Match Document Document Title
7608416 Targeting mPGES-1 as a treatment for inflammation which avoids cardiovascular risk  
The present invention relates to methods for the treatment of inflammation and pain without increasing cardiovascular risk by administration of an inhibitor of mPGES-1. The invention further is...
7598063 Process for producing ethanol by using recombinant coryneform bacterium  
The present invention provides a process for highly efficiently producing ethanol at a high productivity consisting of using a coryneform bacterium which has been transformed by a DNA containing a...
7598054 Rapid peptidoglycan-based assay for detection of bacterial contamination of platelets  
The invention relates to a colorimetric method for detecting bacterial or fungal pathogens by detecting peptidoglycan or (1-3)-β-D-glucan in a sample.
7592153 Method of reducing metal ions to elemental metal in the vicinity of an oxido-reductase enzyme  
Disclosed are methods and materials for utilizing enzymes to act on metal ions in solution so that the ions are reduced to metal. Additionally disclosed is how to use enzymes to accumulate metal...
7588911 Assays for detecting inhibitors of binding between COX-2 and PDZ proteins  
The invention provides an assay for determining whether a test agent is a COX modulator. In general terms, the assay includes: determining whether a test agent modulates binding of a PDZ-containing...
7588910 Hemoglobin A1c determination method, enzyme to be used therefor, and production method thereof  
There is provided a method for specifically determining a glycated β-chain N-terminal of glycated hemoglobin using enzymes without a separation operation, and a determination reagent kit therefor....
7575866 Ligand/binding partner bio-labeling systems  
The present invention relates to methods and compositions which utilize binding relationships between detector molecules and their ligands for labeling molecules of interest in vivo. A “target”...
7572616 Alternative oxidase and uses thereof  
The invention relates to a method for combating disorders affecting the mitochondrial oxidative phosphorylation system by allotopic expression of the cyanide-insensitive alternative oxidase (AOX)...
7550273 Colorimetric method and reagent used for the same  
The present invention provides a calorimetric method that can perform a simple and reliable analysis in a short time. The method includes transferring an electron from an analyte to a coloring...
7544480 Assays for modulators of asparaginyl hydroxylase  
A method of identifying an agent which modulates hydroxylation of hypoxia inducible factor (HIF), comprises contacting a HIF asparagine hydroxylase and a test substance in the presence of a...
7537919 Cytochrome P450RAI-2 and related proteins  
The present invention provides a novel all-trans-RA inducible all-trans-RA metabolizing cytochrome P450, P450RAI-2, that is predominantly expressed in the brain, cerebellum in particular. Human...
7534583 Analyte measurement  
A method for determining the concentration of an analyte in a sample is disclosed which comprises contacting the sample with a micro electrode which comprises an enzyme capable of reacting with...
7531335 Modified cytochrome p450 monooxygenases  
The present invention relates to modified cytochrome P450 monooxygenases with an altered substrate profile, to nucleic acid sequences coding therefor, to expression constructs and vectors, to...
7524872 Method and composition for treating cancer using cellular organelle crystallizing agents  
This invention provides a method for treating cancer in mammals through cellular-organelle-crystallization-induced-death (herein defined as “Cocid”), a method for treating cancer using cellular...
7524666 Reductase gene and use thereof  
Provided are genes coding a protein having an ability of asymmetrically reducing a 2-oxo-4-phenylbutyrate to produce a (R)-2-hydroxy-4-phenylbutyrate advantageously from the industrial standpoint,...
7524664 Regio- and enantioselective alkane hydroxylation with modified cytochrome P450  
Cytochrome P450 BM-3 from Bacillus megaterium was engineered using a combination of directed evolution and site-directed mutagenesis to hydroxylate linear alkanes regio- and enantioselectively...
7521200 Method for non-invasive rinse diagnosis and monitoring of periodontal diseases using colourimetric reagents  
An assay test kit is used in a mouth rinse sample collection procedure involving collecting a mouth rinse sample from a patient. A neutrophil reactant diagnostic reagent is delivered to the rinse...
