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8741283 Adenosine deaminase anticancer therapy  
What is provided is a method of treating a patient having a tumor comprising administering an effective amount of adenosine deaminase, preferably polyalkylene oxide conjugated, to a patient in...
8742074 Optimized FC variants  
A variant of a parent polypeptide including an Fc region, which variant exhibits increased binding to FcRn as compared to the parent polypeptide and includes at least one amino acid modification...
8741620 Human lysosomal proteins from plant cell culture  
A device, system and method for producing glycosylated proteins in plant culture, particularly proteins having a high mannose glycosylation, while targeting such proteins with an ER signal and/or...
8741613 Microorganisms and processes for the production of isoprene  
The present invention provides a novel biosynthetic pathway for the production of isoprene from 3-methyl-2-buten-1-ol or 2-methyl-3-buten-2-ol. Further embodiments provide non-naturally occurring...
8741603 Enhancing spinosyn production with oxygen binding proteins  
The invention describes the integration of polynucleotides into chromosomal DNA of S. spinosa species, which are useful for the production of insecticides, integrants thereof, and also to the use...
8741307 Hybrid prokaryotic-eukaryotic tubulins and use thereof  
The present invention embraces hybrid Prosthecobacter-eukaryotic tubulin proteins and use thereof for identifying agents that modulate the activity of tubulin.
8741621 Enhanced production and purification of a natural high intensity sweetener  
Recombinant P. pastoris producing natural sweet proteins and methods for engineering these recombinant yeast are described. Methods for enhancing foreign protein production in yeast fermentation...
8741599 Fermentative production of organic compounds  
A process for the fermentative production of at least one organic compound having at least 3 C atoms or having at least 2 C atoms and at least one 1 N atom, comprising the following steps: a1)...
8741624 Production of polyhydroxyalkanoates from polyols  
Recombinant processes are provided whereby additional genes are introduced into E. coli which have been genetically engineered to produce PHA so that the improved strains produce PHA homopolymers...
8735546 Dual variable domain immunoglobulins and uses thereof  
Engineered multivalent and multispecific binding proteins, methods of making, and their uses in the prevention, diagnosis, and/or treatment of disease are provided.
8735133 Constructs and methods for the production and secretion of polypeptides  
Described herein are molecules, constructs and methods for the production and secretion of polypeptides of interest by host cells, preferably bacterial host cells, and more particularly gram...
8734779 5-fluorouracil-resistant bacteria and method for production thereof  
The present invention provides a method for producing a cytosine deaminase (CD)-expressing, 5-fluorouracil (5-FU)-resistant microorganism which can grow in anaerobic tumor tissues, can express CD,...
8735106 Immobilization of psicose-epimerase and a method of producing D-psicose using the same  
The present invention relates to a method of successively producing D-psicose from D-fructose or D-glucose by using a psicose-epimerase derived from Agrobacterium tumefaciens which is expressed in...
8735093 Mutant pyrrolysyl-tRNA synthetase, and method for production of protein having non-natural amino acid integrated therein by using the same  
Method for incorporating a lysine derivative (particularly an Nε-benzyloxycarbonyl-lysine (Z-Lys) derivative) having useful functional group such as heavy atom, selenium, reactive functional...
8735559 Mutant protease biosensors with enhanced detection characteristics  
A polynucleotide encoding a biosensor polypeptide comprising a modified circularly-permuted thermostable luciferase and a linker linking the C-terminal portion of the thermostable luciferase to...
8735112 Dicarboxylic acid production in a recombinant yeast  
The present invention relates to a recombinant yeast comprising a nucleotide sequence encoding a heterologous enzyme that catalyses the conversion of malic acid to fumaric acid. The invention...
8735134 Isoprene synthase variants with improved solubility for production of isoprene  
The present invention provides methods and compositions of variant polypeptides having isoprene synthase activity with improved solubility. In particular, the present invention provides isoprene...
8735543 Chimeric MOMP antigen  
The present invention regards polypeptides capable of eliciting an immunological response that is protective against Chlamydia trachomatis. The polypeptide comprises a first amino acid sequence...
8735114 Fermentive production of four carbon alcohols  
Methods for the fermentative production of four carbon alcohols is provided. Specifically, butanol, preferably isobutanol is produced by the fermentative growth of a recombinant bacterium...
8728788 Dehydrogenase variants and polynucleotides encoding same  
The present invention relates to 3-hydroxypropionate dehydrogenase variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host...
8728789 DNA fragment encoding a polyphosphate-driven nucleoside 5′-diphosphate kinase polypeptide  
The invention provides a method for producing 3′-phosphoadenosine 5′-phosphosulfate (PAPS), the method including subjecting ATP to sulfation and phosphorylation by use of adenosine 5′-triphosphate...
8728795 Pgro expression units  
The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for...
8728762 Fermentative production of organic compounds  
The invention relates to a method for producing at least one organic compound comprising at least 3 C-atoms or at least 2 C-atoms and at least 1 N-atom by fermentation. Said method comprises the...
