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5780256 |
Method and composition for quantitative determination of ammonia, α-amino acid, or α-keto acid
The present invention is directed to a method for the quantitative determination of ammonia, an α-amino acid and an α-keto acid corresponding to the α-amino acid, or a chemical substance...
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5776701 |
Materials and methods for detecting oxalate
The subject invention pertains to a novel assay device for detecting oxalate in a sample. The assay device comprises enzyme and dye compositions immobilized on a solid carrier matrix. The subject...
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5773270 |
Three-layered membrane for use in an electrochemical sensor system
A system for electrochemical measurement of glucose concentration in an undiluted test sample, e.g. blood is provided containing a sensor including a three-layered contiguous membrane. The membrane...
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5770391 |
Reagents and methods for use in bioluminescence
The subject invention pertains to a combination of enzyme activities comprising an ATP-degrading enzyme and one or more enzymes capable of degrading substances, other than ATP, that are substrates...
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5766873 |
Intracellular glutathione raising agents for therapeutic treatments
The invention is directed to therapeutic methods for treating diseases associated with tumour necrosis factor-alpha (TNF-α) induced cell toxicity and/or complement induced cell toxicity, and...
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5763245 |
Method of controlling insects
3-Hydroxysteroid oxidase in combination with Bacillus thuringiensis CryIA(b) or CryIA(c) crystal proteins or polypeptides controls insects, particularly lepidopterans. The combination when applied...
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5759796 |
Method for the determination of lactic acid in organic materials of alimentary interest and biosensor for putting this method into effect
A method is described for the determination of lactic acid in organic materials of alimentary interest that involves reacting, in a buffered aqueous medium, a sample of the said materials, or a...
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5753454 |
Sequencing of oligosaccharides: the reagent array-electrochemical detection method
Oligosaccharides are structurally characterized utilizing enzymatic digestion with an array of highly specific exoglycosidases followed by electrochemical detection and measurement of the molar...
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5753453 |
Stable single liquid reagent for the determination of carbon dioxide in serum
A stable single reagent for the determination of carbon dioxide in serum is provided as an aqueous solution of diagnostically amounts and NADH and/or NADPH, and a stabilizing system therefore...
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5750698 |
Aryl N-alkylacridancarboxylate derivatives useful for chemiluminescent detection
Acridans which are reactable with a peroxidase and peroxide. The acridans are characterized by having an aromatic leaving group ArO which is a di- or polyhalosubstituted phenoxy group. The...
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5747277 |
Process for detecting microorganisms
Microorganisms in a sample can be detected easily and rapidly with high precision by a process which comprises filtering the sample through a filter, washing the filter, reacting the residue on the...
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5741660 |
Method of measuring enzyme reaction by Raman scattering
As to reaction solutions in which the amount of each potassium ferricyanate, glucose oxidase and glucose substrate are set at a constant value while glucose concentrations are varied, intensity...
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5741659 |
Rapid microbial protease assay
An assay for detecting microbial protease activity in clinical and laboray samples is described which comprises gathering a sample suspected of containing certain microorganisms having the desired...
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5741687 |
Sorbitol oxidase reagent from xanthomonas
The sorbitol oxidase of the present invention catalyzes the reaction in which D-sorbitol is oxidized D-glucose and hydrogen peroxide.
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5736352 |
Method and apparatus for determination of the activity of cholesterol oxidase and method and apparatus for evaluation of the toxicity of chemical substances
A method for determination of activity of a cholesterol oxidase comprises the following steps. A monomolecule film comprising a sterol and a phospholipid is formed on a surface of a cholesterol...
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5731158 |
Catalyzed reporter deposition
The present invention concerns a method to catalyze reporter deposition to improve detection or quantitation of an analyte in a sample by amplifying the detector signal which comprises reacting an...
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5728684 |
Determination of prodrugs metabolizable by the liver and therapeutic use thereof
A method of ascertaining if a prodrug is useful for treating a disease is disclosed. The prodrug is acceptable if it is metabolized in liver cells by aldehyde oxidase to produce an active drug or...
