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7608416 |
Targeting mPGES-1 as a treatment for inflammation which avoids cardiovascular risk
The present invention relates to methods for the treatment of inflammation and pain without increasing cardiovascular risk by administration of an inhibitor of mPGES-1. The invention further is...
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7598063 |
Process for producing ethanol by using recombinant coryneform bacterium
The present invention provides a process for highly efficiently producing ethanol at a high productivity consisting of using a coryneform bacterium which has been transformed by a DNA containing a...
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7598054 |
Rapid peptidoglycan-based assay for detection of bacterial contamination of platelets
The invention relates to a colorimetric method for detecting bacterial or fungal pathogens by detecting peptidoglycan or (1-3)-β-D-glucan in a sample.
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7592153 |
Method of reducing metal ions to elemental metal in the vicinity of an oxido-reductase enzyme
Disclosed are methods and materials for utilizing enzymes to act on metal ions in solution so that the ions are reduced to metal. Additionally disclosed is how to use enzymes to accumulate metal...
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7588911 |
Assays for detecting inhibitors of binding between COX-2 and PDZ proteins
The invention provides an assay for determining whether a test agent is a COX modulator. In general terms, the assay includes: determining whether a test agent modulates binding of a PDZ-containing...
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7588910 |
Hemoglobin A1c determination method, enzyme to be used therefor, and production method thereof
There is provided a method for specifically determining a glycated β-chain N-terminal of glycated hemoglobin using enzymes without a separation operation, and a determination reagent kit therefor....
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7575866 |
Ligand/binding partner bio-labeling systems
The present invention relates to methods and compositions which utilize binding relationships between detector molecules and their ligands for labeling molecules of interest in vivo. A “target”...
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7572616 |
Alternative oxidase and uses thereof
The invention relates to a method for combating disorders affecting the mitochondrial oxidative phosphorylation system by allotopic expression of the cyanide-insensitive alternative oxidase (AOX)...
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7550273 |
Colorimetric method and reagent used for the same
The present invention provides a calorimetric method that can perform a simple and reliable analysis in a short time. The method includes transferring an electron from an analyte to a coloring...
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7544480 |
Assays for modulators of asparaginyl hydroxylase
A method of identifying an agent which modulates hydroxylation of hypoxia inducible factor (HIF), comprises contacting a HIF asparagine hydroxylase and a test substance in the presence of a...
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7537919 |
Cytochrome P450RAI-2 and related proteins
The present invention provides a novel all-trans-RA inducible all-trans-RA metabolizing cytochrome P450, P450RAI-2, that is predominantly expressed in the brain, cerebellum in particular. Human...
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7534583 |
Analyte measurement
A method for determining the concentration of an analyte in a sample is disclosed which comprises contacting the sample with a micro electrode which comprises an enzyme capable of reacting with...
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7531335 |
Modified cytochrome p450 monooxygenases
The present invention relates to modified cytochrome P450 monooxygenases with an altered substrate profile, to nucleic acid sequences coding therefor, to expression constructs and vectors, to...
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7524872 |
Method and composition for treating cancer using cellular organelle crystallizing agents
This invention provides a method for treating cancer in mammals through cellular-organelle-crystallization-induced-death (herein defined as “Cocid”), a method for treating cancer using cellular...
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7524666 |
Reductase gene and use thereof
Provided are genes coding a protein having an ability of asymmetrically reducing a 2-oxo-4-phenylbutyrate to produce a (R)-2-hydroxy-4-phenylbutyrate advantageously from the industrial standpoint,...
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7524664 |
Regio- and enantioselective alkane hydroxylation with modified cytochrome P450
Cytochrome P450 BM-3 from Bacillus megaterium was engineered using a combination of directed evolution and site-directed mutagenesis to hydroxylate linear alkanes regio- and enantioselectively...
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7521200 |
Method for non-invasive rinse diagnosis and monitoring of periodontal diseases using colourimetric reagents
An assay test kit is used in a mouth rinse sample collection procedure involving collecting a mouth rinse sample from a patient. A neutrophil reactant diagnostic reagent is delivered to the rinse...
