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8623625 Sulfotransferase, peptide thereof and DNA encoding the same  
A glycosaminoglycan sulfotransferase, a peptide thereof, a nucleic acid comprising a nucleotide sequence encoding the same, an enzyme agent for the synthesis of a glycosaminoglycan, which comprises...
8623619 Process for producing L-amino acid  
The present invention provides a method of improving efficiency of a fermentative production of an L-amino acid. To be specific, the present invention provides a process for producing a L-amino...
8623632 Extracellular polyhydroxyalkanoates produced by genetically engineered microorganisms  
The present invention is in the field of biosynthesis of polyhydroxyalkanoates (PHA). The invention relates to a genetically engineered microorganism having at least one gene involved in the...
8624009 Spinosyn-producing polyketide synthases  
The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling...
8623631 Modified promoter  
The present invention provides a modified promoter DNA capable of enhancing transcription of genes encoding proteins or polypeptides, and a method for producing proteins or polypeptides efficiently...
8624007 Alteration of Fc-fusion protein serum half-lives by mutagenesis  
The present invention provides for a modified Fc-fusion protein in which at least one amino acid from the heavy chain constant region selected from the group consisting of amino acid residues 250,...
8623999 Modified Clostridial toxins with enhanced targeting capabilities for endogenous Clostridial toxin receptor systems  
The specification discloses modified Clostridial toxins comprising a Clostridial toxin enzymatic domain, a Clostridial toxin translocation domain and an enhanced Clostridial toxin binding domain;...
8624010 Nucleic acids encoding B7RP1  
Polypeptides comprising ligands and receptors involved in T-cell activation are disclosed. Nucleic acid molecules that encode such polypeptides, and vectors and host cells for expressing...
8623620 Microorganism which produces L-amino acid and method for producing L-amino acid using the same  
The present invention relates to a microorganism belonging to the genus Escherichia sp. and a method for producing L-amino acid using the same. The microorganism belonging to the genus Escherichia...
8623618 Engineered cleavage half-domains  
Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and...
8617868 Asparaginase enzyme variants and uses thereof  
The present invention relates to newly identified asparaginase polypeptide variants of SEQ ID NO: 3 and to polynucleotide sequences that encode such novel asparaginase variants. Furthermore the...
8617864 Polynucleotides encoding ketoreductases for producing stereoisomerically pure statins and synthetic intermediates therefor  
The present disclosure provides ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the...
8618271 Fagopyritol synthase genes and uses thereof  
The present invention relates to an isolated DNA molecule encoding a fagopyritol synthase. A method for producing a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin...
8618358 Transgenic maize event MON 87427 and the relative development scale  
The invention provides transgenic maize event MON 87427 and plants, plant cells, seeds, plant parts, and commodity products derived from event MON 87427. The invention also provides nucleotides...
8618357 Sweetpotato SRD1 cDNA and transgenic plants with high-numbered storage roots using the same  
Disclosed herein are a sweetpotato SRD1 cDNA, a plant transformation vector carrying the same, and a transgenic plant comprising the vector. The thickening growth of storage roots of the transgenic...
8617861 Method for producing butanol using extractive fermentation with electrolyte addition  
A method for producing butanol through microbial fermentation, in which the butanol product is removed during the fermentation by extraction into a water-immiscible organic extractant in the...
8617853 Ketoreductase polypeptides for the production of (S,E)-methyl 2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-hydroxypropyl)benzoate  
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides...
8617852 Method for producing a target substance by fermentation  
A method is described for producing a target substance utilizing a microorganism by culturing the microorganism in a medium to produce and accumulate the target substance in the medium, and then...
8617565 Surface exposed Haemophilus influenzae protein (protein E; pE)  
The present invention relates to a surface exposed protein (protein E; pE), a virulence factor, which can be detected in Haemophilus influenzae, having an amino acid sequence as described in SEQ ID...
8614075 Mutant Δ-5 desaturases mutated in the heme-binding motif (HPGG)  
The present invention relates to mutant Δ5 desaturases, which have the ability to convert dihomo-γ-linolenic acid [DGLA; 20:3 ω-6] to arachidonic acid [ARA; 20:4 ω-6] and/or eicosatetraenoic aci...
8614306 Polynucleotides encoding humanized anti-factor D antibodies  
The invention relates to anti-Factor D antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their production and their use in the...
8614308 Nucleic acid molecules encoding A-beta binding polypeptides  
The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains...
8614077 Recovery of higher alcohols from dilute aqueous solutions  
This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the...
8609385 Methods for the direct conversion of carbon dioxide into a hydrocarbon using a metabolically engineered photosynthetic microorganism  
The present invention relates to methods for the production of isoprene by the direct conversion of atmospheric carbon dioxide using metabolically engineered genetically engineered photosynthetic...
8609389 Milk-clotting protease derived from a microorganism  
The present invention provides an improved type protease which comprises an amino acid sequence that is at least 75% identical to SEQ ID NO:3, said improved type protease has at least one mutation...
8609395 Agonist and antagonist peptides of carcinoembryonic antigen (CEA)  
The invention provides a polypeptide comprising an agonist of a MHC Class I binding native sequence having amino acid substitution(s) and enhanced immunogenicity compared to the native sequence....
