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4975367 |
Catalytic test composition intended to produce a range of colors
Test compositions, indicators, and test device are provided which are capable of generating different hues at different analyte concentrations. The compositions are capable of generating a yellow...
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4973549 |
Quantitative diagnostic assay employing signal producing agent bound to support and measuring migration distance of detectable signal
Methods and kits are provided for detecting analytes, which can be measured directly or indirectly, by production of an enzymatic product. The enzymatic product reacts with a signal producing...
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4971901 |
Process for preparing enzyme electrodes
An enzyme electrode is prepared by a process wherein an albumin solution containing 0.05 to 0.5% by weight of a multifunctional aldehyde is applied onto the surface of an electroconductive...
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4970145 |
Immobilized enzyme electrodes
Enzyme electrodes are disclosed which are capable of responding amperometrically to the catalytic activity of the enzyme in the presence of its respective substrate and comprising the enzyme...
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4970152 |
Reagents for determining peptidoglycan and β-1,3-glucan
A reagent comprising a fraction obtained from plasma of an insect such as silkworm larvae and capable of reacting specifically with β-1,3-glucan or peptidoglycan can be used for determining...
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4965194 |
Pyruvate oxidase and an analytical method using the same
A pyruvate oxidase with excellent thermal stability, which is stable at pH 7.0 for 10 minutes at a temperature of up to 45° C., an analytical method using said pyruvate oxidase, and an analytical...
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4962025 |
Reagent alcohol test strip device
A new method and apparatus for detection and analysis of substrates in a sample is described. The apparatus consists of a rigid or semi-rigid strip having a reaction site, a sample collector or...
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4962024 |
Signal enhancement in assay for an enzyme
A method for assay for an unknown enzyme suspected to be present in a liquid includes signal amplification by use of a second enzyme and a blocked modulator for the second enzyme. Unknown enzyme in...
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4960693 |
System of reactants involving an apo-enzyme useful in immunological analysis and a method for carrying out immuoassays with this system
A quick and simple immunoassay technique applicable to the determination of large molecules like proteins, polynucleotides and others involves labelling competitive immunospecies with an enzyme as...
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4956290 |
Large scale process for the purification of alcohol oxidase
A process for the purification of alcohol oxidase from whole cells of Pichia pastoris grown on methanol by the sequential steps of autolysis, crossflow filtration, ultrafiltration and...
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4956275 |
Migratory detection immunoassay
Novel methods and devices are provided for detecting analytes, where the sample is placed upstream from a reagent which is a component of a signal-producing system. The detection zone is provided...
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4954435 |
Indirect colorimetric detection of an analyte in a sample using ratio of light signals
The method of the present invention employs an enzyme immunoassay for measuring the concentration of an analyte in a sample by indirect colorimetric detection. An incident light beam at a plurality...
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4950609 |
Stabilized sarcosine oxidase preparation
The present invention provides a stabilized sarcosine oxidase preparation which contains creatineamidinohydrolase covalently bound to a water-soluble polysaccharide.
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4945045 |
Electrochemical methods of assay
A ligand in a sample can be assayed using electrochemical apparatus containing a working electrode and components comprising: (a) the sample, (b) a specific binding partner to the ligand, or...
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4940659 |
Screening extra-cellular body fluids for superoxide dismutase (SOD-1) for determining fetal trisomy 21 down syndrome
Disclosed is a screening assay for determining the amount of Superoxide Dismutase (SOD-1) in extra-cellular body fluids, for use in determining Trisomy 21 Down syndrome in a fetus. The assay can be...
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4940660 |
Color developing method in clinical examinations
A process for the determination of peroxidase activity or hydrogen peroxide in a clinical sample colorometrically by adding to the sample a reduced form coenzyme, a reagent selected from amines,...
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4939085 |
Oxidized coenzyme-containing dry analytical element
A dry analytical element having functional layers which contain dehydrogenase, oxidized nicotinamide coenzyme, pyruvate, an electron transport compound and an electron acceptable dye-forming...
