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8722371 Cytochrome P450 oxygenases  
Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent...
8722365 Metabolically engineered Escherichia coli for enhanced production of sialic acid  
A metabolically engineered E. coli strain which produces sialic acid and a method of making said strain. In the engineered E. coli cells, the nanT (sialic acid transporter) and nanA (sialic acid...
8722855 Dual variable domain immunoglobulins and uses thereof  
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
8722369 Glucoamylase variants  
The invention relates to a variant of a parent fungal glucoamylase, which exhibits altered properties, in particular improved thermal stability and/or increased specific activity.
8722869 Class of therapeutic protein based molecules  
The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that...
8716002 Re-engineering bacteria for ethanol production  
The invention provides recombinant bacteria, which comprise a full complement of heterologous ethanol production genes. Expression of the full complement of heterologous ethanol production genes...
8715989 Glucose dehydrogenase and method for producing the dehydrogenase  
A glucose dehydrogenase, having high substrate specificity, can be produced at a low cost, is not affected by oxygen dissolved in a measurement sample and, in particular, has superior thermal...
8715676 Production and uses of type I ribosome inactivating proteins  
Described herein are methods to express and purify recombinant type 1 ribosome inactivating proteins. Included are methods for using recombinant cucurmosin as a therapeutic to treat cancer and...
8716003 Targeted gene deletions for polysaccharide slime formers  
The present invention provides improved polysaccharides (e.g., gellan and diutan) produced by mutant gene R Sphingomonas strains containing at least one genetic modification that favors...
8715993 Glycosidase enzymes  
A thermostable glycosidase enzymes derived from various Thermococcus, Staphylothermus and Pyrococcus organisms is disclosed. The enzymes are produced from native or recombinant host cells and can...
8716450 Dual variable domain immunoglobulins and uses thereof  
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
8715992 I-CreI meganuclease variants with modified specificity, method of preparation and uses thereof  
Method of preparing I-CreI meganuclease variants having a modified cleavage specificity, variants obtainable by said method and their applications either for cleaving new DNA target or for genetic...
8715972 Homolactic fermentation from pentose  
Provided is a lactic acid bacterium capable of homolactic fermentation using a pentose as a substrate, the lactic acid bacterium utilizing a pentose, and in which a phosphoketolase pathway is...
8715997 Variant Hypocrea jecorina CBH2 cellulases  
Described herein are variants of H. jecorina CBH2, a Cel6A enzyme. The present invention provides novel cellobiohydrolases that have altered thermostability.
8710207 Compositions, organisms, systems, and methods for expressing a gene product in plants using SCBV expression control sequences operable in monocots and dicots  
The present disclosure relates, in some embodiments, to compositions, organisms, systems, and methods for expressing a gene product in a plant using a expression control sequence (ECS) operable in...
8709772 Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them  
This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having transferase activity,...
8709785 Compositions and methods for producing isoprene  
The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.
8709781 System and method for the heterologous expression of polyketide synthase gene clusters  
A system and method for heterologous expression of polyketide biosynthetic pathways from streptomycetes hosts in Escherichia coli for the production and discovery of secondary metabolites. Genomic...
8709444 Live-attenuated compositions for bacterial infections  
The present invention relates to compositions and methods for disease treatment and prevention through administration of a live attenuated composition. In particular, the present invention provides...
8709798 Nucleic acids for cloning and expressing multiprotein complexes  
The present invention relates to a nucleic acid containing at least one homing endonuclease site (HE) and at least one restriction enzyme site (X) wherein the HE and X sites are selected such that...
8710299 Processes for producing polyunsaturated fatty acids in transgenic organisms  
The present invention relates to polynucleotides from Ostreococcus lucimarinus which code for desaturases and elongases and which can be employed for the recombinant production of polyunsaturated...
8709813 DNA promoters and anthrax vaccines  
The invention is related to intracellularly induced bacterial DNA promoters and vaccines against Bacillus anthracis.
8710296 Defensin polynucleotides and methods of use  
Methods and compositions for modulating development and defense responses are provided. Nucleotide sequences encoding defensin proteins are provided. The sequences can be used in expression...
8709759 Method for increasing expression of active tumor necrosis factor receptor family member-Ig fusion proteins  
Methods for high level expression of active lymphotoxin-β receptor immunoglobulin chimeric proteins and their purification.
8709775 Hydrolases, nucleic acids encoding them and methods for making and using them  
Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides....
8709782 Targeted gene deletions for polysaccharide slime formers  
The present invention provides improved polysaccharides (e.g., gellan and diutan) produced by mutant gene M or gene N Sphingomonas strains containing at least one genetic modification that favors...
8709773 DFPase enzymes from Aplysia californica  
The present invention relates to isolated polypeptides having organophosphorous hydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid...
