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6395502 |
Method and means for modulating PGE synthase activity
Isolated PGE synthase, provided from encoding nucleic acid. Methods of production and use. Assays for modulators, especially inhibitors, of PGE synthase activity.
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6391577 |
Rapid electrochemical assay for antibiotic and cytotoxic drug susceptibility in microorganisms
This invention presents rapid methods for evaluating the effects of antimicrobial compounds on microorganisms based upon the microorganism's ability to transport electrons to an external chemical...
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6387647 |
Cytochrome P-450 reductase screen for ergosterol biosynthesis inhibitors
A method for screening for potential fungicides identifies biochemical or chemical agents that inhibit the formation of the fungal sterol ergosterol by inhibiting cytochrome P450 reductase or...
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6383819 |
Method for determining cholesterol and sensor applicable to the same
The present disclosure relates to a method for determining cholesterol in low density lipoprotein comprising the steps of (a) measuring total cholesterol level in a sample containing at least high...
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6383771 |
Enzyme-based assay for determining effects of exogenous and endogenous factors on cellular energy
Disclosed herein is a method for determining the effect of either endogenous and exogenous factors on the energy producing capacity of cells comprising the steps of obtaining a sample of whole...
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6379883 |
Microfabricated aperture-based sensor
A chemical sensor includes an enzyme layer, a diffusion layer and an analyte barrier layer positioned over the diffusion layer. Apertures are formed by microfabrication in the analyte barrier layer...
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6379914 |
Method and apparatus for measuring use of a substrate in a microbially catalyzed reaction
A sample substrate in a microbially catalysed biochemical reaction is measured by incubating the substrate with an excess of a microorganism and an excess of a co-substrate until the substrate is...
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6380380 |
Use of nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucliotide phosphate (NADP) analogs to measure enzyme activities metabolites and substrates
Kits and methods for measuring enzyme activities and metabolites using NAD analogs and NADP analogs are disclosed. The analogs can be used as replacements for NAD and NADP cofactors in analytical...
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6379915 |
Diagnostic compositions and devices utilizing same
A dry chemistry dye indicator composition provides improved shelf life, stable color indication end point and capability for a system at near normal pH. The novel dry chemistry dye indication...
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6376212 |
Polypeptide compounds and nucleotide sequences promoting resistance to eutypa dieback in plants
The subject of the invention is a nucleotide sequence coding for an enzyme with eutypine reductase activity, capable of metabolizing the eutypine synthesized in plants by a fungus of the Eutypa...
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6365363 |
Method of determining skin tissue cholesterol
A method of determining skin tissue cholesterol includes preparing a section of skin surface, applying a dosed amount of an enzyme-containing mixture onto the skin, exposing, evaluating the...
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6361960 |
Method and test kit for measuring concentration of a cleaning agent in a wash liquor
A method of determining the concentration of a surfactant-based neutral cleaner in a wash liquor, a hand-held apparatus, and a test kit for carrying out the method are provided. According to the...
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6361961 |
Gravity responsive NADH oxidase of the plasma membrane
A method and apparatus for sensing gravity using an NADH oxidase of the plasma membrane which has been found to respond to unit gravity and low centrifugal g forces. The oxidation rate of NADH...
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6358754 |
(Bio)chemical reagent solid phases, process for their production and their applications
Novel solid phase reaction supports are disclosed. The solid phase reaction supports include (a) a solid phase carrier having a multiplicity of NH 2 functional groups; (b) a coupling compound...
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6350601 |
Enzyme composition for use as a clinical diagnostic reagent
Disclosed is a stabilized enzyme composition for use in clinical examination, comprising: (a) an enzyme component comprising at least two enzymes selected from the group consisting of alkaline...
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6350577 |
Plasmids originating in ammonia oxidizing bacteria and use of the same
There are provided a plasmid characterized by having the nucleotide sequence of SEQ ID NO: 1, a plasmid characterized by having the nucleotide sequence of SEQ ID NO: 2, a plasmid characterized by...
