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6054311 |
Recovering cryopreserved cells using gassed polyfluorinated compounds
After the cryopreservation of living cells, the cells in a post-thaw recovery stage are supported by a gas permeable medium. This medium comprises at least one polyfluorinated compound. This...
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6054298 |
Fringe proteins and pattern formation
Isolated DNA encoding a protein or polypeptide having at least one biological activity of a vertebrate fringe protein, as well as the protein or polypeptide encoded thereby, are described. Assays...
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6048713 |
Pseudomonas fluorescens
A novel Pseudomonas fluorescens is disclosed which has an antagonist property against pathogenic fungi of the genera Pythium, Rhizoctonia, Sclerotinia and Gaeumannomyces and which has a DNA that...
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6043088 |
Prostate/colon tumor suppressor gene located on human chromosome 8
This invention provides a novel nucleic acid molecule encoding a prostate/colon tumor suppressor gene product. The means and methods for detecting mutations and/or loss of prostate/colon tumor...
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6033897 |
Phytase-producing bacteria
This invention relates to the isolation of thermophilic phytase-producing microorganisms, method for producing phytase using such microorganisms, phytase obtained therefrom, and usage of the...
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6030625 |
Bordetella pertussis and Bordetella parapertussis strains
An immunogenic composition, characterized in that it comprises an adenyl cyclase-hemolysin (Ac-Hly) protein, or an immunogenic portion of this AC-Hly, of a strain of Bordetella chosen from B....
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6030609 |
Method and composition for treating paramyxovirus
The present invention relates to a method of treating respiratory syncytial virus (RSV) through the exogenous administration of recombinant or natural interferon-beta (IFN-β) to lung epithelial...
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6030811 |
Polynucleotides encoding a human mystrophin clone, HSABH01
A human cDNA encoding human myotrophin and the polypeptide encoded thereby and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for...
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6027909 |
Bacillus strain and sporulation assay method
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6027888 |
Methods for producing soluble, biologically-active disulfide-bond containing eukaryotic proteins in bacterial cells
Disclosed are methods of producing eukaryotic disulfide bond-containing polypeptides in bacterial hosts, and compositions resulting therefrom. Co-expression of a eukaryotic foldase and a disulfide...
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6022728 |
Method for producing a bacterial vaccine and novel vaccines produced thereby
A new method for the preparation of a whole cell bacterial vaccine for improved protection against bacterial pathogens, particularly against those pathogens which have multiple antigenic serotypes...
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6022709 |
Nucleic acid encoding an altered telomere repeat binding factor
The present invention provides an isolated altered vertebrate telomere repeat binding factor (A-TRF) that hinders the binding of a TRF to its specific telomere repeat sequence. Also included are...
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6022711 |
Human growth hormone variants having enhanced affinity for human growth hormone receptor at site 1
Growth hormone participates in the regulation of normal growth and development processes. The binding affinity of growth hormone for its target receptors is dependent upon the interaction of site 1...
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6022741 |
Regulatory genetic DNA that regulates the Class II transactivator (CIITA)
Novel DNAs that regulate expression of the Class II Transactivator (CIITA) gene are disclosed. Recombinant DNA comprising CIITA regulatory elements operably associated with a heterologous DNA are...
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6022828 |
Xanthomonas campestris as biological control of Poa trivialis
A method for controlling Poa trivialis using a bacterium which is a Xanthomonas campestris pathovar which produces a wilt in the weed grass is described. In particular, the use of a Xanthomonas...
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6022727 |
Method for forming reversible colloidal gas or liquid aphrons and compositions produced
A method for forming gas or liquid aphrons with reversible surfactants or emulsifiers is described. Polymers which change their emulsifying properties upon change of pH, temperature or other...
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6020194 |
DNA encoding a Myt1 polypeptide
The present invention provides a threonine/tyrosine kinase, Myt1, that phosphorylates the cyclin-dependent kinase, Cdc2, to provide regulation of the cell cycle at the G2/M interphase. Also...
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6020160 |
RsbV-1 polynucleotides of Staphylococcus aureus
RsbV-1 polypeptides and DNA (RNA) encoding such RsbV-1 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such RsbV-1...
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6019984 |
Bacterial preparations, method for producing same, and their use as vaccines
Novel bacterial preparations containing one or more isolated and purified strain of a microorganism which produces one or more RTX toxins, and which strain has at least one RTX toxin which is...
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6017748 |
Cloning host organisms
Methods and materials for the cloning of DNA, in particular, for the cloning of "unclonable" DNA using genetically engineered host cells. Host cell organisms have been discovered that stabilize and...
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6017758 |
DMNPE caged nucleic acid and vector
The present invention provides an isolated nucleic acid covalently linked to a photolabile caging group which reversibly prevents expression of the nucleic acid. The present invention further...
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6013468 |
RNA component of telomerase
Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents.
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6010896 |
Lyophilized ionizing radiation sterilized microorganisms as an additive for nutrient media for growing bacteria
A media additive for the promotion of the growth of anaerobic and aerobic bacteria is presented. The additive comprises lyophilized microorganisms exposed to ionizing radiation. The microorganisms...
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6011146 |
Altered major histocompatibility complex (MHC) determinant and methods of using the determinant
An altered MHC class I determinant comprises α 1 , α 2 , α 3 , β 2 -microglobulin (β 2 m) polypeptide domains encoded by a mammalian MHC class I locus in which the α 3 domain is covalently...
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6008010 |
Method and apparatus for holding cells
The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled closed environment in which the cells are...
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6008040 |
Procedures for efficient separation of cells, cellular materials and proteins
A process and device are provided for achieving cascade flow to achieve rapid separations of target components from fluid mixtures is provided. The devices of the invention have a cascading flow...
