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8173386 Method of assaying enzyme-mediated oxidative demethylation  
Methods of assaying enzyme-mediated oxidative demethylation are provided according to embodiments of the present invention which includes combining, under reaction conditions, an oxidative...
8173402 Modified yeasts and uses thereof, in particular for producing steroid derivatives  
The present invention relates to novel yeast strains, methods and genetic constructs for their preparation, and their use for the synthesis or modification of steroidal compounds. More...
8163880 Production of biologically active proteins  
A fusion protein that is expressed in a recombinant protein body-like assembly (RPBLA) in host eukaryotic cells and organisms is disclosed. More particularly, a biologically active polypeptide...
8163499 Drug selection for breast cancer therapy using antibody-based arrays  
The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of...
8153392 Method(s) of preventing, arresting, reversing and treatment of atherosclerosis  
A method of detecting, diagnosing and prognosticating atherosclerosis by measuring the activities of Δ6 and Δ5 desaturases is described. It is suggested that enhancing the activities of Δ6 and Δ5...
8148100 Mina53 assays  
The present invention comprises a method for assaying oxygenase activity the method comprising monitoring oxygenase activity of Mina53.
8137927 Molded protein material in form of pellet for sensor  
A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix...
8128803 Method and system for determining the concentration of an analyte/enzyme complex or of an analyte/enzyme conjugate, especially for the electrochemical detection of the analyte, and corresponding measuring device  
A method follow the change in concentration of a redox-active substance, whereby suitable potentials for a reduction process or an oxidation process are applied to the working electrode of a...
8114606 ARL-1 specific antibodies  
This invention provides antibodies immunologically specific for human ARL-1 (also referred to AKR1B10), a species of the aldo-keto reductase superfamily of proteins. The invention also provides...
8114650 Nucleic acid and its use effecting ciliate tetrahymena bifunctional dihydrofolate reductase-thymidylate synthase deficiency  
A method for producing a ciliate cell with reduced or essentially no dihydrofolate reductase (DHFS) activity or reduced or essentially no thymidylate synthase (TS) activity or both reduced or...
8105800 Composition for assaying glycated proteins  
Composition for accurately assaying a glycated protein by: 1) avoiding effects of globulin and ascorbic acid components, 2) siabilizing proteases and at least enzymes acting on glycated amino...
8093029 Bilirubin oxidase mutant having thermal stability  
A heat-resistant bilirubin oxidase mutant is disclosed. The bilirubin oxidase mutant is obtained by deletion, replacement, addition or insertion of at least one amino acid residue of a wild type...
8080385 Crosslinked adduct of polyaniline and polymer acid containing redox enzyme for electrochemical sensor  
A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble...
8080404 Enzymatic decontamination  
Compositions and methods for enzymatic decontamination by inactivation of Hazardous agents are provided. Hazardous agents of microbial and chemical origin can be neutralized by H2O2. The methods...
8076114 Cytochrome P450 oxygenases  
Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent...
8057659 Detection of analytes in a dual-mediator electrochemical test strip  
Determination of an analyte such as glucose in a sample is done making use of a plurality of electron transfer reagents, for example two electron transfer reagents, that work together to transfer...
8053018 Techniques to improve polyurethane membranes for implantable glucose sensors  
The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the...
8050873 Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase  
The crystal structure of ligand-bound EGLN1 catalytic domain of prolyl hydroxylase is disclosed. These coordinates are useful in computer aided drug design for identifying compounds that regulate...
8030018 Method for measuring enzymatic activity in vivo by use of laser  
A method of measuring an enzymatic activity, includes measuring the quantity of a substrate metabolite produced upon metabolism of a substrate by an enzyme, through detecting a radiant wave...
8026089 Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids  
The present invention relates to mutant Δ8 desaturase genes, which have the ability to convert eicosadienoic acid [20:2 ω-6, EDA] to dihomo-γ-linolenic acid [20:3, DGLA] and/or eicosatrienoic ac...
8026085 Methods and systems for selective fluorination of organic molecules  
A method and system for selectively fluorinating organic molecules on a target site wherein the target site is activated and then fluorinated are shown together with a method and system for...
8026078 Method of quantifying glycosylated protein using redox reaction and quantification kit  
The present invention provides a method of measuring a glycated protein in a sample using a redox reaction, by which the glycated protein can be measured accurately with high sensitivity. In order...
8021855 Method of decomposing protein with sulfonic acid compound  
A method of assaying a glycated protein in a sample with the use of redox reaction, in which highly reliable measurement can be obtained. A sample containing a glycated protein is treated with...
8017352 Seafood spoilage indicator  
An enzyme based nondestructive sensor for the qualitative detection of spoilage in seafood is provided wherein the sensor does not alter the physical composition of the seafood specimen. The sensor...
8017314 Immersion sensor for measuring the concentration of an analyte with the help of an oxidase  
The invention relates to measuring the concentration of analytes with the aid of an oxidase in an immersion sensor situated in a fluid or in a matrix containing fluid. Oxygen diffuses into the...