7520970 Immobilization support, process for producing the same, electrode, process for producing the same, electrode reaction utilizing apparatus and process for producing the same  
An immobilization carrier containing an electron acceptor compound is used in addition to glutaraldehyde and poly-L-lysine to immobilize an enzyme and an electron acceptor compound simultaneously...
7514247 Systems and processes for cellulosic ethanol production  
A cellulosic ethanol production process. An implementation of a process for producing fuel ethanol and biodiesel from cellulose may include: providing a raw cellulose stream by mixing a waste...
7511142 Mediator-modified redox biomolecules for use in electrochemical determination of analyte  
Compositions and methods for electrochemical detection of an analyte comprising a transition metal compound wherein M is a metallic element that can form a coordinate bond to nitrogen; R and...
7510851 Compositions and methods for diagnosing and treating diabetes, insulin resistance and dyslipidemia  
The present invention provides compositions and methods for diagnosing and treating diabetes, insulin resistance and dyslipidemia. In particular, the invention provides methods of identifying...
7507553 Galleria mellonella derived composition for detecting peptidoglycan, a method for use thereof, and a diagnostic kit containing the same  
The present invention relates to a composition for selectively detecting an extremely small amount of peptidoglycan in sample, a preparation method of the composition, and a detection kit for...
7497996 Liquid delivery apparatus and liquid delivery method  
A liquid delivery apparatus 1 has a rotary substrate 2 . The substrate 2 formed with a fluid passage 8 A for communicating a supply chamber 6 A and target chamber 7 A. An inlet end portion ...
7495106 O-aminophenol-containing AB-monomer for heterocyclic rigid-rod polymers  
A novel o-aminophenol-carboxylic AB-monomer with the following chemical structure: for synthesizing new rigid-rod polybenzobisazoles was prepared from the corresponding...
7485705 Water-soluble tetrazolium compounds  
The purpose of the present invention is to provide a water-soluble tetrazolium compound that will form a water-soluble formazan exhibiting long-wavelength absorption and is stable in aqueous...
7485436 Method of stabilizing oxidation color former  
A method of stabilizing an oxidation color former in a solution is provided. N-(carboxymethylaminocarbonyl)-4,4′-bis(dimethylamino) diphenylamine sodium salt as an oxidation color former is...
7482141 Methods and compositions for vitamin K epoxide reductase  
The present invention provides a method of identifying a human subject having increased or decreased sensitivity to warfarin, comprising detecting in the subject the presence of a single nucleotide...
7479384 Nematode MDH-like sequences  
Disclosed are two nucleic acid molecules from M. incognita encoding malate dehydrogenase-like (MDH-like) polypeptides. The MDH-like polypeptide sequences are also provided, as are vectors, host...
7479382 Nematode fatty acid desaturase-like sequences  
Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and...
7476524 Canine COX-2 nucleic acid molecules  
The present invention relates to canine COX-1 and COX-2 proteins; to canine COX-1 and COX-2 nucleic acid molecules, including those that encode such COX-1 and COX-2 proteins, respectively; to...
7465567 Peroxide-driven cytochrome P450 oxygenase variants  
The invention relates to novel variants of cytochrome P450 oxygenases. These variants have an improved ability to use peroxide as an oxygen donor as compared to the corresponding wild-type enzyme....
7449305 Method of pre-treating sample for measuring saccharified amine and method of measuring saccharified amine  
The present invention provides a method of pretreating a sample containing a glycated amine as an analyte, thereby enabling highly reliable measurement of a glycated amine. A glycated amino acid in...
7445909 Method for detecting reactive metabolites using a combination of glutathione and a stable isotopic derivative of glutathione and mass spectroscopy-based pattern recognition  
The present invention is directed to a method for detecting reactive metabolites using a combination of glutathione and a stable isotopic derivative of glutathione and mass spectroscopy. More...
