an aglycosylated antibody Fc domain. In certain embodiments, polypeptides have an aglycosylated Fc domain that contains one or more...
8679821 Bacteriophage derived methods to control lactic acid bacterial growth  
Compositions and methods for protection against bacterial contamination are disclosed Antibacterial proteins and methods of use thereof are also disclosed.
8673590 Method for producing dipeptide  
The invention provides a microorganism having an ability to produce a protein having a dipeptide synthesizing activity and in which an activity of the protein to transport a dipeptide in a...
8673591 Genetic incorporation of 3-aminotyrosine into reductases  
This invention provides reductase proteins that comprise NH2Y unnatural amino acid residues, systems of orthogonal elements for incorporating NH2Y into reductases and methods of using NH2Y amino...
8673601 Methods and organisms for growth-coupled production of 3-hydroxypropionic acid  
The invention provides a non-naturally occurring microorganism having one or more gene disruptions, the one or more gene disruptions occurring in genes encoding an enzyme obligatory coupling...
8674083 Polypeptide variants with altered effector function  
The present invention concerns polypeptides comprising a variant Fc region. More particularly, the present invention concerns Fc region-containing polypeptides that have altered effector function...
8673602 Recombinant bacteria having improved sucrose utilization  
Recombinant bacteria having an improved ability to utilize sucrose are provided. These recombinant bacteria have nucleotide sequences encoding sucrose utilization polypeptides integrated into their...
8673578 Methods of identifying antagonists of the hTAS2R46 bitter taste receptor  
The present invention relates to antagonists and agonists of the human bitter-taste receptors hTAS2R40, hTAS2R43, hTAS2R44, hTAS2R46, and hTAS2R47. The invention also relates to methods for...
8673614 Anaerobic microbial composition and methods of using same  
A microbial composition for concurrent dechlorination of a mixture of chlorinated ethanes and chlorinated ethenes includes a isolated consortium of bioremediative microorganisms comprising strains...
8673607 Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine  
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides...
8669092 Urocortin-III and uses thereof  
A search of the public human genome database identified a human EST, GenBank accession number AW293249, which has high homology to known pufferfish urocortin sequences. The full length sequence was...
8669379 Microbial production of 3,4-dihydroxybutyrate (3,4-DHBA), 2,3-dihydroxybutyrate (2,3-DHBA) and 3-hydroxybutyrolactone (3-HBL)  
The invention relates to recombinant cells and their use in the production of 3,4-dihydroxybutyrate, 2,3-dihydroxybutyrate and 3-hydroxybutyrolactone.
8669350 TNF receptor Fc fusion proteins and in vivo methods of use  
The embodiments of the invention relate to compositions, methods, and kits comprising a fusion protein. The fusion proteins of the embodiments include monomer polypeptides which in one embodiment...
8669103 Oplophorus-derived luciferases, novel coelenterazine substrates, and methods of use  
An isolated polynucleotide encoding a modified luciferase polypeptide and substrates. The OgLuc variant polypeptide has at least 60% amino acid sequence identity to SEQ ID NO: 1 and at least one...
8668903 Biologic female contraceptives  
This invention provides, inter alia, commensal organisms engineered to express antibody fragments, which inhibit sperm motility or fertilization and compositions comprising the same. The present...
8669073 Compositions of orthogonal lysyl-tRNA and aminoacyl-tRNA synthetase pairs and uses thereof  
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal lysyl-tRNAs, orthogonal lysyl-aminoacyl-tRNA synthetases, and orthogonal pairs of...
8669080 Mutated D-aminotransferase and method for producing optically active glutamic acid derivatives using the same  
A D-aminotransferase can be modified so as to efficiently produce (2R,4R)-monatin having high sweetness intensity from 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid by mutating the amino acid...
8669087 Luciferase mutant  
A recombinant protein having luciferase activity and at least 60% similarity to a wild-type luciferase wherein in the sequence of the enzyme, the amino acid residue corresponding to residue 357 in...
8669089 Ulvan lyase, method for manufacturing same, and uses thereof  
The present invention notably relates to ulvan lyases, to nucleic acid sequences coding for these ulvan lyases, to vectors comprising these coding sequences, to a method of manufacturing these...
8669091 Microorganisms as carriers of nucleotide sequences coding for antigens and protein toxins, process of manufacturing and uses thereof  
A Escherichia, Salmonella, Yersinia, Vibrio, Listeria, Shigella, or Pseudomonas bacterium that has the following components: (I) a polynucleotide encoding a heterologous antigenic determinant that...
8669076 Cow rumen xylose isomerases active in yeast cells  
Polypeptides were identified among translated coding sequences from a metagenomic cow rumen database, that were shown to provide xylose isomerase activity in yeast cells. The xylose isomerase...
