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8557544 Polynucleotides encoding antibodies that bind both IL-17A and IL-17F  
The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A and IL-17F. IL-17A and IL-17F are cytokines that are involved in inflammatory...
8557555 Synthetic phytase variants  
The invention relates to a synthetic phytase with elevated thermostability, elevated stability to acids at pH 2, elevated stability to pepsin and with a broadened active pH range, and to an...
8551758 Substrate-selective co-fermentation process  
Biological method for conversion of a lignocellulosic hydrolysate into a desired biochemical product. Use of a plurality of substrate-selective cells allows different sugars in a complex mixture to...
8552151 Mutant blue fluorescent protein and method of using the same for fluorescence energy transfer and blue fluorescent fish  
The present invention discloses a mutant blue fluorescent protein (BFP), mutated by an error-prone PCR method or a DNA shuffling method with using a BFPvv D7 of SEQ ID NO:2 as parents, obtained...
8551755 Glucoamylase variants  
The present invention relates to glucoamylase variants. In particular, the invention relates to variants in the starch binding domain (SBD) of a glucoamylase. The invention also relates to variants...
8551751 BX11 enzymes having xylosidase activity  
This invention relates to novel enzymes and novel methods for producing the same. More specifically this invention relates to a variety of fungal enzymes. Nucleic acid molecules encoding such...
8552168 Nucleic acids for inducing expression of transcripts and proteins and methods for making and using them  
The invention provides nucleic acids and polypeptides for enhanced expression of nucleic acids and proteins. In one aspect, the sequences serve as transcription and translation enhancers or...
8551482 Compositions and methods for increasing muscle growth  
This disclosure is in the field of anti-Activin receptor IIB (ActRIIB) antibodies. In particular, it relates to the use of said antibodies for treating muscle disorders, such as muscle wasting due...
8546122 Subtilases  
The present invention relates to methods for producing variants of a parent TY145 subtilase and of a parent BPN′ subtilase and to TY145 and BPN′ variants having altered properties as compared to ...
8546118 Aldolases, nucleic acids encoding them and methods for making and using them  
This invention relates to polypeptides having aldolase activity, including pyruvate activity such as, without limitation, HMG and/or KHG aldolase activity, polynucleotides encoding these...
8541222 Modified microorganisms with inactivated lactate dehydrogenase gene  
Modified microorganisms are prepared by inactivation of the endogenous lactate dehydrogenase gene. The microorganisms are deposited under NCIMB Accession Nos. 41277, 41278, 41279, 41280 or 41281.
8541558 Fluorescent proteins and uses thereof  
A fluorescent sensor and methods for producing and using the fluorescent sensor. Such fluorescent sensors have broad applicability in characterizing cells and organisms, in detecting or measuring...
8541652 Mutants of PHA synthase from Pseudomonas sp. 6-19 and method for preparing lactate homopolymer or copolymer using the same  
The present invention relates to polyhydroxyalkanoate synthase (PHA synthase) mutant originated from Pseudomonas sp. 6-19 (KCTC 11027BP) which can prepare lactate polymer and/or copolymer by using...
8540992 Methods and vectors for generating asialylated immunoglobulins  
The properties of an Fc-containing protein, for example, an antibody, are controlled by altering the sialylation of the oligosaccharides in the Fc region by transfecting the cell line expressing...
8541191 Hydrolases, nucleic acids encoding them and methods for biocatalytic synthesis of structured lipids  
Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides....
8541212 Genetic modification for production of 3-hydroxypropionic acid  
A method of increasing 3-HP production efficiency by inhibiting expression of a lactate dehydrogenase, a phosphotransacetylase, and an alcohol dehydrogenase in production of 3-HP using a malonic...
8535931 Non-photosynthetic micro-organisms enriched with organic selenium from seleno-hydroxyacid compounds and applications thereof in the field of nutrition, cosmetics and pharmacueuticals  
The invention relates to the enrichment of non-photosynthetic micro-organisms with organic selenium, and more particularly with selenomethionine, from a compound of the seleno-hydroxyacid type such...
