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5114350 |
Controlled-volume assay apparatus
Method and apparatus for use in determining the concentration of a selected analyte in a body-fluid sample. As the fluid sample is applied to a wettable, absorbent reaction pad, the extent of...
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5112741 |
Acetaldehyde trapping system
The invention provides a reagent system for the enzymatic determination of an oxidizable substrate in a fluid sample; the system includes an active amine trap for inactivating high concentrations...
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5110724 |
Multi-analyte assay device
An assay device for assaying multiple analytes in a drop-size blood sample. The device includes a sample dispenser designed to distribute a small-volume blood sample to multiple transfer sites, by...
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5108903 |
Reducible compounds which provide leuco dyes for analytical compositions, elements and methods of using same
Certain reducible compounds are useful in analytical compositions, elements and methods, for example for the detection of bacterial cells. These compounds comprise a moiety which provides a leuco...
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5108893 |
Use of oxidase enzyme systems in chemiluminescent assays
A xanthine oxidase enzyme system to provide long lived entities capable of being recognized by a chemiluminescent reagent is disclosed. In the examples provided, a specific binding pair ligand or...
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5104794 |
Quantitative determination of bilirubin and a reagent therefor
Disclosed is a process for measuring an amount of all bilirubins in a specimen, comprising deconjugating conjugated bilirubins with a reagent comprising an enzyme capable of deconjugation to form...
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5100779 |
Method for determining function of a unique cytochrome P-450 activity
A method for determining the function of a unique cytochrome activity of the type which uniquely catalyses the N-demethylation of erythromycin in a patient's body, the method including the steps of...
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5096813 |
Visual indicator system
Packages which are subject to tampering while in a store or deterioration over time due to the presence of oxygen may be readily identified by placing therein a multi-component visual indicator...
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5094943 |
Process and reagent for the improved quantitative colorimetic determination of hydrogen peroxide
The present invention provides a process for the improved colorimetric determination of hydrogen peroxide as formed by a hydrogen peroxide-producing oxidase, by addition of a chromogenic system and...
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5093239 |
Reagents for detecting oxidase positive microorganisms
Compounds and reagents containing the compounds are disclosed for detecting oxidase positive organisms. The compounds have the structure COUP--LINK) n R wherein COUP-- represents a radical...
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5093238 |
Chemiluminescent assay for the determination of density of activity of viable cells
A chemiluminescent assay for the determination of density or activity of viable cells which comprises incubating viable cells in the presence of a quinone whose reduced form redcues dissolved...
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5093236 |
Microbiological oil prospecting
This invention provides methods and systems for prospecting for subterranean oil and gas deposits by detecting the presence of hydrocarbon-consuming microorganisms in soil samples taken from a...
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5085989 |
Method and reagent for quantitative analysis of 3-oxo-5β-steroid
A quantitative analysis of 3-oxo-5β-steroid is carried out by acting 3-oxo-5β-steroidΔ 4 -dehydrogenase on a sample in the presence of a reducing chromophoric agent, and measuring the optical...
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5084381 |
Assay method for detecting hydrogen peroxide
An improved method of chemiluminescence assay for hydrogen peroxide wherein a peroxidase of microorganism origin is used in place of horseradish peroxidase. This allows an assay of unexpectedly...
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5082770 |
Method for quantitative determination of polyamines
A method for the quantitative determination of polyamines, which comprises allowing a polyamine oxidizing enzyme, an ω-aminoalkylaldehyde dehydrogenase, an oxidized nicotinamide coenzyme and, as...
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5081016 |
Method for measuring the amount of polyamines in a biological sample
A method for measuring the amount of polyamines in a biological sample is provided. The method comprises utilizing diamine oxidase and/or polyamine oxidase, aminoalkylaldehyde dehydrogenase and NAD...
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5079140 |
Agent for reducing ascorbic acid interference in liquid or dry phase assay systems and method relating thereto
The present invention is directed to the elimination of ascorbic acid interference in assay systems, particularly assay systems based upon oxidase-peroxidase coupled reactions. When ascorbic acid...
