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5916759 |
Cholesterol oxidase from Brevibacterium sterolicum
The invention concerns a cholesterol oxidase, a process for the production of a recombinant cholesterol oxidase, a DNA sequence suitable for this process which causes a cytoplasmatic expression of...
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5914235 |
Potentiation of .sup.3 H! 2-(2-benzofuranyl)-2-imidazoline (BFI) binding sites in human tissue by tranylcypromine (TCP)
The present invention relates to a process for discovering compounds that modulate novel I 2 binding sites (e.g. BFI binding sites) in human tissue, as well as a process for identifying TCP-like...
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5914245 |
Solid phase enzyme kinetics screening in microcolonies
A MicroColonyImager instrument and solid phase methods to screen cells expressing mutagenized enzymes for enhanced activity. The MicroColonyImager instrument and methods permit high throughput...
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5906921 |
Biosensor and method for quantitative measurement of a substrate using the same
A biosensor is disclosed for application to a method for quantitative measurement of a substrate comprising a first step of causing a substrate contained in a sample to react with an oxidoreductase...
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5895749 |
Male fertility and contraception home test kits
Kits and assays, incorporating antibodies specific for glutathione peroxidase, for determining the fertilizing ability of a male at home or in a clinical laboratory are disclosed.
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5891622 |
Assessment of oxidative stress in vivo
A method to assess oxidative stress in vivo by measuring the amount of free, esterified and glucuronidated forms of isoprostanes (8EPGF2) in a biological sample which contains the isoprostanes is...
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5888755 |
Method of determining the amount of cholesterol in a high-density lipoprotein
Provided is a method of determining the amount of cholesterol in high-density lipoprotein (HDL), which comprises reacting an HDL-containing sample with cholesterol esterase and cholesterol oxidase...
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RE36175 |
Methods for detecting acetohydroxyacid synthase inhibitors
The invention provides a method for determining whether a compound inhibits acetohydroxyacid synthase. The invention further provides a method for determining whether a plant is resistant to an...
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5885788 |
Method for measuring an amount of LDL-Cholesterol
The present invention is to provide a method for measuring an amount of cholesterol in low density lipoproteins (LDL-cholesterol) in a sample specifically at high accuracy and a reagent used in...
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5882878 |
INHA crystals and three dimensional structure
This invention relates to InhA enzyme crystals and to the use of said crystals to determine the three dimensional structure of InhA enzyme. This invention is further directed to a method of...
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5879888 |
Light emitting method of acridinium derivative and method of detecting substance to be examined using same
A light emitting method of an acridinium ester, comprising reacting said acridinium ester and a superoxide anion, and a method of detecting a substance to be examined, comprising detecting a light...
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5876952 |
Non-invasive glucose biosensor: determination of glucose in urine
An amperometric glucose biosensor having high sensitivity and accuracy over a wide range of glucose concentrations and a method for the rapid detection of glucose in urine are provided. The...
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5871948 |
Alkaline reagent solution for eliminating ammonia in an assay
The invention relates to an ammonia elimination reagent for use in an enzymatic assay of a biological substance which produces ammonia as the reaction product. The reagent is an alkaline solution...
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5869276 |
Method for determination of direct bilirubin and reagent therefor
There is provided a method for determination of direct bilirubin which comprises the steps of contacting a bilirubin oxidase with a sample suspected of containing bilirubin; and, measuring direct...
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5866352 |
Kit for fructosamine determination
A kit of two liquid reagent components for determining the fructosamine content of a blood sample measured by color change, and methods of determining fructosamine content of a blood sample using...
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5866353 |
Electro chemical biosensor containing diazacyanine mediator for co-enzyme regeneration
A variety of diazacyanine mediators that are soluble in aqueous media and which do not inhibit enzymatic activity are provided for use on the surface of a working electrode of a electrochemical...
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5861268 |
Method for induction of tumor cell apoptosis with chemical inhibitors targeted to 12-lipoxygenase
A method and test kit for determining tumor cell apoptosis by inhibition of 12-lipoxygenase is described. A method for selectively inducing tumor cell apoptosis by inhibiting 12-lipoxygenase is...