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4937186 |
Method for the determination of bilirubin in solution
A novel analytical method for bilirubin in biological fluids. Bilirubin is catalytically oxidized to biliverdin in the presence of bilirubin oxidase (BOX) and the latter is revertedly...
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4937047 |
Analytical element
An analytical element for analyzing a specific component in a liquid sample, comprising a light-transmissive and liquid-impermeable support having thereon successively a first reagent layer and a...
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4931387 |
Analysis implement having an oxygen supplying layer
Disclosed is an analysis implement including a support and a reagent layer containing an oxidase applied to the support such that one surface of the reagent layer is exposed to an air atmosphere. A...
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4927767 |
Method for the detection of diseases associated with the metabolic abnormality of L-fucose
A method is provided for the detection of a disease associated with the metabolic abnormality of L-fucose in a subject. The concentration of free L-fucose in a specimen from the subject is...
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4921786 |
Novel NAD synthetase, assay method using said novel NAD synthetase and a process for production thereof
A novel NAD synthetase is produced by culturing a broth of Bacillus stearothermophilus H-804 FERM BP-1408. This new enzyme selectively catalyzes the reaction ##STR1## without catalyzing the...
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4916058 |
Method and test composition for determination of hydrogen peroxide
Disclosed is a method for the colorimetric determination of hydrogen peroxide in a sample by reacting a particular chromogen with the hydrogen perioxide in the presence of peroxidase and measuring...
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4914020 |
Multi-layer analytical element with preserved enzyme containing spreading layer
An analytical element to measure a specific component in a fluid samples comprising support, a layer containing a reagent provided the support and a spreading layer provided on above the reagent...
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4912041 |
Determination of amylase
A method of assay for the presence of α-amylase in a sample employs a derivatized α-oligosaccharide which can be hydrolyzed by an enzyme mix including α-amylase to yield an electroactive...
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4912035 |
Method for minimizing interference by reductants when detecting cells in biological fluids
A method for the determination of cells in a sample is disclosed. The sample is typically urine and the method is useful in removing interfering reductants from the sample. The method comprises the...
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4910134 |
Ascorbic acid decomposing method
A method for decomposing ascorbic acid in a sample is descirbed wherein in the method water and dehydroascorbic acid are produced without generation of hydrogen peroxide characterized in that the...
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4910133 |
Diagnostic test drug comprising monoclonal antibody to human copper.zinc-superoxide dismutase and diagnostic test method using the same
There is disclosed a measurement reagent for a human Cu.Zn-superoxide dismutase (SOD) which comprises an anti-human Cu.Zn-SOD monoclonal antibody labelled with an enzyme, a method for measuring a...
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4906563 |
Detection of skatole for meat quality
A method for detecting boar taint in a pig sample is provided. Anti-skatole antibodies are combined in a reaction buffer with a pig sample to form a reaction mixture. After incubating, the amount...
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4900658 |
Chromophoric peptides for detecting peptidylglycine-α-amidizing monooxygenase
A chromophoric peptide is prepared of the formula DIS--D--Ala-Pro-R and salts thereof in which R represents Gly-OH, NH 2 or Gly-R 2 wherein R 2 denotes a carboxyl protective group, and DIS...
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4900666 |
Colorimetric ethanol analysis method and test device
A disposable test strip device for detecting and measuring ethanol in aqueous solutions is disclosed. The test strip includes an inert support pad that contains a stabilized dry form of the enzyme...
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4897347 |
Multilayer analysis film for analyzing transaminase
A multilayer analysis film for assaying transaminase in a coupled reaction system by a kinetic method comprises (1) a porous layer containing a transaminase substrate, (2) a coloring indicator...
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4897346 |
Stabilized liquid enzyme composition for glucose determination
A homogeneous liquid enzyme reagent for the quantitative determination of glucose comprises the enzymes hexokinase and glucose-6-phosphate dehydrogenase in a solution of glycerol (30% v/v) in...
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4895799 |
Process and reagent for the determination of total bilirubin
The present invention provides a process for the determination of total bilirubin in samples of body fluids. The method comprises the incubation of a sample of body fluid with both subtilisin which...
