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8617565 Surface exposed Haemophilus influenzae protein (protein E; pE)  
The present invention relates to a surface exposed protein (protein E; pE), a virulence factor, which can be detected in Haemophilus influenzae, having an amino acid sequence as described in SEQ ID...
8614075 Mutant Δ-5 desaturases mutated in the heme-binding motif (HPGG)  
The present invention relates to mutant Δ5 desaturases, which have the ability to convert dihomo-γ-linolenic acid [DGLA; 20:3 ω-6] to arachidonic acid [ARA; 20:4 ω-6] and/or eicosatetraenoic aci...
8614306 Polynucleotides encoding humanized anti-factor D antibodies  
The invention relates to anti-Factor D antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their production and their use in the...
8614308 Nucleic acid molecules encoding A-beta binding polypeptides  
The invention relates to biparatopic A-beta binding polypeptides and, more specifically, to biparatopic A-beta binding polypeptides comprising at least two immunoglobulin single variable domains...
8614077 Recovery of higher alcohols from dilute aqueous solutions  
This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the...
8609385 Methods for the direct conversion of carbon dioxide into a hydrocarbon using a metabolically engineered photosynthetic microorganism  
The present invention relates to methods for the production of isoprene by the direct conversion of atmospheric carbon dioxide using metabolically engineered genetically engineered photosynthetic...
8609389 Milk-clotting protease derived from a microorganism  
The present invention provides an improved type protease which comprises an amino acid sequence that is at least 75% identical to SEQ ID NO:3, said improved type protease has at least one mutation...
8609395 Agonist and antagonist peptides of carcinoembryonic antigen (CEA)  
The invention provides a polypeptide comprising an agonist of a MHC Class I binding native sequence having amino acid substitution(s) and enhanced immunogenicity compared to the native sequence....
8609388 Modified family 5 cellulases and uses thereof  
The present invention relates to a modified Family 5 cellulase comprising a substitution of an amino acid at position 363 with a non-native alanine, serine or threonine, the position determined...
8609394 Biotechnological production of chondroitin  
Chondroitin is produced by culturing a recombinant microorganism which is obtained by inactivation of a gene encoding an enzyme responsible for addition of fructose residues to the linear...
8609387 Fungal endoglucanases, their production and use  
Novel fungal endoglucanases with substantial performance at low temperatures are disclosed. The endoglucanases are conveniently produced by recombinant technology, and means for their production...
8609378 Polyhydroxyalkanoate production from polyols  
Organisms are provided which express enzymes such as glycerol dehydratase, diol dehydratase, acyl-CoA transferase, acyl-CoA synthetase β-ketothiolase, acetoacetyl-CoA reductase, PHA synthase, ...
8609393 Fluorescent proteins and genes encoding them  
Fluorescent proteins comprising the following internal amino acid sequence (SEQ ID NO: 47)Gly Tyr Xaa Xaa Xaa Gln Tyr Leu Pro Xaa Pro1 5 10 wherein Xaa in position 3 is Ala or Gly,Xaa in position 4...
8609367 Genes and proteins for the biosynthesis of the lantibiotic 107891  
The invention relates to the field of lantibiotics, and more specifically to the isolation of nucleic acid molecules that code for the enzymes required for the biosynthetic pathway of the...
RE44648 Enzyme for the production of long chain peracid  
The present invention provides methods and compositions comprising at least one perhydrolase enzyme for cleaning and other applications. In some embodiments, the present invention provides methods...
8603823 Methods and compositions for producing vitamin K dependent proteins  
The present invention relates to methods and compositions for improving the productivity of recombinant vitamin K dependent protein expression in host cells.
8603788 Modified yeast strains exhibiting enhanced fermentation of lignocellulosic hydrolysates  
The present invention relates to novel xylose-fermenting yeast strains (for example, yeast of the genus Saccharomyces, e.g., S. cerevisiae) with an enhanced ability to ferment the xylose (and/or...
8603785 Method of organic polymer degradation by dihydrolipoamide dehydrogenase  
A dihydrolipoamide dehydrogenase (DLD) in a germ is recombined. The new DLD is applied in a solution to degrade an ether bond of an organic polymer. With the present invention, bioremediation is...
8603822 Method for designing heat-resistant tyrosine-dependent short-chain dehydrogenase/reductase and heat-resistant tyrosine-dependent short-chain dehydrogenase/reductase  
A method for designing a heat-resistant mutant enzyme, the method including the step of reducing a distance between the α4 helix and the α6 helix in a protein three-dimensional structure to b...
8603797 Methods and compositions for targeted mutagenesis in bacteria  
This disclosure provides methods and compositions for targeted mutagenesis of specific genes in a bacterial strain. By inducibly over-expressing error-prone polymerases such as Pol IV or Pol V in...
8604180 DNA fragment having promoter function  
The present invention relates to a method of inducing expression of a promoter function of various genes in a Coryneform bacterium related to function exertion, in order to exert the function of a...
8603790 Systems, methods and compositions for optical stimulation of target cells  
Methods, systems and devices are implemented in connection with light-responsive ion channel molecules. One such method is implemented using a light-activated ion channel molecule that responds to...
8603778 Anti-TNF antibodies, compositions, methods and uses  
The present invention relates to anti-TNF antibodies comprising all of the heavy chain variable CDR regions of SEQ ID NOS:1, 2 and 3 and/or all of the light chain variable CDR regions of SEQ ID...