8669088 Enzyme associated with equol synthesis  
An object of the present invention is to provide enzymes associated with equol synthesis, genes coding such enzymes, and a process for producing equol and its intermediates using the enzymes and...
8664183 SPANX-B polypeptides and their use  
It is disclosed herein that SPANX-B is uniquely expressed in a number of human tumors and that SPANX-B is an immunogenic antigen that is recognized by human T cells inducing helper CD4+ and...
8663967 Arginine deiminase mutant and preparation and application thereof  
The present invention relates to an arginine deiminase mutant with partial lysine-deficient and preparation and application thereof. The arginine deiminase mutant of the present invention has...
8663958 Oxygen-resistant hydrogenases and methods for designing and making same  
The invention provides oxygen-resistant iron-hydrogenases ([Fe]-hydrogenases) for use in the production of H2. Methods used in the design and engineering of the oxygen-resistant [Fe]-hydrogenases...
8663653 Efficient cell culture system for hepatitis C virus genotype 2B  
The present inventors developed hepatitis C virus 2b/2a intergenotypic recombinants in which the JFH1 structural genes (Core, E1 and E2), p7 and the complete NS2 were replaced by the corresponding...
8658169 Antibodies against IL-25  
The present invention relates to IL-25 antibody VH domains and target binding members (e.g., antibodies) that comprise such antibody VH domains and bind IL-25. The invention also relates to...
8658858 Polynucleotides encoding proteins involved in plant metabolism  
The invention provides isolated pyruvate dehydrogenase kinase nucleic acids and their encoded polypeptides. The present invention provides methods and compositions relating to altering pyruvate...
8658410 Subtilases  
The present invention relates to novel JP170 like subtilases from wild-type bacteria, hybrids thereof and to methods of construction and production of these proteases. Further, the present...
8658766 Soluble hybrid Fcγ receptors and related methods  
Disclosed are soluble hybrid Fcγ receptor (FcγR) polypeptide compositions and related methods of using such polypeptides to treat IgG-mediated and immune complex-mediated inflammation. Also d...
8658406 EGVII endoglucanase and nucleic acids encoding the same  
The present invention provides a novel endoglucanase nucleic acid sequence, designated egl7, and the corresponding EGVII amino acid sequence. The invention also provides expression vectors and host...
8658413 Mutant HPGG motif and HDASH motif delta-5 desaturases and their use in making polyunsaturated fatty acids  
Mutant delta-5 desaturases, having the ability to convert dihomo-gamma-linolenic acid [DGLA; 20:3 omega-6] to arachidonic acid [ARA; 20:4 omega-6] and/or eicosatetraenoic acid [ETA; 20:4 omega-3]...
8658400 Biocatalysts for manufacturing duloxetine alcohol  
The present invention relates to novel phenylethanol dehydrogenase mutants, to a method for the manufacture thereof; to coded nucleic acid sequences therefor, to expression cassettes, to vectors...
8652819 Paenibacillus spp. and methods for fermentation of lignocellulosic materials  
Provided herein are methods for producing a fermentation product, such as ethanol, by co-culture of a member of the genus Paenibacillus and an ethanologenic microbe, such as yeast or E. coli. Also...
8652816 Compositions and methods for 3-hydroxypropionate bio-production from biomass  
Methods of obtaining mutant nucleic acid sequences that demonstrate elevated oxaloacetate α-decarboxylase activity are provided. Compositions, such as genetically modified microorganisms that ...
8652823 Strain for butanol production with increased membrane unsaturated trans fatty acids  
Bacteria that are not natural butanol producers were found to have increased tolerance to butanol when the membrane content of unsaturated trans fatty acids was increased. Feeding cells with...
8652838 Platensimycin biosynthetic gene cluster of Streptomyces platensis  
The present invention relates to the cloning and sequence of a biosynthetic gene cluster from Streptomyces platensis that produces platensimycin and platencin. Also provided are engineered...
8652825 Microbial production of pyruvate and other metabolites  
Microbial production of pyruvate and metabolites derived from pyruvate in cells exhibiting reduced pyruvate dehydrogenase activity compared to wild-type cells. Acetate and glucose are supplied as a...
8652820 Thermotolerant Non-K12 Escherichia coli phytase and its production  
This invention relates to cloning and sequencing of thermotolerant phytase gene from Non-K12 Escherichia coli strain, ATCC 9637, phytase gene expression in Escherichia coli expression system, codon...
8652808 Method for the production of fucosyllactose in bacterial cells  
The present invention relates to a cell to be stably cultured in a medium, which cell is adjusted for the production of oligosaccharides, the cell being transformed to comprise at least one nucleic...
8653007 Compositions, methods and related uses for cleaving modified DNA  
Compositions, methods and related uses are provided relating to cleaving modified DNA. For example, a set of DNA fragments obtainable by enzymatic cleavage of a large DNA is described where at...