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5726041 |
Method for detecting a receptor-ligand complex using a cytochrome P450 reporter gene
An improved method for measuring the activity of a promoter sequence in a mammalian cell using a reporter gene is provided. The improvement involves using a reporter cassette containing a DNA...
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5723284 |
Control solution and method for testing the performance of an electrochemical device for determining the concentration of an analyte in blood
The present invention relates to a control solution for and a method of testing the performance of an electrochemical sensing device for determining the concentration of an analyte in a blood...
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5710011 |
Mediators to oxidoreductase enzymes
Half-sandwich complexes of transition metals having a single π-ligand with delocalised π bonding are of use in mediating electron transfer between an electrode and a redox protein, for example an...
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5707820 |
Reagent and assay methods including a phenazine-containing indicator
A new reagent and methods for measuring the concentration of (or detecting the presence of) an analyte in a sample. The reagent includes a phenazine-containing compound and an enzyme. The...
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5705356 |
Reagent for invitro diagnostic determination of bicarbonate
The invention provides a reagent for enzymatic determination of serum bicarbonate levels in a patient wherein the degree of oxidation of a coenzyme is measured and said reagent is stabilized...
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5700654 |
Method and compositions to assess oxidative stress in vivo
This invention relates to a method to assess oxidative stress in vivo by quantification of prostaglandin F 2 -like compounds and their metabolites produced by a noncyclooxygenase free radical...
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5695947 |
Amperometric cholesterol biosensor
A sensor for the amperometric assay of cholesterol is provided which comprises a sensing electrode containing a first redox mediator and a reference electrode in simultaneous contact with a reagent...
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5686260 |
Method and composition for the enzymic determination of aspartame
The invention relates to a method and a composition for the enzymic determination of aspartame in aqueous solutions. The method is carried out such that the sample solution is incubated essentially...
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5667983 |
Reagents with enhanced performance in clinical diagnostic systems
It has been found that imidazole and related buffers enhance the activity of certain preservatives, for example either (1) a mixture of 5-chloro-2-methyl-4-isothiazolin-3-one and...
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5667984 |
Sequencing of oligosaccharides
A process suitable for use in the sequencing of an oligosaccharide compound includes a first analysis of a primary oligosaccharide compound's monosaccharide composition, selection of sequencing...
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5656422 |
Compositions and methods for detection of 2,4-dichlorophenoxyacetic acid and related compounds
Methods and compositions are provided for the detection of 2,4-dichlorophenoxyacetic acid (2,4-D) and other phenoxy ether compounds. The phenoxy ether bond of 2,4-D is enzymatically cleaved by...
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5654164 |
Method and device for reducing oxygen with a reduced oxidase with color formation
A method and device for removing oxygen using a reduced oxidase enzyme and for providing a colorimetrically detectable signal of the presence of the oxygen is disclosed. A reduced laccase or...
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5654152 |
Method of measuring enzyme activity by using a column having an immobilized substrate
Enzyme activity is measured promptly with a high accuracy by introducing an enzyme, the activity of which is to be measured, into a column comprising a hollow tube packed with a filler comprising a...
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5643853 |
Thiol activation of cytotoxic and auxin-herbicidal agents and root formation stimulation
Thiol compounds are employed in conjunction with compounds which modulate self proliferation, both as to plants and mammals. The thiol compounds find effect in enhancing the effectiveness of auxin...
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5641639 |
Binding assay device
A device for performing an enzyme-labelled binding assay comprises an absorbent material and a developing solution containing a substrate for said enzyme, wherein the absorbent material is provided...
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5633143 |
Method for the quantitative determination of D-3-hydroxybutyric acid and acetoacetic acid, and analytical reagent therefor
Disclosed is a method for the quantitative determination of D-3-hydroxybutyric acid and acetoacetic acid, which comprises reacting a biological sample containing D-3-hydroxybutyric acid and...
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5629168 |
Chemiluminescent enhancers
Method of increasing the light output and/or signal:background ratio of light output from a chemiluminescent reaction of a dihydrophthalazinedione, a peroxidase enzyme catalyst and an oxidant, by...