8012761 Detection of formaldehyde in urine samples  
A method for rapidly detecting the presence of formaldehyde in a urine sample (e.g., urine or a urinary material associated therewith, such as headspace gas located associated with urine) is...
8012725 Method for the production of optically-active alcohols  
The present invention relates to enzymic processes for preparing S-butan-2-ol; and to enzymes for carrying out said processes; to nucleic acid sequences coding for said enzymes, to expression...
8012729 Mutant glucose dehydrogenase  
Substrate specificity for glucose of a glucose dehydrogenase having the amino acid sequence of SEQ ID NO: 13 is improved by substituting another amino acid residue for the amino acid residue at...
8003358 Two-step enzyme method for preparing 7-aminocephalosporanic acid  
The present invention discloses a two-step enzyme method for preparing 7-aminocephalosporanic acid from cephalosporin C, wherein D-amino acid oxidase used is purified D-amino acid oxidase mutant of...
8003343 Method for determining diamine oxidase  
Disclosed is a method for determining histaminase (DAO; EC 1.4.3.6) activity in a sample. Said method comprises the following steps: an aqueous solution is supplied which contains a predefined...
7998698 Method for predicting susceptibility to radiation pneumonitis  
Provided is a method for determining whether an individual is likely to be susceptible to radiation pneumonitis from radiation therapy and for developing a treatment based on the determination of...
7993894 Nematode fatty acid desaturase-like sequences  
Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and...
7981634 Method for positively detecting toxic material  
Disclosed herein is a method of positively detecting toxic materials within a sample, the method including contacting sub-mitochondrial particles with an electron donor. The electron donor is...
7977078 Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane  
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides...
7968314 Methods employing a multi-time point IC50 assay for selecting time points for time dependent inhibition assays of a test compound  
The invention provides a method of evaluating metabolism-based drug interactions. The method involves selecting time points for the determination of the inactivation rate constant of a...
7968290 Method of detecting gene  
A method of detecting a gene including immobilizing a primer for DNA elongation onto an insoluble carrier having on the surface thereof a polymer substance containing a first unit having a...
7964372 Size self-limiting compositions and test devices for measuring analytes in biological fluids  
A test strip or electrochemical sensor for measuring the amount of an analyte in a biological fluid, e.g. the glucose content of whole blood, includes a size self-limiting reagent formulation...
7960605 Methods for testing for caloric restriction (CR) mimetics  
Methods for treating neurological diseases and for testing Caloric Restriction (CR) mimetics or CR mimetic candidates. In one exemplary method, a CR mimetic candidate is administered to a...
7960155 Cytochrome p450 monooxygenases and their use for oxidizing organic compounds  
The invention relates to novel cytochrome P450 monooxygenases comprising a modified substrate specificity, to nucleotide sequences which code therefor, to expression constructs and vectors...
7951550 Luminogenic and fluorogenic compounds and methods to detect molecules or conditions  
A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided.
7951554 Kit for enzymatic deposition of a metal  
The present invention provides compositions, kits, assemblies of articles and methodology for carrying out processes that permit biological enzymes to act directly on metals and metal particles. In...
7943338 Autoimmune conditions and NADPH oxidase defects  
The invention relates to methods and materials involved in diagnosing and treating autoimmune conditions. In particular, the invention relates to methods and materials involved in diagnosing...
7943385 Methods for assaying percentage of glycated hemoglobin  
The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in...
7943337 Method for screening a protease  
There is provided a method for specifically determining a glycated β-chain N-terminal of glycated hemoglobin using enzymes without a separation operation, and a determination reagent kit therefor. ...
7939290 Method for analyzing the activity of lipoxygenase using a water-soluble substrate  
The present invention discloses methods for analyzing the activity of lipoxygenase by using polyunsaturated lysophosphatidylcholine as a water-soluble substrate. In these methods, lipoxygenase...
7927588 Skin dressings containing oxidoreductase enzyme  
A skin dressing comprises a first dressing component (16) carrying oxidoreductase enzyme in dried condition; and a second dressing component (18) carrying a source of water, such that when the...
7927849 Laccase enzyme and use thereof  
The present invention relates to a novel laccase enzyme obtainable from the strains of genus Thielavia. The invention relates also to the nucleic acid sequence encoding the enzyme, a recombinant...
7922483 Method of using a polynucleotide encoding 2.5-diketo-D-gluconic acid reductase  
Described herein are novel nucleic acids, proteins and methods that can be used to provide new catalysts with desirable traits for industrial processes. In particular, novel reductases isolated...
7914663 Structure, porous body, sensor, process of structure and detecting method for specimen  
A mesoporous silica structure having a plurality of mesopores includes a dendritic framework having mesopores. 90% or more of the mesopores observable in a 500 nm×500 nm area pass through the ...
7915021 Mutant firefly luciferase  
This invention relates to: the development of a mutant firefly luciferase in order to use dATP as a DNA polymerase substrate upon pyrosequencing, such luciferase being subjected to substrate...