8603781 Prevention of incorporation of non-standard amino acids into protein  
The instant invention is drawn to the methods and compositions necessary to provide recombinant proteins with a substantially reduced or eliminated content of norleucine or other non-standard amino...
8597901 2,5-diketo-L-gluconic acid reductases and methods of use  
Described herein are novel nucleic acids, proteins and methods that can be used to provide new catalysts with desirable traits for industrial processes. In particular, novel reductases isolated...
8597916 Multimeric oxidoreductases  
The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C...
8597648 Fully human anti-TNF-alpha monoclonal antibody, preparation method and use thereof  
The present invention provides a full human anti-TNF-α monoclonal antibody, the preparation method and use thereof. The antibody in the present invention has an amino acid sequence of heavy chain ...
8597912 Methods and compositions for generation of Bax-and Bak-deficient cell lines  
Disclosed herein are methods and compositions for generation of Bak- and/or Bax-deficient cell lines using engineered nucleases.
8597908 Process for producing protein A-like protein with use of Brevibacillus genus bacterium  
The present invention relates to an efficient and economical process for producing a protein A-like protein. Hosts such as Escherichia coli and Bacillus subtilis have been used in the production of...
8597922 Methods and compositions for producing olefins  
Compositions and methods for producing olefins are described herein. The olefins can be used to produced biofuels.
8592195 Fungal endoglucanases, their production and use  
Novel fungal endoglucanases Ce15 and Ce112 are disclosed. The endoglucanases are conveniently produced by recombinant technology, and means for their production are described. The endoglucanases...
8592557 Multimeric TNF receptor fusion proteins and nucleic acids encoding same  
The present invention refers to fusion proteins comprising a TNF receptor family extracellular domain fused to a trimerization domain, and a nucleic acid molecule encoding the fusion protein. The...
8591909 Recombinant carrier molecule for expression, delivery and purification of target polypeptides  
Recombinant carrier molecules having amino acid sequences from thermostable enzymes and methods of use for expression, recovery and delivery of foreign sequences (peptides and polypeptides)...
8592178 Process for the preparation of testosterone  
The present invention relates to an industrial process for the reduction of 4-androstene-3,17-dione in order to obtain testosterone using a particularly stable and selective enzyme produced in a...
8592194 Glucoamylase variants with altered properties  
The present invention relates to variant glucoamylases wherein the variant has altered properties (e.g., improved thermostability and/or specific activity) compared to a corresponding parent...
8592188 Tailored oils produced from recombinant heterotrophic microorganisms  
Methods and compositions for the production of oil, fuels, oleochemicals, and other compounds in recombinant microorganisms are provided, including oil-bearing microorganisms and methods of low...
8586032 Use of alkaline phosphatase in the treatment of reduced renal function  
The invention relates to the field of medicine and in particular to the use of alkaline phosphatase in the treatment of renal diseases, such as reduced renal function. The present invention also...
8586037 Antibodies against IL-17BR  
The invention provides the antibody D9.2 and antibody molecules based on D9.2 which bind interleukin-17 receptor B. These may be useful in therapy, e.g. the treatment of asthma, ulcerative colitis...
8586328 Method for producing sclareol  
The present invention provides a method of producing sclareol, said method comprising contacting a particular polypeptide having a sclareol synthase activity with labdenediol diphosphate (LPP). In...
8586336 Nucleic acid molecule encoding xylose isomerase and xylose isomerase encoded by the nucleic acid molecule  
A novel xylose isomerase nucleotide sequence obtained from a bovine rumen fluid metagenomic library and also provides the amino acid sequence encoded by the nucleotide sequence, and a vector and a...
8586031 Method of reusing rinse water from disinfecting packages with peracid and catalase  
The present invention relates to specially selected catalase enzymes and their use in reducing hydrogen peroxide in applications, and particularly in aseptic packaging applications.
8586332 Method for producing oligopolysaccharides  
The invention concerns the production by microbiological process of oligopolysaccharides of biological interest. More particularly, the invention concerns a method for synthesizing in vivo the...
8586832 Bacillus thuringiensis gene with Lepidopteran activity  
The invention provides nucleic acids, and variants and fragments thereof, obtained from strains of Bacillus thuringiensis encoding polypeptides having pesticidal activity against insect pests,...
8586339 Facilitated process for purification of proteins  
A two-stage heat treatment process is provided to improve the processability of recombinant microbial biomass comprising an enzyme having perhydrolytic activity. More specifically, a process is...
8580937 cDNA-derived nucleic acids encoding red-shifted channelrhodopsins  
Methods and compositions are used to identify and characterize new channelrhodopsins derived from algae and several of which are red-shifted. The rhodopsin domain of these red-shifted...
8580556 Sulfonylurea-responsive repressor proteins  
Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific...
8580552 Method for treating cellulosic material and CBHII/CEL6A enzymes useful therein  
The present invention relates to the production of sugar hydrolysates from cellulosic material. The method may be used, for example for producing fermentable sugars for the production of bioethanol...
8580547 Variants of PQQ-dependent glucose dehydrogenase having improved substrate specificity  
The invention relates to novel PQQ-dependent soluble glucose dehydrogenases (sPQQGDH) which have an increased substrate specificity compared with the wild type, and also to methods for production...
8580543 Microorganisms and methods for the biosynthesis of butadiene  
The invention provides non-naturally occurring microbial organisms having a butadiene pathway. The invention additionally provides methods of using such organisms to produce butadiene.
8580527 Methods for identifying compounds which modulate T2R bitter taste receptors  
The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and...