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5624811 |
Bilirubin oxidase from alfalfa and use of the enzyme
Enzyme specific for bilirubin which has a phenol oxidase activity of less than 0.5% and an activity for biliverdin of less than 10%, a broad pH optimum as well as a good thermostability. The enzyme...
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5618686 |
Method of measuring the total ketone body and a sample reagent
A method of measuring the total ketone body in a sample comprising converting acetoacetic acid in the sample to 3-hydroxybutyric acid in advance and subsequently converting the whole...
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5614374 |
Glycerol dehydrogenase, process for its production and its use
Pyrroloquinoline quinone-dependent glycerol dehydrogenase is provided which requires no surfactant for its solubilization and stabilization. The glycerol dehydrogenase has the following properties:...
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5614375 |
Method and test kit for the rapid detection of biotoxic contaminants
The invention provides a method for the rapid detection of biotoxic contaants in a test material comprising combining a sample of the test material with activated spores essentially devoid of...
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5612178 |
Method of quantitative enzyme determination
Methods and kits are provided for the quantitative determination of the presence of an enzyme analyte in a sample by determination of the rate of analyte catalyzed reaction on a chromatographic...
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5612208 |
Ascorbate oxidase, gene encoding the same, process for producing the same, and reagent composition using the same
The present invention provides a novel ascorbate oxidase (ASOD) which catalyzes oxidation reaction of L-ascorbic acid with molecular oxygen to form L-dehydroascorbic acid and hydrogen peroxide, a...
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5610026 |
Agent for the determination of peroxidase activity, a process for its preparation and its use
An agent for the detection of peroxidase or of pseudoperoxidase activity, and its preparation and its use are described. The agent contains a tetraalkylbenzidine, a peroxide and buffer substances....
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5610025 |
Inhibition of interfering endogenous enzyme activity in assays of biological fluids
The invention describes biological assays in which hydrogen peroxide is used as an oxidizing agent, or wherein hydrogen peroxide is used to oxidize a dye or other intermediate to generate a...
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5605810 |
NADH oxidase assay for neoplasia determination
NADH oxidase is shown to be a target for a variety of uses in diagnosis and therapy. Particularly, the NADH oxidase associated with neoplastic cells is immunologically and biologically different...
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5605795 |
Assays using chemiluminescent, enzymatically cleavable substituted 1,2-dioxetanes and kits therefor
Dioxetane compounds reactable with an enzyme to release optically detectable eneregy are disclosed. These compounds have the formula: ##STR1## wherein T is a cycloalkyl group or a fused...
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5601981 |
Methods for determining and agents for modulating cellular redox potential and genotoxic states
Methods for determining the genotoxic or carcinogenic status of a subject by analyzing the cellular redox potential of a test specimen where an increased risk of, or presence of, genotoxic injury...
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5599661 |
Reagent for measuring direct bilirubin
A reagent system and method are described for optically measuring direct bilirubin by the reaction of a bilirubin oxidase, oxidizing agent or diazonium salt, with the direct bilirubin, wherein a...
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5597704 |
Bioconversion of cephalosporin C to glutaryl-7-aminocephalosporanic acid
A method of converting cephalosporin C to glutaryl-7-aminocephalosporanic acid. The method including obtaining a cell preparation from a microorganism which produces D-amino acid oxidase, the...
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5597703 |
Methods for determing cholesterol oxidase activity in an aqueous test sample, determining whether a test compound is capable of inhibiting cholesterol oxidase activity and determining the degree of cholesterol oxidase inhibitory activity
The invention provides a method for measuring the activity of cholesterol oxidase. First, a monolayer including sterol, a phospholipid and fluorescent dye labeled phospholipid is formed on a...
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5591576 |
Sterol Δ14 reductase screen
A binary assay identifies agents that inhibit sterol Δ14 reductase involved in ergosterol biosynthesis. In the primary screen, sterol Δ14 reductase inhibition by a test sample is assayed by...
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5589326 |
Osmium-containing redox mediator
A new group of Os(II) and Os(III) compounds useful as redox mediators in electrochemical biosensors. These compounds have 1) low oxidation potential, 2) fast reaction kinetics between the...
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