8535922 Method for producing ethanol  
The present invention provides a method for producing an ethanol from a lignocellulose resource efficiently. According to the method for producing the ethanol of the present invention, an enzyme...
8536315 Production and purification of recombinant arylsulftase  
The present invention pertains to a process for production of recombinant arylsulfatase A in a cell culture system, the process comprising culturing a mammalian cell capable of producing rASA in...
8535915 Promoter, and a production method for L-lysine using the same  
Disclosed are a nucleic acid molecule of Corynebacterium glutamicum origin, having an improved promoter activity, which is operably linked to a gene encoding diaminopimelate dehydrogenase, a vector...
8535920 Process for producing glutamate derivatives  
The present invention relates to a process for producing efficiently glutamic acid derivatives (including salts thereof) such as monatin by converting a substituted α-keto acid of formula (1) into ...
8535939 Transfection vector  
The present invention relates to a secretory signal, a plasmid containing the secretory signal, a transformed anaerobic bacterium transformed with said plasmid, a gene transfer carrier consisting...
8535930 Expression of proteins in plants  
The invention relates to a method of producing a HPV polypeptides and/or an influenza virus H5 polypeptide in a plant comprising the steps of cloning a HPV gene; and/or an influenza virus H5 gene...
8530218 Proteases with modified pro regions  
The present invention provides methods and compositions for the production of mature proteases in bacterial host cells. The compositions include modified polynucleotides that encode modified...
8530234 Hepatitis C virus vaccine  
The present invention features Ad6 vectors and a nucleic acid encoding a Met-NS3-NS4A-NS4B-NS5A-NS5B polypeptide containing an inactive NS5B RNA-dependent RNA polymerase region. The nucleic acid is...
8530207 Photosynthetic microorganisms comprising exogenous prokaryotic acyl-ACP thioesterases and methods for producing fatty acids  
The described invention provides genetically engineered photosynthetic microorganisms expressing prokaryotic acyl-ACP thioesterases and methods of using the genetically engineered photosynthetic...
8530422 Chimeric aquaretic and natriuretic polypeptides lacking vasodilatory activity  
This document provides aquaretic and natriuretic polypeptides. For example, this document provides polypeptides having aquaretic and/or natriuretic activities. In some cases, a polypeptide provided...
8530225 Therapeutic agents comprising pro-apoptotic proteins  
The present invention relates to targeted killing of a cell utilizing a chimeric polypeptide comprising a cell-specific targeting moiety and a signal transduction pathway factor. In a preferred...
8530224 Marker of Streptococcus anginosus/ Streptococcus constellatus (Moac) and uses thereof  
The present invention relates to nucleic acids, vectors and polypeptides that are suitable markers for detecting Streptococcus strains of the anginosus group, preferably for detecting Streptococcus...
8530204 Method for producing carboxylic acid using methanol-assimilating bacterium  
A method for producing a carboxylic acid by a fermentation process which comprises culturing a methanol-assimilating bacterium capable of producing the carboxylic acid in a liquid medium containing...
8530221 Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells  
Recombinant microbial cells are provided which have been engineered to produce branched chain products such as branched fatty acid derivatives by the fatty acid biosynthetic pathway, and methods of...
8524472 Method for producing 2-butanol and recombinant microorganism having 2-butanol production capacity  
This invention is intended to produce 2-butanol with excellent productivity via a fermentation process. Recombinant microorganisms into which the acetoacetyl-CoA synthase gene and a group of genes...
8524243 Avirulent Salmonella gallinarum variants and pharmaceutical composition using the same  
The present invention relates to avirulent Salmonella Gallinarum variants by inactivating virulence gene clusters of Salmonella Gallinarum (SG), a main pathogen of avian salmonellosis, and various...