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5861265 |
Binding assay method using a signal preventing reagent
A device for performing an enzyme-labelled binding assay comprises an absorbent material and a developing solution containing a substrate for said enzyme, wherein the absorbent material is provided...
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5858644 |
Analysis of analytes in biological fluids
A method for detecting an analyte in a sample uses both the specificity of an enzymatic reaction and the separation power of capillary electrophoresis. In general, the method comprises: (1)...
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5858691 |
Method and agent for the simultaneous colorimetric and electrochemical measurement of an analyte
The invention concerns a method for the simultaneous colorimetric and electrochemical measurement of an analyte using an oxidizing enzyme and a chromogen A that accepts electrons from the enzyme...
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5858696 |
Method and compositions to assess oxidative stress in vivo
This invention relates to a method to assess oxidative stress in vivo by quantification of prostaglandin F 2 -like compounds and their metabolites produced by a noncyclooxygenase free radical...
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5858695 |
Method of quantitative determination of bilirubin and a reagent therefor
Disclosed are a method for quantitative determination of bilirubin and a reagent for the method, which are useful in clinical examinations. The method comprises subjecting the bilirubin in a sample...
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5856156 |
Microbial cholesterol dehydrogenase, process for its production and use
Oxygen-independent cholesterol-converting enzyme obtainable from Actinomycetes or Basidiomycetes which utilizes artificial electron acceptors as well as a method and reagent for the determination...
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5849474 |
Diagnosis of preeclampsia in mammals
An improved method of diagnosing preeclampsia comprising the steps of a. collecting blood from a pregnant female mammal; and b. detecting in said blood significantly elevated levels of at...
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5846702 |
Reagent including an osmium-containing redox mediator
A new group of Os(II) and Os(III) compounds useful as redox mediators in electrochemical biosensors. These compounds have 1) low oxidation potential, 2) fast reaction kinetics between the...
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5846725 |
Methods for identifying cisplatin resistant tumor cells
Isolated nucleic acids which can confer on a cell at least a 5-fold increase in cisplatin resistance relative to a cisplatin sensitive cell are disclosed. The nucleic acids of the invention can...
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5846744 |
Sensors based on polymer transformation
A sensor format is based on impedance analysis of polymer coatings of electrodes. A detectable signal is produced by the effect of a reactive or catalytic species at or very near the polymer coated...
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5843696 |
Bioassay for toxic substances activated by metabolic enzyme system
A method for bioassaying for metabolic activation of toxicants from a xenobiotic compound by a metabolic enzyme system includes incubating the xenobiotic compound with a metabolic enzyme system...
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5837479 |
Screening assays for inhibitors of mammalian prostaglandin H synthase-2
The invention relates to the gene encoding the mammalian prostaglandin H synthase-2 and its product. More specifically, the invention relates to the diagnosis of aberrant PGHS-2 gene or gene...
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5837454 |
Process for the manufacture of wholly microfabricated biosensors
An efficient method for the microfabrication of electronic devices which have been adapted for the analyses of biologically significant analyte species is described. The techniques of the present...
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5837480 |
Method and compounds for inhibiting lipid biosynthesis of bacteria and plants
This invention relates to InhA enzyme crystals and to methods of growing said crystals. This invention is further directed to the utilization of said crystals to determine the three dimensional...
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5834224 |
Electrochemical sensor containing an enzyme linked to binding molecules bound to a noble metal surface
An electrochemical sensor is provided containing a supporting material having a surface of noble metal such as gold or palladium to which is bound an enzyme such as glucose oxidase via binding...
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5827677 |
Method and device for specifically detecting myoglobin using a non-discriminating peroxidase sensitive assay
A method and device for detecting myoglobin amongst other mammalian peroxidatively active substances like hemoglobin is disclosed. Since the existing peroxidase-sensitive components do not...
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5824491 |
Dry reagent test strip comprising benzidine dye precursor and antipyrine compound
A dry reagent test strip for determining the concentration of an analyte in a liquid sample is described. The test strip has a matrix containing reagent detection chemistry, which includes an...