8729337 Production of polyunsaturated fatty acids, novel biosynthesis genes, and novel plant expression constructs  
The present invention relates to a method for the production of unsaturated fatty acids with at least two double bonds. The invention furthermore relates to the use of nucleic acid sequences SEQ...
8728760 Microcin H47 plasmid selection system  
The present invention relates generally to stabilized expression plasmid systems. The stabilized expression plasmid systems comprise an expression vector that includes a plasmid maintenance system...
8722371 Cytochrome P450 oxygenases  
Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher...
8722855 Dual variable domain immunoglobulins and uses thereof  
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
8722411 Brucella phage polynucleotides and uses thereof  
An isolated polynucleotide is disclosed which comprises a nucleic acid sequence of a Brucella phage, the nucleic acid sequence being specific to the Brucella phage and comprising a sequence...
8722639 Means and methods for the treatment of hearing loss and phantom hearing  
This invention relates to modulators of NADPH oxidase as a medicament for the treatment and/or prevention of hearing loss and/or phantom hearing. Such modulators preferably act by inhibiting NADPH...
8722385 Biological synthesis of difunctional hexanes and pentanes from carbohydrate feedstocks  
Provided herein are methods for the production of difunctional alkanes in microorganisms. Also provided are enzymes and nucleic acids encoding such enzymes, associated with the difunctional alkane...
8722365 Metabolically engineered Escherichia coli for enhanced production of sialic acid  
A metabolically engineered E. coli strain which produces sialic acid and a method of making said strain. In the engineered E. coli cells, the nanT (sialic acid transporter) and nanA (sialic acid...
8722869 Class of therapeutic protein based molecules  
The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that...
8722369 Glucoamylase variants  
The invention relates to a variant of a parent fungal glucoamylase, which exhibits altered properties, in particular improved thermal stability and/or increased specific activity.
8722384 Methods and compositions for synthesis of long chain polyunsaturated fatty acids  
The present invention relates to fatty acid desaturases able to catalyze the conversion of oleic acid to linoleic acid, linoleic acid to γ-linolenic acid, or of alpha-linolenic acid to stearidonic...
8716003 Targeted gene deletions for polysaccharide slime formers  
The present invention provides improved polysaccharides (e.g., gellan and diutan) produced by mutant gene R Sphingomonas strains containing at least one genetic modification that favors...
8716002 Re-engineering bacteria for ethanol production  
The invention provides recombinant bacteria, which comprise a full complement of heterologous ethanol production genes. Expression of the full complement of heterologous ethanol production genes...
8716450 Dual variable domain immunoglobulins and uses thereof  
The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.
8715989 Glucose dehydrogenase and method for producing the dehydrogenase  
A glucose dehydrogenase, having high substrate specificity, can be produced at a low cost, is not affected by oxygen dissolved in a measurement sample and, in particular, has superior thermal...
8715997 Variant Hypocrea jecorina CBH2 cellulases  
Described herein are variants of H. jecorina CBH2, a Cel6A enzyme. The present invention provides novel cellobiohydrolases that have altered thermostability.
8715676 Production and uses of type I ribosome inactivating proteins  
Described herein are methods to express and purify recombinant type 1 ribosome inactivating proteins. Included are methods for using recombinant cucurmosin as a therapeutic to treat cancer and...
8715992 I-CreI meganuclease variants with modified specificity, method of preparation and uses thereof  
Method of preparing I-CreI meganuclease variants having a modified cleavage specificity, variants obtainable by said method and their applications either for cleaving new DNA target or for genetic...
8715993 Glycosidase enzymes  
A thermostable glycosidase enzymes derived from various Thermococcus, Staphylothermus and Pyrococcus organisms is disclosed. The enzymes are produced from native or recombinant host cells and can...
8715972 Homolactic fermentation from pentose  
Provided is a lactic acid bacterium capable of homolactic fermentation using a pentose as a substrate, the lactic acid bacterium utilizing a pentose, and in which a phosphoketolase pathway is...
8709785 Compositions and methods for producing isoprene  
The invention features methods for producing isoprene from cultured cells. The invention also provides compositions that include these cultured cells.
8709781 System and method for the heterologous expression of polyketide synthase gene clusters  
A system and method for heterologous expression of polyketide biosynthetic pathways from streptomycetes hosts in Escherichia coli for the production and discovery of secondary metabolites. Genomic...
8709772 Transferases and oxidoreductases, nucleic acids encoding them and methods for making and using them  
This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having transferase activity,...
8709813 DNA promoters and anthrax vaccines  
The invention is related to intracellularly induced bacterial DNA promoters and vaccines against Bacillus anthracis.
8709798 Nucleic acids for cloning and expressing multiprotein complexes  
The present invention relates to a nucleic acid containing at least one homing endonuclease site (HE) and at least one restriction enzyme site (X) wherein the HE and X sites are selected such that...
8709775 Hydrolases, nucleic acids encoding them and methods for making and using them  
Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides....
8710296 Defensin polynucleotides and methods of use  
Methods and compositions for modulating development and defense responses are provided. Nucleotide sequences encoding defensin proteins are provided. The sequences can be used in expression...