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7520970 |
Immobilization support, process for producing the same, electrode, process for producing the same, electrode reaction utilizing apparatus and process for producing the same
An immobilization carrier containing an electron acceptor compound is used in addition to glutaraldehyde and poly-L-lysine to immobilize an enzyme and an electron acceptor compound simultaneously...
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7514247 |
Systems and processes for cellulosic ethanol production
A cellulosic ethanol production process. An implementation of a process for producing fuel ethanol and biodiesel from cellulose may include: providing a raw cellulose stream by mixing a waste...
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7511142 |
Mediator-modified redox biomolecules for use in electrochemical determination of analyte
Compositions and methods for electrochemical detection of an analyte comprising a transition metal compound
wherein M is a metallic element that can form a coordinate bond to nitrogen; R and...
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7510851 |
Compositions and methods for diagnosing and treating diabetes, insulin resistance and dyslipidemia
The present invention provides compositions and methods for diagnosing and treating diabetes, insulin resistance and dyslipidemia. In particular, the invention provides methods of identifying...
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7507553 |
Galleria mellonella derived composition for detecting peptidoglycan, a method for use thereof, and a diagnostic kit containing the same
The present invention relates to a composition for selectively detecting an extremely small amount of peptidoglycan in sample, a preparation method of the composition, and a detection kit for...
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7497996 |
Liquid delivery apparatus and liquid delivery method
A liquid delivery apparatus 1 has a rotary substrate 2 . The substrate 2 formed with a fluid passage 8 A for communicating a supply chamber 6 A and target chamber 7 A. An inlet end portion ...
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7495106 |
O-aminophenol-containing AB-monomer for heterocyclic rigid-rod polymers
A novel o-aminophenol-carboxylic AB-monomer with the following chemical structure:
for synthesizing new rigid-rod polybenzobisazoles was prepared from the corresponding...
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7485705 |
Water-soluble tetrazolium compounds
The purpose of the present invention is to provide a water-soluble tetrazolium compound that will form a water-soluble formazan exhibiting long-wavelength absorption and is stable in aqueous...
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7485436 |
Method of stabilizing oxidation color former
A method of stabilizing an oxidation color former in a solution is provided. N-(carboxymethylaminocarbonyl)-4,4′-bis(dimethylamino) diphenylamine sodium salt as an oxidation color former is...
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7482141 |
Methods and compositions for vitamin K epoxide reductase
The present invention provides a method of identifying a human subject having increased or decreased sensitivity to warfarin, comprising detecting in the subject the presence of a single nucleotide...
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7479384 |
Nematode MDH-like sequences
Disclosed are two nucleic acid molecules from M. incognita encoding malate dehydrogenase-like (MDH-like) polypeptides. The MDH-like polypeptide sequences are also provided, as are vectors, host...
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7479382 |
Nematode fatty acid desaturase-like sequences
Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and...
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7476524 |
Canine COX-2 nucleic acid molecules
The present invention relates to canine COX-1 and COX-2 proteins; to canine COX-1 and COX-2 nucleic acid molecules, including those that encode such COX-1 and COX-2 proteins, respectively; to...
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7465567 |
Peroxide-driven cytochrome P450 oxygenase variants
The invention relates to novel variants of cytochrome P450 oxygenases. These variants have an improved ability to use peroxide as an oxygen donor as compared to the corresponding wild-type enzyme....
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7449305 |
Method of pre-treating sample for measuring saccharified amine and method of measuring saccharified amine
The present invention provides a method of pretreating a sample containing a glycated amine as an analyte, thereby enabling highly reliable measurement of a glycated amine. A glycated amino acid in...
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7445909 |
Method for detecting reactive metabolites using a combination of glutathione and a stable isotopic derivative of glutathione and mass spectroscopy-based pattern recognition
The present invention is directed to a method for detecting reactive metabolites using a combination of glutathione and a stable isotopic derivative of glutathione and mass spectroscopy. More...
