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8173386 |
Method of assaying enzyme-mediated oxidative demethylation
Methods of assaying enzyme-mediated oxidative demethylation are provided according to embodiments of the present invention which includes combining, under reaction conditions, an oxidative...
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8173402 |
Modified yeasts and uses thereof, in particular for producing steroid derivatives
The present invention relates to novel yeast strains, methods and genetic constructs for their preparation, and their use for the synthesis or modification of steroidal compounds. More...
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8163880 |
Production of biologically active proteins
A fusion protein that is expressed in a recombinant protein body-like assembly (RPBLA) in host eukaryotic cells and organisms is disclosed. More particularly, a biologically active polypeptide...
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8163499 |
Drug selection for breast cancer therapy using antibody-based arrays
The present invention provides compositions and methods for detecting the activation states of components of signal transduction pathways in tumor cells. Information on the activation states of...
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8153392 |
Method(s) of preventing, arresting, reversing and treatment of atherosclerosis
A method of detecting, diagnosing and prognosticating atherosclerosis by measuring the activities of Δ6 and Δ5 desaturases is described. It is suggested that enhancing the activities of Δ6 and Δ5...
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8148100 |
Mina53 assays
The present invention comprises a method for assaying oxygenase activity the method comprising monitoring oxygenase activity of Mina53.
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8137927 |
Molded protein material in form of pellet for sensor
A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix...
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8128803 |
Method and system for determining the concentration of an analyte/enzyme complex or of an analyte/enzyme conjugate, especially for the electrochemical detection of the analyte, and corresponding measuring device
A method follow the change in concentration of a redox-active substance, whereby suitable potentials for a reduction process or an oxidation process are applied to the working electrode of a...
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8114606 |
ARL-1 specific antibodies
This invention provides antibodies immunologically specific for human ARL-1 (also referred to AKR1B10), a species of the aldo-keto reductase superfamily of proteins. The invention also provides...
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8114650 |
Nucleic acid and its use effecting ciliate tetrahymena bifunctional dihydrofolate reductase-thymidylate synthase deficiency
A method for producing a ciliate cell with reduced or essentially no dihydrofolate reductase (DHFS) activity or reduced or essentially no thymidylate synthase (TS) activity or both reduced or...
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8105800 |
Composition for assaying glycated proteins
Composition for accurately assaying a glycated protein by: 1) avoiding effects of globulin and ascorbic acid components, 2) siabilizing proteases and at least enzymes acting on glycated amino...
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8093029 |
Bilirubin oxidase mutant having thermal stability
A heat-resistant bilirubin oxidase mutant is disclosed. The bilirubin oxidase mutant is obtained by deletion, replacement, addition or insertion of at least one amino acid residue of a wild type...
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8080385 |
Crosslinked adduct of polyaniline and polymer acid containing redox enzyme for electrochemical sensor
A polymer matrix that may coated on an electrode is created by co-crosslinking (1) an adduct of a polyaniline formed by templated oxidative polymerization on a polymer acid; (2) a water-soluble...
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8080404 |
Enzymatic decontamination
Compositions and methods for enzymatic decontamination by inactivation of Hazardous agents are provided. Hazardous agents of microbial and chemical origin can be neutralized by H2O2. The methods...
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8076114 |
Cytochrome P450 oxygenases
Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent...
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8057659 |
Detection of analytes in a dual-mediator electrochemical test strip
Determination of an analyte such as glucose in a sample is done making use of a plurality of electron transfer reagents, for example two electron transfer reagents, that work together to transfer...
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8053018 |
Techniques to improve polyurethane membranes for implantable glucose sensors
The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the...
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8050873 |
Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
The crystal structure of ligand-bound EGLN1 catalytic domain of prolyl hydroxylase is disclosed. These coordinates are useful in computer aided drug design for identifying compounds that regulate...
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8030018 |
Method for measuring enzymatic activity in vivo by use of laser
A method of measuring an enzymatic activity, includes measuring the quantity of a substrate metabolite produced upon metabolism of a substrate by an enzyme, through detecting a radiant wave...
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8026089 |
Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids
The present invention relates to mutant Δ8 desaturase genes, which have the ability to convert eicosadienoic acid [20:2 ω-6, EDA] to dihomo-γ-linolenic acid [20:3, DGLA] and/or eicosatrienoic ac...
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8026085 |
Methods and systems for selective fluorination of organic molecules
A method and system for selectively fluorinating organic molecules on a target site wherein the target site is activated and then fluorinated are shown together with a method and system for...
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8026078 |
Method of quantifying glycosylated protein using redox reaction and quantification kit
The present invention provides a method of measuring a glycated protein in a sample using a redox reaction, by which the glycated protein can be measured accurately with high sensitivity. In order...
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8021855 |
Method of decomposing protein with sulfonic acid compound
A method of assaying a glycated protein in a sample with the use of redox reaction, in which highly reliable measurement can be obtained. A sample containing a glycated protein is treated with...
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8017352 |
Seafood spoilage indicator
An enzyme based nondestructive sensor for the qualitative detection of spoilage in seafood is provided wherein the sensor does not alter the physical composition of the seafood specimen. The sensor...
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8017314 |
Immersion sensor for measuring the concentration of an analyte with the help of an oxidase
The invention relates to measuring the concentration of analytes with the aid of an oxidase in an immersion sensor situated in a fluid or in a matrix containing fluid. Oxygen diffuses into the...