8609388 Modified family 5 cellulases and uses thereof  
The present invention relates to a modified Family 5 cellulase comprising a substitution of an amino acid at position 363 with a non-native alanine, serine or threonine, the position determined...
8609394 Biotechnological production of chondroitin  
Chondroitin is produced by culturing a recombinant microorganism which is obtained by inactivation of a gene encoding an enzyme responsible for addition of fructose residues to the linear...
8609387 Fungal endoglucanases, their production and use  
Novel fungal endoglucanases with substantial performance at low temperatures are disclosed. The endoglucanases are conveniently produced by recombinant technology, and means for their production...
8609378 Polyhydroxyalkanoate production from polyols  
Organisms are provided which express enzymes such as glycerol dehydratase, diol dehydratase, acyl-CoA transferase, acyl-CoA synthetase β-ketothiolase, acetoacetyl-CoA reductase, PHA synthase, ...
8609393 Fluorescent proteins and genes encoding them  
Fluorescent proteins comprising the following internal amino acid sequence (SEQ ID NO: 47)Gly Tyr Xaa Xaa Xaa Gln Tyr Leu Pro Xaa Pro1 5 10 wherein Xaa in position 3 is Ala or Gly,Xaa in position 4...
8609367 Genes and proteins for the biosynthesis of the lantibiotic 107891  
The invention relates to the field of lantibiotics, and more specifically to the isolation of nucleic acid molecules that code for the enzymes required for the biosynthetic pathway of the...
RE44648 Enzyme for the production of long chain peracid  
The present invention provides methods and compositions comprising at least one perhydrolase enzyme for cleaning and other applications. In some embodiments, the present invention provides methods...
8603823 Methods and compositions for producing vitamin K dependent proteins  
The present invention relates to methods and compositions for improving the productivity of recombinant vitamin K dependent protein expression in host cells.
8603788 Modified yeast strains exhibiting enhanced fermentation of lignocellulosic hydrolysates  
The present invention relates to novel xylose-fermenting yeast strains (for example, yeast of the genus Saccharomyces, e.g., S. cerevisiae) with an enhanced ability to ferment the xylose (and/or...
8603785 Method of organic polymer degradation by dihydrolipoamide dehydrogenase  
A dihydrolipoamide dehydrogenase (DLD) in a germ is recombined. The new DLD is applied in a solution to degrade an ether bond of an organic polymer. With the present invention, bioremediation is...
8603822 Method for designing heat-resistant tyrosine-dependent short-chain dehydrogenase/reductase and heat-resistant tyrosine-dependent short-chain dehydrogenase/reductase  
A method for designing a heat-resistant mutant enzyme, the method including the step of reducing a distance between the α4 helix and the α6 helix in a protein three-dimensional structure to b...
8603797 Methods and compositions for targeted mutagenesis in bacteria  
This disclosure provides methods and compositions for targeted mutagenesis of specific genes in a bacterial strain. By inducibly over-expressing error-prone polymerases such as Pol IV or Pol V in...
8604180 DNA fragment having promoter function  
The present invention relates to a method of inducing expression of a promoter function of various genes in a Coryneform bacterium related to function exertion, in order to exert the function of a...
8603790 Systems, methods and compositions for optical stimulation of target cells  
Methods, systems and devices are implemented in connection with light-responsive ion channel molecules. One such method is implemented using a light-activated ion channel molecule that responds to...
8603778 Anti-TNF antibodies, compositions, methods and uses  
The present invention relates to anti-TNF antibodies comprising all of the heavy chain variable CDR regions of SEQ ID NOS:1, 2 and 3 and/or all of the light chain variable CDR regions of SEQ ID...
8603781 Prevention of incorporation of non-standard amino acids into protein  
The instant invention is drawn to the methods and compositions necessary to provide recombinant proteins with a substantially reduced or eliminated content of norleucine or other non-standard amino...
8597901 2,5-diketo-L-gluconic acid reductases and methods of use  
Described herein are novel nucleic acids, proteins and methods that can be used to provide new catalysts with desirable traits for industrial processes. In particular, novel reductases isolated...
8597916 Multimeric oxidoreductases  
The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C...
8597648 Fully human anti-TNF-alpha monoclonal antibody, preparation method and use thereof  
The present invention provides a full human anti-TNF-α monoclonal antibody, the preparation method and use thereof. The antibody in the present invention has an amino acid sequence of heavy chain ...
8597912 Methods and compositions for generation of Bax-and Bak-deficient cell lines  
Disclosed herein are methods and compositions for generation of Bak- and/or Bax-deficient cell lines using engineered nucleases.
8597908 Process for producing protein A-like protein with use of Brevibacillus genus bacterium  
The present invention relates to an efficient and economical process for producing a protein A-like protein. Hosts such as Escherichia coli and Bacillus subtilis have been used in the production of...
8597922 Methods and compositions for producing olefins  
Compositions and methods for producing olefins are described herein. The olefins can be used to produced biofuels.
8592195 Fungal endoglucanases, their production and use  
Novel fungal endoglucanases Ce15 and Ce112 are disclosed. The endoglucanases are conveniently produced by recombinant technology, and means for their production are described. The endoglucanases...
8592557 Multimeric TNF receptor fusion proteins and nucleic acids encoding same  
The present invention refers to fusion proteins comprising a TNF receptor family extracellular domain fused to a trimerization domain, and a nucleic acid molecule encoding the fusion protein. The...