8524475 Polypeptides having colanic acid-degrading activity  
The present disclosure generally relates to polypeptides having colanic acid-degrading activity and methods of using the same. Polynucleotides encoding such polypeptides are also described. The...
8524476 Bacterium producing a product of a reaction catalyzed by a protein having 2-oxoglutarate-dependent enzyme activity and a method for manufacturing the product  
A method for manufacturing a product of a reaction catalyzed by a protein having 2-oxoglutarate-dependent enzyme activity such as (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof using a...
8524252 Temperature sensitive vaccine strain of Mycoplasma hyopneumoniae and uses thereof  
The present invention relates to a Mycoplasma hyopneumoniae vaccine strain comprising a mutation in at least one of the genes listed or as deposited with the National Measurements Institute...
8524484 Immunogenic minicells and methods of use  
The disclosed invention relates to immunogenic minicells cells (anucleated) and their use to induce an immune response from a subject.
8518678 Strain comprising increased expression of a CFA coding region for butanol production  
Screening of fatty acid fed bacteria which are not natural butanol producers identified increased membrane cyclopropane fatty acid as providing improved butanol tolerance. Increasing expression of...
8518679 Complementation of the Trichoderma reesei secretome limiting microbiological contaminations within the context of industrial processes  
The present invention describes the use of a genetically improved Trichoderma reesei strain allowing to limit microbiological contaminations during an industrial process. The genetic strain...
8512989 Highly stable beta-class carbonic anhydrases useful in carbon capture systems  
The present disclosure relates to β-class carbonic anhydrase polypeptides having improved properties including increased thermostability and/or stability in the presence of amine compounds, ...
8512995 DNA encoding polypeptide involved in biosynthesis of herboxidiene  
The nucleotide sequence of a DNA involved in the biosynthesis of herboxidiene was determined. Utilizing this DNA, herboxidiene and analogues thereof can be efficiently produced.
8512988 Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway  
The invention relates to recombinant expression of a taxadiene synthase enzyme and a geranylgeranyl diphosphate synthase (GGPPS) enzyme in cells and the production of terpenoids.
8513175 Alpha-amylase mutants  
The invention relates to a variant of a parent Termamyl-like alpha-amylase, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative...
8513493 Hemipteran and coleopteran active toxin proteins from Bacillus thuringiensis  
A novel Bacillus thuringiensis crystal protein exhibiting insect inhibitory activity is disclosed. Growth of Lygus insects is significantly inhibited by providing the novel crystal protein in Lygus...
8507235 Isoprene production using the DXP and MVA pathway  
The invention provides for methods for producing isoprene from cultured cells using various components of the DXP pathway and MVA pathway, or components associated with the DXP pathway and MVA...
8507241 Cloning, expression and use of acid lysophospholipases  
The invention relates to a DNA sequence that encodes a polypeptide with lysophospholipase activity and was isolated from Aspergillus and sequences derived therefrom, polypeptides with...
8507227 Method of producing sialylated oligosaccharides  
The present invention relates to a method for the large scale in vivo synthesis of sialylated oligosaccharides, culturing a microorganism in a culture medium, optionally comprising an exogenous...
8507250 Methods and genetically engineered micro-organisms for the combined production of PDO, BDO and PHP by fermentation  
The present invention relates to genetically engineered micro-organisms for the combined production of 1,3-propanediol (PDO), 2,3-butanediol (BDO), and polyhydroxypropionic acid (PHP) by...
8507249 Bacterial virulence factors and uses thereof  
The invention relates to, in part, secreted proteins of bacterial pathogens and methods for their use. More specifically, the invention provides in part several new common secreted proteins for A/E...
8506969 Efficient cell culture system for hepatitis C virus genotype 7a  
Genotype 7a has been identified recently, thus not much is known about the biology of this new, major HCV genotype. The present inventors developed hepatitis C virus 7a/2a intergenotypic...