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7445908 |
Detection of oxidizing agents in urine
A method of detecting oxidants in a biological sample comprising: adding a source of ferrous ions to said sample, whereby the presence of oxidants in said sample oxidize at least a portion of said...
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7435574 |
NADH oxidase from Lactobacillus
The present invention is directed to a new NADH oxidase from Lactobacillus , nucleic acids encoding the NADH oxidase, methods of producing the NADH oxidase, as well as there use in producing...
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7435570 |
Thermostable peroxide-driven cytochrome P450 oxygenase variants and methods of use
The invention relates to novel variants of cytochrome P450 oxygenases. These variants have at least one mutation improving their ability to use peroxide as an oxygen donor as compared to the...
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7435569 |
Method of forming a molded protein matrix for use in a sensor
A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix...
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7435559 |
Methods and compositions employing a novel stearoyl-CoA desaturase-hSCD5
A cDNA encoding a novel human stearoy-CoA desaturase (dubbed “hSCD5”) as well as vectors and cells comprising such polynucleotide are disclosed. Also described are assay methods for determining...
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7435558 |
Ascertaining the patient related risk of caries
The invention relates to a method for the determination of the patient-related risk of caries by determination of lactic acid and/or lactate in saliva and to a method for the location-specific...
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7432096 |
Glucose dehydrogenase and production thereof
The invention relates to novel PQQ-dependent soluble glucose dehydrogenases (sPQQGDH) from Acinetobacter and to a process for their preparation by overexpression in suitable microbial expression...
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7432072 |
Method of preventing wrong color formation of n-(carboxymethylaminocarbony)-4,4′-bis(dimethylamino) diphenylamine sodium, reagent solution for the method, and measurement method employing the method
The present invention provides a method of preventing erroneous color development of N-(carboxymethylaminocarbonyl)-4,4′-bis(dimethylamino)diph
enylamine sodium salt as a color-developing...
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7425433 |
Carboxylic acid reductase polypeptide, nucleotide sequence encoding same and methods of use
The invention provides the nucleotide sequence and amino acid sequence for the enzyme carboxylic acid reductase isolated from bacteria. Expression cassettes, vectors, transformed cells, and...
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7419813 |
Fructosyl peptide oxidase
The present invention has an object of providing a novel fructosyl peptide oxidase having superior physicochemical properties such as stability that is useful as an enzyme for clinical diagnosis,...
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7416872 |
Taxoid oxygenases and their uses
Oxygenase enzymes and the use of such enzymes to produce paclitaxel (Taxol™), related taxoids, as well as intermediates in the Taxol biosynthetic pathway are disclosed. Also disclosed are nucleic...
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7410755 |
ADP detection using an enzyme-coupled reaction
Methods and compositions are provided for determining ADP in the presence of ATP. These comprise including among the assay reagents at least one of the correcting components creatine phosphokinase...
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7407774 |
Method for reducing influence of hemoglobin with albumin in an assay
A method for quantitatively determining a specific component in a biological specimen, which includes reacting a biological specimen, in the presence of an electron acceptor, with an enzyme which...
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7407743 |
Kit and method of screening wilson's disease
The present invention relates to a method for measuring a ceruloplasmin concentration, and more particularly, to a method for measuring a ceruloplasmin in a blood spot based on a standard...
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7402417 |
P450 oxygenases and methods of use
This disclosure provides the nucleic acid and protein sequences of novel P450 oxygenases that utilize, at least, taxoid substrates, including taxadiene isomers. The disclosed oxygenases, such as a...
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7402408 |
Assay for inhibitors of ispH
Assay for testing a sample for the presence or absence of inhibition of the enzymatic conversion of 1-hydroxy-2-methyl-(E)-butenyl 4-diphosphate into isopentenyl diphosphate and/or dimethylallyl...
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7396659 |
Inhibitors of nitric oxide synthase to treat type 1 diabetes
A method for treating type 1 diabetes in a human in need of such treatment, comprising administering to the human a biologically effective amount of at least one inhibitor of inducible nitric oxide...
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