7445908 Detection of oxidizing agents in urine  
A method of detecting oxidants in a biological sample comprising: adding a source of ferrous ions to said sample, whereby the presence of oxidants in said sample oxidize at least a portion of said...
7435574 NADH oxidase from Lactobacillus  
The present invention is directed to a new NADH oxidase from Lactobacillus , nucleic acids encoding the NADH oxidase, methods of producing the NADH oxidase, as well as there use in producing...
7435570 Thermostable peroxide-driven cytochrome P450 oxygenase variants and methods of use  
The invention relates to novel variants of cytochrome P450 oxygenases. These variants have at least one mutation improving their ability to use peroxide as an oxygen donor as compared to the...
7435569 Method of forming a molded protein matrix for use in a sensor  
A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix...
7435559 Methods and compositions employing a novel stearoyl-CoA desaturase-hSCD5  
A cDNA encoding a novel human stearoy-CoA desaturase (dubbed “hSCD5”) as well as vectors and cells comprising such polynucleotide are disclosed. Also described are assay methods for determining...
7435558 Ascertaining the patient related risk of caries  
The invention relates to a method for the determination of the patient-related risk of caries by determination of lactic acid and/or lactate in saliva and to a method for the location-specific...
7432096 Glucose dehydrogenase and production thereof  
The invention relates to novel PQQ-dependent soluble glucose dehydrogenases (sPQQGDH) from Acinetobacter and to a process for their preparation by overexpression in suitable microbial expression...
7432072 Method of preventing wrong color formation of n-(carboxymethylaminocarbony)-4,4′-bis(dimethylamino) diphenylamine sodium, reagent solution for the method, and measurement method employing the method  
The present invention provides a method of preventing erroneous color development of N-(carboxymethylaminocarbonyl)-4,4′-bis(dimethylamino)diph enylamine sodium salt as a color-developing...
7425433 Carboxylic acid reductase polypeptide, nucleotide sequence encoding same and methods of use  
The invention provides the nucleotide sequence and amino acid sequence for the enzyme carboxylic acid reductase isolated from bacteria. Expression cassettes, vectors, transformed cells, and...
7419813 Fructosyl peptide oxidase  
The present invention has an object of providing a novel fructosyl peptide oxidase having superior physicochemical properties such as stability that is useful as an enzyme for clinical diagnosis,...
7416872 Taxoid oxygenases and their uses  
Oxygenase enzymes and the use of such enzymes to produce paclitaxel (Taxol™), related taxoids, as well as intermediates in the Taxol biosynthetic pathway are disclosed. Also disclosed are nucleic...
7410755 ADP detection using an enzyme-coupled reaction  
Methods and compositions are provided for determining ADP in the presence of ATP. These comprise including among the assay reagents at least one of the correcting components creatine phosphokinase...
7407774 Method for reducing influence of hemoglobin with albumin in an assay  
A method for quantitatively determining a specific component in a biological specimen, which includes reacting a biological specimen, in the presence of an electron acceptor, with an enzyme which...
7407743 Kit and method of screening wilson's disease  
The present invention relates to a method for measuring a ceruloplasmin concentration, and more particularly, to a method for measuring a ceruloplasmin in a blood spot based on a standard...
7402417 P450 oxygenases and methods of use  
This disclosure provides the nucleic acid and protein sequences of novel P450 oxygenases that utilize, at least, taxoid substrates, including taxadiene isomers. The disclosed oxygenases, such as a...
7402408 Assay for inhibitors of ispH  
Assay for testing a sample for the presence or absence of inhibition of the enzymatic conversion of 1-hydroxy-2-methyl-(E)-butenyl 4-diphosphate into isopentenyl diphosphate and/or dimethylallyl...
7396659 Inhibitors of nitric oxide synthase to treat type 1 diabetes  
A method for treating type 1 diabetes in a human in need of such treatment, comprising administering to the human a biologically effective amount of at least one inhibitor of inducible nitric oxide...