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5077199 |
Ready to use liquid reagent for determining the glucose content in blood
Stable and ready to use liquid reagent for determining the glucose content in blood, comprising a glucose-oxidase free from catalase and a nonionic surface-active agent, such as, for example, the...
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5066372 |
Unitary multiple electrode sensor
A unitary multiple electrode sensor for detecting analytes in test samples and devices for using them. The unitary multiple electrode sensor includes a sensor support member and at least one...
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5059526 |
Dry multilayer analytical element for analysis of enzymes or triglycerides
A stable dry multi-layer analytical element for enzyme or triglyceride analysis in a fluid sample is prepared containing first and second layers on a support. The first layer contains a tetrazolium...
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5055388 |
Process and reagent composition for determination of fructosamine in body fluids
A process for the determination of fructosamine in body fluids by the reaction of a sample solution with a color reagent, wherein the sample liquid is mixed with a buffer solution having a pH value...
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5055398 |
Process for measuring the concentration of a component in body fluid such as urine or blood
A process for determining the concentration of a component, such as glucose, uric acid or polyamine, in a body fluid, such as urine, blood, blood serum, blood plasma, saliva or gastric juice,...
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5047329 |
Method for the measurement of creatine or creatinine and reagents for these measurements
A method for measuring creatine in a sample by the use of creatine amidinohydrolase which comprises decomposing the N-ethylglycine present in the sample enzymatically and thereafter reacting...
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5037739 |
N-acetylmannosamine dehydrogenase, process for its production, method for quantitatively analyzing N-acetylmannosamine or sialic acid, and kit for the quantitative analysis
N-Acetylmannosamine dehydrogenase which takes off hydrogen from N-acetylmannosamine to convert it into N-acetylmannosaminolactone and, at the same time, reduces coenzyme NAD into NADH. This enzyme...
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5037738 |
Simultaneous assay for glucose and urea
A method for the simultaneous determination of glucose and urea in a specimen with a single reagent system. A reagent system containing a reactant for each of glucose and urea to be determined is...
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5036000 |
Threshold color control system
A system for quantitative colorimetric analysis of biological fluids or organic compounds, including NAD(P)H, or a substrate of an enzyme which reacts with the formation or consumption of NAD(P)H....
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5032506 |
Color control system
An assay system useful for the determination of NAD(P)H, NAD(P), or a substrate of an enzyme which reacts with the formation or comsumption of NAD(P)H. Concentrations of organic substrates for...
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5024936 |
Assessing fetal lung maturity
A method for assessing whether the lungs of a fetus are mature comprising obtaining a sample of the amniotic fluid surrounding the fetus and determining the presence or absence of phosphatidyl...
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5023181 |
Process for preparing a calcium-dependent oxygenase
A process for preparing a Ca-dependent oxygenase having a continuously photogenic performance for a long time when it is continuously added to a substrate such as coelenterazine, which process...
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H000930 |
Dry-type glucose analyzing element
A dry-type quantitative glucose-analyzing element comprising a water-impermeable light-transmissive support having thereon a group of water-permeable layers comprising a reagent layer, an...
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5019505 |
Enzymes having alpha-glycerol-3-phosphate oxidase activity, production and use thereof
An enzyme having α-glycerol-3-phosphate oxidase activity characterized in that it has a Km of less than 2.5 mM is disclosed, as is the production and use thereof. More particularly, such enzymes...
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5017475 |
Fluorescent detection method based on enzyme activated conversion of a fluorophore precursor substrate
Methods are provided for the fluorescent detection of an analyte of interest wherein an amine-substituted, ortho-fused pyrazine fluorophore, with neither nitrogen of the pyrazine ring being fused...
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5013647 |
Removal of interfering reducing substances with tetrazolium salts in redox measurement reactions
A process for the determination of substrate or enzyme activities by the use of a redox reaction as a measurement reaction is carried out in the presence of one or more additionally added...
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5013648 |
Enzymatic detection of monovalent anions
An enzymatic reagent, kit and method for determining the concentration of monovalent anions, especially chloride, particularly in clinical samples, and especially in a single-reagent format...