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5814472 |
Measurement of LDL-cholesterol
Cholesterol in low density lipoproteins can be measured specifically and precisely by optically measuring a reaction product of a living sample with cholesterol oxidase or cholesterol dehydrogenase...
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5811253 |
Use of vanadium bromoperoxidase as a signal-generating enzyme for chemiluminescent systems: test kits and analytical methods
Aqueous compositions, test kits and methods can be used to detect hydrogen peroxide or vanadium bromoperoxidase by generating a chemiluminescent signal in the presence of the analyte. Signal...
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5807696 |
Method for determination of cholesterol in low-density lipoprotein
The present invention relates to a method for the determination of cholesterol in low-density lipoprotein (LDL) in a sample containing LDL, which comprises eliminating cholesterol in high-density...
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5804404 |
Stable substrate-chromogen solutions for enenzyme activity detection
The preparation and use of stable, ready-to-use substrate-chromogen solutions for the detection and quantification of peroxidase or pseudoperoxidase activity are described. The substrate-chromogen...
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5804402 |
Reagent
This invention relates to a reagent for enzymatic determination of an analyte concentration in a patient wherein the degree of oxidation of a coenzyme is measured, characterized in that said...
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5804368 |
Method for screening for prostate cancer by measuring apolipoprotein D levels in body fluid
The invention is directed to a method for screening for possible prostate cancer presence. The method calls for assaying apolipoprotein D ("ApoD") levels in body fluids, such as serum. Assays for...
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5804401 |
Device for detecting oxygen with oxidase
A method and device (10) for removing oxygen using a reduced oxidase enzyme and for providing a calorimetrically detectable signal of the presence of the oxygen. A reduced laccase or ascorbate...
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5804405 |
Bilirubin detection
A method is taught by which a sample can be analyzed for the selective determination of the total concentration of bilirubin (B t ), the concentration of conjugated bilirubin (B c ), the...
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5801008 |
Method of quantitative determination of peroxide, a peroxidation-active substance or a pyrazolopyridopyridazine derivative
Disclosed is a chemiluminescent method of quantitatively determining one of peroxide, a peroxidation-active substance or a pyrazolopyridopyridazine derivative represented by the formula (I):...
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5795729 |
Reductive, energy-transfer fluorogenic probes
An energy transfer fluorescent probe for detecting a reagent is provided which includes a fluorescent reporter molecule and a quencher molecule positioned on the probe relative to the reporter...
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5792621 |
Fiber-optic chemiluminescent biosensors for monitoring aqueous alcohols and other water quality parameters
A "reagentless" chemiluminescent biosensor and method for the determination of hydrogen peroxide, ethanol and D-glucose in water. An aqueous stream is basified by passing it through a solid phase...
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5792618 |
Liquid single-component substrates for detection or assay of horseradish peroxidase
Colorless single component TMB reagents for the detection of HRP and their processes of manufacture including the encapsulation of substrate within a cyclodextrin cavity are described.
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5786166 |
Methods for determining effects of a compound on the activity of bacterial periplasmic oxidoreductase enzymes
A screening method to determine whether a chemical inhibits the function of a class of bacterial periplasmic oxidoreductase enzymes, exemplified by TcpG of Vibrio cholerae, DsbA E. coli, and Por of...
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5783410 |
Bacteria identification method and apparatus
The present invention discloses a bacteria-coding identification method,bacteria biochemical properties identifying papers which detect the biological properties using this method, and apparatus or...
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5783382 |
Method for storing liquid diagnostic reagents
Disclosed is a method for stably storing a liquid diagnostic reagent, comprising air-hermetically keeping the liquid diagnostic reagent in a closed container in the presence of a disoxidant...
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5780257 |
Method and reagent for detecting peroxidase or hydrogen peroxide
Method for detecting peroxidase or hydrogen peroxide with high sensitivity. Both peroxidase and hydrogen peroxide are prepared such that one of them is overabundant to the other. Phenoxy radicals...
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