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4892815 |
Process and reagent for the specific determination of the cholesterol of the HDL fraction
The present invention provides a process for the specific determination of the cholesterol of the HDL fraction in the presence of the LDL fraction of serum lipoproteins. Pancreatic cholesterol...
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4892816 |
Method for the determination of cholesterol
An enzymatic method for measurement of cholesterol comprises incubating: (a) a test sample; (b) a cholesterol dehydrogenase; (c) an oxidizing agent selected from the group consisting of...
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4889801 |
3α-hydroxysteroid oxidase and quantitative analysis of 3α-hydroxysteroid making use of same
Disclosed herein is a 3α-hydroxysteroid oxidase which oxidizes a 3α-hydroxysteroid into a 3-oxosteroid and hydrogen peroxide. The oxidase may preferably be obtained from a culture broth of...
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4886740 |
Enzyme-electrode sensor with organosilane treated membrane
A membrane for an enzyme-electrode type sensor treated to increase the range of linearity of the sensor response.
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4883579 |
Photoresponsive redox detection and discrimination
Devices and methods are provided for making a plurality of determinations of the local (site-specific) redox state of a liquid system, by employing a photoresponsive element, which can be...
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4877727 |
Substrate for determining leucine aminopeptidase or gamma-glutamyltranspeptase activity
Leucine aminopeptidase (LAP) activity or γ-glutamyltranspeptidase (γ-GTP) activity in a sample is determined by converting a substrate represented by the formula (I): ##STR1## wherein Z...
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4873187 |
Bifunctional DNA-protein conjugating agent
A cationic detergent having a positively charged group and a hydrophobic group is used to conjugate an enzymatically active enzyme molecule with a single-stranded nucleic acid molecule. The...
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4865972 |
Antibody-based bioassay for enzyme-inducing chemicals
An antibody-based bioassay for enzyme-inducing chemicals is disclosed. The percent induction of an enzyme or class of related enzymes in living cells by an enzyme-inducing chemical in a sample is...
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4861709 |
Detection and/or identification of microorganisms in a test sample using bioluminescence or other exogenous genetically-introduced marker
A method for determining the presence of microorganisms in a tests sample. Exogenous DNA containing a luminescent system or other genetic marker system derived from a suitable donor source is...
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4857457 |
Screening test for large intestinal cancer
The disaccharide β-D-Gal (1->>3)-D-GalNAc, which specifically binds with peanut agglutinin (PNA) or oxidized by galactose oxidase, has been discovered in the colorectal mucus of patients...
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4857455 |
Method for the determination of peroxidase using fluorogenic substrates
Novel fluorogenic peroxidase substrates are provided employing novel water soluble activated capped aromatic fluorescent compounds for use as peroxidase substrates. The novel compounds can be used...
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4855228 |
Multiple oxidative indicator system for visual determination of hydrogen peroxide
The invention involves visual determination of hydrogen peroxide with a multiple oxidative indicator system capable of generating different hues at different concentrations of hydrogen peroxide or...
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4853328 |
Reagent for assaying hydrogen peroxide and method of quantitative assay for hydrogen peroxide
A reagent suitable for assaying a very small amount of hydrogen peroxide is composed of a moiety having a residue formed by removing one hydrogen from an active methylene group or an active methine...
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4849342 |
Method for carrying out enzyme assays
Peroxidatively active enzyme assays have a variety of clinical and industrial applications. Such assays are based on color development resulting from the addition of the appropriate substrate to...
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4849346 |
Method for determining thioredoxin reductase activity
The present invention provides a method for measuring the activity of thioredoxin reductase in mammalian cells by contacting the cells in vivo or in vitro with a quaternary ammonium salt...
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4845029 |
Method for the determination of sarcosine creatine or creatinine
The present invention provides a method of use for a hydrogen peroxide-forming oxidase, wherein the enzyme is obtained from Streptomycetaceae and at 25° C., in 0.15 mol/liter potassium phosphate...
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