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8012761 |
Detection of formaldehyde in urine samples
A method for rapidly detecting the presence of formaldehyde in a urine sample (e.g., urine or a urinary material associated therewith, such as headspace gas located associated with urine) is...
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8012725 |
Method for the production of optically-active alcohols
The present invention relates to enzymic processes for preparing S-butan-2-ol; and to enzymes for carrying out said processes; to nucleic acid sequences coding for said enzymes, to expression...
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8012729 |
Mutant glucose dehydrogenase
Substrate specificity for glucose of a glucose dehydrogenase having the amino acid sequence of SEQ ID NO: 13 is improved by substituting another amino acid residue for the amino acid residue at...
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8003358 |
Two-step enzyme method for preparing 7-aminocephalosporanic acid
The present invention discloses a two-step enzyme method for preparing 7-aminocephalosporanic acid from cephalosporin C, wherein D-amino acid oxidase used is purified D-amino acid oxidase mutant of...
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8003343 |
Method for determining diamine oxidase
Disclosed is a method for determining histaminase (DAO; EC 1.4.3.6) activity in a sample. Said method comprises the following steps: an aqueous solution is supplied which contains a predefined...
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7998698 |
Method for predicting susceptibility to radiation pneumonitis
Provided is a method for determining whether an individual is likely to be susceptible to radiation pneumonitis from radiation therapy and for developing a treatment based on the determination of...
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7993894 |
Nematode fatty acid desaturase-like sequences
Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and...
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7981634 |
Method for positively detecting toxic material
Disclosed herein is a method of positively detecting toxic materials within a sample, the method including contacting sub-mitochondrial particles with an electron donor. The electron donor is...
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7977078 |
Ketoreductase polypeptides for the production of (R)-3-hydroxythiolane
The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides...
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7968314 |
Methods employing a multi-time point IC50 assay for selecting time points for time dependent inhibition assays of a test compound
The invention provides a method of evaluating metabolism-based drug interactions. The method involves selecting time points for the determination of the inactivation rate constant of a...
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7968290 |
Method of detecting gene
A method of detecting a gene including immobilizing a primer for DNA elongation onto an insoluble carrier having on the surface thereof a polymer substance containing a first unit having a...
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7964372 |
Size self-limiting compositions and test devices for measuring analytes in biological fluids
A test strip or electrochemical sensor for measuring the amount of an analyte in a biological fluid, e.g. the glucose content of whole blood, includes a size self-limiting reagent formulation...
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7960605 |
Methods for testing for caloric restriction (CR) mimetics
Methods for treating neurological diseases and for testing Caloric Restriction (CR) mimetics or CR mimetic candidates. In one exemplary method, a CR mimetic candidate is administered to a...
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7960155 |
Cytochrome p450 monooxygenases and their use for oxidizing organic compounds
The invention relates to novel cytochrome P450 monooxygenases comprising a modified substrate specificity, to nucleotide sequences which code therefor, to expression constructs and vectors...
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7951550 |
Luminogenic and fluorogenic compounds and methods to detect molecules or conditions
A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided.
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7951554 |
Kit for enzymatic deposition of a metal
The present invention provides compositions, kits, assemblies of articles and methodology for carrying out processes that permit biological enzymes to act directly on metals and metal particles. In...
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7943338 |
Autoimmune conditions and NADPH oxidase defects
The invention relates to methods and materials involved in diagnosing and treating autoimmune conditions. In particular, the invention relates to methods and materials involved in diagnosing...
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7943385 |
Methods for assaying percentage of glycated hemoglobin
The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in...
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7943337 |
Method for screening a protease
There is provided a method for specifically determining a glycated β-chain N-terminal of glycated hemoglobin using enzymes without a separation operation, and a determination reagent kit therefor. ...
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7939290 |
Method for analyzing the activity of lipoxygenase using a water-soluble substrate
The present invention discloses methods for analyzing the activity of lipoxygenase by using polyunsaturated lysophosphatidylcholine as a water-soluble substrate. In these methods, lipoxygenase...
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7927588 |
Skin dressings containing oxidoreductase enzyme
A skin dressing comprises a first dressing component (16) carrying oxidoreductase enzyme in dried condition; and a second dressing component (18) carrying a source of water, such that when the...
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7927849 |
Laccase enzyme and use thereof
The present invention relates to a novel laccase enzyme obtainable from the strains of genus Thielavia. The invention relates also to the nucleic acid sequence encoding the enzyme, a recombinant...
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7922483 |
Method of using a polynucleotide encoding 2.5-diketo-D-gluconic acid reductase
Described herein are novel nucleic acids, proteins and methods that can be used to provide new catalysts with desirable traits for industrial processes. In particular, novel reductases isolated...
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7914663 |
Structure, porous body, sensor, process of structure and detecting method for specimen
A mesoporous silica structure having a plurality of mesopores includes a dendritic framework having mesopores. 90% or more of the mesopores observable in a 500 nm×500 nm area pass through the ...
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7915021 |
Mutant firefly luciferase
This invention relates to: the development of a mutant firefly luciferase in order to use dATP as a DNA polymerase substrate upon pyrosequencing, such luciferase being subjected to substrate...
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