8703471 System and method for the production of recombinant glycosylated proteins in a prokaryotic host  
A system and a method for the production of recombinant N-glycosylated target proteins. The system comprises a prokaryotic organism (e.g. Escherichia coli) into which is introduced a genetic...
8703449 Bioabsorbable polymer containing 2-hydroxyacid monomers  
Genetically engineered organisms for production of PHA copolymers containing 2-hydroxyacid monomers and the methods of making and using thereof have been developed. The copolymers containing...
8703905 Endoplasmic reticulum localization signals  
The invention relates to cellular localization signals. In particular, the invention relates to endoplasmic reticulum localization signals in monomeric or multimeric form. The localization signals...
8703439 Point of care iodine sensor  
Methods and devices for use in detecting the iodine status of a subject are provided. The methods and devices utilize an iodide binding protein (IBP) to specifically bind to and facilitate...
8703455 Production of volatile dienes by enzymatic dehydration of light alkenols  
Described is a method for generating conjugated dienes through a biological process. More specifically, the application describes a method for producing conjugated dienes (for example butadiene,...
8703473 Recombinant microbial host cells for high eicosapentaenoic acid production  
Engineered strains of the oleaginous yeast Yarrowia lipolytica are disclosed herein that are capable of producing microbial oil comprising greater than 25 weight percent of eicosapentaenoic acid...
8697085 Group A Streptococcus multivalent vaccine  
Immunogenic compositions are provided herein that are useful for inducing an immune response specific against group A streptococcus (GAS). Immunogenic compositions provided herein are multivalent...
8697054 Strain of Lactobacillus rhamnosus  
The invention relates to a novel strain of Lactobacillus rhamnosus, having antimicrobial and immunomodulatory properties, and to compositions containing said strain.
8697407 Compositions and methods for inhibiting MMSET  
The present invention relates to agents that find use in the treatment, management, and/or study of cancer. In particular, the present invention relates to agents (e.g., small molecules, nucleic...
8697421 Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol  
The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention...
8697416 Recombinant polynucleotide, host cells containing the same and a process for producing a protein having aldolase activity  
4-(Indol-3-ylmethyl)-4-hydroxy-2-oxoglutarate, which is useful as an intermediate in the synthesis of monatin, may be synthesized from indole pyruvic acid and pyruvic acid (and/or oxaloacetic acid)...
8697409 Ketoreductase mutant  
Disclosed are a ketoreductase mutant which can be used for an efficient production of daunorubicin derivatives, a DNA encoding the mutant, a transformant prepared by introducing the DNA thereinto...
8697850 Process for preparing L-amino acids  
A process for preparing L-amino acids employing coryneform bacteria in which the AmtR regulator has been attenuated is provided. Recombinant bacteria, polynucleotides and vectors corresponding to...
8697398 Compositions and methods for bacterial production of chondroitin  
The invention relates to the field of recombinant DNA technology for the production of chondroitin, including the production of chondroitin sulfate via a combination of recombinant bacterial...
8697412 Polypeptides having glucoamylase activity and polynucleotides encoding same  
The present invention relates to isolated polypeptides having glucoamylase activity, catalytic domains, carbohydrate binding domains and polynucleotides encoding the polypeptides, catalytic domains...
8697392 Processes of producing fermentation products  
The invention relates to a process of fermenting plant material in a fermentation medium into a fermentation product using a fermenting organism, wherein one or more carbonic anhydrases are present...
8691553 Methods and organisms for utilizing synthesis gas or other gaseous carbon sources and methanol  
The invention provides a non-naturally occurring microbial organism having an acetyl-CoA pathway and the capability of utilizing syngas or syngas and methanol. In one embodiment, the invention...
8691539 Materials and methods for efficient succinate and malate production  
Genetically engineered microorganisms have been constructed to produce succinate and malate in mineral salt media in pH-controlled batch fermentations without the addition of plasmids or foreign...
8691525 Methods of combined bioprocessing and related microorganisms, thermophilic and/or acidophilic enzymes, and nucleic acids encoding said enzymes  
A genetically modified organism comprising: at least one nucleic acid sequence and/or at least one recombinant nucleic acid isolated from Alicyclobacillus acidocaldarius and encoding a polypeptide...
8691537 Method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family with attenuated expression of the rcsA gene  
The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which...
8691547 Coenzyme-linked glucose dehydrogenase and polynucleotide encoding the same  
The present invention provides members that produce on a large scale a coenzyme-linked glucose dehydrogenase which has excellent substrate-recognizing ability toward glucose while providing low...
8691960 Oxidoreductases for enantioselective reactions  
Described herein are compositions and methods for generating oxidoreductases for enantioselective reactions. Described herein are compositions and methods for generating neomorphic...
8691541 Biological production of pentose sugars using recombinant cells  
The invention provides, inter alia, compositions and methods for the biological production of pentose sugars, such as 2-methylerythritol (2-ME), 1-deoxyxylulose (1-DX), and...