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6344332 |
Methods for the rapid detection of actively respiring microorganisms
A method for the rapid detection of actively respiring microorganisms comprises the steps of detecting the presence of microorganisms utilizing microbial enzymatic conversion of tetrazolium salts...
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6342364 |
Cholesterol sensor and method of determining cholesterol
The present invention provides a sensor that electrochemically determines cholesterol in low density lipoprotein by only one feed of a sample. The sensor has: an electrode system that is mounted on...
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6340597 |
Electrochemical biosensors and process for their preparation
The present invention concerns new electrochemical biosensors for the determination of analytes concentration in sample solutions or suspensions, based on composite transducers containing an...
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6326160 |
Microprocessors for use in a device for predicting physiological values
The invention relates generally to methods, systems, and devices for measuring the concentration of target analytes present in a biological system using a series of measurements obtained from a...
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6326164 |
Methods for determining deoxyxylulose 5-phosphate synthase activity
The invention is directed to methods and compositions for the determination of deoxyxylulose 5-phosphate synthase (DXPS) activity. The methods and compositions of the invention are amenable to...
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6316214 |
ETM-775 metabolite of ecteinascidin 743
The purification and structure elucidation of several products of the metabolism of Et 743 by human cytochrome CYP3A4 have been accomplished. These compounds are abbreviated herein as "ETM"...
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6312917 |
Method of screening candidate compounds for susceptibility to oxidative metabolism
A method of screening a candidate compound for susceptibility to metabolism by a selected enzyme. The method includes the steps of reacting the candidate compound, an indicator compound precursor...
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6309851 |
Method for producing a recombinant protein
A method to inhibit the function of a class of bacterial periplasmic oxidoreductase enzymes, exemplified by TcpG of Vibrio cholerae, DsbA of E. coli, and Por of Haemophilus influenzae, is...
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6300092 |
Methods of use of a novel lysyl oxidase-related protein
Novel Lor-2 polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length Lor-2 proteins, the invention further provides isolated Lor-2 fusion proteins,...
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6274565 |
Inhibitor of activation of β-glucan recognition protein
The present invention relates to an inhibitor of an activation of β-glucan recognition protein in a body fluid of an insect comprising a sugar compound comprising plural member of sugar residues,...
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6268192 |
Delta 1-pyrroline-5-carboxylate reductase homolog
The invention provides a human delta 1-pyrroline-5-carboxylate reductase homolog (P5CRH) and polynucleotides which identify and encode P5CRH. The invention also provides expression vectors, host...
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6268161 |
Biosensor
A biosensor (10) has a pH-sensitive polymeric hydrogel (30) in a rigid and preferably biocompatible enclosure (20). The hydrogel (30) includes an immobilized oxidoreductase enzyme such as glucose...
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6268166 |
Method of quantitative assay for 1,5-anhydroglucitol
There is provided an enzymatic method of rapid quantitative assay for 1,5-anhydroglucitol which is also applicable to an automated analysis device. The enzymatic method of quantitative assay for...
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6265178 |
Assay for determining oxazolidinone antibiotics having minimum monoamine oxidase inhibitory activity
Anti-microbial oxazolidinone antibiotics are provided having formula I and formula II wherein R 1 is methyl, ethyl, cyclopropyl, or dichloromethyl; R 2 and R 3 are independently hydrogen or...
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6265179 |
Detection of phosphate using coupled enzymatic reactions
Inorganic phosphate may be detected and optionally quantified via the coupling of a phosphate-dependent enzymatic reaction with an enzyme system that generates hydrogen peroxide in the presence of...
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6255063 |
Disease conditions by measuring lysophosphatidic acid
The present invention is an enzymatic method and diagnostic kits for detecting and quantifying the presence of one or more lysophospholids in a sample of bodily fluid taken from a test subject. The...