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5009994 |
Particles containing mannitol suitable for tabletting into diagnostic reagents
A completely water-soluble, solid, labile biochemical-containing diagnostic reagent is prepared without the need of a lyophilization step, by spraying, preferably by a fluidized bed process, an...
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5006458 |
Analytical element having a polyacrylamide or derivative to minimize background for assaying enzyme activity
A dry-type analytical element suitable for measuring enzyme activity of in a liquid sample, characterized by incorporating a polyacrylamide, polymethacrylamide or their derivatives into at least...
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5004685 |
Dry-type multilayer analytical element
A dry-type multilayer analytical element containing a color reagent composition comprising an oxidase specifically reaction with an analyte or derived therefrom to produce hydrogen peroxide,...
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5002893 |
Single color reading method for determining fructosamine
A single color determination method of quantization of the amount of fructosamine in a sample such as serum by removing other interfering reducing agents and developing a color with a coloring...
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5001054 |
Method for monitoring glucose
A method for monitoring the glucose level in a body fluid uses an apparatus which includes a conjugate of glucose oxidase and a fluorescent dye coated onto an optical fiber in contact with the body...
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4999287 |
Direct measuring assay strip and method of use thereof
Methods and compositions are provided for measuring an analyte without instrumentation. The device employs a stripstick which may include as its components, a discontinuous flow path, which is made...
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4999286 |
Sulfate reducing bacteria determination and control
Sulfate reducing bacteria are detected by preparing a lysate so as to release an enzyme essential to derive energy by reduction of sulfate such as adenosine 5'-phosphosulfate reductase (APS...
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4994377 |
Method for assaying 1,5-anhydroglucitol and kit therefor
This invention relates to a novel method for assaying 1,5-anhydroglucitol, which is expected to serve as a marker for diabetes, and a kit therefor. More particularly, it relates to: (1) a method...
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4985360 |
Novel bilirubin oxidase which has a substrate specifity to bilirubin, but not to biliverdin, catechol and hemin
A novel bilirubin oxidase is provided having a substrate specificity for bilirubin but not to, at least, biliverdin, catechol and hemin and which catalyzes the enzyme reaction between two moles of...
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4983514 |
Method for detecting the antiaggregatory effect of vasoactive substances, specifically of inhibitors of phosphodiesterase and/or cyclooxygenase
The antiaggregatory effect of phosphodiesterase inhibitors (A) and/or of cyclooxygenase inhibitors (B) is detected outside the human or animal body by sampling blood, addition of (A) and/or...
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4983510 |
Enzymes immobilized on latex polymer particles for use with an amino acid electrosensor
Enzymes such as L-methionine gamma lyase, L-lysine decarboxylase, L-aspartase and L-tryptophanase are immobilized by contacting with a latex of polymer particles having a negative surface charge...
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4983513 |
Sulfhydryl compounds for suppressing the inhibitory effects of NAD degradation products on LD-L activity
A liquid coenzyme reagent comprises the coenzyme nicotinamide adenine dinucleotide (NAD), or nicotinamide adenine dinucleotide phosphate (NADP), and a sulfhydryl compound capable of counteracting...
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4981779 |
Apparatus for monitoring glucose
A method for monitoring the glucose level in a body fluid uses an apparatus which includes a conjugate of glucose oxidase with a fluorescent dye coated onto an optical fiber in contact with the...
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4978612 |
Analytical element for determination of hydrogen peroxide and analytical method using the same
Disclosed is an analytical element for determination of hydrogen peroxide, which comprises using an analytical element containing a substance having the action of peroxidation, a compound...
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4978610 |
Method of assay employing a magnetic electrode
In its broadest aspect, the present invention provides a method of effecting an electrochemical specific-binding assay of a ligand, either qualitatively or quantitatively, in an apparatus...
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4978615 |
Method for the determination of the compound having mercapto group
The present invention provides a method for the determination of a compound having mercapto group which comprises reacting the compound with a chromogen represented by the following general formula...
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