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6004805 |
Transcriptional enhancer from milk protein genes
The invention relates to novel enhancer nucleotide sequences which stimulate transcription of heterologous DNA in cells in culture. The enhancers are derived from major milk protein genes by the...
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6001585 |
Micro hollow fiber bioreactor
A "micro" hollow fiber bioreactor and method of use are provided for use in screening different cell lines and process conditions. The bioreactor includes the use of an oxygen permeable (e.g.,...
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5997881 |
Method of making non-pyrogenic lipopolysaccharide or A
The present invention provides gram-negative bacterial strains that produce substantially pure non-pyrogenic lipopolysaccharide or lipid A. The present invention also relates to a use of said...
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5998170 |
Polynucleotides encoding hepatocyte-specific members of the FGF family
Nucleic acid molecules are described which are useful in vectors, transformed or transfected host cells, and methods for the recombinant expression of hepatocyte growth-specific polypeptide members...
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5989862 |
Tab1 protein and DNA coding therefor
TAB1 protein having activity which activates factor TAK1 in the TGF-β signaling pathway, and having the amino acid sequence shown in FIG. 1.
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5989848 |
Use of human immortalized endothelial cells to isolate and propagate Ehrlichia chaffeensis and Ehrlichia canis
This invention provides a purified immortalized human endothelial cell infected with Ehrlichia chaffeensis or Ehrlichia canis. Also provided is a method of simultaneously screening a sample from a...
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5985620 |
TNF-α Ribozymes
This invention describes compounds active against TNF-α mRNA. It further describes RNA molecules capable of conferring stability to RNA in vivo through an endogenous ribozyme binding protein(s)....
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5985286 |
Bordetella strains
The invention relates to an immunogenic composition, characterized in that it comprises an adenyl cyclase-hemolysin (AC-Hly) protein, or an immunogenic portion of this AC-Hly, of a strain of...
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5981260 |
Process for the production of cell mass and/or fermentation products under sterile conditions
Process for the production of cell mass and/or fermentation products under sterile conditions, during which the fermentation mixture, at least at times, is recycled and the metabolic products of...
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5981274 |
Recombinant hepatitis virus vectors
The present invention relates to recombinant hepatitis viral vectors useful for the expression of functional heterologous gene products in liver cells. It is contemplated that these vectors will...
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5976833 |
Method for animal cell culture
The object of the present invention is to provide a method for improving productivity in the production of useful substances by animal cells. The present invention discloses a method for animal...
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5972643 |
Isolated polynucleotide molecules encoding CTCF, a CCCTC-binding factor
Polynucleotide molecules encoding CTCF are isolated and purified and sequenced. The CTCF proteins and antibodies thereto can be used to identify mutant CTCFs in methods of diagnosis.
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5968807 |
Culture media containing glycerol that are pH and color stable when heat sterilized
A heat stable culture medium is prepared by substituting glycerol for carbohydrate components such as dextrose that are prone to Maillard reactions. A preferred medium contains pancreatic digest of...
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5968525 |
Inactivated Mycolplasma hyopneumoniae and uses therefor
The invention relates to a method for making an inactivated vaccine of Mycoplasma hyopneumoniae by inactivating the bacteria with Thimerosal. The resulting bacterin is mixed with an adjuvant of...
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5968771 |
Global ischemia induced gene
The nucleotide sequence is provided for a novel death regulatory gene. In particular the present invention relates to a DNA segment encoding a giig15b gene; polypeptides encoded by that DNA...
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5968738 |
Two-reporter FACS analysis of mammalian cells using green fluorescent proteins
Two spectrally distinguishable GFPs are used as reporters in mammalian cells to simultaneously and independently analyze the expressions of two transcriptional elements. The two GFPs, encoded by...
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5965396 |
Human lymph node derived GTPase
A novel human GTPase polypeptide intracellular molecular switch is described. A full length cDNA which encodes the signal transduction polypeptide is disclosed as well as the interior structural...
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5965422 |
Lysophospholipase produced from aspergillus by recombinant methods
This invention relates to a recombinant deoxyribonucleic acid (DNA) isolatable from Aspergillus, preferably Aspergillus foetidus, wherein it codes for a lysophospholipase (LPL) and has the...
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5962267 |
Proinsulin derivative and process for producing human insulin
A process for preparing human insulin, which comprises the steps of: preparing a DNA encoding a human proinsulin derivative having the following formula (I); inserting the DNA into a vector to...
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5962314 |
Calcium receptor-active molecules
The present invention relates to the different roles inorganic ion receptors have in cellular and body processes. The present invention features: (1) molecules which can modulate one or more...
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5958754 |
Secretion of insulin-like growth factor-I in E. coli
A method for bacterially producing IGF-I is disclosed in which Gram-negative bacteria are caused to express a gene consisting of a lamB or ompF signal sequence operatively joined to a DNA sequence...
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5958735 |
Polynucleotides encoding urogenital sinus derived growth inhibitory factor and vectors
Urogenital sinus derived growth inhibitory factor is a protein having growth-inhibitory and antiprotease properties. The present invention relates to amino acid and nucleotide sequences for...
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5958414 |
Composition to protect a mammal against Bartonella henselae infection
The present invention relates to a therapeutic composition to protect a mammal from B. henselae infection that includes an isolated B. henselae antigen and an adjuvant comprising a phosphazene...
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5958697 |
Isolated nucleic acids encoding CYP7 promoter-binding factors
The invention provides methods and compositions relating to CPF proteins which regulate transcriptional activation, and related nucleic acids. The polypeptides may be produced recombinantly from...
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