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6251622 |
Screening methods for presqualene diphosphate analogs
The present invention is directed to presqualene diphosphate (PSDP) analogs having an active region of natural PSDP and a metabolic transformation region resistant to rapid intracellular...
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6248553 |
Enzyme method for detecting lysophospholipids and phospholipids and for detecting and correlating conditions associated with altered levels of lysophospholipids
The present invention is an enzymatic method and diagnostic kits for detecting and quantifying the presence of one or more lysophospholids in a sample of bodily fluid taken from a test subject. The...
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6235495 |
Methods for the quantitation of oxidized glutathione
The present invention is directed to a method for determining the level of oxidized glutathione, or the ratio of reduced glutathione to oxidized glutathione, in a biological sample utilizing the...
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6235491 |
Assay utilizing magnetic particles
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6232060 |
Assay system for anti-stress agents
Methods and compositions are provided for screening compounds for anti-stress activity. A rat hepatoma-derived cell line is employed, which is particularly responsive to mitochondrial function...
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6225078 |
Method for quantitative measurement of a substrate
The invention provides a method for quantitative measurement of a substrate with high accuracy by electrochemically oxidizing an electron mediator which has been reduced by enzyme reaction thereby...
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6210895 |
Ho-1 as a diagnostic and prognostic test for dementing diseases
The invention relates to a method for predicting the onset of, diagnosing, and/or prognosticating dementing diseases. The method comprises determining the concentration of heme oxygenase-1 (HO-1)...
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6210918 |
Non-invasive method for detection, diagnosis or prediction of term or pre-term labor
Methods for diagnosis, detection and prediction of preterm labor by detecting levels of nitric oxide in myometrium using non-invasive non-surgical methods for detection of nitric oxide in blood,...
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6207404 |
Coumarin-based CYP3A fluorescent assay reagents
Novel fluorescent substrates of human cytochrome P450 enzymes are provided. Also provided are methods for their manufacture and use. These substrates are useful in assessing cytochrome P450 enzyme...
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6204001 |
Methods for determining compounds capable of inhibiting the activities of the Ha-Ras oncongene
This invention provides a method for determining whether a compound is capable of suppressing ras functions comprising: (a) contacting an effective amount of the compound with Ha-ras transformed...
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6204039 |
Plant isocitrate dehydrogenase homologs
This invention relates to an isolated nucleic acid fragment encoding an isocitrate dehydrogenase. The invention also relates to the construction of a chimeric gene encoding all or a portion of the...
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6200772 |
Modified polyurethane membrane sensors and analytical methods
Sensor devices, and analytical methods using them, employing a detector protected from direct contact with samples being examined by a membrane made of a polyurethane modified with a non-ionic...
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6200771 |
Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia
A method for identifying compounds useful for the treatment of neoplasia involves acertaining whether such compounds exhibit an ability to inhibit a PDE that is characterized by cGMP specificity,...
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6197534 |
Engineered proteins for analyte sensing
Disclosed are methods and sensors for detecting the presence or concentration of an analyte in a sample, preferably a sugar such as glucose, which preferably utilizes a labeled engineered protein,...
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6194164 |
Method for quantitating cholesterol present in low density lipoproteins
A method for quantifying LDL cholesterol, by which LDL cholesterol is separately quantified simply without requiring complicated centrifuge operation is disclosed. The method for quantifying...
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6194222 |
Methods for monitoring the status of assays and immunoassays
The invention relates in part to the use of independent assay controls (IACs) for the optical communication between an assay device and an instrument in monitoring and performing assays, preferably...
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6183981 |
Diagnostic assay for late-onset Alzheimer's disease
The present invention provides a quantitative assay for early diagnosis of late-onset sporadic AD in living individuals using peripheral tissue biopsy. The assay may also be used for post-mortem...
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6177260 |
Measurement of antioxidant (reducing) power and/or antioxidant concentration
A method for measuring the antioxidant capacity and/or the amount of a specific antioxidant in a sample, which comprises: a) at least two samples (A) and (B) to be assayed in parallel; b)...
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